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Articles 21961 - 21990 of 31588
Full-Text Articles in Entire DC Network
اتجاهات أعضاء هيئة التدريس بكليات العلوم بجامعة طيبة نحو استخدام الجدل العلمي في تدريسهم, نواف بن مقبل السراني
اتجاهات أعضاء هيئة التدريس بكليات العلوم بجامعة طيبة نحو استخدام الجدل العلمي في تدريسهم, نواف بن مقبل السراني
Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي
هدفت الدراسة التعرف على اتجاهات أعضاء هيئة التدريس بجامعة طيبة نحو استخدام الجدل العلمي في تدريسهم، وقد استخدمت الدراسة المنهج الوصفي، من خلال استخدام مقياس اتجاه أعضاء هيئة التدريس نحو استخدام الجدل العلمي في تدريسهم تكون من (27) عبارة. تم تطبيقها على كليات العلوم والعلوم الطبية التطبيقية وكلية الصيدلة بجامعة طيبة وتكونت العينة من (445) عضو هيئة تدريس، وتم اجراء الدراسة في الفصل الدراسي الثاني من العام الدراسي 1444 ه. استخدمت الدراسة عدد من الاختبارات الإحصائية كالمتوسطات الحسابية والانحراف المعياري، وتحليل التباين الأحادي (ANOVA) واختبار ت. وقد أظهرت نتائج الدراسة أن هناك فروقاً ذات دلالة إحصائية لمتغير التخصص لصالح كلية …
Targeting Ion Channels: Blockers Suppress Calcium Signals And Induce Cytotoxicity Across Medulloblastoma Cell Models., Darani Ashley Thammavongsa, Taylor N Jackvony, Markus J Bookland, Min D Tang-Schomer
Targeting Ion Channels: Blockers Suppress Calcium Signals And Induce Cytotoxicity Across Medulloblastoma Cell Models., Darani Ashley Thammavongsa, Taylor N Jackvony, Markus J Bookland, Min D Tang-Schomer
Faculty Research 2025
Medulloblastoma (MB) groups 3 and 4 lack targeted therapies despite their dismal prognoses. Ion channels and pumps have been implicated in promoting MB metastasis and growth; however, their roles remain poorly understood. In this study, we repurposed FDA-approved channel blockers and modulators to investigate their potential anti-tumor effects in MB cell lines (DAOY and D283) and primary cell cultures derived from a patient with MB. For the first time, we report spontaneous calcium signaling in MB cells. Spontaneous calcium signals were significantly reduced by mibefradil (calcium channel blocker), paxilline (calcium-activated potassium channel blocker), and thioridazine (potassium channel blocker). These drugs …
Challenging Masculinity To Combat Gbv In Kenya, Teresa Jacques Valenzuela, Juliet S. Sorrensen, Shannon R. Galvin, Megan M. Osadzinski, Patrick Mbullo Owuor
Challenging Masculinity To Combat Gbv In Kenya, Teresa Jacques Valenzuela, Juliet S. Sorrensen, Shannon R. Galvin, Megan M. Osadzinski, Patrick Mbullo Owuor
Southern Illinois University Law Journal
Gender-based violence (GBV) remains a pervasive issue in Kenya, significantly affecting women and girls, particularly in rural areas. This Article examines the importance of involving men and boys in GBV prevention efforts, using insights from Pamoja, a community-based organization in Kisumu, Kenya. Drawing on community-based participatory research, this study highlights the need to address restrictive masculinity norms that perpetuate GBV. The findings underscore the potential of engaging men as allies to foster long-term behavioral change and promote gender equality. By analyzing Pamoja’s intervention strategies, this Article advocates for comprehensive, gender-transformative approaches that challenge entrenched societal norms.
A Standards Perspective On Genomic Data Reusability And Reproducibility, Ishi Keenum, Scott A. Jackson, Emiley Eloe-Fadrosh, Lynn M. Schriml
A Standards Perspective On Genomic Data Reusability And Reproducibility, Ishi Keenum, Scott A. Jackson, Emiley Eloe-Fadrosh, Lynn M. Schriml
Michigan Tech Publications
Genomic and metagenomic sequence data provides an unprecedented ability to re-examine findings, offering a transformative potential for advancing research, developing computational tools, enhancing clinical applications, and fostering scientific collaboration. However, effective and ethical reuse of genomics data is hampered by numerous technical and social challenges. The International Microbiome and Multi’Omics Standards Alliance (IMMSA, https://www.microbialstandards.org/) and the Genomic Standards Consortium (GSC, https://gensc.org) hosted a 5-part seminar series “A Year of Data Reuse” in 2024 to explore challenges and opportunities of data reuse and reproducibility across disparate domains of the genomic sciences. Addressing these challenges will require a multifaceted approach, including common …
Retreatability Of Bioceramic And Resin-Based Root Canal Sealers Using Xp Shaper Rise: An In Vitro Study, Muhammed Ahmed Omar Abouel Seoud Phd, Shehab Saber
Retreatability Of Bioceramic And Resin-Based Root Canal Sealers Using Xp Shaper Rise: An In Vitro Study, Muhammed Ahmed Omar Abouel Seoud Phd, Shehab Saber
Dentistry
Aim: The purpose of this study was to investigate in-vitro the retreatability of premixed calcium-silicate-based sealer versus resin-based sealer when combined with gutta-percha using the single-file system XP-endo Rise.Materials and methods: 26 canals in typodont acrylic Nissin teeth were instrumented with E-flex blue rotary instruments up tosize 0.35mm and taper of 4%. Root canals were divided into two groups, obturated using either hydraulic condensation techniquewith a bioceramic sealer (n=13) or continuous wave of compaction (CWC) technique with a resin-based sealer (n=13). Theretreatment procedure was done for both groups using the XP-endo Rise instruments. The time required to complete theretreatment procedures …
Multi-Ancestry Transcriptome-Wide Association Studies Of Cognitive Function, White Matter Hyperintensity, And Alzheimer's Disease, Dima L Chaar, Zheng Li, Lulu Shang, Scott M Ratliff, Thomas H Mosley, Sharon L R Kardia, Wei Zhao, Xiang Zhou, Jennifer A Smith
Multi-Ancestry Transcriptome-Wide Association Studies Of Cognitive Function, White Matter Hyperintensity, And Alzheimer's Disease, Dima L Chaar, Zheng Li, Lulu Shang, Scott M Ratliff, Thomas H Mosley, Sharon L R Kardia, Wei Zhao, Xiang Zhou, Jennifer A Smith
Faculty, Staff and Student Publications
Genetic variants increase the risk of neurocognitive disorders in later life, including vascular dementia (VaD) and Alzheimer's disease (AD), but the precise relationships between genetic risk factors and underlying disease etiologies are not well understood. Transcriptome-wide association studies (TWASs) can be leveraged to better characterize the genes and biological pathways underlying genetic influences on disease. To date, almost all existing TWASs on VaD and AD have been conducted using expression studies from individuals of a single genetic ancestry, primarily European. Using the joint likelihood-based inference framework in Multi-ancEstry TRanscriptOme-wide analysis (METRO), we leveraged gene expression data from European ancestry (EA) …
Volume 30-2 Complete Issue, C. Nicholas Raphael
Volume 30-2 Complete Issue, C. Nicholas Raphael
The Geographical Bulletin
Volume 30-2 Complete Issue
News From The Chapters 1987-88, C. Nicholas Raphael
News From The Chapters 1987-88, C. Nicholas Raphael
The Geographical Bulletin
The Gamma Zeta Chapter of G.T.U. at Eastern Michigan University had a terrific year. The chapter was reactivated with bi-weekly meetings and 15 new initiates. Each meeting was highlighted by a student presentation of some personal experience of field sessions . Gerald Hopper discussed his experiences on an archaeological dig in southwestern Montana in October. Evelyn Gallegos who was with the Peace Corps talked about her experiences in Peru in November. Bob Merte spent a summer on an archaeological dig in Israel. He said it was hot-politically and weather-wise! Following Bob's December talk, Susan Odom presented a program on Mexico.
Introductory World Geography: A View From The Otherside, James Hisey
Introductory World Geography: A View From The Otherside, James Hisey
The Geographical Bulletin
This paper investigates the perceptions students have about world geography. Fifty-three students were asked to comment on their ideas of the importance of geography and how they would integrate the excitement and fun of geography into their teaching careers. The basic idea was to have students express their view on the content and relevance of basic regional geography. After a semester of exposure to the world, even at a basic, introductory level, the importance of geography is almost a moot question. Many future teachers noted several diverse ways of utilizing geographic techniques into their teaching. Students with different career goals …
Wetland Heritage Of The Upper Great Lakes: An Appreciation, C. Nicholas Raphael
Wetland Heritage Of The Upper Great Lakes: An Appreciation, C. Nicholas Raphael
The Geographical Bulletin
It is doubtful if any resource has been so abused and at the same time used as the earth's wetlands. In spite of an anti wetland prejudice, the resource has been utilized by Native Americans, fur traders and settlers. This investigation reveals that wetlands in the upper Great Lakes were not areas to be avoided but rather attractive resources to be exploited. Wetlands provided dietary and agricul tural resources, aesthetic settings and have contributed significantly to conser vation awareness. Vendable and eco nomic values recognized in the last few years are yet additional services these liquid assets provide.
Federated Learning-Driven Iot And Edge Cloud Networks For Smart Wheelchair Systems In Assistive Robotics, Mazin Abed Mohammed, Mohd Khanapi Abd Ghani, Abdullah Lakhan, Bourair Al-Attar, Waleed Khaled
Federated Learning-Driven Iot And Edge Cloud Networks For Smart Wheelchair Systems In Assistive Robotics, Mazin Abed Mohammed, Mohd Khanapi Abd Ghani, Abdullah Lakhan, Bourair Al-Attar, Waleed Khaled
Iraqi Journal for Computer Science and Mathematics
These days, assistive robotics and their applications for people with disabilities have become a revolutionary field in medical care. It combines edge-cutting technologies such as the Internet of Things (IoT), edge computing networks, and federated learning, offering the best services to disabled people for mobility and navigation in the environment. However, in the state of the art, many conceptual models are presented, and less effort is put into the practical implementation of assistive robots for disabled people in the environment. With this motivation, we propose an intelligent assistive robotics wheelchair system that enhances disabled care in federated learning-enabled IoT and …
Comparative Evaluation Of Bacterial Adhesion And Biofilm Formation On Contact Lenses, Lina M. Shaker, Wan Nor Roslam Wan Isahak
Comparative Evaluation Of Bacterial Adhesion And Biofilm Formation On Contact Lenses, Lina M. Shaker, Wan Nor Roslam Wan Isahak
AUIQ Complementary Biological System
This study evaluates bacterial adhesion, biofilm formation, and Staphylococcus aureus (S. aureus) (ATCC 25923) colonization on medical and cosmetic contact lenses made from Hilafilcon B and Omafilcon B under simulated ocular conditions. Non-incubated lenses served as controls, and experiments were repeated three times with a variability margin of ±5%, ensuring accuracy and reliability. Results revealed that biofilm growth and bacterial adhesion were influenced by lens material, type, and incubation duration. Cosmetic lenses made from Hilafilcon B exhibited the highest biofilm growth (1.95%) after one day, highlighting their susceptibility to microbial colonization. Conversely, medical lenses made from Hilafilcon B …
Removal Of Cr(Vi) From Aqueous Solution Using Magnetic Activated Carbon Prepared From Waste Shell Of Marigold Flower Straw: Kinetics, Isotherm And Mechanism Studies, Shanmukha Rao Metta, Uttam Kumar Sahu
Removal Of Cr(Vi) From Aqueous Solution Using Magnetic Activated Carbon Prepared From Waste Shell Of Marigold Flower Straw: Kinetics, Isotherm And Mechanism Studies, Shanmukha Rao Metta, Uttam Kumar Sahu
AUIQ Complementary Biological System
When Cr(VI) was released from industrial waste into water bodies harms aquatic ecosystems and poses risks to human well-being. To reduce risks, it's crucial to lower Cr(VI) levels through the sustainable process. In order to extract Cr(VI) from a liquid, the magnetic activated carbon adsorbent was created for the current investigation. H3PO4 was utilised as an activating agent in the thermal procedure to prepare activated carbon from marigold flower straw for the first time. The marigold flower straw activated carbon (MFSAC) was further decorated with Fe3O4 nanoparticles (Fe3O4/MFSAC) in the …
Tropical Cyclone Response In Annual Tree Growth At Three Different Coastal Sites Along The Gulf Of Mexico, Usa, Clay S. Tucker, Alyssa C. Crowell, Kayla D. Stan, Thomas W. Patterson
Tropical Cyclone Response In Annual Tree Growth At Three Different Coastal Sites Along The Gulf Of Mexico, Usa, Clay S. Tucker, Alyssa C. Crowell, Kayla D. Stan, Thomas W. Patterson
Faculty Publications
Coastal forests are highly vulnerable to disturbances from tropical cyclones (TCs), yet the long-term impacts of storm surges on tree growth remain understudied. This study examines the relationship between TC-induced storm surges and annual tree-ring growth in Pinus elliottii at three coastal sites along the northern Gulf of Mexico. Using dendrochronological methods, we analyzed total ring width, earlywood, and latewood growth patterns to assess suppressions in response to past TC activity. Our results indicate that storm surge events consistently cause growth suppression, with recovery periods averaging two to three years. However, suppression patterns vary by site, with trees in more …
Renal Transplant Recipients And Complicated Utis: A Path Toward Next-Generation Care, Rob E. Carpenter
Renal Transplant Recipients And Complicated Utis: A Path Toward Next-Generation Care, Rob E. Carpenter
Human Resource Development Faculty Publications and Presentations
Next-generation sequencing (NGS) offers diagnostic potential in managing complicated urinary tract infections (UTIs) in renal transplant recipients by enabling precise pathogen identification and resistance profiling. Integrating NGS into care protocols can improve graft preservation, reduce hospitalizations, and support antimicrobial stewardship. Policies should prioritize its adoption, while research explores cost-effectiveness and clinical outcomes. Medical education must emphasize NGS to prepare clinicians for advanced diagnostic approaches, fostering improved patient outcomes and innovative care solutions. Please cite this paper as: Carpenter RE. Renal transplant recipients and complicated UTIs: a path toward next-generation care. Renal transplant recipients face a heightened risk of complicated urinary …
Building Relationships For Meaningful Co-Created Indigenous Climate Education, B. Hanson, R. Mccann, D. Smiley, S. Hinck, A. R. Archie, N. Butler
Building Relationships For Meaningful Co-Created Indigenous Climate Education, B. Hanson, R. Mccann, D. Smiley, S. Hinck, A. R. Archie, N. Butler
Environment and Society Student Research
This project involved a multicultural team collaboratively co-creating a climate change module by and for Indigenous people. Embracing the framework of cultural humility, we recognized the bidirectional learning inherent in the project and its role in mitigating power dynamics within the team. This endeavor underscored the significance of transparency, effective communication, respect, reciprocity, trust building, and sensitivity to cultural contexts. Our findings emphasized the need for locally grounded programs that echo local traditional wisdom. We discovered that fostering an environment conducive to active listening and patience is pivotal in establishing a secure space. Our research affirms the equal validity and …
Gatad2b O-Glcnacylation Regulates Breast Cancer Stem-Like Potential And Drug Resistance, Giang Le Minh, Jessica Merzy, Emily Esquea, Nusaiba Ahmed, Riley Young, Ryan Sharp, Tejsi Dhameliya, Bernice Agana, Mi-Hye Lee, Jennifer Bethard, Susana Comte-Walters, Lauren Ball, Mauricio Reginato
Gatad2b O-Glcnacylation Regulates Breast Cancer Stem-Like Potential And Drug Resistance, Giang Le Minh, Jessica Merzy, Emily Esquea, Nusaiba Ahmed, Riley Young, Ryan Sharp, Tejsi Dhameliya, Bernice Agana, Mi-Hye Lee, Jennifer Bethard, Susana Comte-Walters, Lauren Ball, Mauricio Reginato
Kimmel Cancer Center Faculty Papers
The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). In breast cancer, the function and maintenance of CSCs are influenced by protein O-GlcNAcylation and the enzyme responsible for this post-translational modification, O-GlcNAc transferase (OGT). However, the mechanism of CSCs regulation by OGT and O-GlcNAc cycling in breast cancer is still unclear. Analysis of the proteome and O-GlcNAcome, revealed GATAD2B, a component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, as a substrate regulated by OGT. Reducing GATAD2B genetically impairs mammosphere formation, decreases expression …
Condensed Low-Dose Total Skin Electron Beam Therapy For Mycosis Fungoides: An Institutional Retrospective Review And Subgroup Analysis Of Patients With Large Cell Transformation, Louis Cappelli, Megan Cappelli, Nilanjan Haldar, Tiara Paul, Jenna Mandel, Tingting Zhan, Neda Nikbakht, Wenyin Shi
Condensed Low-Dose Total Skin Electron Beam Therapy For Mycosis Fungoides: An Institutional Retrospective Review And Subgroup Analysis Of Patients With Large Cell Transformation, Louis Cappelli, Megan Cappelli, Nilanjan Haldar, Tiara Paul, Jenna Mandel, Tingting Zhan, Neda Nikbakht, Wenyin Shi
Department of Dermatology and Cutaneous Biology Faculty Papers
Low-dose total skin electron beam therapy (TSEBT) is an effective treatment option for mycosis fungoides (MF) with proven palliative effects and reduced toxicity. Presented is an institutional analysis of survival/response rate and quality of life for MF patients with subgroup analysis of those possessing pathologic large cell transformation (LCT). This is a single institutional retrospective review of patients with mycosis fungicides treated from 2014 to 2023 with low-dose TSEBT. All patients received 12 Gy in 6 fractions every other day with the modified Stanford technique, with boosts to shadowed sites between treatments, completed in 2 weeks. Outcomes evaluated included clinical …
Comparison Of Deep Learning And Traditional Machine Learning Models For Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers, Kesheng Wang Phd, Ma, Bs, Donald A. Adjeroh, Wei Fang, Suzy M. Walter, Danqing Xiao, Ubolrat Piamjariyakul, Chun Xu
Comparison Of Deep Learning And Traditional Machine Learning Models For Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers, Kesheng Wang Phd, Ma, Bs, Donald A. Adjeroh, Wei Fang, Suzy M. Walter, Danqing Xiao, Ubolrat Piamjariyakul, Chun Xu
Faculty Publications
Mild cognitive impairment (MCI) is a clinical condition characterized by a decline in cognitive ability and progression of cognitive impairment. It is often considered a transitional stage between normal aging and Alzheimer’s disease (AD). This study aimed to compare deep learning (DL) and traditional machine learning (ML) methods in predicting MCI using plasma proteomic biomarkers. A total of 239 adults were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort along with a pool of 146 plasma proteomic biomarkers. We evaluated seven traditional ML models (support vector machines (SVMs), logistic regression (LR), naïve Bayes (NB), random forest (RF), k-nearest neighbor …
Evaluation Of The Gelation Characteristics And Printability Of Edible Filamentous Fungi Flours And Protein Extracts, Lauren Doyle, Suvro Talukdar, Youling Xiong, Akinbode Adedeji, Tyler Barzee
Evaluation Of The Gelation Characteristics And Printability Of Edible Filamentous Fungi Flours And Protein Extracts, Lauren Doyle, Suvro Talukdar, Youling Xiong, Akinbode Adedeji, Tyler Barzee
Animal and Food Sciences Faculty Publications
AbstractThere is a pressing need to produce novel food ingredients from sustainable sources to support a growing population. Filamentous fungi can be readily cultivated from low-cost agricultural byproducts to produce functional proteins for food biomanufacturing of structured products. However, there is a lack of scientific knowledge on the gelling characteristics of fungal proteins or their potential in additive biomanufacturing. Therefore, this study investigated the feasibility of utilizing fungal protein extracts and flours from Aspergillus awamori, Pleurotus ostreatus, Auricularia auricula-judae as sole gelling agents in 3D-printed products. Protein extracts were successfully prepared using the alkaline extraction–isoelectric precipitation method and successful physical …
Genome-Wide Profiling Of Highly Similar Paralogous Genes Using Hifi Sequencing., Xiao Chen, Daniel Baker, Egor Dolzhenko, Joseph M. Devaney, Jessica Noya, April S. Berlyoung, Rhonda Brandon, Kathleen S. Hruska, Lucas Lochovsky, Paul Kruszka, Scott Newman, Emily G. Farrow, Isabelle Thiffault, Tomi Pastinen, Dalia Kasperaviciute, Christian Gilissen, Lisenka Vissers, Alexander Hoischen, Seth Berger, Eric Vilain, Emmanuèle Délot, Uci Genomics Research To Elucidate The Genetics Of Rare Diseases (Uci Gregor) Consortium, Michael A. Eberle
Genome-Wide Profiling Of Highly Similar Paralogous Genes Using Hifi Sequencing., Xiao Chen, Daniel Baker, Egor Dolzhenko, Joseph M. Devaney, Jessica Noya, April S. Berlyoung, Rhonda Brandon, Kathleen S. Hruska, Lucas Lochovsky, Paul Kruszka, Scott Newman, Emily G. Farrow, Isabelle Thiffault, Tomi Pastinen, Dalia Kasperaviciute, Christian Gilissen, Lisenka Vissers, Alexander Hoischen, Seth Berger, Eric Vilain, Emmanuèle Délot, Uci Genomics Research To Elucidate The Genetics Of Rare Diseases (Uci Gregor) Consortium, Michael A. Eberle
Manuscripts, Articles, Book Chapters and Other Papers
Variant calling is hindered in segmental duplications by sequence homology. We developed Paraphase, a HiFi-based informatics method that resolves highly similar genes by phasing all haplotypes of paralogous genes together. We applied Paraphase to 160 long (>10 kb) segmental duplication regions across the human genome with high (>99%) sequence similarity, encoding 316 genes. Analysis across five ancestral populations revealed highly variable copy numbers of these regions. We identified 23 paralog groups with exceptionally low within-group diversity, where extensive gene conversion and unequal crossing over contribute to highly similar gene copies. Furthermore, our analysis of 36 trios identified 7 …
Global, Regional, And National Prevalence Of Child And Adolescent Overweight And Obesity, 1990–2021, With Forecasts To 2050: A Forecasting Study For The Global Burden Of Disease Study 2021, Gbd 2021 Adolescent Bmi Collaborators, Jessica A Kerr, George C Patton, Karly I Cini, Yohannes Habtegiorgis Abate, Nasir Abbas, Abdallah H A Abd Al Magied, Samar Abd Elhafeez, Sherief Abd-Elsalam, Arash Abdollahi, Meriem Abdoun, Deldar Morad Abdulah, Rizwan Suliankatchi Abdulkader, Auwal Abdullahi, Hansani Madushika Abeywickrama, Alemwork Abie, Olumide Abiodun, Shady Abohashem, Dariush Abtahi, Hasan Abualruz, Bilyaminu Abubakar, Eman Abu-Gharbieh, Hana J Abukhadijah, Niveen Me Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Lisa C. Adams, Mesafint Molla Adane, Isaac Yeboah Addo
Global, Regional, And National Prevalence Of Child And Adolescent Overweight And Obesity, 1990–2021, With Forecasts To 2050: A Forecasting Study For The Global Burden Of Disease Study 2021, Gbd 2021 Adolescent Bmi Collaborators, Jessica A Kerr, George C Patton, Karly I Cini, Yohannes Habtegiorgis Abate, Nasir Abbas, Abdallah H A Abd Al Magied, Samar Abd Elhafeez, Sherief Abd-Elsalam, Arash Abdollahi, Meriem Abdoun, Deldar Morad Abdulah, Rizwan Suliankatchi Abdulkader, Auwal Abdullahi, Hansani Madushika Abeywickrama, Alemwork Abie, Olumide Abiodun, Shady Abohashem, Dariush Abtahi, Hasan Abualruz, Bilyaminu Abubakar, Eman Abu-Gharbieh, Hana J Abukhadijah, Niveen Me Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Lisa C. Adams, Mesafint Molla Adane, Isaac Yeboah Addo
Peninsula Medical School
Background: Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-communicable diseases in adulthood, coordinated global action on excess body mass in early life is still insufficient. Inconsistent measurement and reporting are a barrier to specific targets, resource allocation, and interventions. In this Article we report current estimates of overweight and obesity across childhood and adolescence, progress over time, and forecasts to inform specific actions. Methods: Using established methodology from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we modelled overweight and obesity across childhood and adolescence …
Integrative Analysis Of Transcriptomics And Clinical Data Of Slc1a5 In Cervical Cancer, Veronica O'Brien, Vivek Kashyap, Bhuvnesh Sharma, Murali Yallapu, Everardo Cobos, Subhash Chuahan
Integrative Analysis Of Transcriptomics And Clinical Data Of Slc1a5 In Cervical Cancer, Veronica O'Brien, Vivek Kashyap, Bhuvnesh Sharma, Murali Yallapu, Everardo Cobos, Subhash Chuahan
Research Symposium
Background: Cervical cancer is the fourth most common cancer in adult females globally and the second most common cancer in females between the ages of 15 and 44. The alanine-serine- cysteine transporter 2, ASCT2 (solute carrier family 1 member 5, SLC1A5), is a major transporter of the amino acid, glutamine. SLC1A5 expression is associated with the progression of multiple types of tumors, including liver, lung, breast, colon and head and neck cancer. However, the biological significance of SLC1A5 cervical cancer has not been systematically and comprehensively investigated. Using deep data mining and transcriptomics analyses, in this study, we investigated the …
Dysregulation Of Cholesterol Metabolism And Sorafenib Drug Resistance In Hepatocellular Carcinoma, Veerababu Nagati, Dennis Kwabiah, Yamile Abuchard Anaya, Ana Ayala Pazzi, Manish K. Tripathi
Dysregulation Of Cholesterol Metabolism And Sorafenib Drug Resistance In Hepatocellular Carcinoma, Veerababu Nagati, Dennis Kwabiah, Yamile Abuchard Anaya, Ana Ayala Pazzi, Manish K. Tripathi
Research Symposium
Background: Hepatocellular carcinoma (HCC) is among the most prevalent cancers and a leading cause of cancer-related deaths worldwide. Sorafenib, a multikinase inhibitor, serves as a key first-line treatment for HCC when surgical intervention is not an option. However, primary and acquired resistance to sorafenib has significantly limited its effectiveness, reducing the disease control rate. Dysregulation of numerous genes that influence cancer cell proliferation, survival, and drug resistance contributes to this challenge. Identifying the molecular drivers of sorafenib resistance remains critical to improving treatment outcomes. Several factors, including activation of oncogenic pathways (e.g., Akt/mTOR), hypoxia, cholesterol metabolism, EMT, multidrug resistance, and …
Unraveling Genetic Links Between Diabetes And Heart Failure-A Machine Learning Approach, Sunakhi Sahoo, Marzieh Ayati
Unraveling Genetic Links Between Diabetes And Heart Failure-A Machine Learning Approach, Sunakhi Sahoo, Marzieh Ayati
Research Symposium
Background: Diabetic heart failure (DHF) is defined as a chronic and progressive disease which is associated with both diabetes and heart failure (HF). Even though there have been many developments in the knowledge of these diseases, there is still much to learn about the genetic crossovers between the two. In this study, we identified genes that are associated with diabetic heart failure and heart failure by using gene expression data from patients with DHF, HF, and a control group of patients who died of natural causes. We sought to identify genes that had altered expression levels which could possibly play …
Investigating The Ability Of Foxo1 To Maintain Stem Cells, Stella A. Rios, Megan E. Keniry
Investigating The Ability Of Foxo1 To Maintain Stem Cells, Stella A. Rios, Megan E. Keniry
Research Symposium
Background: Our group discovered that FOXO transcription factors drive stem gene expression in cancer to promote aggressiveness. Work by our group and others demonstrated that FOXO factors universally maintain stem cells including in cancer, embryonic, hematogenic and neuronal contents. Our current efforts are delineating the molecular underpinnings by which FOXO factors halt differentiation to maintain stem cells.
In this project, we are employing myoblasts as a valuable model to examine how Foxo1 maintains stem cells. Foxo1-regulated genes in myoblasts closely parallel its targets in glioblastoma and basal breast cancer stem cells, including targets such as Leukemia Inhibitory Factor, …
Exploring Cucurbitacin D'S Protective Mechanism Against Benzo[A]Pyrene-Induced Liver Injury Through Nrf2 Activation, Shabnam Malik, Mohammed Sikander, Anyssa Rodriguiez, Daniel Zubieta, Debanhi Esparaza, Fathi T. Halaweish, Sheema Khan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan
Exploring Cucurbitacin D'S Protective Mechanism Against Benzo[A]Pyrene-Induced Liver Injury Through Nrf2 Activation, Shabnam Malik, Mohammed Sikander, Anyssa Rodriguiez, Daniel Zubieta, Debanhi Esparaza, Fathi T. Halaweish, Sheema Khan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan
Research Symposium
Background: Numerous studies have established a strong association between hepatocellular carcinoma (HCC) and various co-morbidity factors, including smoking. Tobacco smoke is a significant source of benzo[a]pyrene, a highly carcinogenic compound known to cause liver damage. Cucurbitacin, a triterpene with diverse biological activities, exhibits antioxidant, antiinflammatory, and anticancer effects. However, its hepatoprotective properties have not been thoroughly investigated. In this study, we aimed to evaluate the hepatoprotective effects of cucurbitacin D, a novel analog of cucurbitacin, against liver injury induced by benzo[a]pyrene in human HepG2 cells.
Method: To investigate the hepatoprotective effect of cucurbitacin D against benzo[a]pyreneinduced liver damage, proliferation, clonogenicity, …
Myofibrillar Proteomics Of Sustained Load-Carriage Hiking, Rachel Perez, Mahalakshmi Shanakaran, Hussein Mohammed, Marc Hellerstein, Walter Hailes, Brent Ruby
Myofibrillar Proteomics Of Sustained Load-Carriage Hiking, Rachel Perez, Mahalakshmi Shanakaran, Hussein Mohammed, Marc Hellerstein, Walter Hailes, Brent Ruby
UM Graduate Student Research Conference (GradCon)
Load-carriage hiking is a popular recreational activity and an integral part of daily tasks for military personnel and wildland firefighters. Investigation is therefore warranted into myofibrillar responses to such activities. PURPOSE: To evaluate myofibrillar adaptations to acute load-carriage hiking. METHODS: Thirty-two recreationally active adults (12M, 20F; 28±6 yr; VO₂peak: 47.7±8.2 mL・kg-1・min-1) participated in a 5-day load-carriage study. Participants consumed 50ml deuterated water(2H2O) thrice daily for the 10 days prior to and twice daily during the five consecutive days of hiking for the measurement of fractional protein synthesis rates …
3d Digitization Of Yellowstone Wolf (Canis Lupus) Skulls For Education, Research, And Outreach, Madeline K. Rowland
3d Digitization Of Yellowstone Wolf (Canis Lupus) Skulls For Education, Research, And Outreach, Madeline K. Rowland
UM Graduate Student Research Conference (GradCon)
Museums around the world are using the advancement of digital technology to share scientific collections with broader audiences on a digital landscape. Recent innovations in imaging software and virtual platforms have made it possible for museums to create high-resolution 3D models that can be 3D printed as tangible educational aids, made accessible to researchers worldwide, and used to create accessible virtual museum experiences. Yellowstone National Park (YNP) is home to one of the best-studied collections of wolf (Canis lupus) skulls in the world. Long-term research conducted by the Yellowstone Wolf Project has produced an extensive volume of ecological …
Green Carpets In A Blue-Ribbon Fishery: Predicting Nuisance Algal Blooms Using River Metabolism, Cora Mae Steinbach
Green Carpets In A Blue-Ribbon Fishery: Predicting Nuisance Algal Blooms Using River Metabolism, Cora Mae Steinbach
UM Graduate Student Research Conference (GradCon)
Many freshwaters across the Mountain West are experiencing nutrient enrichment, leading to the excessive growth of algae and aquatic plants. In healthy rivers, these primary producers perform critical functions, providing energy for macroinvertebrates and fish, determining water quality, and directing carbon and nutrient cycling for the entire ecosystem. Nutrient enrichment profoundly alters these functions, motivating research to predict and prevent its impacts. Since 2018, nuisance algal blooms in the Gallatin River (Montana) have roused concern. The Gallatin blooms are hypothesized to occur in response to changing nutrient dynamics, likely due to human development in tributary streams. Fortuitously, continuous dissolved oxygen …