Digital Commons Network^™

Optimizing Electrode Configurations For Eeg Mild Cognitive Impairment Detection, Yi Jiang, Xin Zhang, Zhiwei Guo, Xiaobo Zhou, Jiayuan He, Ning Jiang

Faculty, Staff and Student Publications

The Optimal electrode configuration of Electroencephalograms (EEG) systems for mild cognitive impairment (MCI) detection and monitoring in non-clinical settings, i.e. number of electrodes and the positions of the electrodes, remains to be explored. In the current study, we explored the optimization of electrode configuration for MCI detection. We used a 32-channel EEG device to record the data of 21 MCI patients and 20 cognitively normal elderly (NC) undergoing working memory (WM) tasks. Based on the differential value (MCI group vs. NC group) from the Power Spectral Density (PSD) value of each electrode in θ and α frequency band during WM …

Differentiation Of Mullus Barbatus And Mullus Surmuletus (Perciformes, Mullidae) From Turkish Waters Of The Mediterranean Sea Using Otolith Shape Analyses, Semra Saygin

Turkish Journal of Zoology

Red mullet (Mullus barbatus) and surmullet (Mullus surmuletus) are valuable components of the commercial fishery industry in the Mediterranean Sea in Türkiye. To date, morphological and genetic characteristics have been used to distinguish these species. This study aimed to determine whether it was possible to distinguish between the two species using the morphometric features of their sagittal otoliths. Sagittal otoliths were subjected to elliptic Fourier analysis, wavelet analysis, and analysis of otolith shape indices for 117 specimens from the Mediterranean Sea coast of Türkiye (Mullus barbatus: 53 individuals; Mullus surmuletus: 64 individuals). Overall, canonical discriminant analysis (CDA) demonstrated strong discrimination …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

A Single-Cell Compendium Of Human Cerebrospinal Fluid Identifies Disease-Associated Immune Cell Populations, Claudia Cantoni, Roman A. Smirnov, Maria Firulyova, Prabhakar S. Andhey, Tara R. Bradstreet, Ekaterina Esaulova, Marina Terekhova, Elizabeth A. Schwarzkopf, Nada M. Abdalla, Maksim Kleverov, Anne H. Cross, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Et Al.

2020-Current year OA Pubs

Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of cell types along with their relative abundance and immunologic profiles relevant to CNS diseases. Using integration techniques applied to publicly available datasets in combination with our own studies, we generated a compendium with 139 subjects encompassing 135 CSF and 58 blood samples. Healthy subjects and individuals across a wide range of diseases, such as multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, …

Utility Of Candidate Genes From An Algorithm Designed To Predict Genetic Risk For Opioid Use Disorder, Christal N Davis, Alexander S Hatoum, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the candidate genetic variants included in the algorithm has not been independently demonstrated.

OBJECTIVE: To assess the utility of 15 genetic variants from an algorithm intended to predict OUD risk.

DESIGN, SETTING, AND PARTICIPANTS: This case-control study examined the association of 15 candidate genetic variants with risk of OUD using electronic health record data from December 20, 1992, to September 30, 2022. Electronic health record …

Brain Age Modeling And Cognitive Outcomes In Young Adults With And Without Sickle Cell Anemia, Andria L Ford, Slim Fellah, Yan Wang, Kira Unger-Levinson, Maria Hagan, Martin N Reis, Amy Mirro, Josiah B Lewis, Chunwei Ying, Kristin P Guilliams, Melanie E Fields, Hongyu An, Allison A King, Yasheng Chen

2020-Current year OA Pubs

IMPORTANCE: Both sickle cell anemia (SCA) and socioeconomic status have been associated with altered brain structure and cognitive disability, yet precise mechanisms underlying these associations are unclear.

OBJECTIVE: To determine whether brains of individuals with and without SCA appear older than chronological age and if brain age modeling using brain age gap (BAG) can estimate cognitive outcomes and mediate the association of socioeconomic status and disease with these outcomes.

DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study of 230 adults with and without SCA, individuals underwent brain magnetic resonance imaging (MRI) and cognitive assessment. Brain age was estimated using DeepBrainNet, …

T Helper 2 Cell-Directed Immunotherapy Eliminates Precancerous Skin Lesions, Tomonori Oka, Neel S. Raval, Mary Tabacchi, Lynn A. Cornelius, Et Al.

2020-Current year OA Pubs

The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus-5-FU immunotherapy induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes in humans. CD4+ Th2 cells were required and were sufficient downstream of thymic stromal lymphopoietin cytokine induction by calcipotriol to suppress skin cancer development. Th2-associated cytokines induced IL-24 expression in cancer cells, resulting in toxic autophagy and anoikis followed by apoptosis. Calcipotriol-plus-5-FU immunotherapy was dependent …

Meta-Ea: A Gene-Specific Combination Of Available Computational Tools For Predicting Missense Variant Effects, Panagiotis Katsonis, Olivier Lichtarge

Faculty, Staff and Students Publications

Computational methods for estimating missense variant impact suffer from inconsistent performance across genes, which poses a major challenge for their reliable use in clinical practice. While ensemble scores leverage multiple prediction methods to enhance consistency, the overrepresentation of certain genes in the training data can bias their outcomes. To address this critical limitation, we propose a gene-specific ensemble framework trained on reference computational annotations rather than on clinical or experimental data. Accordingly, we generate Meta-EA ensemble scores that achieve comparable performance to the top individual predicting method for each gene set. Incorporating the effects of splicing and the allele frequency …

N-Linked Fucosylated Glycans Are Biomarkers For Prostate Cancer With A Neuroendocrine And Metastatic Phenotype, Joseph E Ippolito, Hani Nakhoul, Cody Weimholt, Elena Nunez, Nikolaos A Trikalinos, Et Al.

2020-Current year OA Pubs

Prostate cancer is a heterogeneous disease with a spectrum of pathology and outcomes ranging from indolent to lethal. Although there have been recent advancements in prognostic tissue biomarkers, limitations still exist. We leveraged matrix-assisted laser desorption/ionization imaging of formalin-fixed, paraffin embedded prostate cancer specimens to determine if N-linked glycans expressed in the extracellular matrix of lethal neuroendocrine prostate cancer were also expressed in conventional prostate adenocarcinomas that were associated with poor outcomes. We found that N-glycan fucosylation was abundant in neuroendocrine prostate cancer as well as adenocarcinomas at the time of prostatectomy that eventually developed recurrent metastatic disease. Analysis of …

The Effects Of Augmented Feedback, Focus Of Attention, And Monetary Reward On Vertical Jump Height: A Replication Study, Javad Bakhshinejad, Jasmin C. Hutchinson, Jennifer Murphy, Lydia Trainor, Sarah Friedman, Nicholas Coker

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 13-26, 2025. Reproducibility and replicability of published empirical scientific evidence are fundamental for verifying key findings, identifying errors and/or boundary conditions, and upholding rigorous research standards. For this replication study, the primary goal was to assess the replicability of the findings from Wälchli et al. (2016), which investigated the role of augmented feedback (AF), external focus of attention (EF), and reward (RE), as well as a combination of these conditions on countermovement jump height. The original study sample included 18 resistance-trained male and female participants, while this replication included 38 (19 male, 19 female). …

The Relationship Between Lower-Body Flexibility And Running Performance In A Half Marathon Downhill Running Event, Logan Petty, Marcus M. Lawrence

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1-12, 2025. Although previous studies examining treadmill or relatively flat overground running events have found relationships for running performance and flexibility, no study has examined these outcomes during downhill events, including between sexes. Therefore, the purpose of this study was to determine if a relationship exists between lower body flexibility and running performance in recreational adult male and female distance runners competing in a downhill half marathon race. Recreational (n=11 male, n=19 female) adult distance runners completed this study. On the day prior to the race, participants performed a standardized warm-up, …

An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa

Spora: A Journal of Biomathematics

Whether immune cells protect or harm the brain is an open question depending on context, and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and other neurological disorders. Microglia, a specific type of immune cell in the central nervous system, play a key role in homeostasis, and genes associated with an elevated risk of Alzheimer's disease correspond with deficiencies in their behavior. We created an agent-based model that incorporates inflammatory signaling, chemotaxis, and phagocytosis of damaged neurons and allows the exploration of crucial pathways in the maintenance of brain health. We specifically investigated pathways related to …

On Solving Differential Equations Describing The Ecology Of Shallow Lakes: A Comparison Of Classical And Modern Computational Methods Through Python, Vruddhi Kapre, Jeffrey R. Anderson, Alessandro Maria Selvitella

Spora: A Journal of Biomathematics

In this exposition paper, we describe some computational methodologies to solve numerically differential equations modeling the shallow lake ecosystem, with particular focus on the dynamics of the phosphorus. We describe in detail Python implementations of classical algorithms, like Runge-Kutta, and more modern approaches, including physics-informed neural networks.

Another Milestone Achieved, Editorial Board

Spora: A Journal of Biomathematics

With due thanks to the Intercollegiate Biomathematics Alliance for their unending support, Spora is offering once again another highly respected platform for collaborative research in mathematics, biology, and related fields. Spora's role in disseminating work especially accessible to students makes it a unique platform to expand the body of knowledge in mathematical biology. Spora welcomes submissions related to Ph.D. dissertations, master's theses, and undergraduate research projects as well as original research.

Why Her Business Is Our Business: Female Psychotherapists’ Experiences Working With The Perinatal Population, Alexa Garber M.S.

Selected Full Text Dissertations, 2011-

Approximately 800,000 women in the United States yearly suffer from maternal mental health (MMH) conditions (Maternal Mental Health Leadership Alliance, 2020). Not only is MMH the most common complication of pregnancy and childbirth, but rates have increased with the COVID-19 pandemic causing pregnant women and new mothers to be even more vulnerable to developing mental health problems (Thapa et al., 2020). Research on the consequences of the pandemic have indicated a pressing demand on the field of psychology to meet the needs of individuals suffering from maternal mental health. Various challenges healthcare professionals face when working with the perinatal population …

Examining Dbt Clinicians’ Perspectives Involving Parents Of Emerging Adults In Treatment: A Qualitative Study, Emma Bernstein M.S.

Selected Full Text Dissertations, 2011-

Emerging adults (ages 18-29) are at a heightened risk for developing mental illnesses, including mood disorders, anxiety disorders, and dying by suicide. Further, some emerging adults are considered to have “failed to launch” from their parents’ homes, leading to a postponement to full-fledged adulthood. While parents often play a significant role in their emerging adults’ lives, there is limited research on evidence-based treatment for emerging adults that systematically incorporate parents. Given the strong research support for Dialectical Behavior Therapy for Adolescents (DBT-A) that includes parent involvement, it is sensible to consider applying developmentally tailored adaptations to additional populations and understand …

Impact Of Nature-Based Tourism On Bird Vocalization Rate In The Bajo Del Tigre Reserve, Monteverde, Costa Rica, Abby K. Bressette, Adriana Arias Aguilar

Environmental Studies Publications

Nature-based tourism benefits economies, communities, and conservation initiatives, but it can also have unintended negative effects on wildlife. For birds, vocal communication is essential, yet it can be disrupted by anthropogenic noise. In this study, I used passive recording to examine how human visitation impacts the rate of bird vocalizations in the Bajo del Tigre Reserve in Monteverde, Costa Rica. Overall, bird vocalization rate was not affected by visitation (p > 0.05), but species-specific differences were found. Vocalizations of the lesser greenlet showed no significant change with visitation (p > 0.05). In contrast, the orange-billed nightingale-thrush exhibited a decrease in vocalization rates …

Defeating Mother Nature: A Feminist Rhetorical Analysis Of Tampax’S “Serena Williams Vs Mother Nature” Advertisement, Elisabeth Stevens

University Honors Theses

No abstract provided.

Navigating Uncertainty As An “Adolescent Organization”: Addressing The Needs Of Lgbtqiaa+ Young People In A Complex And Adaptive Service Organization, Suzie Staley

Master's Theses and Doctoral Dissertations

Throughout history, lesbian, gay, Transgender, queer/questioning, intersex, asexual, and agender plus Students have been marginalized in society and, in particular, K-12 schools. The purpose of this qualitative study was to explore the experiences of young adults and recent high school graduates to gather information about their experience in K-12 educational environments to determine if their developmental needs were met. This study focused on youth who attended K-12 schools in a specific district in Southeast Michigan and participated in out-of-school time programs at a local teen center. Through in-depth interviews with youth participants and focus groups with teen center staff and …

Course Catalog 2025-2026, Csusb

CSUSB Course Catalog

No abstract provided.

Psychological Impact Of Ulcerative Colitis On Pregnancy And Postpartum Period, Stephanie C. Carver

Nursing | Senior Theses

Background

Ulcerative colitis (UC) poses significant challenges during pregnancy, affecting both physical and mental health. While the physiological effects of UC during pregnancy are well documented, less is known about its impact on maternal mental health. This study aims to investigate the psychological effects of UC on pregnant women, focusing on stress levels, postpartum depression (PPD) incidence, and the role of multidisciplinary care in improving mental health outcomes.

Objective

The primary objective of this research proposal is to evaluate the psychological impact of UC during pregnancy and determine whether disease activity increases the risk of PPD and stress. A secondary …

Northeastern Illinois University, Academic Catalog 2025-2026, Northeastern Illinois University

Course Catalogs

No abstract provided.

West Central Minnesota Regional Food Assessment, Ed Brands, Daniel Jahngurske, Allison Koos, Kat Kraemer, Argie Manolis, Mikayla Morris, Isabel Olson, Cristina Ortiz, Annabelle Scafe

Center for Small Towns

This project documents food access, barriers, production, and suggestions for improvement in the food system across a largely agricultural five-county (Douglas, Grant, Pope, Stevens, and Traverse) region in West-Central Minnesota. A variety of methods, including surveys, interviews, and focus groups, were used to gather data. Secondary (e.g., US Census, USDA Census of Agriculture) and historical (e.g., grocery store directories) data were also used in this project.

Approximately half of household food security survey respondents (N= 283) had in the last year at least worried about there not being enough money for food in their household. Respondents experiencing food insecurity were …

Cc Magazine Winter 2025, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

Personal Disruption In The Career Advancement Of Female Executives In Medical Education, Ifeoma Dawodu

Dissertations

Purpose: The purpose of this explanatory mixed methods study was to identify and describe the perceived impact of Johnson and Mohr’s (2013) five disruptive career skills on female medical education executives on their advancement to executive leadership positions.

Methodology: This study employed a sequential explanatory mixed methods approach to explore the career advancement strategies of female leaders in academic medicine. First, a quantitative survey using Likert scales assessed the use and impact of personal disruption strategies among female executives; next, semistructured interviews provided deeper insights into their experiences. The sample focused on senior female leaders in California medical schools who …

2025 Welcome To Soar, Morehead State University. Office Of Communications & Marketing.

Communications and Marketing Publications Archive

The 2025 Morehead State University SOAR Guide Pack.

2025 Career Guide, Morehead State University. Office Of Communications & Marketing.

Communications and Marketing Publications Archive

The 2025 Morehead State University Career Guide.

Circadian And Age-Related Variations Of Amino Acids Levels In Drosophila Brains: Correlations And Descriptive Dimensions, Sandrine Parrot, Jacob Crehan, Chloé Aman, Philippe De Deurwaerdère, Matthew S. Thimgan, Laurent Seugnet

Biological Sciences Faculty Research & Creative Works

A comprehensive view of whole-brain amino acid levels holds the potential to provide valuable insights into the brain's state, given the mutual interconnections through metabolism, food intake, and neurotransmission. We tested this concept by evaluating free amino acid levels in single Drosophila brains across 24 h and at two different ages. A large proportion of these amino acids displayed time-of-day variations, and a subset exhibited age-dependent variations. Cross-correlation analysis of the data sets confirmed broad time-of-day and age dependent interconnections between amino acids. Factor Analysis of Mixed Data revealed further data structuration along key amino acids. For example, 50% of …

Dataset Supporting "Functional Trait Responses Of Alternanthera Philoxeroides To Increasing Salinity: Stress Tolerance, Avoidance And Escape Strategies Support Invasiveness With Sea Level Rise, Brenda J. Grewell*, Blanca Gallego-Tévar, Jesús M. Castillo, Caryn J. Futrell, Rebecca E. Drenovsky, Nathan E. Harms, Paul D. Pratt

Alligator Weed Salinity Exp for NeoBiota

No abstract provided.

Laboratory Exercises For Biol 1011 (Biology For Non-Majors Laboratory), Larry Bowman Baranowski

Open Educational Resources

Laboratory Exercises for BIOL 1011 (Biology for Non-majors Laboratory) provides three laboratory exercises: Climate Change Lab, Species Extinction Lab, and Genetically Modified Organisms Lab.