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Articles 150691 - 150720 of 157175
Full-Text Articles in Entire DC Network
Robot-Assisted Versus Dynamic Navigation In Endodontic Microsurgery: Strengths, Weaknesses And Future Directions, He Liu, Ya Shen
Robot-Assisted Versus Dynamic Navigation In Endodontic Microsurgery: Strengths, Weaknesses And Future Directions, He Liu, Ya Shen
Journal of Dental Sciences
No abstract provided.
Long-Term Stability Of Maxillary Molar Intrusion Using Temporary Anchorage Devices: A 17-Year Case Report, Ting-Hsin Huang, Cheng-Shan Li, Yi-Hung Chen, Shing-Zeng Dung
Long-Term Stability Of Maxillary Molar Intrusion Using Temporary Anchorage Devices: A 17-Year Case Report, Ting-Hsin Huang, Cheng-Shan Li, Yi-Hung Chen, Shing-Zeng Dung
Journal of Dental Sciences
No abstract provided.
Development Of Zinc Partially-Stabilized Cement Carrying Growth Factor And Anti-Inflammatory Drug For Vital Pulp Therapy, Chun-Pin Lin, Tsao-Li Chuang, Chih-Chun Chang, Chun-Liang Yeh
Development Of Zinc Partially-Stabilized Cement Carrying Growth Factor And Anti-Inflammatory Drug For Vital Pulp Therapy, Chun-Pin Lin, Tsao-Li Chuang, Chih-Chun Chang, Chun-Liang Yeh
Journal of Dental Sciences
Abstract Background/purpose Mineral trioxide aggregate (MTA) is recognized as the gold standard for vital pulp therapy. However, its clinical utility is limited by prolonged setting and poor handling characteristics. To overcome these drawbacks, the zinc-containing partially-stabilized cement (ZnPSC), a modified silicate cement, was developed. In this study, the ZnPSC was functionalized with vascular endothelial growth factor (VEGF) and aspirin to enhance its potential as an effective pulp capping material. Materials and methods The ZnPSC cements (5 %,7 %, or 10 % of Zn) were combined with poly-γ-glutamic acid (γ-PGA) 1 % or 2 % as a carrier system for VEGF …
Assessing The Impact Of Apicoectomy On Autotransplantation Success Rates: A Six-Year Retrospective Cohort Study In Taiwan, Yu-Hsueh Wu, Kai-Yun Tso, Wei-Chih Chiu
Assessing The Impact Of Apicoectomy On Autotransplantation Success Rates: A Six-Year Retrospective Cohort Study In Taiwan, Yu-Hsueh Wu, Kai-Yun Tso, Wei-Chih Chiu
Journal of Dental Sciences
Abstract Background/purpose Tooth autotransplantation is a viable surgical approach for rehabilitating edentulous areas. However, the influence of endodontic interventions, particularly apicoectomy, on outcomes of transplanting fully developed teeth remains incompletely understood. This study evaluated success and survival rates of autotransplantation in fully developed teeth and assessed the impact of various endodontic interventions on treatment outcomes in a Taiwanese population over a six-year period. Materials and methods A retrospective cohort study examined records of patients who underwent tooth autotransplantation at National Cheng Kung University Hospital, Taiwan, between 2018 and 2023. The study included 40 patients with 45 fully developed transplanted teeth. …
Single-Cell Isolation Reveals 5 Fluorouracil-Resistant Subclones In Oral Squamous Cell Carcinoma: New Insights Into Stemness And Epithelial–Mesenchymal Transition For Targeted Therapies, Wei-Chia Su, Yi-Ming Chang, Hsin-Hu Chen, Su-Feng Chen, Meng-Hua Yang, Yu-Chun Lin, Jian-Hong Yu
Single-Cell Isolation Reveals 5 Fluorouracil-Resistant Subclones In Oral Squamous Cell Carcinoma: New Insights Into Stemness And Epithelial–Mesenchymal Transition For Targeted Therapies, Wei-Chia Su, Yi-Ming Chang, Hsin-Hu Chen, Su-Feng Chen, Meng-Hua Yang, Yu-Chun Lin, Jian-Hong Yu
Journal of Dental Sciences
Abstract Background/purpose Oral squamous cell carcinoma (OSCC) often recurs and has poor clinical outcomes, partly attributable to subpopulations that develop resistance to 5 fluorouracil (5FU). Elucidating how these resistant clones emerge and drive tumour aggressiveness is essential for improving OSCC treatment approaches. Materials and methods To establish 5FU-resistant cells, SCC25 cells were repeatedly exposed to 5FU, and single-cell clones were subsequently isolated using a microfluidic system. Three subclones-Holoclone, Meroclone, and Paraclone-were evaluated for their 5FU responses, expression of drug-efflux pumps (ABCB1, ABCG2), and resistance in three-dimensional (3D) cultures. Their levels of cancer stem cell (CSC) markers (OCT4, SOX2, CD44, CD133) …
Cone-Beam Computed Tomography-Guided Freehand Technique For Managing Pulp Canal Obliteration: Clinical Tips And Precautions, Ya Shen, He Liu
Cone-Beam Computed Tomography-Guided Freehand Technique For Managing Pulp Canal Obliteration: Clinical Tips And Precautions, Ya Shen, He Liu
Journal of Dental Sciences
No abstract provided.
Boosting The Antibacterial Potency Of Antimicrobial Photodynamic Therapy Against Oral Pathogens Through Supplement Agents: A Narrative Review, Rashin Bahrami, Maryam Pourhajibagher, Ehsan Kazemi Moghaddam, Abbas Bahador
Boosting The Antibacterial Potency Of Antimicrobial Photodynamic Therapy Against Oral Pathogens Through Supplement Agents: A Narrative Review, Rashin Bahrami, Maryam Pourhajibagher, Ehsan Kazemi Moghaddam, Abbas Bahador
Journal of Dental Sciences
Abstract Antimicrobial photodynamic therapy (aPDT) is a promising approach for managing oral infections; however, it faces several limitations, such as limited penetration depth, biofilm resistance, and photosensitizer dimerization or aggregation. To address these challenges, the current study reviews new techniques to enhance the antibacterial effectiveness of aPDT. Recent advances have pointed out the potential of novel supplement agents—including inorganic salts, antimicrobial peptides, surfactant media, and postbiotics—to overcome these limitations significantly. Inorganic salts like potassium iodide, potassium selenocyanate, and potassium thiocyanate can enhance aPDT by generating additional reactive species or increasing reactive oxygen species (ROS)-mediated cytotoxicity. Antimicrobial peptides disrupt membranes selectively …
Prediction Of Dental Students’ Pre-Clinical Crown Preparation Performances By A Virtual Reality Haptic-Based Dental Simulator, Yu-Chao Chang, Min-Hsun Hsu
Prediction Of Dental Students’ Pre-Clinical Crown Preparation Performances By A Virtual Reality Haptic-Based Dental Simulator, Yu-Chao Chang, Min-Hsun Hsu
Journal of Dental Sciences
Abstract Background/purpose Manual dexterity training is essential for dental students. The implementation of virtual reality haptic-based dental simulator Simodont (Nissin Inc., Nieuw-Vennep, Netherlands) can provide the real-time feedback in pre-clinical learning. The aim of this study was hypothesized that Simodont may act as a valuable assessment tool in predicting the performance of pre-clinical crown preparation. Materials and methods This retrospective cohort study was to analyze total 84 dental students' performance among manual dexterity exercises on Simodont, crown preparation on Simodont, and crown preparation test on phantom head. Spearman's correlation coefficient (r) was used to examine the relationships of performances among …
Roles Of Basic Fibroblast Growth Factor, Stem Cells From Dental Pulp And Apical Papilla In The Repair And Regeneration Of Dental Pulp And Other Tissues/Organs, Jiiang-Huei Jeng, Pin-Hsuan Wu, Yan-Hsiung Wang, Ying-Chu Lin, Ya-Shuan Chou, Mei-Chi Chang
Roles Of Basic Fibroblast Growth Factor, Stem Cells From Dental Pulp And Apical Papilla In The Repair And Regeneration Of Dental Pulp And Other Tissues/Organs, Jiiang-Huei Jeng, Pin-Hsuan Wu, Yan-Hsiung Wang, Ying-Chu Lin, Ya-Shuan Chou, Mei-Chi Chang
Journal of Dental Sciences
Abstract Currently, the concept of regeneration and regenerative therapies are already being applied clinically to treat pulpal and periodontal diseases, as well as to repair and regenerate systemic organs and tissues. During wound healing, well-developed, functional vascular networks and revascularization are fundamental factors in restoring regenerative potential. Growth factors, stem cells, and scaffolds alone or in combination are reported to contribute to successful tissue repair and engineering via cell transplantation, cell homing or other technologies. Among the growth factors, basic fibroblast growth factor (bFGF) has been found to regulate the proliferation, stemness, migration, and differentiation of vascular and mineralized tissues …
Performance Of Artificial Intelligence Chatbots In National Dental Licensing Examination, Chad Chan-Chia Lin, Jui-Sheng Sun, Chin-Hao Chang, Yu-Han Chang, Jenny Zwei-Chieng Chang
Performance Of Artificial Intelligence Chatbots In National Dental Licensing Examination, Chad Chan-Chia Lin, Jui-Sheng Sun, Chin-Hao Chang, Yu-Han Chang, Jenny Zwei-Chieng Chang
Journal of Dental Sciences
Abstract Background/purpose The Taiwan dental board exams comprehensively assess dental candidates across twenty distinct subjects, spanning foundational knowledge to clinical fields, using multiple-choice single-answer exams with a minimum passing score of 60 %. This study assesses the performance of artificial intelligence (AI)-powered chatbots (specifically ChatGPT3.5, Gemini, and Claude2), categorized as Large Language Models (LLMs), on these exams from 2021 to 2023. Materials and methods A total of 2699 multiple-choice questions spanning eight subjects in basic dentistry and twelve in clinical dentistry were analyzed. Questions involving images and tables were excluded. Statistical analyses were conducted using McNemar's test. Furthermore, annual results …
The Potential Bactericidal Effect Of Oral Probiotics On Extrinsic Black Stain-Associated Bacteria In Children: An In-Vitro And In-Vivo Study, Nour Abdelmonem Wahba, Dina Sharaf, Mohamed Bissar, Ahmed El-Motayam, Basma Nagi
The Potential Bactericidal Effect Of Oral Probiotics On Extrinsic Black Stain-Associated Bacteria In Children: An In-Vitro And In-Vivo Study, Nour Abdelmonem Wahba, Dina Sharaf, Mohamed Bissar, Ahmed El-Motayam, Basma Nagi
Journal of Dental Sciences
Abstract Background/purpose The extrinsic black stain (EBS) is a resistant esthetic problem in children. The aim of this study was to investigate the bactericidal effect of three probiotics strains on two types of EBS-associated bacteria in-vitro and in-vivo in children. Materials and methods In the in-vitro study, two bacterial strains ( Aggregatibacter actinomycetemcomitans and Actinomyces naeslundii ) were revived and incubated under anaerobic or microaerophilic conditions. Cultures were grown in Brain Heart Infusion broth, adjusted to a 0.5 McFarland standard, and diluted to 1.0 × 10⁶ CFU/mL for minimum inhibitory concentration (MIC) testing. Three Probiotic strains ( Streptococcus Salivarius BLIS …
Conservative Surgical Management Of Stage Iii Medication-Related Osteonecrosis Of The Jaw In The Mandible: A Retrospective Study With Particular Emphasis On Anterior Mandible, Da Young Kim, Jeong Joon Han
Conservative Surgical Management Of Stage Iii Medication-Related Osteonecrosis Of The Jaw In The Mandible: A Retrospective Study With Particular Emphasis On Anterior Mandible, Da Young Kim, Jeong Joon Han
Journal of Dental Sciences
Abstract Background/purpose Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with anti-resorptive therapy, and surgical intervention remains an effective treatment strategy regardless of disease stage. While extensive surgical resection is considered the standard approach for advanced-stage MRONJ, it may not be suitable for elderly patients or those with systemic comorbidities. This study evaluated the outcomes of conservative surgical management in patients with stage III MRONJ affecting the anterior mandible. Materials and methods A retrospective study was conducted on patients with stage III MRONJ of the anterior mandible. All patients underwent conservative surgical treatment, including sequestrectomy, debridement of …
A Novel Buccal Bone Augmentation Technique Around Non-Contained And Exposed Implant Threads: Clinical, Histologic And Histomorphometric Evaluations On The Treatment Outcome, David M Kim, Myron Nevins, Stefano Parma-Benfenati, Primo Gelletti, Chia-Yu Chen, Miruna Maracine, Traian Comanescu, Wei-Jen Chang
A Novel Buccal Bone Augmentation Technique Around Non-Contained And Exposed Implant Threads: Clinical, Histologic And Histomorphometric Evaluations On The Treatment Outcome, David M Kim, Myron Nevins, Stefano Parma-Benfenati, Primo Gelletti, Chia-Yu Chen, Miruna Maracine, Traian Comanescu, Wei-Jen Chang
Journal of Dental Sciences
Abstract Background/purpose Buccal dehiscence defects around dental implants pose a significant clinical challenge, particularly when minimal residual bone remains. This prospective study aimed to evaluate a novel two-layer bovine-derived grafting approach—a moldable paste-type material layered with particulate bone—protected by a collagen membrane to encourage new bone formation on exposed implant threads. Materials and methods Three partially or fully edentulous patients requiring implant-supported rehabilitation were enrolled. A total of 17 implants were placed; among these, three “study implants” exhibited pronounced buccal bone dehiscences and were grafted with the investigated protocol. Six months postoperatively, the designated study implants were retrieved en bloc …
Effects Of Sodium Hypochlorite On The Viability And Osteogenic Differentiation Of Dental Pulp Stem Cells In Regenerative Pulp Therapy, Jiahe Li, Yong Wang
Effects Of Sodium Hypochlorite On The Viability And Osteogenic Differentiation Of Dental Pulp Stem Cells In Regenerative Pulp Therapy, Jiahe Li, Yong Wang
Journal of Dental Sciences
Abstract Background/purpose Regenerative pulp therapy's efficacy is constrained by root canal disinfectants' effects on residual dental pulp stem cells. This study investigates sodium hypochlorite's influence on dental pulp stem cells (DPSCs) viability, mitochondrial function, and osteogenic differentiation, providing cellular and molecular foundations for optimizing clinical protocols. Materials and methods Human deciduous teeth-derived DPSCs were treated with sodium hypochlorite (0.5%–5%) for 1 min. Cell viability, cytoskeletal integrity, and mitochondrial morphology were assessed via CCK-8, immunofluorescence, and MitoTracker labeling. Osteogenic potential was evaluated through ALP activity, mineralized nodule quantification, and osteogenic marker expression. A juvenile rat model validated findings through immunohistochemistry and …
Propofol-Induced Osteogenic Differentiation In Dental Pulp Stem Cells: Modulation Of Mapk Signaling Under Inflammatory Conditions, Eun-Jung Kim, Mi Kyoung Kim, Giyoung Yun, Cheul-Hong Kim, Ji-Young Yoon, Hee Young Kim, Hyae Jin Kim
Propofol-Induced Osteogenic Differentiation In Dental Pulp Stem Cells: Modulation Of Mapk Signaling Under Inflammatory Conditions, Eun-Jung Kim, Mi Kyoung Kim, Giyoung Yun, Cheul-Hong Kim, Ji-Young Yoon, Hee Young Kim, Hyae Jin Kim
Journal of Dental Sciences
Abstract Background/purpose Bone regeneration in an inflammatory environment remains a significant challenge in the field of regenerative dentistry. Previous studies have demonstrated that inflammation inhibits osteogenic differentiation, necessitating the development of novel therapeutic approaches to counteract these effects. We investigated the effects of propofol on the osteogenic differentiation of dental pulp stem cells (DPSCs) under inflammatory conditions and explored the underlying signaling mechanisms. Materials and methods DPSCs were cultured in the presence of lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-α) to mimic inflammatory conditions. Propofol (10, 50, and 100 μM) was administered, and its effects on cell viability, alkaline phosphatase …
Evaluation Of The Accuracy, Occlusal Contact And Clinical Applications Of Zirconia Crowns Using Artificial Intelligence Design Versus Human Design, Wei-Chun Lin, Che-Ming Liu, Tsung-Yueh Lu, Ching-Shuen Wang, Sheng-Wei Feng, Yu-Chieh Lin, Sheng-Yang Lee
Evaluation Of The Accuracy, Occlusal Contact And Clinical Applications Of Zirconia Crowns Using Artificial Intelligence Design Versus Human Design, Wei-Chun Lin, Che-Ming Liu, Tsung-Yueh Lu, Ching-Shuen Wang, Sheng-Wei Feng, Yu-Chieh Lin, Sheng-Yang Lee
Journal of Dental Sciences
Abstract Background/purpose The uniqueness of human teeth necessitated that dental restorations be customized primarily through extensive manual labor. Therefore, this study explored the potential of AI designed dental restorations for clinical applications. Materials and methods Digital artificial design and AI design crown restorations were replicated 10 times, for a total of 20 samples. The zirconia crown restoration was completed by strengthening and glazing according to standard clinical procedures. Samples were digitally archived using a dental scanner to assess reproducibility, precision, and occlusion. The human trial portion included natural tooth preparations by clinical standards. Three participants each designed two crowns, resulting …
Advancing Special Needs Oral Healthcare In Southeast Asia Through Taiwan's New South Bound Project: Institutional Feedback And Sustainable Strategies, Chuan-Hang Yu, Chia-Tze Kao, Tsui-Hsien Huang, Ming-Yi Lu
Advancing Special Needs Oral Healthcare In Southeast Asia Through Taiwan's New South Bound Project: Institutional Feedback And Sustainable Strategies, Chuan-Hang Yu, Chia-Tze Kao, Tsui-Hsien Huang, Ming-Yi Lu
Journal of Dental Sciences
Abstract Background/purpose Providing oral healthcare to individuals with special needs remains inadequate in Southeast Asia. This study evaluated the outcomes from five universities across three Southeast Asian countries participating in Taiwan's “New South Bound Special Needs Patients Oral Care Project” after its four-year implementation (2018–2021). Materials and methods The questionnaires distributed to participating universities collected data on dental professionals' demographics, patient characteristics, and project satisfaction. Descriptive statistics analyzed the responses. Results All universities reported excellent satisfaction with the project. Dental professionals’ ages ranged from 31 to 60 years, and their service experience varied from 1 to 10 years. Special needs …
Alterations In Upper Airway Dimensions Following Bimaxillary And Mandibular Setback Surgery In Skeletal Class Iii Patients: A Cone-Beam Computed Tomography Study, Heng Li Huang, Ramish Hussain, I Chen, Jui-Ting Hsu, Pei-Wen Huang, Yuan-Chien Chen, Jian-Hong Yu
Alterations In Upper Airway Dimensions Following Bimaxillary And Mandibular Setback Surgery In Skeletal Class Iii Patients: A Cone-Beam Computed Tomography Study, Heng Li Huang, Ramish Hussain, I Chen, Jui-Ting Hsu, Pei-Wen Huang, Yuan-Chien Chen, Jian-Hong Yu
Journal of Dental Sciences
Abstract Background/Purpose Orthognathic surgery can result in a decreased upper airway volume, potentially increasing the risk of developing sleep disorders. This study aimed to evaluate upper airway changes following bimaxillary orthognathic surgery and mandibular setback surgery alone. Additionally, to investigate any correlation between factors such as mandibular plane angle and mandibular length on airway changes in skeletal Class III patients, utilizing cone beam computed tomography (CBCT) data. Materials and methods A total of 78 patients with maxillomandibular discrepancy ≤ −2 were divided to Group 1 (mandibular setback, n = 17) and Group 2 (maxillary advancement with mandibular setback, n = …
Impacts Of Surface Characteristics On Biological Responses And Biofilm Formation Of 3d-Printed Denture Base Resins: An In Vitro Study, Tzu-Yu Peng, Chien-Fu Tseng, Chia-Chih Sung, Ya-Ting Yang, Fen-Ni Chen, Yuichi Mine, Yao-Chang Chiang, Zih-Chan Lin, Mei-Ling Fang, Hsin-Ming Chen, Sang-Heng Kok
Impacts Of Surface Characteristics On Biological Responses And Biofilm Formation Of 3d-Printed Denture Base Resins: An In Vitro Study, Tzu-Yu Peng, Chien-Fu Tseng, Chia-Chih Sung, Ya-Ting Yang, Fen-Ni Chen, Yuichi Mine, Yao-Chang Chiang, Zih-Chan Lin, Mei-Ling Fang, Hsin-Ming Chen, Sang-Heng Kok
Journal of Dental Sciences
Abstract Background/purpose With advancements in digital technology, fully digital workflow for complete denture fabrication using 3D-printed denture base resin (DBR) has gained increasing clinical acceptance in recent years. However, the surface characteristics, biocompatibility, and biofilm formation of 3D-printed DBR materials remain insufficiently understood. Therefore, in this study, we investigated and analyzed these aspects. Materials and methods Disk-shaped DBR specimens (Ø 2.5 mm, 3 mm thick) were fabricated using packed (PA), milled (ML), and 3D-printed (3D) processes. All specimens were ground with silicon carbide sandpaper (#600) and ultrasonically cleaned. Surface microtopography and sub-micron roughness were analyzed using scanning electron microscopy and …
Silencing Mir-1291-Lefty2 Axis Diminishes The Myofibroblast Activities And Reactive Oxygen Species Generation Of Fibrotic Buccal Mucosal Fibroblasts, Ming-Yung Chou, Shih-Min Wang, Pei-Ling Hsieh, Yi-Wen Liao, Cheng-Chia Yu, Chang-Yi Tsai
Silencing Mir-1291-Lefty2 Axis Diminishes The Myofibroblast Activities And Reactive Oxygen Species Generation Of Fibrotic Buccal Mucosal Fibroblasts, Ming-Yung Chou, Shih-Min Wang, Pei-Ling Hsieh, Yi-Wen Liao, Cheng-Chia Yu, Chang-Yi Tsai
Journal of Dental Sciences
Abstract Background/purpose Oral submucous fibrosis (OSF) is a potentially malignant disorder characterized by chronic inflammation and excessive collagen deposition, leading to fibrosis in the oral mucosa. This study aimed to explore the contribution of the miR-1291/LEFTY2 axis in the development of OSF progression. Materials and methods Expression of miR-1291 was evaluated in OSF tissues and primary myofibroblasts using RNA sequencing and qRT-PCR. The functional role of miR-1291 and LEFTY2 were investigated using miR-1291 inhibitor and lentiviral-mediated overexpression of LEFTY2, respectively. A luciferase reporter assay was conducted to examine the direct interaction between miR-1291 and LEFTY2. Myofibroblast activities were assessed by …
A Foreign Dentist Practicing In Shanghai, China In The Late Qing Dynasty: The Case Of Dr. Sanger's Letter Notifying The Relocation Of His Dental Office In 1895, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
A Foreign Dentist Practicing In Shanghai, China In The Late Qing Dynasty: The Case Of Dr. Sanger's Letter Notifying The Relocation Of His Dental Office In 1895, Chung-Pin Chiang, Feng-Chou Cheng, Ling-Hsia Wang
Journal of Dental Sciences
No abstract provided.
Effects Of 3d-Printers And Manufacturer-Specified Post-Curing Units On The Dimensional Accuracy, Compressive Strength, And Degree Of Conversion Of Resin For Fixed Dental Prostheses, Wei-Chun Lin, Citra Dewi Sahrir, Wei-Shao Lin, Ching-Shuen Wang, Hwai-En Lin, Chin-Wei Wang
Effects Of 3d-Printers And Manufacturer-Specified Post-Curing Units On The Dimensional Accuracy, Compressive Strength, And Degree Of Conversion Of Resin For Fixed Dental Prostheses, Wei-Chun Lin, Citra Dewi Sahrir, Wei-Shao Lin, Ching-Shuen Wang, Hwai-En Lin, Chin-Wei Wang
Journal of Dental Sciences
Abstract Background/purpose The 3D printer and post-curing unit are important factors in producing the best 3D printed crowns. To explore the effects of different combinations of 3D-printers and manufacturer-specified post-curing units on the dimensional accuracy, compressive strength, and degree of conversion (DC%) of 3D-printable resin for fixed dental prostheses. Materials and methods Specimens were designed in 2 sizes and additively-manufactured using 2 digital light processing (DLP) 3D-printers (NextDent 5100, ND and PrintinDLP+, PN). The 3D-printed samples were polymerized using 2 different post curing units (LC-3D Print box, N and PrintInCure+, P). Dimensional accuracy was evaluated under an optical microscope, while …
Performance Of Chatgpt In Answering The Oral Pathology Questions Of Various Types Or Subjects From Taiwan National Dental Licensing Examinations, Chung-Pin Chiang, Yu-Hsueh Wu
Performance Of Chatgpt In Answering The Oral Pathology Questions Of Various Types Or Subjects From Taiwan National Dental Licensing Examinations, Chung-Pin Chiang, Yu-Hsueh Wu
Journal of Dental Sciences
Abstract Background/purpose ChatGPT, a large language model, can provide an instant and personalized solution in a conversational format. Our study aimed to assess the potential application of ChatGPT-4, ChatGPT-4o without a prompt (ChatGPT-4o-P-), and ChatGPT-4o with a prompt (ChatGPT-4o-P+) in helping dental students to study oral pathology (OP) by evaluating their performance in answering the OP multiple choice questions (MCQs) of various types or subjects. Materials and methods A total of 280 OP MCQs were collected from Taiwan National Dental Licensing Examinations. The chatbots of ChatGPT-4, ChatGPT-4o-P-, and ChatGPT-4o-P+ were instructed to answer the OP MCQs of various types and …
Distribution Of The Dental Education Institutions In China Before 1949, Feng-Chou Cheng, Ling-Hsia Wang, Po-Fang Tsai, Chun-Pin Chiang
Distribution Of The Dental Education Institutions In China Before 1949, Feng-Chou Cheng, Ling-Hsia Wang, Po-Fang Tsai, Chun-Pin Chiang
Journal of Dental Sciences
No abstract provided.
4′-Hydroxywogonin Inhibits Oral Squamous Cell Carcinoma Progression By Targeting Gas6/Axl Signaling Axis, Tong-Hong Wang, Li-Fang Chou, Chin-Chuan Chen, Chau-Ting Yeh, Yi-Tsen Liu, Yu-De Chu, Hsin-Wei Lin, Kai-Yin Chen, Cheng-Chia Yu, Chi-Yuan Chen
4′-Hydroxywogonin Inhibits Oral Squamous Cell Carcinoma Progression By Targeting Gas6/Axl Signaling Axis, Tong-Hong Wang, Li-Fang Chou, Chin-Chuan Chen, Chau-Ting Yeh, Yi-Tsen Liu, Yu-De Chu, Hsin-Wei Lin, Kai-Yin Chen, Cheng-Chia Yu, Chi-Yuan Chen
Journal of Dental Sciences
Abstract Background/purpose Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies, with current therapeutic strategies often limited by low efficacy and drug resistance. In this study, we investigated the anticancer potential and underlying mechanisms of 4′-hydroxywogonin, a flavonoid extracted from Scutellaria baicalensis, in OSCC. Materials and methods OSCC cell lines were treated with 4′-hydroxywogonin, and its anticancer effects were evaluated using cell functional assays. Western blot analysis was performed to examine the regulatory pathways involved, and rescue assays were conducted to validate its mechanism of action. Results 4′-Hydroxywogonin selectively inhibited OSCC cell proliferation, migration, …
Induction Of Retinal Progenitors And Neurons From Dental Follicle Stem Cell Under Defined Conditions, Chung-Hsing Li, Tzu-Pei Lee, Ming-Hua Ho, Yong-Ren Chen, Kuan-Ming Lin
Induction Of Retinal Progenitors And Neurons From Dental Follicle Stem Cell Under Defined Conditions, Chung-Hsing Li, Tzu-Pei Lee, Ming-Hua Ho, Yong-Ren Chen, Kuan-Ming Lin
Journal of Dental Sciences
Abstract Background/purpose Retinopathy affects millions worldwide with increasing prevalence. Dental-derived mesenchymal stem cells (MSCs), primarily originating from the neural crest, possess unique neural-like properties, including high expression of neural markers, making them promising candidates for neural and retinal regenerative medicine. The present study compared two isolation methods for dental-derived MSCs and investigated the potential of dental follicle stem cells (DFSCs) to differentiate into neurons and retinal progenitor cells under defined conditions. Materials and methods The cells of extracted dental tissues were isolated by enzymatic digestion and explant culture methods. The multi-lineage differentiation capabilities of DFSCs were confirmed by Alizarin Red …
A Scientometric Study On Research Trends And Characteristics Of Salivary Adenoid Cystic Carcinoma, Chengsu Hou, Ye Zhang, Yang Wang
A Scientometric Study On Research Trends And Characteristics Of Salivary Adenoid Cystic Carcinoma, Chengsu Hou, Ye Zhang, Yang Wang
Journal of Dental Sciences
Abstract Background/purpose Salivary adenoid cystic carcinoma (SACC) affects the major salivary glands and minor salivary glands mainly within the oral cavity. The purpose of this study was to analyze the scientometric characteristics and research trends of SACC. Materials and methods All the papers on SACC were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2015 and 2015–2024 in the analysis of research trends. Results There were 2406 papers on SACC, with total citations of 54,921 and the h index of 97. Cancer surgery, radiotherapy, chemotherapy, cisplatin, doxorubicin, neck dissection, and combined modality therapy were …
Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Oral Lichen Planus Patients With Or Without Hyperhomocysteinemia, Chun-Pin Chiang, Yi-Pang Lee, Ying-Tai Jin, Julia Chang, Yi-Ping Wang, Andy Sun
Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Oral Lichen Planus Patients With Or Without Hyperhomocysteinemia, Chun-Pin Chiang, Yi-Pang Lee, Ying-Tai Jin, Julia Chang, Yi-Ping Wang, Andy Sun
Journal of Dental Sciences
Abstract Background/purpose Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 464 OLP patients without hyperhomocysteinemia (non-hyperhomocysteinemia/OLP patients) or 588 healthy control subjects. Materials and methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared. Results We found that 124 hyperhomocysteinemia/OLP patients had …
Sugar-Sweetened Beverages And Oral Health In Taiwan: An Emerging Public Health Challenge, Yu-Chao Chang, Hui-Chieh Yu, Tsung-Po Chen
Sugar-Sweetened Beverages And Oral Health In Taiwan: An Emerging Public Health Challenge, Yu-Chao Chang, Hui-Chieh Yu, Tsung-Po Chen
Journal of Dental Sciences
No abstract provided.
Evaluating The Diagnostic Value And Prospects Of Genomic And Mutational Sequencing In Malignant Transformation Of Oral Leukoplakia, Wei Liu, Jian Yuan, Yuhan Zhu, Zirui Wang, Zhongjing Lv
Evaluating The Diagnostic Value And Prospects Of Genomic And Mutational Sequencing In Malignant Transformation Of Oral Leukoplakia, Wei Liu, Jian Yuan, Yuhan Zhu, Zirui Wang, Zhongjing Lv
Journal of Dental Sciences
Abstract Genomic and mutational sequencing in malignant transformation of oral leukoplakia (OLK) has emergingly gained momentum. In this short communication, we identified 5 retrospective follow-up studies and 5 cross-section comparative studies on this issue using formalin-fixed paraffin-embedded tissues. Copy number alteration (CNA) was demonstrated to increase with the grade of oral dysplasia. CNA-based algorithms showed better prediction performances than histological grade in assessing the risk of OLK malignant transformation. Importantly, we conducted a pooled-analysis on the mutation frequencies of the common oral cancer driver genes extracted from individual studies. The most common mutation gene was found to be TP53 (26.26 …