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2025

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An Exploratory Evaluation Of The Kalamazoo River Watershed Council: Assessing Organizational Impact And Value, Alexander Mendez Dec 2025

An Exploratory Evaluation Of The Kalamazoo River Watershed Council: Assessing Organizational Impact And Value, Alexander Mendez

Honors Theses

The Kalamazoo River Watershed Council (KRWC) plays a central role in protecting, restoring, and promoting the long-term health of the Kalamazoo River watershed, a geographically expansive and ecologically complex system facing persistent challenges from legacy contamination, nonpoint source pollution, land-use pressures, and inequitable access to watershed resources. This honors thesis presents an exploratory organizational evaluation of the KRWC, assessing its role and relevance within the watershed, the effectiveness of its programs and partnerships, the strengths and limitations of its governance structure, and opportunities to strengthen its long-term sustainability and impact.

Guided by principles of Practical Participatory Evaluation (PP-E) and Fourth …


A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly Dec 2025

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …


Comparative Analysis Of Color, Texture, And Water Content In Three Shallot Cultivars At Different Harvest Ages, Rahma Wati Lestari, Kusumiyati, Syariful Mubarok Dec 2025

Comparative Analysis Of Color, Texture, And Water Content In Three Shallot Cultivars At Different Harvest Ages, Rahma Wati Lestari, Kusumiyati, Syariful Mubarok

Jurnal Kultivasi

Shallots are a major horticultural commodity with high economic value. The quality of shallots is determined not only by the quantity of the harvest but also by physical characteristics such as bulb color, texture, and water content. This study aims to evaluate the differences in these physical parameters in three popular local cultivars: Brebes, Sumenep, and Tuktuk, harvested at 56, 63, and 70 days after planting (DAP), respectively. This research uses a Randomized Block Design consisting of 9 treatment combinations and analyzed using the SmartstatXL application. Color measurements are conducted using the CIELAB method and converted to CIELCH and RGB …


Analysis Of Source–Sink Organ Dynamics In Kaffir Lime (Citrus Hystrix Dc.) At Different Plant Ages, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok Dec 2025

Analysis Of Source–Sink Organ Dynamics In Kaffir Lime (Citrus Hystrix Dc.) At Different Plant Ages, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok

Jurnal Kultivasi

Kaffir lime (Citrus hystrix DC.) is a leafy spice commodity widely used as a culinary ingredient, in bio-pharmaceuticals, and as a raw material for essential oil production. Despite its high demand, leaf productivity remains relatively low, highlighting the need for improved cultivation practices. A better understanding of source–sink dynamics is essential, as leaf production is strongly influenced by the balance between assimilate-producing and assimilate-consuming organs. Therefore, this study aimed to evaluate the source-sink capacity of kaffir lime plants of different ages as a preliminary step toward identifying cultivation strategies to enhance leaf production. The experiment was conducted at Bale Tatanen …


Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al. Dec 2025

Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of


Tgfbr2 Coordinates The Endometrial Response To Estrogen, Regulating Endometrial Hyperplasia And Fertility, Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand, Renata Prunskaite-Hyyryläinen, Diana Monsivais Dec 2025

Tgfbr2 Coordinates The Endometrial Response To Estrogen, Regulating Endometrial Hyperplasia And Fertility, Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand, Renata Prunskaite-Hyyryläinen, Diana Monsivais

Faculty, Staff and Students Publications

Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cancer. The TGFβ signaling pathway regulates key aspects of endometrial biology, although the direct effects of many individual receptors remain unstudied. In this study, we characterize the role of TGFβR2 within the endometrium using a progesterone receptor-cre conditional knock-out mouse model (Tgfbr2flox/flox;Pgrcre/+; “Tgfbr2 cKO”). We found that conditional deletion of TGFβR2 resulted in female infertility, endometrial hyperplasia, altered estrogen and progesterone response, and, only in bred females, reproductive tract …


International Consensus Guidelines For The Conduct And Reporting Of Car T-Cell Clinical Trials In Aml, Swati Naik, Richard Aplenc, Susanne H C Baumeister, Marco Becilli, Anand S Bhagwat, Challice L Bonifant, Lihua E Budde, Christopher D Chien, Kevin J Curran, Anthony F Daniyan, Alexandra Dreyzin, Rebecca A Gardner, Sara Ghorashian, Stephen Gottschalk, Laquisa C Hill, M Eric Kohler, Adam Lamble, Franco Locatelli, Maksim Mamonkin, Bilal Omer, Jae H Park, Concetta Quintarelli, Benedetta Rambaldi, Rebecca M Richards, David A Sallman, Tim Sauer, Nirali N Shah, Marion Subklewe, Corinne Summers, Sarah K Tasian, Naomi Taylor, Sarah Tettamanti, Michael R Verneris, M Paulina Velasquez, Saar I Gill Dec 2025

International Consensus Guidelines For The Conduct And Reporting Of Car T-Cell Clinical Trials In Aml, Swati Naik, Richard Aplenc, Susanne H C Baumeister, Marco Becilli, Anand S Bhagwat, Challice L Bonifant, Lihua E Budde, Christopher D Chien, Kevin J Curran, Anthony F Daniyan, Alexandra Dreyzin, Rebecca A Gardner, Sara Ghorashian, Stephen Gottschalk, Laquisa C Hill, M Eric Kohler, Adam Lamble, Franco Locatelli, Maksim Mamonkin, Bilal Omer, Jae H Park, Concetta Quintarelli, Benedetta Rambaldi, Rebecca M Richards, David A Sallman, Tim Sauer, Nirali N Shah, Marion Subklewe, Corinne Summers, Sarah K Tasian, Naomi Taylor, Sarah Tettamanti, Michael R Verneris, M Paulina Velasquez, Saar I Gill

Faculty, Staff and Students Publications

Early clinical experience with the use of chimeric antigen receptor (CAR) T-cell therapies for patients with acute myeloid leukemia (AML) has been beset by high rates of toxicities and low rates of response. We convened an international workshop with the goal of bringing investigators in the field of AML-directed CAR T-cell therapy together to facilitate discussion of challenges and to brainstorm potential solutions. Based on discussions at the workshop, it was evident that (1) treating and targeting AML with CAR T cells is associated with unique clinical challenges, and (2) variability in clinical trial design, definitions of toxicities, correlative data …


Biological Parenthood Rates Among Men With Sickle Cell Disease, Anyssa N Young, Sarah R Hayford, Sapuni S Chandrasena, Sara Conroy, Tanvi P Karkare, Barbara L Kroner, Allison King, Robert M Cronin, Luca Badolato, Leena Nahata, Susan E Creary Dec 2025

Biological Parenthood Rates Among Men With Sickle Cell Disease, Anyssa N Young, Sarah R Hayford, Sapuni S Chandrasena, Sara Conroy, Tanvi P Karkare, Barbara L Kroner, Allison King, Robert M Cronin, Luca Badolato, Leena Nahata, Susan E Creary

2020-Current year OA Pubs

No abstract provided.


Understanding Lyme Iaci: Implications For Camp Nurses, Mary Tobin Dec 2025

Understanding Lyme Iaci: Implications For Camp Nurses, Mary Tobin

CompassPoint

Lyme Infection-Associated Chronic Illness (Lyme IACI) is a term adopted by the U.S. National Academies of Sciences, Engineering, and Medicine (NASEM) to describe persistent, often debilitating symptoms that follow Lyme disease infection. Affecting an estimated 10–20% of individuals treated for Lyme disease, Lyme IACI includes fatigue, musculoskeletal pain, cognitive dysfunction, and sleep disturbances that can last months or even years despite standard antibiotic therapy (NASEM, 2025). Unlike acute Lyme disease, Lyme IACI is not well understood and lacks validated diagnostic tools or biomarkers, making it a challenge to diagnose or treat for clinicians and caregivers—especially those working with children in …


Advancing Radiation Shielding For Human Space Exploration, Bryan Trejo, Lea Scott, Eduardo Farfan Dec 2025

Advancing Radiation Shielding For Human Space Exploration, Bryan Trejo, Lea Scott, Eduardo Farfan

Symposium of Student Scholars

Beyond the safety of the Earth's magnetic field, out into the treacherous reaches of space, lies a harsh environment of radiation. This study examines radiation shielding strategies for crewed spacecraft operating in various environments, including Mars transit and deep space. Within these environments, ionizing radiation remains a critical challenge to long-duration, crewed space travel. Galactic Cosmic Rays (GCR), high-energy protons and heavy nuclei originating outside our solar system, as well as Solar Particle Events (SPE), highly energetic protons ejected continuously during the 11-year solar cycle, are all analyzed in their unique interactions with spacecraft material and biological tissues. Shielding to …


Tax Trends, Harry Z. Garian Dec 2025

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.


Current Threat To The Native Endemic Muckalee Crayfish (Procambarus Gibbus) From An Invasive Crayfish (Faxonius Palmeri Creolanus) And Tests Of Cold Tolerance As A Limiting Factor, Alexandria L. Exum, Nickeya Wynn, William Ellerbee, Madaline Toth, Otto T. Lorenz Dec 2025

Current Threat To The Native Endemic Muckalee Crayfish (Procambarus Gibbus) From An Invasive Crayfish (Faxonius Palmeri Creolanus) And Tests Of Cold Tolerance As A Limiting Factor, Alexandria L. Exum, Nickeya Wynn, William Ellerbee, Madaline Toth, Otto T. Lorenz

Georgia Journal of Science

Surveys for native and invasive crayfish were conducted in Muckalee creek in 2015 and 2021. Both surveys used passive minnow traps and examined upstream and downstream sites, including at the mouth of the creek where it connects with the Flint River. The Flint River has been overrun with an invasive crayfish species, Faxonius palmeri creolanus (Creole Painted Crayfish) and its range has spread rapidly throughout southwest Georgia. In Muckalee Creek there were only a few F. p. creolanus found during each survey and both times they were only found at the mouth of the creek. One hypothesis on why they …


Talkin' 'Bout My Genderation: The Effect Of Gender Bias On Arbitral Representation, Amy E. Allen Dec 2025

Talkin' 'Bout My Genderation: The Effect Of Gender Bias On Arbitral Representation, Amy E. Allen

Washington Journal of Social & Environmental Justice

Gender bias is rampant in all industries, and the world of arbitration is no exception. For decades, members of the field of arbitration have debated the suitability of women as arbitrators. This led to a broader discussion regarding different styles of arbitration, how or if these styles are related to the gender of the arbitrator, and whether one arbitration style is more effective than others. This paper begins with a brief assessment of the history of arbitration, as well as a more focused overview of the history of women in arbitration. Next, the paper questions the reasons for gender disparity …


De Facto Death Sentences For Misdemeanor Offenses: A Right To Medication For Opioid Use Disorder Induction Under The Washington Law Against Discrimination, Alena R. Sharp Dec 2025

De Facto Death Sentences For Misdemeanor Offenses: A Right To Medication For Opioid Use Disorder Induction Under The Washington Law Against Discrimination, Alena R. Sharp

Washington Journal of Social & Environmental Justice

The opioid crisis remains one of the deadliest public health emergencies in the United States, disproportionately impacting marginalized communities, including people in the criminal legal system. Medication for opioid use disorder is the recognized standard of care for treating opioid use disorder. Despite the fact that medications have also been shown to reduce overdose deaths and relapse rates, many prisons and jails continue to impose blanket prohibitions on medications for opioid use disorder for nonpregnant individuals, placing them at an elevated risk for acute withdrawal, suicide, and fatal overdose.

This comment examines the systemic barriers to access medication for opioid …


The Validity Of The Hots-Oriented Question Instrument On The Application Of Pancasila In Daily Life In Class Iv Elementary School, Aprilia Dista Lutvitasari, Sri Untari, Didik Sukriono, Mardhatillah Mardhatillah Dec 2025

The Validity Of The Hots-Oriented Question Instrument On The Application Of Pancasila In Daily Life In Class Iv Elementary School, Aprilia Dista Lutvitasari, Sri Untari, Didik Sukriono, Mardhatillah Mardhatillah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Pancasila education is one of the subjects that teaches the importance of understanding values in the surrounding environment. Understanding this value requires a higher order thinking process (HOTS), especially in grade IV elementary school as the beginning of the higher grades. The purpose of the research is to develop five items of HOTS-oriented question instruments in the material of daily application of Pancasila in grade IV that are valid according to elementary school teachers. The research method used is RnD with the ADDIE model (analyze, design, develop, implement, evaluate). The validation results show the first item question is 0.90 very …


Noda News December 2025 Dec 2025

Noda News December 2025

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.


Ink And Ignorance: How Limitations In Research, Captivity And Recognition Obscure Cephalopod Science, Jacob Weniger Dec 2025

Ink And Ignorance: How Limitations In Research, Captivity And Recognition Obscure Cephalopod Science, Jacob Weniger

Saint John’s Preparatory School Student Work

This paper analyzes what the limitations are in modern ocean research and how they relate to the study of cephalopods. To understand this, the paper reviews many known cephalopod species to understand what is unknown about their biology. Research was then conducted to assess why certain aspects of species are unknown. Then each gap the specifications of the limitation and the solutions or strategies to overcome them was examined. This led to examinations of research tools, analysis bias, and public views. Understanding these issues is of great importance because it gives a comprehensive lay out of what needs to be …


The Rider (2025-12-08), Daniela Martinez Salazar Dec 2025

The Rider (2025-12-08), Daniela Martinez Salazar

The Rider Archives

Vol. 11, No. 14


Expanding Epilepsy Representation: On Education And Awareness, Aliyah Wise Dec 2025

Expanding Epilepsy Representation: On Education And Awareness, Aliyah Wise

Honors Projects

The present-day American public education system has evolved to try to teach young students about more cultures and people of different lifestyles. However, despite these reforms to push for an inclusive education system, there is still minimal effort to teach students about disabilities and the people who live with them. As a student living with epilepsy, I have observed a lack of education or conversation about this disability. The purpose of this research project is to ask: How does miseducation on epilepsy contribute to harmful stereotypes and lead to real issues for people living with this disability? How should neurotypical …


Ada News - 12/8/2025, American Dental Association, Publishing Division Dec 2025

Ada News - 12/8/2025, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


2025-05 May Newsletter, Sammi Williams Dec 2025

2025-05 May Newsletter, Sammi Williams

NMOER Newsletters

No abstract provided.


Update To: New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin Dec 2025

Update To: New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Due to the United States government shutdown, GenBank services were unavailable, and accession numbers could not be obtained for the sequences reported in the original publication. This update provides the GenBank accession numbers for these sequences, together with additional taxonomic findings accumulated since the initial study. One genus, 16 species and four subspecies are proposed as new (type species or localities in parentheses): Madaga Grishin, gen. n. (Artitropa alaotrana Oberthür, 1916), Udranomia eurianus Grishin, sp. n. (Ecuador: Napo), Entheus dalina Grishin, sp. n. (Brazil: Pará), Entheus ambo Grishin, sp. n. (Colombia: Cauca), Entheus pico Grishin, sp. n. (Colombia: Valle …


Investigating The Molecular Mechanism Of Pbcv-1 Virus-Induced Lipid Production Enhancement For Renewable Energy, Yoonjung Choi, Amanda Michelle Lopez, Zhi Zhou, Paul B. Brown Dec 2025

Investigating The Molecular Mechanism Of Pbcv-1 Virus-Induced Lipid Production Enhancement For Renewable Energy, Yoonjung Choi, Amanda Michelle Lopez, Zhi Zhou, Paul B. Brown

Discovery Undergraduate Interdisciplinary Research Internship

Algal lipid production is a promising third-generation biofuel platform offering high photosynthetic efficiency and reduced competition with food crops or arable land. Microalgae primarily synthesize and accumulate lipids as triacylglycerol (TAG) via the Kennedy pathway, which involves key enzymes such as glycerol-3-phosphate dehydrogenase (GPDH), lysophosphatidic acid acyltransferase (LPAT), diacylglycerol acyltransferase (DGAT), and phospholipid-diacylglycerol acyltransferase (PDAT). However, large-scale lipid production and recovery remain major bottlenecks in algal biofuel development. The Chlorella-specific lytic virus PBCV-1 has been proposed as a low-energy alternative for lipid recovery through viral-induced cell lysis and has been associated with enhanced lipid yields. Yet, the molecular mechanism driving …


Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang Dec 2025

Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang

Chemistry Faculty Research & Creative Works

In this study, we developed multifunctional nanoparticles based on polyamidoamine (PAMAM) dendrimers functionalized with caffeic acid (CA) and poly (ethylene glycol) maleimide (PEGM) for the topical delivery of hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX). The PAMAM-CA and PAMAM-CA-PEGM conjugates exhibited antioxidant and iron-chelating activities in a dose-dependent manner. BM- and BX-loaded dendrimer nanoparticles produced using a multi-inlet vortex mixer showed uniform spherical morphology (∼80 nm by TEM) and hydrated sizes of ∼135-144 nm by DLS. Both nano formulations demonstrated high cytocompatibility with human corneal epithelial cells and were nonirritant in the HET-CAM assay, with PEGM further improving cytocompatibility. …


Mechanistic Modelling And Parameter Estimation Of Heterogeneous Catalytic Synthesis Of Green Fuel, Rasheed U. Owolabi, Obinna P. Anele, Mohammed A. Usman Dec 2025

Mechanistic Modelling And Parameter Estimation Of Heterogeneous Catalytic Synthesis Of Green Fuel, Rasheed U. Owolabi, Obinna P. Anele, Mohammed A. Usman

Mansoura Engineering Journal

Investigation of the kinetics and mechanistic modelling of biodiesel synthesis through the reaction of castor oil with methanol under catalyzed conditions was carried out in this study. The reaction mechanisms of the Eley-Rideal, Langmuir-Hinshelwood-Hougen-Watson, and Hattori type were employed to identify the rate-determining or controlling step of the reaction. Thirteen rate expressions were developed for reactant adsorption, product desorption, and surface chemical reactions. The experimental data from Sanchez-Cantu et al. were used to validate the models, and the best-fitting model and parameter estimation were evaluated using SAS and MATLAB software. From the results, the Eley-Rideal mechanism with glycerol desorption as …


Investigating The Effect Of Nacl Stress In Raphanus Sativus, Allison G. Norton Dec 2025

Investigating The Effect Of Nacl Stress In Raphanus Sativus, Allison G. Norton

ATU Honors Projects

Salt stress is a significant challenge in food security. Factors such as erratic weather, fertilization practices, and irrigation practice have exacerbated the problem. Therefore, it is important to understand the effects of increased concentrations of salts in the soil that negatively affects plant health with cascading effect on human nutrition and health. For these reasons, this experiment investigated the impacts of NaCl stress on Raphanus sativus (var. Cherry Belle), which is more commonly known as radish. Radish was chosen as an experimental candidate due to their short life cycle, high nutrient content and close relation with members of other vegetables …


Controlling The Size And Surface Chemistry Of Nickel Nanoparticles Via A Modified Polyol Method, Gladel Saintilme Dec 2025

Controlling The Size And Surface Chemistry Of Nickel Nanoparticles Via A Modified Polyol Method, Gladel Saintilme

Electronic Theses and Dissertations

This study presents a detailed exploration of the synthesis, morphological tuning, and physicochemical characterization of nickel nanoparticles (NiNPs) engineered for catalytic applications in aqueous environments. Using a modified polyol method adapted from Couto et al., nanoparticles were synthesized under controlled thermal and chemical conditions with nickel chloride hexahydrate, polyvinylpyrrolidone (PVP), and sodium borohydride in ethylene glycol according to a modified version of this synthesis protocol.1 The reaction temperature and reactivity of the reducing agent were found to significantly influence particle size. Reaction temperatures were varied between 120° C and 170° C, resulting in nanoparticle sizes between 23 ± 7 …


2025-03 March Newsletter, Sammi Williams Dec 2025

2025-03 March Newsletter, Sammi Williams

NMOER Newsletters

No abstract provided.


Gastrectomy Promoted Diabetes Remission Involves The Molecular Clock And Epigenetic Mechanisms In A Rat Model Of Lean Type 2 Diabetes., Aurélie Le Lay, François Brial, Claude Rouch, Xiaojian Shao, Mathieu Bourgey, Kazuhiro Sonomura, Huiting Ou, Sara Ghezzal, Mylène Vincent, Marylène Rugard, Karine Audouze, Jiannis Ragoussis, Fumihiko Matsuda, Guillaume Bourque, Elin Grundberg, Mark Lathrop, Christophe Magnan, Dominique Gauguier Dec 2025

Gastrectomy Promoted Diabetes Remission Involves The Molecular Clock And Epigenetic Mechanisms In A Rat Model Of Lean Type 2 Diabetes., Aurélie Le Lay, François Brial, Claude Rouch, Xiaojian Shao, Mathieu Bourgey, Kazuhiro Sonomura, Huiting Ou, Sara Ghezzal, Mylène Vincent, Marylène Rugard, Karine Audouze, Jiannis Ragoussis, Fumihiko Matsuda, Guillaume Bourque, Elin Grundberg, Mark Lathrop, Christophe Magnan, Dominique Gauguier

Manuscripts, Articles, Book Chapters and Other Papers

Bariatric surgery results in type 2 diabetes (T2D) improvement. To identify mechanisms associated with gastrectomy-promoted T2D remission in lean individuals, we performed pathophysiological, behavioural and molecular (liver transcriptome, metabolome and lipidome) investigations in the Goto-Kakizaki (GK) model of spontaneously-occurring non-obese T2D following vertical sleeve gastrectomy (VSG) or sham operation. VSG resulted in sustained reduction in hyperglycemia and changes in nycthemeral feeding patterns and activity. Liver transcriptome and lipidome profiling pointed to changes in the expression of genes involved in inflammation, PPAR signalling and fatty acid metabolism, and in the regulation of phosphatidylcholine and lysophosphatidylethanolamine classes. Deeper analysis revealed altered expression …


Ecological Drivers Of Habitat Selection And Maternal Survival In Female Mule Deer (Odocoileus Hemionus), Brady R. Knight Dec 2025

Ecological Drivers Of Habitat Selection And Maternal Survival In Female Mule Deer (Odocoileus Hemionus), Brady R. Knight

Theses and Dissertations

Understanding the ecological and biological factors that influence habitat selection by mule deer (Odocoileus hemionus) is crucial for effective management. Mule deer select cover, forage, and water, each critical to energy acquisition and survival of mule deer. Here, we evaluate the factors that influence habitat selection and reproductive decisions by mule deer . In chapter one we evaluate the influence of treatments to restore quaking aspen (Populus tremuloides) on habitat selection by mule deer. We hypothesized that mule deer would not use habitats randomly because of variability in nutrition and perceived risk of predation. We predicted that areas with aspen …