Digital Commons Network^™

The Timing Of Pubertal Onset Affects Adults Anxiety Behavior In A Sex-Specific Manner, Evan Raubenolt

Honors Projects

This study aims to look at the relationship between the timing of pubertal onset and its long-term effects on adult anxiety behavior in rats. Though the topic of pubertal onset has been frequently discussed in developmental research, its exact effects have been inconsistent. Human models have shown that early and late maturing males are associated with a notable increase in adult anxiety behavior, while in rat models, similar sex-specific effects regarding anxiety have been demonstrated, though those studies focus on a causal relationship between exposure to stress and age of pubertal onset. This study first aims to examine that relationship …

Capillary Electrophoresis Vs Massively Parallel Sequencing: A Cost-Benefit Analysis, Samia Williams

Honors Projects

Massively Parallel Sequencing (MPS) is a new Forensic Science field allowing multiple samples to be sequenced simultaneously. In contrast to CE, multiple types of genetic markers including those from different nucleic acids can be used in the same assay. Additionally, MPS has opened the doors to certain fields of Forensic DNA Analysis like Forensic Investigative Genetic Genealogy and Forensic Phenotyping assays containing upwards of 100 SNPs. While quite expensive and requiring a high cost for initiating, MPS has the potential to save time and greatly increase the throughput of Forensic DNA Analysis in crime labs.

Primary And Secondary Hyperaldosteronism, Joanna Lam

Senior Honors Theses

Hyperaldosteronism is characterized by the excess production of aldosterone in the body. This disorder manifests in two subtypes: while primary hyperaldosteronism is due to the excess secretion of aldosterone from the adrenal glands, secondary hyperaldosteronism originates from imbalances elsewhere in the body. Here, recent literature will be reviewed to examine the etiology and effects of both subtypes of hyperaldosteronism across molecular, cellular, and organ levels. Current diagnostic and treatment options for both subtypes of this disorder will also be reviewed, as well as recent research examining the prevalence of hyperaldosteronism over varying demographics.

Artificial Intelligence: A Double-Edged Sword In Support And Subversion Of The Biological Weapons Convention; Part One: Framing The Issues, Elise Annett, Diane Dieuliis, James Giordano

Strategic Insights

This commentary explores how artificial intelligence (AI) is profoundly affecting the biological enterprise, serving both as a powerful tool for scientific advancement and as a potential vector for misuse. The authors explain that AI can accelerate research, improve diagnostics, and enhance biodefense, but it also lowers barriers to creating or modifying biological agents and can be exploited for harmful ends. The dual effects make AI a "double-edged sword" that challenges existing governance, detection systems, and deterrence frameworks in biosecurity. Responsible integration of AI into biology requires policies that balance innovating with safeguards, strengthened international cooperation, and adaptive oversights to ensure …

Elephant In The Classroom: How Ethical Ai Can Improve Student Success, Ibrahim Kocaman, Daniel A. Cutrer

Publications

The integration of artificial intelligence (AI) into teaching and learning in higher education without compromising academic integrity is a pressing issue. To make the benefits of generative AI (GenAI) available to students while upholding principles of ethics and academic honesty, the authors implemented an ethical use of AI policy in their Introduction to Research Methods at Embry-Riddle University. The authors hypothesized and found that allowing ethical utilization of AI would lead to higher student engagement and academic success. These findings offer valuable insights for higher education programs and educators, particularly in security studies.

Chimes: December 8, 2025, Calvin University

Chimes

Women's volleyball's memorable season ends in the DIII quarterfinals by Zach Kern

Facilities expands recycling program on campus by Ian Tjoelker

A history of the liberal arts at Calvin: 1890s to today by McKenna Wilkinson

Christmas beyond Calvin: Letters to Santa by Ellery Johnson

"Energy and vision": Calvin's Black Student Union by Jorie Cho

Running with Sophie by Evangeline Anga

Students prepare for upcoming Fall Film & Media Showcase by Ashley Hamons

Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal

Theses and Dissertations

Protein aggregation within mitochondria emerges early in both aging and Alzheimer’s disease (AD) and contributes to progressive loss of proteostasis. Insoluble mitochondrial aggregate fractions from Caenorhabditis elegans revealed extensive enrichment of metabolic and translational proteins that also appear in human Alzheimer hippocampal aggregates. Comparative analysis across age and genotype identified a conserved subset of aggregation-prone proteins, several of which cluster around elongation factor 2 (eEF-2), a regulator of ribosomal translocation and energy coupling. Cross-species integration defined a network in which eEF-2 links chaperones, metabolic enzymes, and RNA-binding proteins that co-aggregate in both human Alzheimer material and nematode models. Functional tests …

Improving Skin Cancer Knowledge And Screening Among Older Chinese Americans Males, Yan Wang, Anne Derouin, Barbara Turner, Hanzhang Xu

Biennial Convention (CONV)

Skin cancer is the most common cancer in the U.S. with more than 5 million cases diagnosed annually. It is estimated that about 1 in 5 Americans will develop skin cancer by the age of 70, a prevalence that has been increasing annually (Adams et al., 2021; Aggarwal et al., 2021; Dildar et al., 2021; Trager et al., 2022). As reported by the ACS, men are more likely to develop melanoma compared to women. At the age of 80, men are three times more likely to develop melanoma than women, nearly double the number of male deaths due to the …

Side Effects Of Antipsychotics Impacting The Revolving Door Of Admissions At The Bellevue Hospital, Sandra Lorraine Chisholm-Ford

Biennial Convention (CONV)

Background: Antipsychotic medications are very effective in mitigating the symptoms associated with schizophrenia. However, patients receiving these medications often develop side effects with therapy. Side effects to antipsychotic medications is a global problem resulting in non-compliance, relapse, and re-hospitalizations.

Objectives: The study aimed to identify the prevalence of adverse reactions and side effects experienced by patients with schizophrenia taking antipsychotic medication, as well as the prevalence of readmissions to the Bellevue Hospital due to medication noncompliance.

Methods: A descriptive cross-sectional survey was done among forty-four patients diagnosed with schizophrenia admitted to acute and sub-acute care wards at the Bellevue Hospital. …

Turning Setbacks Into Strength: Developing The Emerging Concept Of Reclaiming Power, Nadine Cesaire

Biennial Convention (CONV)

Reclaiming power represents a transformative journey where individuals restore autonomy, resilience, and intentional participation in life. This concept emphasizes a shift from disconnection and diminished engagement to active involvement in personal growth and change. It redefines setbacks as opportunities for self-discovery, fostering openness to life’s unpredictability and challenges.

Substance Use Disorder (SUD) affects 14.5% of individuals aged 12 and older in the United States, equating to 48.7 million people (SAMHSA, 2023). This chronic condition, characterized by compulsive substance use, often leads to cycles of recovery and relapse. Overdose deaths rose by 50.9% between 2019 and 2022 (CDC, 2023), with relapse …

Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge

Biological Engineering Faculty Publications

As humanity prepares for prolonged space missions and future extraterrestrial settlements, developing reliable and resilient food-production systems is becoming a critical priority. Space agriculture, the cultivation of plants beyond Earth (particularly on the Moon and Mars), faces a constellation of interdependent environmental, biological, and engineering challenges. These include limited solar radiation, elevated ionizing radiation, large thermal variability, non-Earth atmospheric pressures, reduced gravity, regolith substrates with low nutrient-holding capacity, high-CO₂/low-O₂ atmospheres, pervasive dust, constrained water and nutrient availability, altered plant physiology, and the overarching need for closed-loop, resource-efficient systems. These stressors create an exceptionally challenging environment for plant …

Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska

Dissertations

Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worse outcomes after acute myocardial infarction, but the mechanism for this is unknown. Polycystin 2 (PC2), one of the two main proteins mutated in ADPKD, is a calcium permeant channel that localizes to the ER/SR. In non-cardiac cells, PC2 regulates the unfolded protein response (UPR) pathway under ER stress. However, whether PC2 is cardioprotective against ER stress is unknown. We found that PC2 expression increased in cardiomyocytes from human ischemic hearts and infarcted murine hearts. Cardiomyocyte-specific PC2 KO (PC2 KO) mice had worsened cardiac function after myocardial infarction …

Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar

Dissertations

Cells interpret biochemical and mechanical signals through dynamic regulation of the cytoskeleton and adhesion complexes, enabling key processes such as shape adaptation, force generation and migration. As these signals vary in both time and space, they can be challenging to resolve using traditional bulk assays. To overcome this limitation, we employ light-based optogenetic tools to reversibly modulate biochemical signals and mechanical equilibrium within cells. Specifically, we use the iLID optogenetic approach to locally activate signaling and manipulate contractility within the cytoskeleton for the purpose of investigating the role of RhoA and contractility on septin organization and adhesion protein localization. We …

Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, David Piwnica-Worms, Brian A Boone, Tracy W Liu

Faculty, Staff and Student Publications

Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical for host defense, prolonged elevation of ROS and dysregulated NETosis mediated by neutrophils have been implicated in autoimmune diseases, chronic inflammation, and cancer. In pancreatic ductal adenocarcinoma (PDAC), a highly aggressive and inflammatory malignancy, an increase in neutrophils infiltrating the tumor microenvironment promotes cancer progression and metastasis through increased ROS production and NET release. Using bioluminescence imaging with the reporter L-012 and NET assays, we assessed …

Thriving Hives: The Apiary - Beekeeping Essentials, Joseph Okoh, Andree' Walker Bravo

All Current Publications

This fact sheet is designed to help honey bee producers optimize their beekeeping practices and improve management systems. It offers essential guidance on selecting an ideal apiary location, choosing the right beehive, and ensuring efficient colony management. Additionally, this document serves as a valuable training resource for aspiring beekeepers.

Collaborative Research: Cif: Medium: Foundations Of Robust Deep Learning Via Data Geometry And Dyadic Structure, Kevin Moon

Funded Research Records

No abstract provided.

Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler

Arts & Sciences Graduate Student Theses and Dissertations

Light-induced chemical transformations are practical across many chemical and biological systems. From intramolecular hydrogen-bonding coordinates to reactions which alter the carbon framework of a molecule, the application of light can induce conformational changes that can subsequently be harnessed for a variety of tasks. However, molecular-level mechanistic insight about photo-induced chemical reactions remains difficult to acquire using current methodologies. In this dissertation, several intramolecular reactions are investigated and characterized, ranging from ground- and excited-state intramolecular proton transfers to the photochemical synthesis of a complex organic cyclization structure. The reaction coordinates are directly interrogated by utilizing ultrafast infrared spectroscopic techniques, such as …

Intouch Week Of December 8, 2025, New York Medical College

InTouch

No abstract provided.

Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz

Dissertations and Theses

This study investigates how type Ia feedback from muscle spindles can be organized into groups representing agonistic muscle pairs through Spike Timing Dependent Plasticity (STDP). A single degree of freedom joint is actuated with four biologically modeled muscles forming two agonistic pairs. In order to emulate the sensory dynamics of biological muscle spindles, sensors in the model record the active length and velocity states of each muscle, the two primary factors eliciting type Ia afferent responses. In biological networks, synapses from Ia sensory neurons frequently activate interneurons representing agonistic muscle sources. This research investigates whether this organization can emerge in …

You Have To Cut&Walk; Before You Can Cut&Run;: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori

Dissertations and Theses

The annual killifish, Austrofundulus limnaeus, found in ephemeral ponds in South America, possesses a remarkable ability to survive extended periods without water and oxygen. This ability is associated with developmental dormancy known as diapause. Numerous genetic and environmental factors influence the entry into diapause and tolerance to environmental stress. Among these is vitamin D3 signaling mediated by the vitamin D receptor (VDR), which plays a crucial role in regulating entry into diapause and the continuous development of an embryo in a temperature-dependent manner. Vitamin D3 signaling influences a variety of physiological processes in vertebrates. While extensively characterized in mammalian …

The Compatibility And Contribution Of Natural Enemies In Western Us Alfalfa Management, Ricardo A. Ramirez, Scott A. Bernhardt, Ryan A. Larsen

Funded Research Records

No abstract provided.

Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane

Funded Research Records

No abstract provided.

Collaborative Research: Seed-Fungal Interactions: Uncovering Functional Specificity And Primary Symbionts As Key Drivers Of Tropical Tree Recruitment, Noelle Beckman

Funded Research Records

No abstract provided.

Collaborative Research: Evolving Thicker Skin: Understanding How Adaptations To A Universal Trade-Off Dictate The Climate Vulnerability And Ecology Of An Imperiled Vertebrate Clade, Molly Womack

Funded Research Records

No abstract provided.

Exploration Of The Microbiome Of Native Plants For Plant Growth-Promoting Microbes To Mitigate Effects Of Abiotic Stresses In Crop Plants, Amita Kaundal

Funded Research Records

No abstract provided.

Harnessing Blueberry Flower Chemistry And Morphology To Boost Pollination And Bee Health, Monica Borghi

Funded Research Records

No abstract provided.

Investigation Of The Endogenous Opioid Neural Circuitry In Pain, Erin Nicole Bobeck

Funded Research Records

No abstract provided.

Myocardial Lipin1 Protects The Heart Against Ischemic Injury By Preserving Lipid Homeostasis, Jiaxi Guo, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulates lipid metabolism-related gene expression. Here, we investigated the roles of lipin1 in cardiac remodeling after myocardial infarction (MI). The expression levels of lipin1 significantly decreased in cardiomyocytes of the human failing heart and murine ischemic myocardium. Cardiomyocyte-specific Lpin1 knockout (cKO) mice showed left ventricle enlargement and reduced fractional shortening after MI, compared with control mice. This was accompanied by elevated cardiac fibrosis, accumulation of reactive oxygen species, and increased …

Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan

School of Nursing and Midwifery

Background: The mental health and wellbeing of children and young people is a global concern. Alongside approaches emphasising mental health promotion in schools, communities and in the home, many countries are also investing in crisis services. These aim to meet the needs of young people experiencing acute psychosocial distress. A recent synthesis of the international evidence found a paucity of research in this area. This study sought to address this gap while simultaneously situating the findings within the international context and drawing out implications for policymakers and practitioners. Methods: A cross-sectional study aiming to describe and map approaches to the …

Artem-Is For Erp: Agreed Reporting Template For Eeg Methodology-International Standard For Event-Related Potential Experiments, Giorgio Ganis

School of Psychology

The choices we make during the recording, preprocessing and analysis of event-related potentials (ERP) data can affect study outcomes. As such, it is critical that they are transparently reported to allow for reproducibility. Yet, systematic reviews of reporting practices in the field have shown that journal articles often do not meet this goal and that existing reporting guidelines have not resulted in a sufficient improvement in reporting transparency. An easier workflow for transparently documenting pipelines used in regular journal articles is needed. The ARTEM-IS (Agreed Reporting Template for EEG Methodology—International Standard) initiative is working towards addressing this issue by building …