Digital Commons Network^™

Evaluating Novel Targeted Combination Therapies For Gastrointestinal Cancers, Joseph A. Goode

Graduate Studies Theses and Dissertations 2026

Gastrointestinal (GI) cancers remain among the leading causes of cancer-related mortality worldwide, with therapeutic resistance continuing to limit the effectiveness of current treatments. Three complementary studies were conducted to identify therapeutic vulnerabilities and evaluate novel combination strategies in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC).  First, dual inhibition of fibroblast growth factor receptor 4 (FGFR4) and phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling was investigated in PDAC models. A combination of targeted drug treatments reduced viability, clonogenic survival, migration, and suppressed signaling pathways involved in translational control. This supported a functional interaction between FGFR4 and PI3K-mTOR co-activation in …

Spectrum Of Neurodevelopmental Disorders In Children Attending A Developmental Clinic In Dar Es Salaam, Tanzania, Aleya Zulfikar Remtulla, Sumayyah Nasiruddin Saudin, Orujul Hassan, Mariam Noorani

Paediatrics and Child Health, East Africa

Background: Neurodevelopmental disorders (NDDs) in children present significant challenges for healthcare systems globally. In Tanzania, children with NDDs and their families face significant challenges due to late diagnosis, lack of standardized screening tools, widespread stigma and cultural beliefs that deter health-seeking behaviours. Awareness about NDDs is low, and financial constraints further complicate access to necessary medical interventions. The country suffers from a severe shortage of specialized healthcare providers, and general healthcare providers often lack adequate training. Additionally, limited specialized facilities, high treatment costs and insufficient healthcare policies dedicated to NDDs make it difficult to manage these conditions effectively. Understanding the …

(Reverse) Piercing The Trust Veil, Eric Kades

Faculty Publications

Emergent doctrine deems trusts legal entities distinct from their trustees and beneficiaries. Venerable doctrine empowers creditors to "pierce the veil" separating entities' and their owners' property to avoid inequitable treatment. This article weaves together the new and old to craft a legal roadmap for reversing the ongoing race to the bottom among the states authorizing indefensible self-settled asset protection trusts (SSAPTs) designed solely for the purpose of swindling creditors. As a matter of both policy and doctrine, piercing (more precisely, reverse piercing) an entity's veil is ideally suited to empower the creditor of a SSAPT beneficiary to get paid from …

Visual Cues Of Human-Likeness, Not Salience, Impact Trust-Related Human-Computer Interaction, Jordan Schotz

Graduate Studies Theses and Dissertations 2026

As interactions with digital agents become increasingly integrated into daily life, understanding how visual representations influence social decision-making is critical. Previous research in human-computer interaction has frequently confounded the psychological effects of an agent's perceived human-likeness with the underlying visual salience of the stimuli. To address these persistent gaps, the present study systematically isolated the effects of human-likeness and visual cue trustworthiness on trust behavior while controlling for objective image properties. The present study expanded on and normed the Virtual Avatar Facial Stimuli Set (VAFSS), a comprehensive database comprising hundreds of identity-matched photographs and computer-generated avatars varying across a spectrum …

Unmasking Pentastomes: Generating Genomic Resources For Enigmatic Parasites, Stephanie Lyn Villella

Graduate Studies Theses and Dissertations 2026

The introduction of invasive species can disrupt ecosystems not only through competition and predation but also by introducing novel pathogens to naïve host populations. In the southeastern United States, the invasive Burmese python (Python bivittatus) has been implicated in the introduction of the pentastome parasite Raillietiella orientalis, which has been associated with increased parasite burdens and mortality in native snakes. Despite their ecological significance and ancient evolutionary history, pentastomes remain poorly represented in genomic databases, limiting efforts to understand their evolutionary origins, host–parasite interactions, and mechanisms underlying parasite emergence. This study addresses these gaps by generating the …

Site Use And Demographic Changes In A Northwest Atlantic Sea Turtle Foraging Ground, Ryan C. Welsh

Graduate Studies Theses and Dissertations 2026

and site fidelity, making mortality difficult to distinguish from redistribution. We developed a behaviorally explicit framework to separate true mortality from changes in availability caused by movement and redistribution. We evaluated this problem for juvenile green turtles (Chelonia mydas) and loggerhead turtles (Caretta caretta) captured at the St. Lucie Nuclear Power Plant intake canal on Florida’s Atlantic coast using a multi-decade capture–mark–recapture record spanning 1977 - 2023. Hidden Markov Models classified individuals into latent habitat-use strategies (Nomadic, Resident, and Transient) based on capture timing and body size. Across both species, these strategies captured consistent differences in site fidelity and recapture …

Ecological And Evolutionary Responses To Environmental Change In Two Large North American Mammals, George Zaragoza

Graduate Studies Theses and Dissertations 2026

Climate change and urbanization are resulting in rapid shifts in ecosystems. The effects of these changes are complex, and understanding how species respond is critical for predicting their impacts on genetic diversity and evolution, as well as changes in habitat suitability. Species can respond to these changes in two major ways: through behavioral or genetic adaptation, or by moving to more suitable habitat as conditions change. Adaptive genetic change, in particular, can support behavioral and physiological responses that enable species to persist in novel or changing environments, and understanding these changes can help predict how species will respond to anthropogenic …

Machine Learning-Based Intrusion Detection System For Iot Networks Using The Rt-Iot 2022 Dataset, Bukunmi Ebenezer Afolabi

Theses, Dissertations and Capstones

The rapid expansion of the Internet of Things (IoT) has transformed modern computing by enabling seamless connectivity among heterogeneous devices across diverse application domains. However, this increased interconnectivity has significantly enlarged the attack surface of IoT networks, exposing them to a wide range of sophisticated cyber threats. Conventional security mechanisms often lack the capability to detect emerging attacks in real time, thereby necessitating the development of intelligent Intrusion Detection Systems (IDS) capable of accurately identifying malicious network activities. This study developed and evaluated a machine learning-based intrusion detection framework for multiclass IoT attack detection using the RT-IoT2022 dataset. The dataset …

Survivors Of Historical Intergenerational And Familial Trauma Scale For Black American Descendants Of Enslaved People: A Development And Initial Validation Study, Loryn Chás Kimbrough

Graduate Research Theses & Dissertations

Despite extensive research documenting cultural and racialized trauma, no validated assessment tool had previously captured the intrafamilial mechanisms of trauma transmission specific to the BADEP population, whose trauma lineage is rooted in slavery. The present study addresses this gap through the development and initial validation of the Survivors of Historical Intergenerational and Familial Trauma Scale (SHIFTS), a culturally grounded instrument designed to measure the transmission of historical trauma (HT) and ongoing intergenerational trauma (IGT) among Black American Descendants of Enslaved People (BADEPs). The SHIFTS examines how HT gives rise to the continued transmission of two interrelated legacies: survival-based and trauma-rooted …

Elucidating The Impacts Of Non-Covalent Interactions In Organic Materials Through A Multiscale Computational Approach, Sashen A. Ruhunage

Theses and Dissertations--Chemistry

Noncovalent interactions (NCIs) in π-conjugated organic materials serve as tunable levers that influence molecular structure and intermolecular interactions in the condensed phase and, in turn, impact the electronic, optical, and mechanical properties of these materials. NCIs include attractive dispersion, electrostatic, and induction interactions, as well as repulsive exchange interactions. However, how to design materials with NCI considerations remains an open question across many fields. Here, we seek to provide an electronic and atomistic perspective on these interactions through multiscale simulations to aid materials design, processing, and performance optimization. In this study, we investigate NCIs and their effects across various systems …

Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo

Theses and Dissertations--Chemistry

Learning element symbol–name associations and the spatial organization of elements on the periodic table is a foundational step in learning chemistry, supporting later understanding of chemical formulas, equations, bonding, and stoichiometry. Although students often rely on memorization strategies to learn periodic table content, this task is challenging due to the large number of elements and the apparent ambiguity in matching some element symbols to their names.

This study explores students’ recall of element names when given element symbols as cues and their knowledge of element locations on the periodic table when given element names as cues. The study also examines …

Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin

Surgery Faculty Publications

Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.

Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson

Surgery Faculty Publications

Introduction: Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72 h after lung transplantation is associated with post-transplant graft survival is unknown. Methods: We performed a retrospective cohort study of 1511 participants in the multi-center Lung Transplant Outcomes Group cohort (2011–2018). Using Cox proportional hazards models and restricted mean survival time, we investigated whether IMV at 72 h was associated with post-transplant graft survival. We secondarily evaluated whether IMV at 72 h was concordant with severe primary graft dysfunction …

Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito

Surgery Faculty Publications

Background – Sepsis survivors commonly suffer from chronic Post-Sepsis Syndrome (PSS). To understand the mechanisms of PSS, it is critical to utilize appropriate animal models. While cecal ligation and puncture (CLP) is a widely used model of sepsis, a concern exists regarding its suitability for studying long-term outcomes. Alternatively, we previously optimized a highly reproducible murine cecal slurry (CS)-injection model of sepsis. The objective of this study was to compare the suitability of CS and CLP models for investigating PSS. Methods – Male 4-month-old C57BL/6 mice were divided into 7 groups: (1) Naïve control; (2) Sham: laparotomy control; (3) CL: …

Assessing Sustainable E-Cigarette Prevention Messaging In Public Health Communication, Addo Anim Adinkrah

Graduate Research Theses & Dissertations

This study examines the sustainability of e-cigarette or vaping prevention messaging on X (formerly Twitter) and the message-design strategies used by public health institutions to maintain message visibility over time. Using the McGuire Communication/Persuasion Model and Media Framing theoretical frameworks, the research employs a qualitative thematic analysis based on Braun and Clarke’s six-phase approach to analyze 506 tweets from official accounts affiliated with the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA). The findings reveal that prevention messages are sustained through repeated core warnings and reinforcement of institutional authority rooted in scientific and …

Identifying Maltreatment Classes And Their Associated Psychological Outcomes From Childhood To Adolescence, Colleen Bartlett

Graduate Research Theses & Dissertations

Previous research has consistently shown that experiencing maltreatment has significant, negative effects on youth’s psychological health; however, research on the psychological impact of maltreatment is often limited by challenges in accurately capturing children’s maltreatment experiences, as most children who are exposed to maltreatment experience multiple types of maltreatment. The present study utilized latent class analyses (LCAs), a person-centered, data-driven approach to empirically identify patterns in children’s maltreatment experiences at ages 3, 5, and 9. Maltreatment class indicators included frequency of behaviorally approximated emotional abuse, physical abuse, and neglect. Following the LCAs, associations between maltreatment class membership and youth internalizing and …

Longitudinal Dechirping Of Electron Beams Using Negative Identity Drifts In A Transverse Deflecting Cavity-Based Chirper, Alex Desimone

Graduate Research Theses & Dissertations

Electron beam chirping for bunch compression is commonly achieved through off-crest acceleration in radio-frequency accelerating cavities. While it is effective, this method reduces average beam energy and introduces nonlinearities in the beam's longitudinal phase space, which can degrade beam quality in applications such as X-ray free electron lasers. An alternative chirping scheme has been proposed, in which accelerating cavities operate on-crest while transverse deflecting cavities generate the required longitudinal chirp. However, the efficiency of this approach and its impact on beam quality have not been systematically investigated, and the previously proposed dechirping scheme for this system is experimentally impractical. This …

Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam

Graduate Research Theses & Dissertations

Paper spray mass spectrometry (PS-MS) is a novel ambient ionization method that allows chemical and biological samples to be rapidly analyzed with little preparation being required. In this paper, PS-MS was set up and streamlined as an acetylcholinesterase (AChE)-monitoring platform in addition to screening an existing and newly produced AChE-inhibitors. The detection of the substrate, acetylcholine (m/z 146), and the AChE catalysis product, choline (m/z 104) was performed without applying chromatographic separation or derivatization to the dried paper substrates. Assay conditions were optimized in a systematic way, to develop a robust MS-compatible enzymatic workflow.

Calibration curves for both, acetylcholine and …

Role Of The Osaa Transcription Factor Gene In Development, Secondary Metabolism And Virulence In The Mycotoxigenic Fungus Aspergillus Flavus, Farzana Ehetasum Hossain

Graduate Research Theses & Dissertations

Aspergillus flavus colonizes oil-seed crops, contaminating them with aflatoxins; highly carcinogenic mycotoxins that cause severe health and economic losses. Genetic studies may reveal new targets for effective control strategies. Here, we characterized a putative WOPR transcription factor gene, osaA, in A. flavus. Our results revealed that osaA regulates conidiation and sclerotial formation. Importantly, deletion of osaA reduces aflatoxin B1 production, while, unexpectedly, transcriptome analysis indicated upregulation of aflatoxin biosynthetic genes, suggesting post-transcriptional or cofactor-mediated regulation. Cyclopiazonic acid production also decreased in the absence of osaA. In addition, the osaA mutant exhibited upregulation of genes in the imizoquin and aspirochlorine clusters. …

Nutritional Niche Separation Amongst Sympatric Threatened Lemurs: The Role Of Micronutrients In Food Selection And Implications For Physiological Health, Maire K. O'Malley

Graduate Research Theses & Dissertations

Madagascar’s biodiversity is heavily affected by anthropogenic change and consequently, conservation management plans need to reflect current research to protect biodiversity. Primate nutritional ecology offers valuable insights into ecology, evolution, health, habitat requirements, social behavior, and conservation management strategies. Macronutrients (fat, carbohydrates, and protein) provide consumers with energy whereas micronutrients (vitamins and minerals) are essential to metabolic processes but are frequently overlooked. This study provides a novel examination of dietary niche separation by comparing mineral consumption between three sympatric species differing in feeding strategies: 1) Grey Bamboo lemur (Hapalemur griseus), a bamboo specialist, 2) Diadema sifaka (Propithecus diadema), a folivore, …

An Integrated Pull System Framework For Disassembly Industries: Bridging The Supply-Demand Mismatch In Duck Meat Processing, Hongchao Yu

Graduate Research Theses & Dissertations

Disassembly-based production systems, such as duck meat processing, face inherent operational challenges due to one-to-many production structures, short product shelf life, and volatile customer demand. A single carcass must be processed into multiple products at largely fixed biological ratios, while demand varies across products and over time. This supply-demand mismatch frequently leads to simultaneous surplus and shortage, resulting in unstable shipment schedules, excess inventory, and unavoidable waste. Traditional order-driven pull systems typically respond to orders independently and are limited in their ability to coordinate these interrelated effects.

This dissertation develops an integrated pull system framework for perishable disassembly processes, using …

Instruction Vs. Infrastructure: Asymmetric Returns In U.S. Higher Education, Shaibu Yahaya

Graduate Research Theses & Dissertations

Despite massive increases in funding, U.S. higher education degree output has stagnated—a paradox often attributed to external cost pressures like Baumol’s cost disease. This paper tests an alternative hypothesis: that internal resource misallocation, specifically the accumulation of noninstructional liabilities, actively crowds out educational productivity. Using a panel of 26,603 institution-year observations, I estimate the university production function via a fixed-effects Poisson specification, adjusting all financial inputs using the Higher Education Price Index. The results expose a stark asymmetry in productive returns: a 10% increase in instructional spending drives a 1.76% increase in degree production (β = 0.176). In contrast, the …

Feasibility Study Of Concurrent Removal Of Organics And Ammonium Using An Iron Dosed Upflow Anaerobic Sludge-Blanket Bioreactor, Morgan Elizabeth Amos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aerobic microbial reactions have commonly been utilized in treatment processes to oxidize and remove organics and nitrogen through aeration, using processes such as nitrification that converts ammonium (NH₄⁺) into nitrite (NO₂^-) and nitrate (NO₃^-). Anoxic microbial reactions like denitrification often require organic compounds as an external source to chemically reduce the oxidized nitrogen (NO₃^- and NO₂^-) to nitrogen gas (N₂) for nitrogen removal from the liquid phase. These mainstream processes have a high chemical cost and energy footprint which results in an increased release …

Operationalizations Of Adverse Childhood Experiences And Health Prediction, Sarah Josephine Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Exposure to adverse childhood experiences (ACEs) has been consistently linked to suboptimal health outcomes and behaviors across the lifespan. As such, there has been widespread adoption of measures like the 10-item cumulative ACEs count measure developed by Felitti and colleagues (1998) across research literature and clinical practice. However, this measure was not developed with consideration of optimal psychometric properties and thus consists of several limitations that inhibit understanding of the specific dimensions of adversity that influence health outcomes. This 3-study dissertation focused on different measurement and statistical techniques to better understand the associations between ACEs and health. In study 1, …

Exploring Phonics Intervention For Elementary Students, Hallee Thomas

Masters Theses

No abstract provided.

Feasibility Of Corn Stover For Biogas Production In Northwestern Illinois: A Case Study Of Jo Daviess And Carroll Counties, Anthony Amotoe-Bondzie

Masters Theses

The growing demand for renewable energy and sustainable waste management has intensified interest in agricultural residues such as bioenergy feedstocks. This study evaluated the feasibility of converting corn stover into biogas through anaerobic digestion (AD) in Jo Daviess and Carroll Counties, Illinois, with consideration of the Savanna Industrial Park as a potential centralized processing hub. Although corn stover represents one of the largest biomass resources in the United States, this research identifies a critical gap between theoretical availability and practically recoverable feedstock. Using a mixed-methods framework, the study integrates biomass quantification, methane yield modeling, economic analysis, and policy assessment. Results …

Epigenetic Modifications In Dedifferentiated Liver Cells To Restore Lost Liver Function, Shreya Sharma

Masters Theses

The goal of the study is to investigate whether the epigenetic modifications can enhance the restoration of liver gene expression in dedifferentiated hepatoma cells or not. For the study, we used dedifferentiated H11 hepatoma cell lines which overexpress one of a panel of introduced candidate liver-enriched transcription factors H11-HNF1a, H11-CREB3L3, H11-CREG1, H11- HHEX, H11-HNF6, and H11-IGFBP1. The cells were treated with the DNA methyltransferase inhibitor 5-azacytidine and the histone deacetylase inhibitor sodium butyrate, both individually and in combination. Gene expression analysis was determined by RT-qPCR, which revealed that while transcription factor overexpression alone produced limited activation, epigenetic modulation, particularly Histone …

Personality-Based Clinical Predictors Of Transdiagnostic Suicidality In Emotional Disorders, Harshini Arun

Masters Theses

No abstract provided.

Sex Differences In Clinical Characteristics, Treatment, And Outcomes Of Cardiovascular Disease: Kenya Heart Registry Analysis, Lilian Mbau, Martha Gulati, Mzee Ngunga, Jasmit Shah, Felix Barasa, Jeilan Mohamed, Anders Barasa, Bernard Gitura, Harun Otieno, Etienne Amendezo

Internal Medicine, East Africa

Background Cardiovascular disease is the leading cause of death globally, with approximately 80% of these deaths occurring in low- and middle-income countries. Sex differences in cardiovascular disease are well described in high-income countries but limited in low- and middle-income countries.

Objectives This study sought to evaluate the sex differences in clinical presentation, cardiovascular risk profile, diagnosis, treatment, and outcomes among patients in the Kenya Heart Registry.

Methods Data were prospectively collected from 3 tertiary hospitals, including patients with heart failure, acute coronary syndrome, venous thromboembolism, and atrial fibrillation. Primary outcomes were in-hospital and 6-month mortality, as well as sex-specific differences …

Layers Of Biodiversity: Linking Urban Garden Plants And Arthropods, Chenyang Su

Dartmouth College Ph.D Dissertations

Diverse arthropods play essential roles in urban agriculture, while urban agriculture provides food and habitat that support arthropod biodiversity in fragmented urban landscapes. In urban community gardens, a form of urban agriculture characterized by allotment-style gardens, arthropods interact with plants and green space across multiple spatial scales of management, from individual gardeners' plots to broad urban landscapes. Understanding how plant communities in urban community gardens and urban landscapes shape arthropod biodiversity and interactions across scales can inform both agricultural management and urban biodiversity conservation. In this thesis, I conducted a series of field studies on ecologically and economically important arthropods …