Digital Commons Network^™

Obesity Promotes Conserved Inflammatory And Metabolic Transcriptional Programs In Colon Tumors: Evidence From Mouse Models And The Colocare Study Patient Cohort, Elaine M Glenny, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: The global prevalence of obesity, an established risk and progression factor for colon cancer, is high and rising. Unfortunately, the mechanisms underlying the obesity-colon cancer association are incompletely understood, and new molecular targets enabling more effective intervention strategies to break the obesity-colon cancer link are urgently needed.

OBJECTIVES: This study integrated RNA sequencing data from mouse and human colon tumor samples, as well as human adipose samples, to rigorously establish obesity-associated transcriptomic signatures conserved between the 2 species.

METHODS: We employed a mouse colon cancer model with colonoscopy-guided orthotopic transplantation of syngeneic Apc

RESULTS: Diet-induced obesity reduced survival in …

Bridging The Gap Between Counselor Education And Trauma Treatment In Practice: A Phenomenology Of Trauma-Specialized Counselors, Ariel Hutcheon

Counseling & Human Services Theses & Dissertations

Trauma impacts the life experiences of a sizable portion of the population. Given that so many clients bring trauma into counseling, even when not the presenting issue, knowledge of trauma’s impact and proficiency with trauma treatment are essential topics in counselor education. This study gave voice to counselors in the field to share what they have found effective from working with clients with trauma. The researcher used a phenomenological approach and interviewed six self-identified trauma-specialized counselors who have practiced for five years or longer. The data was explicated, and four major themes were identified. The first theme was Inadequate Training: …

Tracing The Journey Of Dissolved Organic Matter: From Leaf Litter Photodegradation To Microbial Processing In Tropical Streams, Samantha Nicole Sullivan

Chemistry & Biochemistry Theses & Dissertations

Dissolved organic matter (DOM) is a major reservoir of organic carbon in aquatic ecosystems and plays a central role in global carbon cycling through its transformation and remineralization to carbon dioxide (CO₂). As DOM moves from terrestrial environments into streams and rivers, its chemical composition is altered by a combination of microbial and photochemical oxidation processes that regulate both its reactivity and its persistence during transport. However, the molecular mechanisms governing these oxidative transitions, particularly in tropical ecosystems characterized by strong hydrologic seasonality and substantial inputs of plant-derived material, remain insufficiently resolved. This dissertation integrates ultrahigh-resolution mass spectrometry, optical characterization, …

Exploring Student Confidence And Calibration Accuracy In College Algebra: A Mixed-Methods Explanatory Sequential Study, Courtney T. Hill

STEMPS Theses & Dissertations

Calibration, or students’ ability to predict and postdict their performance on an academic task, has important implications for academic performance. It can influence students' decision making processes concerning learning activities, as well as their levels of motivation and self-regulation (Kolovelonis, 2023). The literature on calibration is clear, often indicating that students are not great at these judgements (Lin et. al, 2001). While this phenomenon is well documented, it is not an easy one to explain. Therefore, a two-phase explanatory-sequential mixed method design was used to examine undergraduate students’ calibration judgements on a college algebra exam. To further contribute to the …

Evaluation Of Ocean Lidar Enhancement Through Miniaturization And Gated Pmt-Based Range Extension, Chandler Austin Slater

OES Theses and Dissertations

Oceanographic lidar systems remotely characterize the vertical structure of the upper ocean by recording the light backscattered from a laser pulse as it propagates through the water column. Historically these systems have been constrained by limited detection ranges, often capturing only a portion of the illuminated water column, typically fading to noise around the 10% isolume. A primary constraint has been the limited dynamic range of digitizers, which inhibits the ability to resolve both intense near-field and faint far-field backscatter signals within a single acquisition. To address this, we developed a novel optical lidar system incorporating gated photomultiplier tubes (PMTs) …

Observed Parenting, Parent-Child Aggression, And Intimate Partner Violence As Predictive Of Family Dysfunction, Paige Munshell

Psychology Theses & Dissertations

Family systems theories contextualize violence as occurring across multiple levels of the family, yet much of the existing literature focuses on a single family member’s outcome (i.e., the child) and neglects to include data collected from fathers. This study examined the associations between indicators of functioning at the dyadic-level in the family system—observed parenting, Intimate Partner Violence (IPV) perpetration, and Parent-Child Aggression (PCA) risk—and later overall family dysfunction. Participants were 180 mothers and 144 of their male partners evaluated when their child was 18 months old and re-evaluated at 4 years old. Measures of observed parenting, IPV perpetration, and PCA …

Component Model Development Of Heat Exchangers, Expanders, And Control Valves For Autonomous Cryogenics Plant Cool-Down, William Harris Buhrig Iv

Mechanical & Aerospace Engineering Theses & Dissertations

The traditional method of cryogenic plant cool-down involves having continuous on-call staff to head into the office at any time to modify the existing multi-layered PID control systems if the on-call staff member detects a significant deviation from the cool-down plan. This thesis aims to outline an effective method for modeling the structure of systems with performance characteristics that deviate from design requirements and from ideal inlet-outlet correspondence, enabling the adjustment and modification of existing control structures across all Thomas Jefferson National Accelerator Facility (JLab) cryogenic refrigeration plants. Analytical Modeling and Gaussian Process Regression (GPR) are applied to model the …

Large Language Models (Llms) For Clinical Note Generation: International Classification Of Disease (Icd) Code, Knowledge Graph (Kg) And Prompt Evaluation, Ivan P. Makohon

Computer Science Theses & Dissertations

In the past decade, a surge in the amount of electronic health record (EHR) data in the United States occurred, driven by a favorable policy environment created by the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 and the 21st Century Cures Act of 2016. Clinical notes for patients’ assessments, diagnoses, and treatments are captured in these EHRs in free-form text by physicians, who spend a considerable amount of time entering them. Manually writing these notes is time-consuming, increasing patient waiting times and potentially delaying diagnoses. Large language models (LLMs), such as GPT-4o, possess the ability …

Gender Considerations When Examining The Association Between Military Sexual Trauma And Chronic Pain Conditions, Lily Sarfaraz

Dissertations

Military sexual trauma (MST) amongst veterans is a growing concern for the Veterans Health Administration (VHA). Veterans who screen positive for MST receive VHA care for any injuries caused as a result of MST, psychological or physical, free of charge. MST is difficult to track, can result in long-term disability, and the burden of illness varies across genders. Current data highlights discrepancies seen across the literature of actual detected MST cases, with rates varying vastly. Efforts to track prevalence of MST identify additional concerns over the various comorbidities seen in MST cases. When examining symptom sequalae of MST, there is …

Assessing Statewide Programming In Wisconsin Environmental Education: The Role Of Culture And Community In Youth Development Programming, Jody Bauer, Robert Justin Hougham, Lily Gruenewald

Journal of Youth Development

Environmental education has the potential to serve as an accessible pathway for diverse learners to improve science achievement, but environmental education (EE) institutions must strive to create spaces that welcome and provide equitable learning outcomes for all students. Embedding cultural and community input, values, and relevancy can be an important component to supporting equity in educational spaces for diverse students. This research aims to identify the status and needs of diversity, equity, and inclusion efforts across environmental education institutions in the state of Wisconsin, and to identify areas of strength or improvement relating to pedagogy, process, and practice. A survey …

Phenotypic Variability And Paternal Inheritance Of A Chd8 Variant Causing Intellectual Developmental Disorder With Autism And Macrocephaly Confirmed By Epigenetic And Structural Analyses, Yutaka Furuta, Jonathan H Sheehan, Et Al.

2020-Current year OA Pubs

BACKGROUND: Intellectual developmental disorder with autism and macrocephaly (IDDAM, OMIM #615032) is an autosomal dominant neurodevelopmental disorder characterized primarily by intellectual disability, autism spectrum disorder, macrocephaly, tall stature, gastrointestinal symptoms, and variable neurological manifestations. Most cases result from de novo pathogenic variants in CHD8.

METHODS: We conducted genome sequencing through the Undiagnosed Diseases Network (UDN) in a female proband harboring a CHD8 variant of uncertain significance (VUS), whose clinical presentation was consistent with IDDAM but included atypical features such as ptosis and hearing loss. Variant pathogenicity was further evaluated using EpiSign DNA methylation analysis and structural biology modeling.

RESULTS: Genome …

Epigenetic Age And Telomere Length Correlations In Pediatric-Onset Multiple Sclerosis, Jennifer H Yang, Soe Mar, Et Al.

2020-Current year OA Pubs

BACKGROUND: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes.

OBJECTIVES: To determine the correlation between DNAm and TL aging markers.

METHODS: We conducted a cross-sectional case-control study within the US Network of Pediatric MS Centers. We calculated age acceleration residuals for the Horvath, Hannum, PhenoAge, and GrimAge epigenetic clocks and measured TL from whole blood samples to estimate telomere to somatic DNA …

State Of Omics-Based Microbial Diagnostics Of Crc, Jerome Prusa, Mark G Gorelik, Kevin S Blake, Gautam Dantas

2020-Current year OA Pubs

Colorectal cancer (CRC) remains a major burden of cancer-related morbidity and mortality globally, especially when detected at later stages. Early detection through improved and more accessible diagnostics is critical for reducing the severity of CRC. As our understanding of CRC and the microbial inhabitants of the gastrointestinal tract continues to improve, it has become increasingly recognized that the bacterial component of the gut microbiome may provide diagnostic utility for detecting CRC. This is because CRC is often accompanied by shifts in bacterial taxa, and the metabolites produced or utilized by the CRC-associated gut bacterial community. Advances in sequencing and metabolite …

Early Life Infection With Cryptosporidium Parvum Induces Inflammatory Responses To Dietary Antigens, Iti Saraav, Wanyi Huang, Jisun Jung, Rui Xu, Yong Fu, Keely Mcdonald, Lawrence A Schriefer, Rachel Rodgers, Megan T Baldridge, Rodney D Newberry, Chyi-Song Hsieh, L David Sibley

2020-Current year OA Pubs

To examine the effect of early-life infection with

Genetic Predisposition To Persistent Fatigue After A Diagnosis Of Colorectal Cancer, Elham Kazemian, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cancer-related fatigue (fatigue) is a common and persistent symptom after cancer treatment, yet the role of genetic susceptibility remains unclear.

METHODS: We used data from a prospective cohort study called the ColoCare Study, conducted over 5 US sites and Germany. Fatigue was assessed at 5 time points using the European Organisation for the Research and Treatment of Cancer Core Quality of Life Questionnaire fatigue subscale and analyzed as (1) a binary summary measure of the trajectory from diagnosis into survivorship (defined as severe: yes/no), (2) a mean score across all time points, and (3) the highest (ie, worst) score …

Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly

2020-Current year OA Pubs

OBJECTIVE: We sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

METHODS: We performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50

RESULTS: 306 patients were included: 124 …

Solar Powered Conservation: The Effects Of Solar Photovoltaic Facilities On Avian Community Composition, Michael Christopher Ferrara

Graduate Theses and Dissertations

The expansion of solar photovoltaic energy infrastructure is transforming landscapes worldwide. Increasingly, facilities are planted with native vegetation, yet how vegetation characteristics and landscape variables shape wildlife communities in solar facilities remains poorly understood. Because avian populations have been in decline and are sensitive to habitat changes, understanding how solar facilities influence avian communities is important. In Chapter 1, we used autonomous recording units, local vegetation measurements, and land use and land cover data to quantify how avian community occupancy is influenced by solar cover in solar facilities and comparable reference sites. We used a Bayesian multi-species occupancy model to …

Freshwater Turtle Assemblages And Densities In Agricultural Ditches And Aquaculture Ponds Of Eastern Arkansas, Andrhea D. Massey, John D. Willson, Brett A. Degregorio

Biological Sciences Faculty Publications and Presentations

The Mississippi Alluvial Plain (MAP) of Arkansas is a landscape where many wetlands have been altered for use as aquaculture ponds or agricultural ditches. Commercial harvest of freshwater turtles within the MAP is not restricted or limited, with reported harvest numbers for 2019 alone exceeding 4000 for spiny softshell turtles (Apalone spinifera) and 39,000 for red-eared sliders (Trachemys scripta elegans). Herein, we attempt to provide baseline estimates of freshwater turtle densities and community composition in aquaculture ponds and agricultural ditches of eastern Arkansas, the habitat types most frequently trapped by commercial harvesters. We used a capture-mark-recapture approach over 3 summers …

Proteogenomics In Cerebrospinal Fluid And Plasma Reveals New Biological Fingerprint Of Cerebral Small Vessel Disease, Ilana Caro, Daniel Western, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific treatment, of which molecular mechanisms remain poorly understood. To identify potential biomarkers and therapeutic targets, we applied Mendelian randomization to examine over 2,500 proteins measured in plasma and, uniquely, cerebrospinal fluid, in relation to magnetic resonance imaging (MRI) markers of cSVD in more than 40,000 individuals. Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. We highlight associations that are consistent across platforms and ancestries, and supported by complementary observational analyses, and we explore differences …

From Sex Differences To Sex Inequalities In Life Expectancy: A Cross-Country Observational Benchmarking Analysis, Angela Y. Chang, Emily K. Johnson, Sarah Bolongaita, Kent Buse, Sarah J. Hawkes, Omar Karlsson, Felicia M. Knaul, Margaret E. Kruk, Ole F. Norheim, Osondu Ogbuoji, David Watkins, Dean T. Jamison

2020-Current year OA Pubs

BACKGROUND: The answer to whether females or males have better health, and which sex is the more disadvantaged, has depended in part on the metric and how the inequality is measured. This study introduces a new method for analyzing and interpreting sex inequalities in health outcomes-defined as the avoidable sex differences in health outcomes-that is systematic and potentially more objective. For this paper, we focus on life expectancy at different ages.

METHODS AND FINDINGS: We introduce the adjusted sex ratio as a measure of sex inequalities and determining sex disadvantage. First, we calculated the sex ratio of life expectancy at …

The Role Of Servant-Leadership And Employee Work Engagement On Employee Innovative Work Behaviour: An Emerging Economy Perspective, S. M. Ashik Hossain, Muhammad Abdul Aziz

International Journal of Servant-Leadership

This study investigates the impact of servant-leadership (SL) and employee work engagement (EWE) on the innovative work behaviour (IWB) of the professionals in a developing country’s perspective. Besides, the mediation impact of EWE between the SL and IWB link has been assessed that created unique contribution to the literature. This quantitative research utilized cross-sectional survey design where data has been collected using both paper based and online survey. Using structured questionnaire, we collected responses from 215 professionals from manufacturing and service sectors who are working at mid-levels and semi-mid-levels positions in different organizations in Bangladesh. The descriptive analysis and normality …

Clinical Decision Support For Pharmacologic Management Of Treatment-Resistant Depression With Augmented Large Language Models, Martha Sajatovic

Faculty Scholarship

Background: We evaluated whether a large language model could assist in selecting psychopharmacological treatments for adults with treatment-resistant depression. Methods: We generated 20 clinical vignettes reflecting treatment-resistant depression among adults based on distributions drawn from electronic health records. Each vignette was evaluated by 2 expert psychopharmacologists to determine and rank the 5 best next-step pharmacologic interventions, as well as contraindicated or poor next-step treatments. Vignettes were then presented in random order, permuting gender and race, to a large language model (Qwen 2.5:7B), augmented with a synopsis of published treatment guidelines. Model output was compared to expert rankings, as well as …

Progress In Clinical Trials Of Cdkk4/6 Inhibitors, Takae Mizukami, Alberto J. Montero

Faculty Scholarship

Purpose of Review: To discuss the biological mechanisms of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, the rationale for using CDK4/6 inhibitors in estrogen receptor-positive (ER+) and human epidermal growth factor receptor-2-negative (HER2-) breast cancer (BC), data from landmark phase III clinical trials that led to U.S. Food and Drug Administration (FDA) approval, and updates on recently published and ongoing clinical trials. Finally, we explore future directions of CDK4/6 inhibitors in the management of ER+ and HER2- BC. Recent Findings: Based on landmark phase III clinical trials, CDK4/6 inhibitors have become essential to treat ER+ and HER2- BC. Summary: New …

Black Women’S Experiences Accessing Health Care And Law Enforcement After Intimate Partner Violence: A Qualitative Pilot Study, Kaylen M. Moore, Linda M. Wesp, Jeneile Luebke, Peninnah M. Kako

College of Nursing Faculty Research and Publications

Background:

Intimate partner violence (IPV) is a global public health issue impacting millions of people each year. Black women constitute 14% of the US population but alarmingly comprise 31% of homicides resulting from IPV. African American women survivors of IPV experience intersecting impacts of racism, sexism, and historical mistrust. This research aimed to raise awareness about their experiences of violence and perceptions of institutional support.

Objective:

This study sought to explore African American women’s experiences with IPV and navigation of health care and law enforcement after experiences of violence.

Method:

Critical ethnography was used as an approach for this qualitative …

Addressing Critiques Refines Global Estimates Of Reforestation Potential For Climate Change Mitigation, Kurt A. Fesenmeyer, Erin E. Poor, Drew E. Terasaki Hart, Joseph W. Veldman, Forrest Fleischman, Pooja Choksi, Sally Archibald, Mohammed Armani, Matthew E. Fagan, Evan C. Fricke, César Terrer, Natalia Hasler, Christopher A. Williams, Peter W. Ellis, Susan Cook-Patton

Geography

Reforestation is a prominent climate change mitigation strategy, but available global maps of reforestation potential are widely criticized and highly variable, which limits their ability to provide robust estimates of both the locations and total area of opportunity. Here we develop global maps that address common critiques, build on a review of 89 reforestation maps created at multiple scales, and present eight reforestation scenarios with varying objectives, including providing ecosystem services, minimizing social conflicts, and delivering government policies. Across scenarios, we find up to 195 Mha (million hectares) are available (2225 TgCO2e (teragrams of carbon dioxide equivalent) per year total …

Real-Time Malaria Detection In The Amazon Rainforest Via Drone-Collected Edna And Portable Qpcr, Yin Cheong Aden Ip, Luca Montemartini, Jia Jin Marc Chang, Andrea Desiderato, Nicolás D. Franco-Sierra, Christian Geckeler, Mailyn Adriana Gonzalez Herrera, Michele Gregorini, Meret Jucker, Steffen Kirchgeorg, Martina Lüthi, Elvira Mächler, Frederik Bendix Thostrup, Guglielmo Murari, Marina Mura, Paola Pulido-Santacruz, Florencia Sangermano, Tobias Schindler, Claus Melvad, Stefano Mintchev, Kristy Deiner

Geography

Zoonotic malaria risk at human-wildlife-environment interfaces requires surveillance that integrates signals from reservoirs, vectors and the environment. We coupled a drone-based environmental DNA (eDNA) canopy swabbing approach with portable quantitative PCR (qPCR) to detect Plasmodium DNA in situ during a 24-h field exercise in the Amazon rainforest. Drone-lowered sterile swabs into the canopy, which were then extracted and subjected to a multiplex pan-Plasmodium assay targeting five human-infecting Plasmodium species (limit of detection 0.2 parasites μL−1). Of 12 samples (10 canopy swabs, 2 field blanks; 13 total runs including repeats), one canopy swab amplified in duplicate (Ct = 28.7 and 29.23), …

Loss Of The Lysosomal Protein Cln3 Triggers C-Abl-Dependent Yap1 Pro-Apoptotic Signaling, Neuza Domingues, Alessia Calcagni', Sofia Freire, Joana Pires, Ricardo Casqueiro, Ivan L Salazar, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo

Duncan NRI Faculty and Staff Publications

Batten disease is characterized by early-onset blindness, juvenile dementia and death within the second decade of life. The most common genetic cause are mutations in CLN3, encoding a lysosomal protein. Currently, no therapies targeting disease progression are available, largely because its molecular mechanisms remain poorly understood. To understand how CLN3 loss affects cellular signaling, we generated human CLN3 knock-out cells (CLN3-KO) and performed RNA-seq analysis. Our multi-dimensional analysis reveals the transcriptional regulator YAP1 as a key factor in remodeling the transcriptome in CLN3-KO cells. YAP1-mediated pro-apoptotic signaling is also increased as a consequence of CLN3 functional loss in retinal pigment …

Surgical Removal Of Implanted Microchips To Correct Mri Susceptibility Artifacts In Mice, Elizabeth Hipskind, Nicole Hernandez, Sydney Fox, Tina Manirambona, Rita Schack, Brian Gibson, Robia G Pautler

Center on Aging Staff Publications

Purpose: Implanted microchips are becoming increasingly common in research for animal identification and have been adopted by commercial vendors for some mouse strains. However, they often contain metal components, which generate magnetic susceptibility artifacts on MR images. Despite this, some microchips are marketed as MR-compatible, even though they are likely to affect image quality.

Methods: We assessed the impact of a radiofrequency identification microchip on MR images of the mouse brain and present a method for precise surgical removal. A handheld magnet was used to locate and stabilize the microchips during removal. Mice were imaged before and after microchip removal. …

Ataxia-Telangiectasia Mutated Activation Mediates Transforming Growth Factor Beta Signaling In Acetaminophen-Induced Liver Injury In Mice, Matthew Mcmillin, Christopher S Chu, Elaina Williams, Juliet Venter, Kiersten Bell, Anca D Petrescu, Patrick Mireles, Sharon Demorrow

Faculty and Staff Publications

Acetaminophen (APAP) overdose is associated with increased transforming growth factor beta 1 (TGFβ1) signaling and elevated oxidative stress, which exacerbate DNA damage. TGFβ1 has been shown to regulate ataxia-telangiectasia mutated (ATM) signaling and DNA repair in other cell types. This study investigates the DNA damage response (DDR) during APAP-induced liver injury, focusing on ATM-mediated regulation of TGFβ1 signaling. APAP administration in vitro and in vivo resulted in DNA damage, increased ATM signaling, accumulation of γH2AX, and activation of phosphorylated ataxia telangiectasia mutated (pATM) and phosphorylated checkpoint kinase 2 (pChk2). Pretreatment with an ATM inhibitor, KU55933, attenuated APAP-induced hepatocyte damage and …

Differential Microrna Profiling Of Blood L1cam And Bulk Extracellular Vesicles In Bipolar Disorder, Gabriel R Fries, Salahudeen Mirza, Jun Wang, Camila N C Lima, Wei Zhang, Marcela Carbajal Tamez, Giselli Scaini, Jair C Soares, Joao Quevedo

Faculty, Staff and Student Publications

Objective: This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources.

Method: In two parallel studies of individuals with BD and controls (CON), we characterized miRNA expression profiles of blood EVs selected for L1CAM, a putative marker of neuronal origin (n = 20 BD/20 CON), as well as bulk EVs (n = 21 BD/20 CON). For each study, analyses identified miRNAs differentially expressed between groups, followed by functional interrogation and testing for associations with clinical features.

Results: Results of …