Digital Commons Network^™

Early Math Readiness And Later Achievement: A Longitudinal Study, Bailey Bontrager

Theses and Dissertations

The current body of literature provides much evidence that mathematics skills at the start of kindergarten are predictive of later mathematics achievement, and that students enrolled in early childhood education (ECE) programs are better prepared for mathematics at the start of kindergarten. However, the potential for children to develop mathematical skills prior to entering kindergarten relies on access to ECE programs and resources in families’ surrounding communities. Recent use of geospatial data collection techniques and measures of community resource availability have enabled researchers to examine specific localities for the ways in which community organizations and institutions support residents in particular …

Comparison Of Artificial Intelligence Vs Human Observer For Periapical Radiolucency Detection, Adam J. Pink

Theses and Dissertations

Objective: The aim of this study was to assess the performance of an Artificial Intelligence (AI) program (OverJet AI) with that of experienced endodontic residents, endodontists, a radiologist, and dental students in detecting periapical radiolucencies using radiographic images.

Methods: One hundred and fifty periapical radiographic images were analyzed using the OverJet AI software to determine the presence/absence of a periapical radiolucency as well as the size (small 1-3mm, medium 4-6mm, and large 6+mm). The unaltered images were also evaluated by two endodontic residents, two practicing endodontists, an oral radiologist and two 4th year dental students.

Results: Agreement between the AI …

Nanomagnet Based Reservoir Computing And Quantum Control, Fahim F. Chowdhury

Theses and Dissertations

Conventional CMOS scaling has driven remarkable advances in computing but faces increasing physical and energy constraints, motivating alternative computing paradigms that integrate memory and computation while improving energy efficiency. Nanoscale magnetic systems offer a promising platform for such approaches because their intrinsic nonlinear dynamics and localized magnetic fields can support both classical and quantum information processing. This thesis investigates nanomagnetic systems for physical reservoir computing and, with primary emphasis, for localized quantum control of spin qubits.

The first part explores dipole-coupled nanomagnet arrays as physical reservoirs. Micromagnetic simulations demonstrate nonlinear dynamical behavior with high short-term memory and parity-check capacity, enabling …

Integration Of Whole Genome Sequence And Rna-Sequencing Data For Disease-Specific Phenotype Prediction, Leiliani M. Clark

Theses and Dissertations

Breast cancer is a heterogeneous disease driven by complex genomic and transcriptomic alterations, making accurate phenotype prediction a challenging task. Recent advances in genomic foundation models and representation learning provide new opportunities to extract biologically meaningful features directly from sequencing data. The objective of this study was to develop and evaluate a multimodal framework integrating whole genome sequence (WGS) and RNA sequencing (RNA-Seq) embeddings for breast cancer classification. DNABERT-2, a DNA foundation model, was evaluated for its ability to generate genomic representations from The Cancer Genome Atlas breast cancer (TCGA-BRCA) WGS data, and the impact of downstream fine-tuning on embedding …

Local Lung Delivery Of Ginkgetin For Therapeutic Intervention In Lung Fibrosis, Cimone L. Richardson

Theses and Dissertations

Lung fibrosis (LF) is a progressive, irreversible pathological condition in the lungs that is ultimately fatal. Current drug treatments (nintedanib, pirfenidone, and nerandomilast) slow disease progression but cause significant systemic adverse effects due to oral administration. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, may play a role in LF progression and represent a novel anti-LF target. Ginkgetin (GKT), a natural biflavonoid, is a potent TRPV4 inhibitor with anti-inflammatory and antioxidative properties. Local lung delivery could achieve high local lung concentrations while minimizing systemic exposure. Accordingly, this project evaluates GKT's therapeutic intervention efficacy in LF via local lung …

Discrete Cell Signaling Differences Cause Female-Dominant Il-33 Responses In Mast Cells, Tania D. Maldonado

Theses and Dissertations

Many allergic diseases are more common and severe in women than in men. A key component of allergic inflammation is IL-33, a cytokine released by epithelial cells after allergen exposure. Because mast cells are a central early responder in allergic disease and are activated by IL-33, we investigated sex differences in mast cell responses to IL-33. We first found that male mast cells expanded poorly in standard RPMI-based culture media containing phenol red, which has estrogenic properties. Male cells also responded poorly to IL-33 when cultured with in media containing phenol red. In contrast, female mast cells expanded 3-fold less …

Climate, Biogeography, And Dispersal: A Unifying Framework For Ameri-Caribbean Dry Forests, Pablo Lopez Bustamante

Theses and Dissertations

Seed dispersal is a crucial ecological function that enables plants to alter their distributional range, avoid intense competition and natural enemies near the parent plant, and recover from disturbances. These processes shape species and functional composition of forests. Wind has traditionally been considered the dominant dispersal mechanism in Ameri-Caribbean dry forests, yet growing evidence suggests that other dispersal mechanisms also play significant roles in this ecosystem, responding differently to biotic and abiotic conditions. Still, how dispersal syndrome composition influences plant communities, the ecological drivers underlying these patterns, and the effects of climate change on dispersal syndrome dominance remain poorly understood. …

Sex In Plants: Birth, Death, And Trying To Survive In Changing Climates, Elena M. Meyer

Theses and Dissertations

Plant mating systems are key determinants of fitness. Angiosperms exhibit a wide variety of reproductive strategies, including self-fertilization (or selfing), outcrossing, and mixed mating. It has been estimated that up to 43% of plant species are capable of selfing, and selfing has been hypothesized to provide reproductive assurance where opportunities for mating may be limited, such as in marginal environments. However, questions regarding the overall distribution of selfing rates across angiosperms, the maintenance of mixed mating in the face of inbreeding depression, and the impact of self-fertilization on diversification rates remain incompletely resolved. Here, we explore the dynamics of self-fertilization …

Empirical Dynamical Modeling Of Cortico-Hippocampal Information Transfer During Memory Encoding, Sam Y. Cole

Theses and Dissertations

Understanding how brain dynamics support successful memory formation remains a central challenge in neuroscience. This dissertation applies tools from empirical dynamical systems theory to investigate the neural mechanisms underlying episodic encoding, with a focus on cortico-hippocampal interactions. Using stereoelectroencephalography (sEEG) data recorded during a delayed free recall of word lists task, this work reveals nonlinear, state-dependent shifts in directed information flow between cortex and hippocampus that distinguish successful from unsuccessful encoding. To further characterize these dynamics, state-space trajectories are reconstructed using time-delay embedding and recurrence-based methods, and features derived from these trajectories are used to classify memory outcomes. By integrating …

Machine Learning Modeling Of In-Situ Effective Thermal Conductivities And Ablation Behaviors Of Ceramic Matrix Composites Under Hydrogen Combustion Environments For Gas Turbine Engines, Jayanta Bhusan Deb

Graduate Studies Theses and Dissertations 2026

Through the integration of experimental characterization, machine learning, deep learning, numerical modeling, and physics-informed artificial intelligence, this dissertation explores the thermal performance of polymer-derived ceramic matrix composites (CMCs) for hydrogen combustion environments. The polymer infiltration and pyrolysis (PIP) process was used to create Yttria-stabilized zirconia (YSZ)-fiber-reinforced ceramic matrix composites, which were then experimentally assessed under hydrogen torch and hydrogen combustion conditions typical of next-generation gas turbine and aerospace propulsion systems. Front- and back-surface temperature measurements were used to continually monitor thermal reactions, and post-test microstructural characterization and numerical simulations were carried out to evaluate material integrity and heat-transfer behavior. To …

Assessment Of Major Adverse Cardiovascular Event Across Diverse Racial Groups Of Psoriasis Patients On Biologic Therapy: A Retrospective Cohort Study, Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Clinton W. Enos

Department Dermatology Faculty Publications

Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE …

Implementation Of Tg-351 Reference Dosimetry For A 6 Mv Photon Beam In An Mr-Guided Radiotherapy System, Nicholas A. Castellano Jr.

Theses and Dissertations

Magnetic resonance guided radiation therapy (MRgRT) combines magnetic resonance imaging (MRI) and radiation therapy to enable the visualization of anatomy in real time during treatment. The presence of a magnetic field in MRgRT affects charged particle radiation and detector responses, necessitating changes to traditional reference dosimetry procedures. The American Association of Physicists in Medicine (AAPM) Task Group 351 (TG-351) provides a formalism for reference dosimetry in MRgRT. In this study, the TG 351 formalism is used to perform reference dosimetry for a 6 MV flattening filter-free (FFF) photon beam from a Viewray MRIdian MR-Linac radiation therapy system. Beam quality determination, …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Conceptual Concerns Regarding The Content Validity Of The Construct Of Gender Dysphoria In The Diagnostic And Statistical Manual Of Mental Disorders, Fifth Edition, Text Revision, Waverley Vesely

Theses and Dissertations

The diagnostic classification of gender dysphoria in the DSM-5-TR elicits a number of clinical, political, and philosophical concerns, ranging from those that are diagnostic and taxonomical in nature to those that fall within the domains of ontology, phenomenology, and hermeneutics. Part of the reason for the complexity of studying the diagnostic and nosological validity of gender dysphoria as an extant diagnostic classification is that, unlike many disorders, gender dysphoria is inextricably tethered to identity. While the recent change from gender identity disorder to gender dysphoria has nominally removed the status of disorder, in practice, both clinicians and the general population …

The Relationship Between Symptom Catastrophizing And Sociocultural Factors Among Adults With Persistent Sympathetic Activation Syndromes, Whitney M. Redemer

Theses and Dissertations

Persistent Sympathetic Activation (PSA) has emerged as a potential unifying mechanism underlying a range of complex chronic health conditions yet remains poorly characterized within biomedical and psychosocial research. Limited research has delineated how PSA manifests across diverse populations or how diagnostic and sociocultural factors shape lived experiences of this phenomenon; thus, the objective of the present study was to examine whether diagnostic certainty – operationalized as provider-confirmed versus self-suspected PSA-related diagnoses – is associated with symptom catastrophizing, and whether this relationship varies as a function of sociocultural factors. Drawing on data from a larger study aimed at characterizing the lived …

Foreign-National Families, Education, And Parenting: Unpacking The Influence Of Cultural Transitions On Child-Rearing And Expectations, Yuqi Zhang

Theses and Dissertations

This qualitative study examines how highly skilled foreign-national parents navigate parenting and educational decision-making within the context of cultural transition in the United States. While existing research on foreign-national parenting has largely focused on socioeconomically disadvantaged populations, less is known about families who possess substantial educational and professional capital. Despite these advantages, these parents encounter unique challenges related to institutional navigation, identity negotiation, and social constraints. Guided by Bronfenbrenner’s bioecological theory, Coleman’s social capital theory, Berry’s acculturation framework, and Yosso’s community cultural wealth model, this study explores how cultural background and migration experiences shape highly skilled foreign-national families’ parenting beliefs …

Evaluating Novel Targeted Combination Therapies For Gastrointestinal Cancers, Joseph A. Goode

Graduate Studies Theses and Dissertations 2026

Gastrointestinal (GI) cancers remain among the leading causes of cancer-related mortality worldwide, with therapeutic resistance continuing to limit the effectiveness of current treatments. Three complementary studies were conducted to identify therapeutic vulnerabilities and evaluate novel combination strategies in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC).  First, dual inhibition of fibroblast growth factor receptor 4 (FGFR4) and phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling was investigated in PDAC models. A combination of targeted drug treatments reduced viability, clonogenic survival, migration, and suppressed signaling pathways involved in translational control. This supported a functional interaction between FGFR4 and PI3K-mTOR co-activation in …

Spectrum Of Neurodevelopmental Disorders In Children Attending A Developmental Clinic In Dar Es Salaam, Tanzania, Aleya Zulfikar Remtulla, Sumayyah Nasiruddin Saudin, Orujul Hassan, Mariam Noorani

Paediatrics and Child Health, East Africa

Background: Neurodevelopmental disorders (NDDs) in children present significant challenges for healthcare systems globally. In Tanzania, children with NDDs and their families face significant challenges due to late diagnosis, lack of standardized screening tools, widespread stigma and cultural beliefs that deter health-seeking behaviours. Awareness about NDDs is low, and financial constraints further complicate access to necessary medical interventions. The country suffers from a severe shortage of specialized healthcare providers, and general healthcare providers often lack adequate training. Additionally, limited specialized facilities, high treatment costs and insufficient healthcare policies dedicated to NDDs make it difficult to manage these conditions effectively. Understanding the …

(Reverse) Piercing The Trust Veil, Eric Kades

Faculty Publications

Emergent doctrine deems trusts legal entities distinct from their trustees and beneficiaries. Venerable doctrine empowers creditors to "pierce the veil" separating entities' and their owners' property to avoid inequitable treatment. This article weaves together the new and old to craft a legal roadmap for reversing the ongoing race to the bottom among the states authorizing indefensible self-settled asset protection trusts (SSAPTs) designed solely for the purpose of swindling creditors. As a matter of both policy and doctrine, piercing (more precisely, reverse piercing) an entity's veil is ideally suited to empower the creditor of a SSAPT beneficiary to get paid from …

Visual Cues Of Human-Likeness, Not Salience, Impact Trust-Related Human-Computer Interaction, Jordan Schotz

Graduate Studies Theses and Dissertations 2026

As interactions with digital agents become increasingly integrated into daily life, understanding how visual representations influence social decision-making is critical. Previous research in human-computer interaction has frequently confounded the psychological effects of an agent's perceived human-likeness with the underlying visual salience of the stimuli. To address these persistent gaps, the present study systematically isolated the effects of human-likeness and visual cue trustworthiness on trust behavior while controlling for objective image properties. The present study expanded on and normed the Virtual Avatar Facial Stimuli Set (VAFSS), a comprehensive database comprising hundreds of identity-matched photographs and computer-generated avatars varying across a spectrum …

Unmasking Pentastomes: Generating Genomic Resources For Enigmatic Parasites, Stephanie Lyn Villella

Graduate Studies Theses and Dissertations 2026

The introduction of invasive species can disrupt ecosystems not only through competition and predation but also by introducing novel pathogens to naïve host populations. In the southeastern United States, the invasive Burmese python (Python bivittatus) has been implicated in the introduction of the pentastome parasite Raillietiella orientalis, which has been associated with increased parasite burdens and mortality in native snakes. Despite their ecological significance and ancient evolutionary history, pentastomes remain poorly represented in genomic databases, limiting efforts to understand their evolutionary origins, host–parasite interactions, and mechanisms underlying parasite emergence. This study addresses these gaps by generating the …

Site Use And Demographic Changes In A Northwest Atlantic Sea Turtle Foraging Ground, Ryan C. Welsh

Graduate Studies Theses and Dissertations 2026

and site fidelity, making mortality difficult to distinguish from redistribution. We developed a behaviorally explicit framework to separate true mortality from changes in availability caused by movement and redistribution. We evaluated this problem for juvenile green turtles (Chelonia mydas) and loggerhead turtles (Caretta caretta) captured at the St. Lucie Nuclear Power Plant intake canal on Florida’s Atlantic coast using a multi-decade capture–mark–recapture record spanning 1977 - 2023. Hidden Markov Models classified individuals into latent habitat-use strategies (Nomadic, Resident, and Transient) based on capture timing and body size. Across both species, these strategies captured consistent differences in site fidelity and recapture …

Ecological And Evolutionary Responses To Environmental Change In Two Large North American Mammals, George Zaragoza

Graduate Studies Theses and Dissertations 2026

Climate change and urbanization are resulting in rapid shifts in ecosystems. The effects of these changes are complex, and understanding how species respond is critical for predicting their impacts on genetic diversity and evolution, as well as changes in habitat suitability. Species can respond to these changes in two major ways: through behavioral or genetic adaptation, or by moving to more suitable habitat as conditions change. Adaptive genetic change, in particular, can support behavioral and physiological responses that enable species to persist in novel or changing environments, and understanding these changes can help predict how species will respond to anthropogenic …

Machine Learning-Based Intrusion Detection System For Iot Networks Using The Rt-Iot 2022 Dataset, Bukunmi Ebenezer Afolabi

Theses, Dissertations and Capstones

The rapid expansion of the Internet of Things (IoT) has transformed modern computing by enabling seamless connectivity among heterogeneous devices across diverse application domains. However, this increased interconnectivity has significantly enlarged the attack surface of IoT networks, exposing them to a wide range of sophisticated cyber threats. Conventional security mechanisms often lack the capability to detect emerging attacks in real time, thereby necessitating the development of intelligent Intrusion Detection Systems (IDS) capable of accurately identifying malicious network activities. This study developed and evaluated a machine learning-based intrusion detection framework for multiclass IoT attack detection using the RT-IoT2022 dataset. The dataset …

Survivors Of Historical Intergenerational And Familial Trauma Scale For Black American Descendants Of Enslaved People: A Development And Initial Validation Study, Loryn Chás Kimbrough

Graduate Research Theses & Dissertations

Despite extensive research documenting cultural and racialized trauma, no validated assessment tool had previously captured the intrafamilial mechanisms of trauma transmission specific to the BADEP population, whose trauma lineage is rooted in slavery. The present study addresses this gap through the development and initial validation of the Survivors of Historical Intergenerational and Familial Trauma Scale (SHIFTS), a culturally grounded instrument designed to measure the transmission of historical trauma (HT) and ongoing intergenerational trauma (IGT) among Black American Descendants of Enslaved People (BADEPs). The SHIFTS examines how HT gives rise to the continued transmission of two interrelated legacies: survival-based and trauma-rooted …

Elucidating The Impacts Of Non-Covalent Interactions In Organic Materials Through A Multiscale Computational Approach, Sashen A. Ruhunage

Theses and Dissertations--Chemistry

Noncovalent interactions (NCIs) in π-conjugated organic materials serve as tunable levers that influence molecular structure and intermolecular interactions in the condensed phase and, in turn, impact the electronic, optical, and mechanical properties of these materials. NCIs include attractive dispersion, electrostatic, and induction interactions, as well as repulsive exchange interactions. However, how to design materials with NCI considerations remains an open question across many fields. Here, we seek to provide an electronic and atomistic perspective on these interactions through multiscale simulations to aid materials design, processing, and performance optimization. In this study, we investigate NCIs and their effects across various systems …

Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo

Theses and Dissertations--Chemistry

Learning element symbol–name associations and the spatial organization of elements on the periodic table is a foundational step in learning chemistry, supporting later understanding of chemical formulas, equations, bonding, and stoichiometry. Although students often rely on memorization strategies to learn periodic table content, this task is challenging due to the large number of elements and the apparent ambiguity in matching some element symbols to their names.

This study explores students’ recall of element names when given element symbols as cues and their knowledge of element locations on the periodic table when given element names as cues. The study also examines …

Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin

Surgery Faculty Publications

Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.

Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson

Surgery Faculty Publications

Introduction: Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72 h after lung transplantation is associated with post-transplant graft survival is unknown. Methods: We performed a retrospective cohort study of 1511 participants in the multi-center Lung Transplant Outcomes Group cohort (2011–2018). Using Cox proportional hazards models and restricted mean survival time, we investigated whether IMV at 72 h was associated with post-transplant graft survival. We secondarily evaluated whether IMV at 72 h was concordant with severe primary graft dysfunction …

Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito

Surgery Faculty Publications

Background – Sepsis survivors commonly suffer from chronic Post-Sepsis Syndrome (PSS). To understand the mechanisms of PSS, it is critical to utilize appropriate animal models. While cecal ligation and puncture (CLP) is a widely used model of sepsis, a concern exists regarding its suitability for studying long-term outcomes. Alternatively, we previously optimized a highly reproducible murine cecal slurry (CS)-injection model of sepsis. The objective of this study was to compare the suitability of CS and CLP models for investigating PSS. Methods – Male 4-month-old C57BL/6 mice were divided into 7 groups: (1) Naïve control; (2) Sham: laparotomy control; (3) CL: …