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Genomic Signatures Of Decline And Recovery In An Endangered Bat, Myotis Grisescens, Marxe Altman-Orbach

Graduate Theses/Dissertations

Tremendous population declines may result in the loss of genetic diversity, which can, in turn, lead to reduced adaptive potential, overexpression of deleterious phenotypes, and further population declines. In this way, genetic drift from a severe demographic decline may ultimately lead to an extinction vortex. However, populations that avoid the loss of genetic diversity may remain viable, despite demographic crashes. Therefore, understanding genetic diversity is vital for assessing the conservation status of species that have undergone declines, and can even reflect the effectiveness of management actions. I investigated signatures of genetic bottlenecks in the gray bat (Myotis grisescens), …

United States Mainstream Meat Market Entry: An Analysis On Speciality Goat Meat Products, Madison Raye Schmitz

Graduate Theses/Dissertations

Understanding consumers' perspectives and motivations is key when looking into making goat meat more accepted in the mainstream meat market. Previous research has shown there is a demand for goat meat from different populations in the US. Consumers also care more about the quality of the food they purchase. Understanding that goat meat has lower cholesterol and is leaner than other red meat is important to incorporating goat meat in niche consumer markets. Providing consumers with a product that is familiar to them is more acceptable than giving consumers a cut of meat they are unfamiliar with. Standard products like …

Exploring Factors Mediating White-Nose Syndrome In Little Brown Bats, Carly R. Trujillo

Graduate Theses/Dissertations

The little brown bat (Myotis lucifugus) has experienced drastic population declines across North America due to the recent disease white-nose syndrome (WNS). Previous studies have identified putatively adaptive alleles (PAAs) that may give individuals a greater likelihood of survival. However, there could be geographic-specific adaptation, creating different adaptive landscapes. Additionally, there may be energetic trade-offs between disease survival and reproductive output, and it is not clear what the long-term survival outcomes for the species may be as a result. Long-term evolutionary outcomes are unclear because this species has a lifespan exceeding the arrival of WNS and is difficult …

The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee

Graduate Theses/Dissertations

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional mechanism mediated by ADAR enzymes that can alter RNA sequence, protein function, and gene regulation. Because ADAR1 is upregulated during inflammation and plays a critical role in innate immunity, previous studies investigated the effects of acute inflammation on RNA editing in male and female mice. Lipopolysaccharide (LPS) was used to induce inflammation, and RNA editing levels were examined in the heart, brain, and skeletal muscle. While editing levels in the heart and brain remained unchanged, skeletal muscle exhibited tissue- and sex-specific differences in editing. In this thesis, LPS treatment affected selective editing, increasing …

Operationalizing Cyber-Routine Activities Theory For Senior Cybercrime Prevention: An Evaluation Of The Shield Training-The-Trainer Program, Kyung-Shick Choi, Insun Park, Mijin Kim, Ji Yae Bong

International Journal of Cybersecurity Intelligence & Cybercrime

Older adults face growing risks of cyber-enabled fraud, yet scalable, evidence-based prevention programs remain limited. Guided by Cyber-Routine Activities Theory (Cyber-RAT), this study evaluates the pilot implementation of the Seniors Harnessing Internet Education for Lasting Defense (SHIELD) Training-the-Trainer program, designed to prepare law enforcement officers and community leaders to deliver cybercrime prevention education to older adults. A key innovation of SHIELD is its integration of interactive game-based simulations, which allow participants to practice verification, refusal, and reporting behaviors in realistic cybercrime scenarios. Following the December 2025 pilot session in Boston, semi-structured interviews were conducted with 12 participants from law enforcement, …

If You Build It, Will They Stay? Fish Communities Continue To Utilize Restored Habitat A Decade Following An Instream Restoration, Alexis L. Vandenberg

Masters Theses

Lotic ecosystems are degraded at an alarming rate due to anthropogenic activities. In order to combat these changes, stream restorations are implemented to improve conditions such as water quality, habitat heterogeneity, and bank stability. However, the impacts of these restorations are often understudied and long-term impacts are unknown. Restorations are typically designed to be ‘fish attractors’; this idea is known as the ‘Field of Dreams hypothesis’ – ‘if you build it, they will come’. This study uses data collected in Kickapoo Creek, Coles County from 2009 to 2015 and again in 2021 and 2022 to assess the long-term impacts of …

Compositional And Functional Shifts In Fish Community Structure In Response To Low-Head Dam Removals, Joshua D. Bruegge

Masters Theses

Low-head dams serve as intermittent barriers to aquatic connectivity and directly alter both upstream and downstream habitats and biotic communities. In 2018 and 2019, two low-head dams in the Vermilion River watershed of eastern Illinois were removed, reconnecting over 1,700 kilometers of upstream habitat within the basin. To determine the impacts of these dam removals, fish community surveys were conducted at 12 fixed sites across three reaches in two rivers from 2012-2022. This study assessed reach-specific temporal responses of the fish community and habitat characteristics. I linked trait expressions within the fish community to abiotic variables using the co-inertia RLQ …

The Role Of International Student Office Directors In Facilitating The Transitional Adjustment Of International Students In U.S Higher Education, Agnes Afi Yigah

Masters Theses

This qualitative study explored how International Student Office Directors facilitate the transitional adjustment of international students in U.S. higher education institutions. Guided by Schlossberg’s Transition Theory (1981) and Schlossberg’s Mattering and Marginality Theory (1989), this study examined the challenges international students face, the support strategies implemented by International Student Office Directors, and the institutional factors influencing student adjustment and well-being. International students experience challenges related to housing and logistical adjustment, financial and immigration-related stressors, academic system adjustment and self-advocacy, and social integration and emotional adjustment. Proactive and holistic support approaches, including pre-arrival communication, orientation programs, academic support, emotional support, and …

Latent Classification Of Time-Dependent Transition Rates In Longitudinal Binary Outcome Data, Joonha Chang, Wenyaw Chan

Faculty, Staff and Student Publications

Continuous-time Markov chain (CTMC) models and latent classification methods are commonly used to analyze longitudinal categorical outcomes in medical research. While CTMC models are popular for their simplicity and effectiveness, their assumption of constant transition rates presents limitations in capturing dynamic behaviors. To address this, non-homogeneous continuous-time Markov chains (NH-CTMCs) have been developed, incorporating time-varying transition rates to enhance model flexibility. In this study, we leverage closed-form transition probabilities for a fully ergodic two-state NH-CTMC model and propose a latent class clustering approach to identify heterogeneous transition rate patterns within the population. We emphasize the potential advantages of these models …

“If He Did It, I Can Do It, Too. I Can Change My Life Around”: The Social Model Of Recovery Within The Context Of Recovery Homes Accepting Residents Prescribed Medications For Opioid Use Disorder, Jodie M Dewey, Kathryn R Gallardo, Meenakshi S Subbaraman, Amy A Mericle

Faculty, Staff and Student Publications

Introduction: This paper provides an in-depth examination of examines four recovery residences, that serve individuals prescribed medications for opioid use disorder (MOUD). The study has two primary aims: first, to deepen understanding of how recovery residences adopt and operationalize Social Model of Recovery principles; and second, to identify gaps in staff integration of residents receiving MOUD-gaps that may either support or undermine the integrity of the social model within these settings.

Methods: We conducted semi-structured interviews with 17 residents receiving MOUD living in four participating recovery homes. The interviews were conducted between August 2022 and January 2024 using a semi-structured …

Pregnancy And Breastfeeding Are Associated With Less Later-Life Cognitive Decline In A Longitudinal, Prospective Cohort, Molly M Fox, Jennifer E Bramen, Dayoon Kwon, Mark A Espeland, Yijia Sun, Li Zhang, Aladdin H Shadyab, Ramon Casanova, Joann E Manson, Marcus Y Chang, Verna R Porter, Leslie V Farland, Qian Xiao, Robert A Wild, Prabha Siddarth, Carolyn J Crandall

Faculty, Staff and Student Publications

Introduction: The brains of female mammals evolved to undergo structural and functional changes during pregnancy and lactation, equipping them for motherhood. However, long-term cognitive health implications of these adaptations in women are poorly understood.

Methods: In the Women's Health Initiative (WHI) Memory Study (WHIMS; n = 7427) and WHI Study of Cognitive Aging (WHISCA; n = 2304), postmenopausal women completed reproductive history interviews, annual global cognitive assessment from mean age 70 for up to 13 years, and multi-domain cognitive testing for up to 8 years.

Results: Each additional month pregnant was associated with higher scores of global cognition. Each additional …

Artificial Light At Night Extends Pollen Season And Elevates Allergen Exposure, Brandt Geist, Lin Meng, Daniel S W Katz, Huidong Li, Franz Hölker, Qian Xiao

Faculty, Staff and Student Publications

Artificial light at night (ALAN), a growing environmental stressor in urban ecosystems, disrupts natural light-dark cycles and alters plant phenological events such as leaf-out and flowering. However, the extent to which ALAN influences airborne pollen season timing and exacerbates allergy-related health risks remains largely understudied. This study investigates how ALAN influences the timing and duration of the airborne pollen season across the Northeastern United States from 2012 to 2023 and the consequences of allergenic pollen exposure. Using daily pollen concentrations from the National Allergy Bureau, ALAN data from the Visible Infrared Imaging Radiometer Suite product, and gridded Daymet climate data, …

Plasma Proteomic Profile Of Dietary Potassium And Incident Ckd, Jiaqi Yang, Lauren Bernard, Jingsha Chen, Valerie K Sullivan, Bing Yu, Eugene P Rhee, Paul A Welling, Casey M Rebholz

Faculty, Staff and Student Publications

Background:: There is a need for objective biomarkers of dietary potassium. The mechanisms through which dietary potassium influences kidney health are incompletely understood.

Methods:: Atherosclerosis Risk in Communities study participants at visit 3 (1993–1995) with dietary and proteomics data were randomly divided into discovery (N=6,814) and replication (N=3,380) sets. We examined associations between dietary potassium and 4,955 aptamers using multivariable linear regression, adjusting for sociodemographic factors, health behaviors, and estimated glomerular filtration rate, with a false discovery rate of 0.05. Then, we tested the prospective associations between potassium-related proteins and incident chronic kidney disease (CKD).

Results:: …

Adapting A Smartphone-Based Auricular Point Acupressure Self-Management Program For Rural Chronic Musculoskeletal Pain: Qualitative Study, Jungkyung Min, Peiyin Hung, Jane N Bolin, Rupsikha Bora, Sarah Pace, Patricia Pitones, Hulin Wu, Jennifer Kawi

Faculty, Staff and Student Publications

Background: Chronic musculoskeletal pain is more prevalent in rural areas where access to pain interventions, including complementary approaches like Auricular Point Acupressure (APA), remains limited. APA is a non-invasive, needle-free approach, and its smartphone-based self-management delivery model has not been optimized for rural contexts.

Objectives: To explore the perspectives of rural partners on adapting a smartphone-based Auricular Point Acupressure-Self-Management (APA-SM) program to better meet rural needs. Study objectives were to: (1) refine the APA-SM program for rural adults, (2) identify implementation barriers, (3) understand practice workflows and engagement, and (4) identify strategies to integrate the APA-SM program into rural pain …

Data For Forthcoming Article: "Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors", Colleen Carpenter-Swanson

Biology Faculty Publications

Forthcoming from Frontiers in Pharmacology:

"Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based …

Subgroup Identification Of Disparities In Buprenorphine Discontinuation In Opioid-Use Disorder: A Virtual Twins Machine Learning Approach Using Nationwide United States Claims Data, 2006–2022, Kehe Zhang, Paula A Jaimes-Buitron, Wanru Guo, Yanmin Gong, Yuanxiong Guo, Carolina Vivas Valencia, Cici Bauer

Faculty, Staff and Student Publications

Buprenorphine retention is crucial for effective treatment of opioid use disorder (OUD), yet disparities in treatment discontinuation persist. This study aims to identify and quantify disparities in buprenorphine treatment retention using a machine learning framework adapted from Virtual Twins approach focusing on disparities related to sex, age, insurance type, geographic region, mental health status and community-level Social Vulnerability Index (SVI). Using a nationwide longitudinal cohort, we applied a two-stage machine learning approach. In Stage one, we trained classification models to estimate the counterfactual differences in treatment discontinuation across disparity types. Model performance was assessed using C-statistics and precision-recall curve. In …

Improving Overall Risk Ranking Via Subgroup-Level Information Borrowing In Survival Risk Stratification, Tia S Thomas, Jing Ning, Ruosha Li

Faculty, Staff and Student Publications

Effective risk stratification is essential for providing tailored therapies, improving patient outcomes, and optimizing healthcare resources by identifying sub-populations with similar health risks. However, accurate risk ranking is challenging in the presence of heterogeneous subgroups. Under these instances, subgroup-level information can be leveraged to refine the overall risk ranking. We propose a novel approach that integrates within-subgroup risk ranking percentiles to enhance the overall cohort risk stratification. This method uses both a global model and subgroup-specific models along with optimized weights to improve discriminatory performance across the entire cohort. The proposed method is validated through extensive simulations and applied to …

Relationship Between Foraminiferal Assemblages And Cassiopea Coverage Across A Gradient Of Human Influence In Jobos Bay National Estuarine Research Reserve, Puerto Rico, Nylah Barber, Angelique Rosa Marín, Natalia López-Figueroa, Darma Ramos-Negrón, Xiomara Cruz-De León, Andrea Acevedo Colón, Pamela Hallock

Making Waves REU

Ecological Relevance: Foraminifera and Cassiopea (upside down-jellyfish) are symbiont-bearing organisms that respond rapidly to environmental changes in tropical systems, hence potential candidates as bioindicators to support ecological monitoring at JBNERR. Purpose: By using foraminiferal assemblages and Cassiopea as potential bioindicators, we can assess environmental conditions and contribute to management needs in the reserve. Hypothesis: Foraminiferal assemblages and the percent coverage of Cassiopea will reflect the habitat conditions of sites with varying levels of human influence at JBNERR.

Organizations, Businesses, Religious Groups In Alabama Supporting The Moratorium, Unsigned

Moratorium Advocacy

A list of more than 200 religious groups, businesses and organizations supporting the proposed moratorium on executions in Alabama.

Investigation Of Succinylated Zwitterionic Polyethylenimine/Dna Complexes: Performance In Serum, Internalization, And Intracellular Fate, Levi Lampe

Theses and Dissertations--Chemical and Materials Engineering

Gene therapy has promised to revolutionize medicine since the earliest clinical trials, but a lack of delivery methods that are both safe and efficient has hampered progress. Gene therapy with viral vectors is effective at delivering nucleic acids to cells, but is associated with dangerous immunogenic responses and cancer-causing insertions into the genome. Viral vectors are also among the most prohibitively costly therapeutics in medicine. Polymeric vectors avoid these dangers and are made from inexpensive, off-the- shelf materials, but have been hindered by poor efficiency compared to viral vectors.

A benchmark polymer for in vitro nucleic acid delivery has been …

Impact Of Preoperative Symptom Duration On Postoperative Outcomes Following Lumbar Spine Surgery, Ahmed Anas Zahra, Ayman Mohamed Basha

Mansoura Medical Journal

Background: The optimal timing for lumbar spine surgery (LSS) relative to symptom duration remains debatable. While surgical delays are common, their impact on postoperative outcomes is not fully elucidated. This study evaluated the relationship between preoperative symptom duration and postoperative outcomes following LSS.

Methods: A prospective observational study was conducted on 60 adults undergoing LSS (decompression and/or fusion) at a single university hospital. Participants were stratified into three groups based on symptom duration:Months, 3-12 months, and >12 months. The primary outcome was functional disability assessed by the Oswestry Disability Index (ODI). Secondary outcomes included pain intensity (Visual Analog Scale, VAS), …

Fetal Foot Length As A Predictor Of Gestational Age, Ruman Bashir Abdi Kadie, Hossam El-Dyn El-Sayed Gouda, Mohamad Ahmad El-Sayed Mohamad Emam, Alhussein Ahmed Mohamed

Mansoura Medical Journal

Background: Accurate estimation of gestational age (GA) is essential for obstetric care. Conventional ultrasound (US) biometric parameters may be limited in certain clinical situations. Fetal foot length (FFL) has been proposed as an alternative measurement, but its role requires further evaluation.

Aim of study: To examine the association between fetal foot length and ultrasound-based gestational age, and to explore its relationship with other fetal biometric parameters in uncomplicated singleton pregnancies.

Methods: This cross-sectional study included 200 pregnant women who underwent two-dimensional transabdominal ultrasound. Standard fetal biometric parameters—including biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length …

“Thou Hast Taught Me, Silent River, Many A Lesson, Deep And Long”: Metabolism, Development, And Evolution As Team Sports, Scott F. Gilbert

Biology Faculty Works

We recognize three great fluxes in nature. First there is the metabolic flow of molecules that pervades our cells and which creates organisms. Second, there is the developmental flow of cells that is our cycle of life. Third, there is the evolutionary flow of genes, organisms, and populations from the first single-celled prokaryotes to the extensive biodiversity present on earth today. Recent studies have shown that organisms are consortia of several species acting together. What we had thought of as metabolism based on a single genome is actually the co-metabolism of more than one species. What we had thought as …

Signs Of Life: Interkingdom Communication And The Sympoietic Organism, Scott F. Gilbert

Biology Faculty Works

No abstract provided.

Hybridization Of Genetic Algorithm, Principal Component Analysis And Deep-Learning For Networks Intrusion Detection Systems, Mostafa A. R. Eltokhy, Hend M. A. Mahmoud, Mohammad Sammany

Trends in advanced sciences and technology

With cyber-attacks on the rise, the demand for precise and efficient Intrusion Detection Systems (IDS) is more critical than ever. Traditional machine learning methods struggle with high false alarm and poor detection rates. IDS are crucial for creating secure digital environments by classifying and responding to network intrusions. However, the large volume of inputs for classification often leads to reduced accuracy and misclassification errors. To address this problem, Principal Component Analysis (PCA) is used to optimize the number of classifier inputs, enhancing simplicity without compromising accuracy. A significant challenge in PCA for feature selection lies in determining the best cutoff …

Immuno-Toxic Effects Of Zinc Oxide Nanoparticles And Protective Role Of Moringa Olifera On Thymus Of Male Albino Rats, Marwa Abdelsalam Abdallah, Alaa Fehaid, Aml Abdelmonem Halawa, Mmdouh Mohammed Abou Ealmagd

Mansoura Veterinary Medical Journal

Background and Aim The present study aims to evaluate the protective role of Moringa olifera (MO) extract against Zinc Oxide Nanoparticles (ZnO NPs) induced immunotoxicity in male albino rats. Methods Forty-eight Male albino rats were divided into six groups. The 1st group (control) orally received distilled water. The 2nd group received 100 mg/kg of MO extract. The 3rd group was administered 200 mg/kg B.W ZnO NPs. The 4th group received 200 mg/kg B.W ZnO NPs in combination with 100 mg/kg of MO extract. The 5th group received 400 mg/kg B.W ZnO NPs. The 6th group received 400 mg/kg B.W ZnO …

International Human Rights Intervention: Collective Self-Defense Of Humanity, Anthony J. Colangelo

Emory International Law Review

No abstract provided.

Impact Of Family And Social Determinants Of Health On Behavioral And Bmi Outcomes In Adolescents With And Without Intellectual And Developmental Disabilities: An Ecological System Perspective, Pingnan Li

Social Work Theses

Adolescence is a critical developmental period during which behavioral and physical health outcomes are shaped by social and family determinants of health; yet limited research has examined how these determinants operate among adolescents with intellectual and developmental disabilities (IDD) within a multilevel ecological framework. To address this gap, this thesis used data from Years 9 and 15 of the Future of Families and Child Wellbeing Study (FFCWS), with a final analytic sample of 3,176 adolescents at Year 15, including 150 with IDD. Descriptive analyses first examined the differences in demographic characteristics, behavioral outcomes (externalizing and internalizing behaviors), and physical outcomes …

Analyzing Changes In Russian Olive Distributions Along The Missouri River In Response To Flooding, Zachary Schild

Dissertations and Theses

Russian olive (Elaeagnus angustifolia; RO) is an invasive, nitrogen-fixing tree that has spread across riparian ecosystems in the western United States, potentially hindering native tree recruitment, reducing species richness, and impacting wildlife. RO has established within the Missouri National Recreational River (MNRR) in part due to modified flow regimes following dam construction. This study aimed to map the spread of RO using high-resolution National Agriculture Imagery Program (NAIP) imagery (2010, 2012, 2018, 2022) and evaluate the effects of the 2011 and 2019 floods on RO distributions in the Missouri National Recreational River (MNRR). RO cover in this area has expanded …

Identifying Rna Splicing Changes During Alcohol Withdrawal Using An Optimized Rna-Seq Analysis Pipeline, Yasaswi Veera, Luana Martins De Carvalho, Amy Lasek

Undergraduate Research Posters

Alcohol use disorder (AUD) causes long-lasting changes in brain gene expression and RNA splicing, particularly in the ventral hippocampus. This study analyzes RNA-Seq data from rats exposed to chronic alcohol and withdrawal to identify transcript-level and splicing alterations. An optimized RNA-Seq pipeline using STAR, FeatureCounts, edgeR, and WGCNA improved efficiency by 25-40% while maintaining consistency across 25 datasets. Results reveal changes in neural signaling and stress-response pathways associated with withdrawal. This work provides both biological insight into AUD and a reproducible computational framework for transcriptomic analysis.