Digital Commons Network^™

Dupilumab For Patients With Allergic Fungal Rhinosinusitis, Amber U. Luong, Joshua M. Levy, Sarah K. Wise, Joseph K. Han, Mamoru Yoshikawa, Luo Zhang, Rodney Schlosser, Prerna Ranganathan, Paula Dakin, Jennifer Maloney, George D. Yancopoulos, Andrew P. Fontenot, Neelam A. Phadke, Lacey R. Robinson

Department of Otolaryngology (ENT) Faculty Publications

Background

Allergic fungal rhinosinusitis (AFRS) is a severe subtype of chronic rhinosinusitis characterized by fungal hypersensitivity and accentuated type 2 inflammation. Dupilumab-a fully human monoclonal antibody blocking interleukin-4/13, approved for type 2 inflammatory diseases, including chronic rhinosinusitis with nasal polyps-may benefit patients with AFRS.

Objective

We sought to understand the effect of dupilumab in AFRS

Methods

In this phase 3 trial, patients with AFRS aged ≥6 years were randomized to dupilumab or matched placebo for 52 weeks. The primary end point was Lund-Mackay computed tomography (LMK-CT) score, quantifying sinus opacification, at 52 weeks. Secondary end points were multiplicity-controlled and hierarchically …

Structural Design And Development Of Deployable Propeller Blade, Annan Mashin

Graduate Studies Theses and Dissertations 2026

Aerospace systems frequently face competing requirements between compact packaging and high aerodynamic performance. Large propellers improve efficiency and thrust generation, yet launch constraints and confined storage volumes limit their maximum span. Conventional deployable solutions rely on hinges, locking mechanisms, and external actuation, increasing mechanical complexity and reducing reliability. This dissertation investigates an alternative approach in which elastic instabilities in thin composite shells are deliberately harnessed to enable rapid, mechanism- free deployment of aerodynamic structures. This work harnesses propagating instability in open- section thin-walled airfoil geometries to enable reversible transformation between compact stowed and stiff deployed configurations. By tailoring structural architecture, …

Perceptions Of High School Students’ Sports Participation And Potential Impact On Post-Secondary Involvement, Anthony J. Wishart

Graduate Studies Theses and Dissertations 2026

This dissertation examined the shifting culture of youth sports in the United States and its impact on academic motivation among adolescent student athletes. The study utilized Self-Determination Theory (SDT) as a framework. Traditionally, youth sports have helped students with personal growth and academic success. However, the contemporary emphasis on early sport specialization and the decline of opportunities in nonrevenue male sports are part of broader cultural shifts and require deeper exploration.

This study investigated the relationship between sport specialization among high school male junior and senior student athletes and their levels of academic motivation, as well as the consequences of …

Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar

Graduate Studies Theses and Dissertations 2026

Dextran sodium sulphate (DSS) is widely used in vivo to induce epithelial injury; however, the molecular effects of DSS on intestinal epithelial cells, that investigate inflammatory and metabolic repair mechanisms remain unclear. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayer. Exposure to 2.5%(w/v) DSS for 24 hours resulted in significant upregulation of pore forming protein Claudin-2(2.677-fold) and oxidative marker, NOX-1(1.866-fold), accompanied by increased ROS production confirmed via DHE staining. Increased epithelial permeability was observed by TEER analysis, without significant cytotoxicity. Surprisingly, ELISA analysis revealed significant downregulation of IL-6 (p-value …

Mapping Cave Vulnerability And Priority Areas For Biospeleological Conservation, C. Lael Anderson

Theses

Alabama contains some of the highest levels of subterranean biodiversity in North America, yet no statewide assessment of cave vulnerability has previously been conducted. A spatially explicit vulnerability assessment was developed for Alabama caves using species occurrence records, landscape characteristics, anthropogenic threat data, and groundwater vulnerability metrics. Distribution maps were generated for cave- obligate and bat species, and vulnerability was assessed using human population, land- use, groundwater quality, groundwater quantity, and modified DRASTIK models. Results identified numerous single-site endemic species, regional biodiversity hotspots, and cave systems facing elevated anthropogenic threats. Conservation priority rankings highlighted species and caves of greatest management …

Design And Characterization Of A Low-Power Bulk-Driven Two-Stage Ota In 65nm, 90nm, And 130nm Cmos Technologies For 0.4v-0.6v Biomedical Applications, Raihan Khan Akash

Theses

Biomedical instrumentation requires low-power amplifiers to maximize battery life. Due to threshold voltage limitations, standard gate-driven operational transconductance amplifiers (OTAs) require higher supply voltages. To overcome this, a differential bulk-driven two-stage OTA is introduced for low-power applications. The proposed topology is implemented in 65nm, 90nm, and 130nm complementary metal-oxide-semiconductor (CMOS), with supply voltages ranging from 0.4V to 0.6V. Key metrics such as DC gain, gain-bandwidth product (GBWP), phase margin, common-mode rejection ratio (CMRR), slew rate, power, and noise are measured. The analysis confirms the robustness of the low-power solution provided by the proposed topology.

The Future Of The English Class Essay: Reimagining Multimodal Composition In The Chatgpt Era, Taylor Rose-Dougherty, Christy Goldsmith

The Utah English Journal

As English teacher educators, we are on the frontlines of navigating the technological elephant in the 2025 writing classroom: Generative Artificial Intelligence (GenAI) technologies like ChatGPT, Claude, and Gemini that can produce pages of text in mere seconds. English teachers’ philosophies on GenAI are as diverse as their preferred novels or their favorite poets. But, as the two dozen publications in major English education journals1 in the past two years suggest, what is at stake is not the end of high school English (Herman, 2022), but the opportunity to give it a makeover (Herman, 2023) by reimagining what writing experiences …

Teaching Students To Write For The Future By Writing For The Present, Amber Jensen, Meridith Reed

The Utah English Journal

“When you get to eighth grade, you’ll need to know how to write a topic sentence.”

“The five-paragraph essay will prepare you to write in high school.”

“College professors expect you to accurately cite your sources in MLA format.”

“When you graduate from college, you need to be able to write a professional email.”

Perhaps you heard messages like these from your writing teachers as you moved through middle school, high school, college, and into your careers. We certainly did. And perhaps, like we have, you have been a writing teacher in a middle school, high school, or college classroom …

Exploring And Increasing Women’S And Girls’ Recreational Ocean Access In A Coastal Community In The Tropical Majority, Florence Barraud

School of Law, Humanities and Social Sciences Theses

Vast gender inequalities restrict women’s and girls’ access to ocean spaces, particularly in the tropical majority. Globally, 68% of women cannot swim, compared to 43% of men. In many coastal communities, women are key stewards of highly biodiverse yet vulnerable marine environments that people rely upon for food security, livelihoods, culture, and coastal protection. Being able to swim is imperative for enabling access to the dominant environment and a core recreational, educational, and economic space. This study aimed to explore and increase women’s and girls’ recreational ocean access in the Maldives, a tropical majority island nation.Utilising a pragmatic feminist approach, …

Generalization Bounds For Semi‑Supervised Matrix Completion With Distributional Side Information, Antoine Ledent, Mun Chong Soo, Minh Hieu Nong

Research Collection School Of Computing and Information Systems

We study a matrix completion problem where both the ground truth R matrix and the unknown sampling distribution P over observed entries are low-rank matrices, and share a common subspace. We assume that a large amount M of unlabeled data drawn from the sampling distribution P is available, together with a small amount N of labeled data drawn from the same distribution and noisy estimates of the corresponding ground truth entries. This setting is inspired by recommender systems scenarios where the unlabeled data corresponds to ‘implicit feedback’ (consisting in interactions such as purchase, click, etc. ) and the labeled data …

A Systematic Review And Characterization Of Privacy Noncompliance In Real-World Applications, Alexander E. Charkiewicz

Graduate Studies Theses and Dissertations 2026

Software applications increasingly rely on user data to provide their functionality, but improper handling of such data can lead to serious privacy noncompliance with applicable regulations and policies. A prominent example is the Facebook–Cambridge Analytica scandal, in which a third-party application collected the personal data of approximately 87 million Facebook users without users' consent. Despite growing attention to privacy compliance, two key challenges hinder the systematic understanding and analysis of privacy noncompliance. First, unlike security vulnerabilities, which have been systematically categorized through taxonomies such as the Common Weakness Enumeration (CWE), privacy noncompliance lacks a technical taxonomy describing how it manifests …

Dimension Reduction Involving Exogenous Variables With Applications In Manufacturing And Healthcare, Linxi Li

Theses and Dissertations

High-dimensional data analysis presents diverse challenges, including the curse of dimensionality, the complexities of working with datasets that combine large feature spaces with limited sample sizes, and difficulties in identifying meaningful relationships among variables. As datasets grow in size and complexity across different fields, it is increasingly important to develop practical approaches for extracting essential information from such data. Dimension reduction methods address these challenges by alleviating the effects of high dimensionality, enhancing the ability to reveal hidden patterns, and uncovering latent structures within the data to support further analysis. Some methods reduce dimensionality while preserving all relevant information, offering …

Towards Sample-Efficient Deep Reinforcement Learning, Guang Yang

Theses and Dissertations

Deep reinforcement learning (DRL), combining reinforcement learning and high-performance function approximations such as deep neural networks (DNN), is a powerful approach to solving complex sequential decision-making problems. However, due to the complex solution space of the sequential decision-making problems and the inefficient design of the DRL algorithms, DRL algorithms usually require a prohibitively large number of data samples to train effective strategies. Consequently, it is difficult to apply these DRL algorithms to complex real-world problems that require high costs to collect a large volume of data samples. This dissertation proposes new mechanisms to address this sample inefficiency issue, realizing sample-efficient …

Gz17.602, A Combination Of Three Nutraceuticals, Interacts With Carboplatin And Etoposide To Kill Neuroblastoma, Michael R. Booth

Theses and Dissertations

This study examined the efficacy of GZ17.602, a combination of Harmine, Isovanillin, and Curcumin as a therapeutic for MYCN-amplified Neuroblastoma, both alone and in combination with standard of care chemotherapeutics. This was done due to the low survival rate associated with these neuroblastomas, the large degree of morbidity associated with current treatments, previous experiments in the Dent lab having shown 602 as effective for killing cancers of other types, and the current lack of understanding of the biology of GZ17.602 in solid pediatric cancers. Due to the GZ17.602 components being present at different concentrations in tumors than those administered, the …

Regulation Of Tgf-Β1–Induced Epithelial–Mesenchymal Transition By Integrin Inhibition, Wesam Elhawabri

Theses and Dissertations

Epithelial–mesenchymal transition (EMT) is a critical process underlying cancer progression, fibrosis, and tissue remodeling, characterized by coordinated changes in cell morphology, nuclear structure, and extracellular matrix (ECM) organization. Transforming growth factor beta 1 (TGF-β1) is a primary inducer of EMT; however, the extent to which integrin-mediated signaling and ECM remodeling regulate these structural changes remains incompletely understood. In this study, we quantitatively investigated EMT-associated remodeling in A549 lung carcinoma cells and MCF10A epithelial cells following TGF-β1 stimulation. Cells were cultured on ECM-coated substrates and treated with TGF-β1 in the presence or absence of integrin-targeting inhibitors (ATN-161, 28-G11, and STX-100). Im …

Daisyworld, Eva Foldy

Theses and Dissertations

Daisyworld explores how painting can represent ecological and sociopolitical crisis without relying on narratives of total collapse as a catastrophic end, instead framing the present as a condition of ongoing, uneven transformation. Drawing on ecological models of adaptation, interdependence, and planetary self-regulation, it uses plant fasciation as both a biological reference and speculative metaphor for distorted yet generative forms of survival. Situating painting within a broader history of visual culture, it examines how images function as accessible systems of knowledge while challenging colonial and human-centered modes of representation. In dialogue with contemporary, systems-based artistic practices, the project repositions painting as …

All Other Ground Is Sinking Sand, Kevin Hopkins

Theses and Dissertations

My thesis project, All Other Ground Is Sinking Sand, is a body of work that frames soft sculpture as "prophetic charm" and collaborative performance as the ceremony that charges them. In this essay, I will explore the conceptual chronology of the charms, their connection to the notion of décalage, and their potential to compel witnesses toward the immediate liberation of queer, Black individuals.

With my research centered on the necessity of shifting cultural responses to enduring racial trauma, I focus my work on deconstructing Black hypermasculine archetypes shaped by white supremacy and unpacking the tension between individual autonomy and social …

Between The Veins: Materializing Memory In The Age Of Digital Storage, Alice Mohammed Aslem

Theses and Dissertations

What happens to a childhood stored behind a password? This thesis began with a simple moment of scrolling through my son’s photographs on my phone. As the images multiplied, they began to lose clarity, turning into an overwhelming digital archive. This made me ask: What kind of memories am I preserving for him?

Having grown up between analog and digital worlds, Between the Veins explores how I navigate memory through material objects and digital archives. Using weaving, images are transferred onto screw pine and palm leaves. In this process, digital files of his childhood are translated into organic fibers of …

Examining Mental Healthcare Underutilization Among Latino Immigrants: Healthcare Providers’ And Community Health Workers' Perspectives, Geovani Muñoz

Theses and Dissertations

Latinos continue to experience many logistical and systemic barriers to professional mental health services (Derr, 2016) despite being the second-largest racial-ethnic group in the United States (U.S.). With a community of 65 million people (U.S. Census Bureau, 2024), Latinos experience mental healthcare inequalities (Cook et al., 2019) due to structural, cultural, and systemic barriers. Although prior research has emphasized culturally responsive care as a pathway to reducing disparities (Nagy et al., 2025), much of the literature has focused on Western medical models, with limited attention to community-based perspective. Guided by the Knowledge, Attitude, and Practices (KAP) framework, the present study …

Comorbid Psychosis In The General Population, Mariam Sankoh

Theses and Dissertations

Psychosis is a complex psychiatric phenotype characterized by substantial heterogeneity in symptom presentation, psychosis diagnosis, comorbidity patterns, and genetic architecture across diverse populations in the general population. Despite advances in psychiatric epidemiology and genomics, important gaps remain in understanding how psychosis symptoms and psychosis-related diagnoses manifest across racial and ethnic groups and how evolutionary genomic factors may contribute to disease risk and cross-ancestry genetic prediction. This dissertation, Characterizing Comorbidity in Psychosis in the General Population, integrates epidemiological, psychometric, and evolutionary genetic approaches to examine psychosis across diverse populations.

Aim 1 examined racial and ethnic differences in psychosis comorbidity patterns …

Munajat: Design As A Dialogue With The Divine, Shawky Abdalla

Theses and Dissertations

Contemporary design discourse remains grounded in functional, seemingly user-centered paradigms, often neglecting what lies beyond the tangible within a human experience. This research challenges such frameworks by positioning design as a dialogue with what exceeds the physical, moving toward the experiential, where meaning precedes and informs form. Drawing on Islamic philosophy, particularly the relationship between zahir and batin (outward form and inward meaning), the study repositions design as a medium for remembrance (dhikr) rather than mere utility.

Through a critique of modernist and postmodernist principles, the research proposes a series of objects that engage with memory, introspection, and transcendence in …

From Cultural Binaries To Coexistence: A Graphic Autoethnography Of Individualism And Collectivism In An International Context, Shahad Alsubaie

Theses and Dissertations

This arts-based autoethnographic study investigates individualism and collectivism, specifically through my study-abroad experience traveling from Saudi Arabia to the United States. Through arts-based reflective practice, I depicted the diasporic experience of being ontoepistemologically collectivistic while navigating a primarily individualistic society. I use the medium of a graphic memoir to illustrate and develop frameworks of confluence that embrace the two distinct cultural orientations simultaneously. This arts-based self-study not only contributes to the body of transnational scholarship but also serves as a reference for international students, researchers, and educators to use arts-based subgenres and data analysis methods to gain better insights into …

Contours Of Duration: Movement Authored Through Form—A Behavior Archive, Jood Senussi Elbeshti

Theses and Dissertations

Insect anatomy offers an elegant example of motion derived from structure. Inspired by insect movement, Contours of Duration employs a cam-and-follower system consisting of moving, leg-like parts, designed to engage a series of rotating cams, such that the shape of each cam’s surface activates the legs in unique ways, generating repetitive movement, and demonstrating how geometry produces distinct motion behaviors over time. Through iterative experimentation and controlled variation, trace emerges as a central methodology, whereby movement, over time, creates a distinct pattern of marks, making motion legible and reflecting how subtle changes to surface and form generate different behavioral outcomes. …

Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha

Theses and Dissertations

Background and Objectives: Immigrants in the United States undergo acculturation — a process of sociocultural and behavioral adaptation to the host country. Increasingly, behavioral adaptations have been associated with cardiometabolic health and chronic disease risk. Metabolic syndrome (MetS), a cluster of conditions including abdominal obesity, elevated blood pressure, impaired fasting glucose, elevated triglycerides, and reduced HDL cholesterol, is a major risk factor for type 2 diabetes mellitus, cardiovascular diseases and other chronic diseases, including cancer. Despite the growing immigrant population in the U.S., the role of diet and dietary acculturation in MetS development remains poorly understood in this population. This …

24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim

Theses and Dissertations

Physical frailty is a prevalent geriatric syndrome characterized by age-related decline across multiple physiological systems. Physical frailty is associated with an elevated risk of adverse health outcomes, including chronic disease progression and all-cause mortality, representing a significant and growing public health concern. Disrupted circadian rest-activity rhythms (RARs) are increasingly recognized as clinically meaningful markers of physical frailty in older adults. However, the extent to which biological sex and social determinants of health (SDoH), particularly social capital, contribute to or modify the associations between RARs and physical frailty remains underexplored.

Therefore, this dissertation summarizes the existing literature on age-related changes in …

A Mathematical Frameworks For Singular, Nonlinear Phenomena: Applications To Nematocyst Firing And Inhomogeneous Nls With Coulomb Potential, Abdulrahman Alharbi

Theses and Dissertations

Nematocysts are specialized cellular organelles found in all cnidarians, including corals and jellyfish, as well as in some single-celled protists such as dinoflagellates. These organelles display remarkable diversity in morphology and function, playing roles in prey capture and defense. The firing of a nematocyst is one of the fastest accelerations in nature, yet the underlying physical mechanisms remain not fully understood. In this work, we address key questions: how sufficient force is generated to overcome the fluid boundary layer, whether fluid–structure interaction models can reproduce observed dynamics, and what mechanisms trigger discharge.

Our research investigates models based on osmotic pressure …

Internalizing Symptoms In Lgbtq+ Young Adults: Understanding The Roles Of Social Support And Resilience To Social Stigma, Chloe M. Sobolewski

Theses and Dissertations

LGBTQ+ young adults are at increased risk of adverse mental health outcomes including internalizing symptoms. The current study seeks to better incorporate strengths when modeling internalizing symptoms outcomes in LGBTQ+ young adults. The present study is secondary analysis of data collected as part of a three-wave longitudinal study. LGBTQ+ young adults (N = 250) completed baseline questionnaires assessing resilience to social stigma, types of perceived social support (i.e., family, friend, significant other), and internalizing symptoms. Moderation models were not practically or statistically significant; however, covariates (i.e., age, socioeconomic standing, and childhood basic needs) stood out in their significant contribution in …

Examining Youth Ethnic Identity And Parental Familismo As Protective Factors Against Bicultural Stress And Internalizing Symptoms In Latino Youth, Daniella Olivares

Theses and Dissertations

Adolescence is a critical developmental period marked by increased vulnerability to mental health challenges. For Latino adolescents living in the U.S., experiences of bicultural stress may heighten the risk for adverse mental health outcomes. However, cultural strengths–such as youth ethnic identity and parental familismo–may serve as protective factors. The current study examined whether youth ethnic identity and parental familismo moderated the relationship between bicultural stress and internalizing symptoms among a diverse sample of Latino youth in central Virginia. Latino adolescents (n = 60) completed measures assessing bicultural stress, ethnic identity, and internalizing symptoms, while parents (n = 60) reported on …

Synthesis Of Iso-Dityrosine, A Potential Biomarker Of Neurodegenerative Diseases, Brandon R. Knouse

Theses and Dissertations

As the population of the United States continues to age, the prevalence of neurodegenerative disorders is rising, increasing the societal and clinical burden of diseases such as Parkinson’s disease and dementia-related conditions. Lewy Body Dementia (LBD), the second most common cause of dementia, shares underlying neuropathological features with Parkinson’s disease, including the aggregation of misfolded α-synuclein into Lewy bodies and Lewy neurites. Current diagnostic approaches rely heavily on cerebrospinal fluid biomarker analysis; however, significant overlap exists among biomarkers associated with Alzheimer’s disease and other neurodegenerative conditions, limiting diagnostic specificity. Emerging evidence suggests that oxidative modifications of α-synuclein, particularly the formation …

Tuberculosis In Jim Crow Virginia, 1900-1972, Elizabeth Dooley

Theses and Dissertations

Tuberculosis (TB) was a major public health concern in the United States, especially in the first half of the twentieth century. Transmission and treatment of the disease, which is spread between humans through close contact, was complicated by racial segregation laws in the South known as Jim Crow laws. Virginia subscribed to these laws, which played a role in how and where Black Virginians with TB could be treated. Segregated treatment facilities with an inadequate number of beds for the number of infected people and deaths in the state added to these complications of disease control and plan for eradication. …