Digital Commons Network^™

Uca1 As A Key Regulator Of The Warburg Effect During Anoikis Resistance In Colorectal Cancer Metastasis, Ricardo Pequeno Bracho, Salique Hassan Shaham, Yamile Abuchard Anaya, Sophia Leslie, Kyle Doxtater, Subhash Chauhan, Bilal Hafeez, Tamer Oraby, Manish K. Tripathi

Research Symposium

Colorectal carcinoma (CRC) is the second leading cause of cancer-related mortality in the United States. While localized CRC has a 90% five-year survival rate, this drops sharply to 14% upon metastasis. Metastasis occurs in approximately 40–50% of CRC cases and requires cancer cells to acquire anoikis resistance—a critical adaptation allowing survival after detachment from the extracellular matrix, enabling migration and colonization of secondary sites. Understanding the molecular mechanisms driving anoikis resistance, particularly those linked to altered glucose metabolism, is essential for developing targeted therapies for metastatic CRC.

Cancer cells frequently exhibit the Warburg Effect, a metabolic adaptation favoring glycolysis over …

Stepwise Regression Analysis To Assess Various Factors Affecting On Fresh Sperm Quality In Ouled Djellal Ram, Yamina Belkhiri, Souheyla Benbia, Farida Bouzebda-Afri, Zoubir Bouzebda, Ramzi Lamraoui

The Thai Journal of Veterinary Medicine

The aim of this study was to evaluate the effect of various factors on fresh semen quality in Ouled Djellal rams. Specifically, we examined the impact of semen collection method, season, ram age, testosterone levels, body weight , and testicular weight. Twelve mature Ouled Djellal rams were used in the trial. Six rams were trained for semen collection using an artificial vagina (AV), while semen from the other six rams was collected using an electroejaculator (EE) biweekly throughout the year. Stepwise regression analysis showed that 62.50% of the variation in sperm volume, 48.60% of the variation in mass motility, 62.70% …

Assessing The Micro- And Macroscopic Changes Of Taphonomically Altered Bone, Shelby Feirstein

UM Graduate Student Research Conference (GradCon)

Forensic identifications may be hampered when perpetrators find unique ways of obscuring their victims’ identities, such as fire and household corrosive substances. Thermal alteration, sodium hydroxide, and hydrochloric acid are known to change both the structural integrity and composition of skeletal elements; but the patterns of these processes, nor how each may affect the potential for obtaining identifying DNA data, are well understood.

Burned bone concomitantly follows a defined color spectrum and eventually reaches calcination, consisting only of its original inorganic mineral, hydroxyapatite, which is naturally white in color and brittle.

In contrast, analyses of chemical exposure focus on total …

Novel Nanoformulation Of Piperlongumine Attenuates Pancreatic Tumor Desmoplasia And Modulates Tumor Immune Responses, Vivek K. Kashyap, Reinaldo Mandes, Neeraj Chauhan, Daniel Zubieta, Mohammed Sikander, Eswara N.H.K Ghali, Bilal B. Hafeez, Murali M. Yallapu, Subhash C. Chauhan

Research Symposium

Pancreatic cancer (PanCa) is characterized by a lack of early diagnosis, poor response to available therapeutic modalities, and chemoresistance. Gemcitabine (GEM) is currently considered the most effective therapy for PanCa; however, it shows only a marginal survival benefit of 6 months. This poor drug response has been attributed to desmoplasia, causes suboptimal drug delivery, alters tumor microenvironment (TME), which includes tumor surrounding blood vessels, fibroblasts, immune cells, extracellular matrix, and other signaling molecules and induces chemo-resistance in tumors. To overcome these existing issues associated with chemotherapy, the identification and development of novel therapeutic modalities are a pressing need. Piperlongumine (PL) …

Impact Of Acute Stress On Circadian Rhythm Regulation Of Locomotor Activity In Syrian Hamsters, Raquel A. Villarreal, Laura E. Garcia, Mario Gil

Research Symposium

Background: Disruptions of circadian rhythms, caused by factors such as environmental changes or stress, are linked to health conditions, including metabolic disorders, cardiovascular diseases, and mood disorders. Circadian rhythm disturbances are particularly relevant for understanding the etiology of conditions like insomnia, depression, and anxiety. The circadian rhythm, primarily regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, coordinates biological processes to align with daily environmental cycles. Acute stress, especially when experienced immediately upon waking, has been shown to disrupt these rhythms, impair sleep regulation, and exacerbate mood dysregulation. Given the significant clinical implications, understanding how stress impacts circadian rhythms is …

Fabrication Of Docetaxel Loaded Pcl/Plga Electrospun Nanofibers For Lung Cancer Therapy, Rahul Tiwari, Fnu Pranav, Eswara N. Hanuma Kumar Ghali, Subhash Chauhan, Murali Yallapu, Luis Chavez

Research Symposium

Background: Electrospinning is a commonly employed method in tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that mimic the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modeling and as patches for in vivo therapeutic delivery. This research aims to investigate the efficient delivery of anticancer drug in lung cancer treatment.

Methods: Three different biocompatible polymeric nanofibers (i.e. PCL fibers, PCL-PLGA mixed fibers, and PCL-PLGA tetra-layered fibers) loaded with docetaxel, were prepared using electrospinning technique. …

Heterogeneity Of Rna-Binding Protein Dnd1 In G0 Male Germ Cells May Provide A Selection Process For Spermatogonial Stem Cell Development, Kayla Friedman, Talia Hatkevich, Blanche Capel

Osmosis Magazine

The ability to reproduce is dependent upon proper development of the germline. In male Mus musculus, germline development involves male germ cells (MGCs) differentiating into spermatogonial stem cells (SSCs), the precursors for male gametes. During this differentiation period, MGCs enter a quiescent phase (G0), an essential stage for SSC development. This G0 phase accompanies changes in transcription as well as chromatin accessibility and re-methylation of DNA.

Using Machines To Guide Your Online Shopping Decisions, Daniel Verdi Do Amarante

Osmosis Magazine

I bet you’ve heard the term artificial intelligence in various conversations by now. But do you understand the process of teaching machines to develop abilities that are comparable – sometimes even better – to those of humans? At the University of Richmond, Dr. Park’s lab does just that.

An Ever-Growing Web: Spider Silk In Medicine, Andrew Watts

Osmosis Magazine

For decades, graduates from the University of Richmond have crafted a robust web of alumni spanning various regions and professions. Much like its graduates, Richmond’s famed spider mascot has been capitalizing on the strength of its own web and engineering solutions to the most pressing problems in a new and rather unexpected territory–medicine.

Spider silk has unique chemical and physical properties that allow it to be used in many different capacities.

Re-Captcha, Isabel Dilandro

Osmosis Magazine

They tried to warn us of what would come, but we didn’t listen. Why should we? For years the world had told us that we were smarter than everything else. Better. More advanced. The very science of biology existed to remind us that we were the superior race. We were untouchable. Until now. If only we hadn’t ignored the warning signs. Perhaps we could have stopped the madness before it began. Unfortunately, we neglected to put a leash on the dog because we assumed it wouldn’t bite.

Osmosis Magazine - Fall 2022

Osmosis Magazine

Osmosis is a student read, led, and written publication from the University of Richmond, focusing on all aspects of healthcare and science.

Ormeloxifene-Mediated Attenuation Of Β-Catenin Signaling In Hepatocellular Carcinoma Progression, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Molly Vela, Sheema Khan, Fathi T. Halaweish, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, with approximately 41,000 new cases and 29,000 deaths annually in the U.S. The management of HCC poses significant challenges due to severe toxicity and inadequate responses to existing chemotherapeutic agents. Aberrant β-catenin signaling is recognized as a crucial factor influencing the differentiation grades of HCC patients. Therefore, there is an urgent need to identify more effective and non-toxic β-catenin inhibitors for cancer treatment. Notably, ormeloxifene (ORM), a clinically approved selective estrogen receptor modulator with a favorable therapeutic index, has demonstrated remarkable anticancer activity, making it a promising …

The Science Of Tattoos, Isabel Dilandro

Osmosis Magazine

From face paint to temporary stick-on tattoos, children are taught that art on bodies is something beautiful and playful, associated with memories of fun and joy. Why is it then that tattoos get such an infamous reputation? The answer is pretty simple: tattoos are not temporary. But why? How does the ink get there? How does it stay put? In order to understand this process a bit more, it is important to have a basic understanding of the skin’s structure and function.

Late! I’M Late For A Very Important Physics Update I’M Late! I’M Late For A Very Important Physics Update, Caterina Erdas

Osmosis Magazine

Modern physics is my only class where half the students are consistently late. It’s not a forgivable one or two minutes late, but five to fifteen. I say this as a culprit myself; I slept in late on the third day of class and didn’t go. It’s ironic, considering we spend a good portion of lecture re-defining time.

A Creature That Has Seen It All, Dusan Vukcevic

Osmosis Magazine

What if there was a creature that is so indecisive about its habitat, that it decides to live both in rainforests and in the Antarctic? What if this creature was taking a swim in the Mariana Trench, and warming itself up at the bottom of a mud volcano? Their appearance gave them many names, so today we call them water bears, moss piglets or simply, Tardigrades. Be that as it may, the number of their names is negligible compared to the number of harsh conditions they are able to withstand. Just how resilient are these creatures?

Osmosis Magazine - Fall 2021

Osmosis Magazine

Osmosis is a student read, led, and written publication from the University of Richmond, focusing on all aspects of healthcare and science.

Georgia Academy Of Science 2025 Annual Meeting Program, Paul Arnold, Jennifer Schroeder, Linda Jones, Andrea Kwiatkowski, Brian Hoffman, Amy L. Boggan, Lauren Albin

Georgia Journal of Science

Program for the 2025 GAS Annual Meeting.

Nursing Now, 2011, Vol 10 Iss 1, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Medical Center and Hope Children's Hospital, Oak Lawn, IL: Internal newsletter publication written by nurses for nurses and published 6 times a year (bi-monthly). The mission of NURSING Now was to communicate, educate and motivate CMC nursing professionals towards continued excellence.

The Vulnerability Of The Heart During Diarrhea: A Case Report On Pericarditis Linked To Inflammatory Bowel Disease, Phani Bhavana Cherukuri, Jayasree Ravilla, Siva Naga S. Yarrarapu, Penny Turtel, Du Doantrang

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease, often involves extraintestinal manifestations, affecting up to 40% of patients. Cardiovascular complications, although rare, can include pericarditis, the most common cardiac manifestation in IBD.

Case Presentation: We report the case of a 34-year-old male with a long-standing history of UC who presented with pleuritic chest pain, shortness of breath, and worsening colitis symptoms. This case is particularly noteworthy due to the complexity added by the patient's 24-year history of UC, diverse treatment modalities (including mesalamine, 6-mercaptopurine, infliximab, vedolizumab, upadacitinib, and ustekinumab), and the patient not being on any …

Biomolecular Science, University Of Mississippi. Biomolecular Sciences

Annual Poster Session 2024-2025

Our mission is to drive innovation through combined excellence in the disciplines of Pharmacognosy, Medicinal Chemistry, Pharmacology, and Environmental Toxicology in order to understand and improve human and environmental health. We provide positive impacts to our school, the state of Mississippi, and the world, via education and mentored research at the undergraduate, graduate, and postdoctoral levels, and through our leadership in interdisciplinary chemical and biological sciences.

The Student Movement Volume 109 Issue 17: Stay Strong And March On: Spring Break Is Only One Week Away, Ayanda Dewa, Andrew Francis, Melanie Webb, Anna Rybachek, Nora Martin, Lexie Dunham, Madison Vath

The Student Movement V. 109 (2024-2025)

HUMANS

A Voice for the People: Alyssa Caruthers' Plans for Presidency, Ayanda Dewa

AUSA Social Affairs VP Wins Another Year of Service, Andrew Francis

ARTS & ENTERTAINMENT

Andrews Composers Concert 2025: An Insider's View

The Winners (and Losers) of the 97th Academy Awards, Melanie Webb

NEWS

History of Our Prillwitz Mammoth, Anna Rybachek

AUSA Cabinet Election Results Revealed for '25-'26 School Year, Andrew Francis

PULSE

A Beginner's Guide to Graduate School Applications, Nora Martin

Students React to Change of Venue for Andrews Graduation, Nora Martin

Lexie's Spring Clean, Lexie Dunham

The Black Walnut Crisis: Why are we cutting down our …

The Fierce Green Fire: Vol. 15 Issue 7, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Teacher Persistence: A Narrative Study On The Perceptions Of Career Oklahoma Teachers, Reggy Yount

Student Theses and Dissertations

The topic of this study identified characteristics of successful educators who had persisted as secondary classroom teachers in western Oklahoma. The problem that was studied was the teacher shortage that was impacting students in school districts throughout Oklahoma. The purpose of the study was to find the characteristics of individuals who had persisted in the field of education as classroom teachers. Human Capital Theory was the guiding theoretical framework, which provided a lens that views humans as the critical component in the success of systems. The methodology of this qualitative, narrative study included interviewing secondary classroom teachers in western Oklahoma …

Lgbtq+ Identity Development And Individual Vs Group Psychotherapy Experience: A Consensual Qualitative Analysis, Aileen Marie Rands

Theses and Dissertations

Multicultural topics, such as LGBTQ+ experience, have accrued predominance within the field of psychology. It has become clear that better understanding minority experience is of utmost importance. Pervasive stigma, discrimination, and mistreatment culminate into minority stress; thus LGBTQ+ individuals face greater risk for poor mental health and seek out psychotherapy at higher rates. Despite this reality, limited psychotherapy research exists in this area generally and essentially no research has looking into the experience of LGBTQ+ individuals in group therapy. The current study investigated experiences of LGBTQ+ clients who have participated in both individual and group psychotherapy. Eleven participants were interviewed …

Medical School Watercooler Newsletter - March 7, 2025, Lindsay Hughes

Watercooler Newsletter

This is the Friday, March 7, 2025 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• Graduate Research Forum set for April 1
• GHHS celebrates Thank a Resident Day
• Students planning reproductive health fair at Mobile community center
• USA Center for Lung Biology hosts first ReSPIRE conference
• Three USA Health physicians selected for national honor medical society

Corrigendum To “ Phylogenomics Of The Tribe Leonureae Reveals A New Genus: Paraleonurus (Lamiaceae, Lamioideae) , [Turkish Journal Of Botany 48 (Si-1) 2024 427-440] “, Mei-Lin Qian, Ya-Ping Chen, Tuncay Di̇rmenci̇, Yue Zhao, Guo-Xiong Hu, Fei Zhao, Ferhat Celep, Bo Li, Chunlei Xiang

Turkish Journal of Botany

This corrigendum is written to correct an error in our previous publication. The term “ Yi Mu Cao Shu (益母草属; Chinese name).” was incorrectly spelled as “Jia Yi Mu Cao Shu (假益母草属; Chinese name)” in the article. The correct term should be “Yi Mu Cao Shu (益母草属; Chinese name)”. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected.

Link to the original article: https://doi.org/10.55730/1300-008X.2825

Ai-Powered Education: Innovative Teaching Strategies To Elevate Student Learning, Karen J. Magruder, Ann M.L. Cavallo, Andrew M. Clark

Mavs Open Press Open Educational Resources - Archive

AI-Powered Education is a practical teaching resource crafted by educators, for educators, focusing on the integration of AI to enhance student learning. The book provides a collection of practical, step-by-step activities from a variety of disciplines in higher education. Each activity integrates AI tools and technologies into the classroom in innovative ways, with detailed guidance for instructors to seamlessly adopt these ideas.

Kylee Morris, Of Morehead City, N.C. Crowned Miss Gardner- Webb 2025, Office Of University Communications, Chloe Cloutier

Gardner-Webb NewsCenter Archive

Kylee Morris, a junior biology major, was recently crowned Miss Gardner- Webb 2025 for her outstanding musical ability and stage presence. Performing a four-mallet marimba solo of “Ghost Garden,” by Adam Hopper, she impressed the judges and audience.

Earth Orbital Rhythms Links Timing Of Deccan Trap Volcanism Phases And Global Climate Change, Thomas Westerhold, Edoardo Dallanave, Donald Penman, Blair Schoene, Ursula Röhl, Nikolaus Gussone, Junichiro Kuroda

Geosciences Faculty Publications

At the end of the Cretaceous, the massive Deccan trap (DT) volcanic eruptions are regarded as the primary driver of global climate deterioration. Accurate age models are key to unravel the sequence of events related to DT volcanism onset and effects on the global climate system. We establish a direct geochemical link between DT volcanism as recorded in marine osmium isotopic data and global climate change documented in benthic foraminifera carbon and oxygen isotope records. Based on our state-of-the-art astronomically calibrated age model, two major shifts in marine ¹⁸⁷Os/¹⁸⁸Os at 66.49 and 66.28 million years ago are …

Complete Genome Characterizations Of Two Novel Mitoviruses Hosted By The Hypogeous, Mycorrhizal Fungi Statesia Pompholyx And Tuber Sp., Ilgaz Akata, Gülce Edi̇ş, Eda Kumru, Emre Keski̇n, Ergi̇n Şahi̇n

Turkish Journal of Botany

The study of viral diversity in uncultivated fungi, including those involved in mycorrhizal relationships, alongside research on viral communities in phytopathogenic and economically important fungi, is crucial for a comprehensive understanding of mycovirus diversity and evolution. Mycorrhizal fungi host various viruses, contributing to our understanding of virus diversity and evolution. Here, we report on the identification and complete genome characterization of two novel mitoviruses that naturally infect the hypogeous, mycorrhizal fungi Statesia pompholyx and Tuber sp. The identified viruses, denominated as “Statesia pompholyx mitovirus 1” (SpMV1) and Tuber mitovirus 3 (TruMV3), have genome lengths of 2549 and 3292 nucleotides and …