Digital Commons Network^™

Meta-Analysis Of Uveal Melanoma Genome-Wide Association Studies Identifies Novel Risk Loci And Population Effect Size Heterogeneity., Georgia Mies, Noah L. Tsao, Alexandre Houy, Sarah E. Coupland, Helen Kalirai, Asta Försti, Kari Hemminki, Hauke Thomsen, Marc-Henri Stern, Carol L. Shields, Scott M. Damrauer, Katheryn G. Ewens, Arupa Ganguly, Iain Mathieson

Wills Eye Hospital Papers

Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified risk loci and identify four additional genome-wide significant loci. We find that eye pigmentation-decreasing variants are systematically associated with increased UM risk and that selection for lighter pigmentation in the past 5,000 years explains about 73% of the difference in UM incidence between …

Increasing The Economic And Social Viability Of Carbon Capture Using Biomass Slurry Fracture Injection, Zachary G. Laird

LSU Master's Theses

The climate is changing. This is a fact not a statement, not a theory, and not a falsehood, this is a fact. At the current projections the world’s average temperature is expected to rise by at least 2°C from pre-industrial averages by 2050 (Emissions Pathways to 2100 - Climate Action Tracker, 2024). This temperature rise will be catastrophic for a vast number of communities. What is driving this changing climate? Humans. In particular the carbon emissions caused by human activities. As humans we consume large amounts of meat, causing the need for cattle to increase, generating large amounts …

Low-Magnitude High-Frequency Mechanical Vibration Enhances Osteogenesis In Human Pdl Cells Through Piezo1 Ion Channel, Mina Oh

Master's Theses (2009 -)

ABSTRACT LOW-MAGNITUDE HIGH-FREQUENCY MECHANICAL VIBRATION ENHANCES OSTEOGENESIS IN HUMAN PDL CELLS THROUGH PIEZO1 ION CHANNEL Mina Oh, D.M.D Marquette University, 2025 Introduction: Low-magnitude high-frequency (LMHF) mechanical vibration has been shown to enhance osteogenesis in various osteogenic tissues and cells, including periodontal ligament (PDL) cells, however its effectiveness remains relatively low. The Piezo1 mechanosensitive ion channel plays a critical role in mechanotransduction, however its specific involvement in the LMHF-induced osteogenesis is unknown. This study aims to elucidate the role of Piezo1 in mediating osteogenic responses in human PDL cells subjected to LMHF mechanical vibration. Materials and Methods: Human PDL cells were …

Cannabis And Covid: An Interrupted Time Series Analysis Of Their Impact On Mental Health-Related Hospital Visits In Rural Arizona (2016-2023), Jennifer Megan Suter

Walden Dissertations and Doctoral Studies

Arizona’s rural communities face shortages in mental health care services. In 2020, the nearly simultaneous onset of the COVID-19 pandemic and the legalization of recreational cannabis introduced overlapping public health stressors that may have disproportionately affected these vulnerable populations. However, their combined impact on rural mental health remains understudied. This three-manuscript dissertation employed interrupted time series analyses to assess how these events influenced monthly hospital visits for schizophrenia, psychosis, cannabis-induced psychosis, and suicidal behaviors among rural Arizona adults aged 21 and older. A total of 16,468 records from the Arizona State Inpatient and Emergency Department Databases (SID and SEDD) met …

Salinity And Moisture Influence Co2 And Ch4 Emissions From High-Latitude Coastal Soils, B. N. Barr, K. C. Kelsey, A. J. Leffler, M. Petit Bon, K. H. Beard

Wildland Resources Faculty Publications

Sea level rise and more frequent and larger storms will increase saltwater flooding in coastal terrestrial ecosystems, altering soil-atmosphere CO₂ and CH₄ exchange. Understanding these impacts is particularly relevant in high-latitude coastal soils that hold large carbon stocks but where the interaction of salinity and moisture on greenhouse gas flux remains unexplored. Here, we quantified the effects of salinity and moisture on CO₂ and CH₄ fluxes from low-Arctic coastal soils from three landscape positions (two Wetlands and Upland Tundra) distinguished by elevation, flooding frequency, soil characteristics, and vegetation. We used a full factorial laboratory incubation experiment …

Integrase-Deficient Lentiviral Vector As A Platform For Efficient Crispr/Cas9-Mediated Gene Editing For Mucopolysaccharidosis Iva, Fnu Nidhi, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder causing systemic skeletal dysplasia due to a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS) enzyme activity, leading to the impaired degradation and accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate. While treatments such as enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation (HSCT) are available, they have significant limitations regarding efficacy in skeletal tissues and long-term safety, highlighting the need for more effective therapies. We evaluated a novel gene therapy approach using a dual Integrase-deficient lentiviral vector (IDLV) to deliver an expression cassette that includes human GALNS cDNA and Cas9 sgRNA, …

The Impacts Of Ocean Warming On Phytoplankton Dynamics And Links To Fisheries Management Around St Helena Island, South Atlantic Ocean, Shelby Bargo

The Plymouth Student Scientist

In the context of a rapidly changing climate, understanding how ocean warming is reshaping the foundation of marine ecosystems has never been more important. This research investigates factors contributing to ocean warming, and where anthropogenically influenced climate change plays a critical role in the functionality of the physical marine environment, phytoplankton, and trophodynamics throughout the pelagic zone. Phytoplankton, whilst microscopic, are vital; they are regulated by physical oceanographic factors that control their access to growth-limiting factors, such as nutrients. With the formidable climate-driven physical and biological changes occurring in the marine environment, alongside the decline in fish stocks, it is …

Evaluating The Ulf Mri (0.64t) Image Quality Through In Vivo Test-Retest, Md Imran Hossain

Master's Theses (2009 -)

Ultra-low-field (ULF) MRI systems, such as the Hyperfine Swoop (64mT), represent a transformative advancement in neuroimaging by offering portable, affordable alternatives to conventional high-field MRI. This system has the potential to significantly expand access to diagnostic imaging in resource-limited, emergency, and point-of-care settings. This study evaluates the clinical reliability and reproducibility of the Hyperfine Swoop by conducting a series of controlled in vivo test-retest scans on a single participant. Quantitative assessment of brain image quality was performed using voxel volume consistency and the Structural Similarity Index Measure (SSIM). The results demonstrated high intra-subject repeatability with minimal variation across sessions, underscoring …

An Upper-Mesopelagic-Zone Carbon Budget For The Subarctic North Pacific, Brandon M. Stephens, Montserrat Roca-Martí, Amy E. Maas, Vinícius J. Amaral, Samantha Clevenger, Shawnee Traylor, Claudia R. Benitez-Nelson, Philip W. Boyd, Ken O. Buesseler, Craig A. Carlson, Nicolas Cassar, Margaret Estapa, Andrea J. Fassbender, Yibin Huang, Phoebe J. Lam, Oliver Marchal, Susanne Menden-Deuer, Nicola L. Paul, Alyson E. Santoro, David A. Siegel, David P. Nicolson

Faculty Publications

Mesopelagic zone (MZ) carbon budgets comparing supply with demand can be difficult to constrain due to the temporal and spatial offsets between key sources and sinks, their associated uncertainties, and potential sampling biases. To address these challenges, the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) campaign increased the number and variety of simultaneous measurements to monitor temporal variability in the MZ carbon budget using both a Lagrangian frame of reference and long-term autonomous observations. In this study, we collate a comprehensive combination of new and previously published organic carbon supply and demand measurements collected from the surface (5 …

2024 Hon. James R. Browning Symposium Keynote Address: Martin, Grants Pass, And Houselessness As A Class, Howard Belodoff

Montana Law Review

No abstract provided.

Comprehensive Resolution And Classification Of The Epstein Barr Virus Transcriptome, Truong D. Nguyen, Jia Wang, Meggie T. Lam, Harris Mcferrin, Tina M. O’Grady, Claire Roberts, Nicholas Van Otterloo, Trang T. Nguyen, Melody Baddoo, Dorota Wyczechowska, Maria Morales, Yan Dong, Erik K. Flemington

School of Graduate Studies Faculty Publications

Virus genomes harbor compacted repertoires of genes and regulatory elements. Through long-read sequencing, we provide a comprehensive Epstein Barr virus (EBV) transcriptome analysis, identifying 1453 transcript isoforms and resolving the major isoform of all but one lytic reading frame. Further, we categorize each transcript according to their dependence on viral DNA replication. We show that the late gene viral preinitiation complex, vPIC also activates early promoters/genes, we identify active alternate promoters with distinct dependencies on viral DNA replication, we discover biphasic promoters with embedded features of both early and late promoters. Genetic and chromatin interaction studies identify an enhancer function …

Prognostic Value Of Lipoprotein(A) For Cardiovascular Events After Lower Limb Revascularization In Diabetic Patients With Chronic Limb-Threatening Ischemia, Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

Department of Surgery Faculty Papers

BACKGROUND: Chronic limb-threatening ischemia (CLTI) presents a major clinical challenge in patients with Type 2 Diabetes Mellitus (T2DM), requiring lower extremity revascularization (LER) to mitigate adverse cardiovascular and limb outcomes. Lipoprotein(a) (Lp(a)) has been implicated in cardiovascular risk, but its role in patients with T2DM and CLTI undergoing revascularization remains unclear. Thus, this study aimed to investigate the prognostic value of Lp(a) levels in diabetic CLTI patients for major adverse cardiovascular events (MACE), major adverse limb events (MALE), or both after LER.

METHODS: In this prospective cohort study of 158 individuals with T2DM and CLTI undergoing LER, baseline clinical data …

Multiple Molecular Diagnoses Identified Through Genome Sequencing In Individuals With Suspected Rare Disease, Jorge Perez

All Publications

Genome sequencing is a powerful and comprehensive test that detects multiple variants of different types. The interrogation of variants across the genome enables the identification of multiple molecular diagnoses (MMDs) in a single individual. In this retrospective study, we describe individuals in whom MMDs were associated with the proband's indication for testing (IFT), secondary findings, or incidental findings. An MMD is considered where at least one of the findings is associated with the primary IFT and all variants are classified as either likely pathogenic or pathogenic. Clinical genome sequencing was performed for all individuals as part of the iHope program …

Bigapp: A User-Friendly Genomic Tool Kit Identified Quantitative Trait Loci For Creeping Rootedness In Alfalfa (Medicago Sativa L.), Alexander M. Sandercock, Michael D. Peel, Cristiane H. Taniguti, Josué Chinchilla-Vargas, Shufen Chen, Manoj Sapkota, Meng Lin, Dongyan Zhao, Arlyn J. Ackerman, Bhoja R. Basnet, Craig T. Beil, Moira J. Sheehan

Plants, Soils and Climate Student Research

Alfalfa (Medicago sativa L.) is a globally vital forage crop valued for its perennial growth and multiple annual harvests. A breeding effort is underway to improve the crop for productivity and persistence against biotic and abiotic stresses using “creeping rootedness,” a trait where plants exhibit horizontal root growth, similar to rhizomes, with increased vegetative ground surface area. In this study, we genotyped a breeding population of 648 alfalfa lines segregating for creeping rootedness using the 3K DArTag marker panel to identify trait-associated genomic loci and evaluate the feasibility of genomic prediction to accelerate breeding cycles. Using genome-wide association studies …

Social Forestry As Solution To Agrarian Conflicts? A Case Study Between Oil Palm Smallholders And Industrial Plantations In Jambi, Indonesia, Muhammad Reza Halomoan, Arya Hadi Dharmawan, Satyawan Sunito

Forest and Society

Extraction activities across Indonesia have caused drastic changes to forest ecologies. The Indonesian government responded to this through a policy of Industrial Plantation Forest concessions, which were given to the private sector in the hopes of overcoming damages from forest extraction activities while at the same time utilizing unproductive forest land. However, this policy does not pay attention to the existence of people who de facto control and use the land and has triggered new conflicts around agrarian claims based on different interpretations of land rights. In an effort to resolve conflicts, the government has implemented a community-based forest area …

The Patchwork Quilt Of Global Mangrove Conservation: Mapping The Landscape Of International Treaties, Pradip Kumar Sarker, Md Faisal Abedin Khan, Fredy Polo Villanueva, Lukas Giessen

Forest and Society

Mangroves at the land-sea interface offer invaluable goods and services through their unique ecosystem. Society has responded by developing governance mechanisms to manage these resources sustainably, which is crucial for societal well-being. The global environmental governance landscape is a complex network of treaty-based regimes addressing various ecological challenges. This study aims to examine the treaty-based regimes governing mangrove conservation, systematically mapping and identifying authoritative global mangrove regimes. It analyses the fragmentation scale regarding synergies, conflicts, and neutral relationships between global environmental treaties. Online scoping reviews and content analysis revealed that the Ramsar Convention serves as the legal authority of the …

Assessing The Potential Of Thailand's National Forest Reserves For Tourism Development And Sustainable Recreational Use, Nantachai Pongpattananurak, Sangsan Phumsathan

Forest and Society

This research aimed to evaluate the potential of Thailand's national forest reserves for promoting sustainable recreational activities. Research tools included a comprehensive tourism potential assessment form for evaluating tourism development. Additionally, semi-structured interviews and focus group meetings with key informants were conducted to gain insights into local perspectives, challenges, and opportunities related to tourism. Site surveys were conducted during January - August 2021. The study initially conducted an assessment of 122 destinations located within 85 national forest reserves across the country to determine their tourism development potential. Subsequently, 16 national forest reserves exhibiting high potential were selected for on-site surveys. …

The Role Of Ecosystem Services In Holistic Conservation Within Protected Areas: A Case Study Of The Song Thanh National Park, Vietnam, Tuyen Nghiem, Sumeet Saksena, Hue T. Ha, Truong Dao, Toan Le, Huong D. Vu, Dien Nguyen, Truong Q. Hoc

Forest and Society

Vietnam has made a strong commitment to biodiversity conservation, as evidenced by its extensive network of protected areas. However, environmental issues persist in protected areas. Often, the resulting violence complicates the situation, making it more challenging to analyze and manage. We studied the perceptions of people in the buffer zone of the Song Thanh National Park, Quang Nam province, regarding the current status of ecosystem services (ES), the importance of ecosystem services, their changes over time, and people's participation in protecting ecosystem services. We employed a mixed-methods approach, combining qualitative and quantitative data. We conducted semi-structured interviews, focus group discussions, …

Community Perspectives On Engaging Stakeholders For Human-Sumatran Tiger Coexistence In The Bukit Barisan Selatan Landscape, Rinekso Soekmadi, Novriyanti Novriyanti, Burhanuddin Masy’Ud, Damayanti Buchori, Christine Wulandari, Ismanto Ismanto

Forest and Society

The Bukit Barisan Selatan (BBS) landscape, a vital habitat for the Sumatran tiger (Panthera tigris sumatrae), is increasingly degraded and fragmented by plantation and agricultural expansion, driving tigers into human-dominated areas and creating conflict zones beyond conservation boundaries. However, despite global frameworks like the Kunming-Montreal 2050 Biodiversity Framework and IUCN advocating coexistence by integrating ecological and socio-economic priorities, the practical implementation at the site level remains uncertain, particularly regarding local perspectives on coexistence and their alignment with competing stakeholder interests. This study analyzes the alignment of parties in the context of the potential coexistence of human-tiger conflicts in …

How Much And Why? Conservation Behavior And Valuation In Katunggan Coastal Ecopark, Mindanao Island, Philippines, Sheenamae P. Loreno, Peter Jan De Vera

Forest and Society

Mangrove forests are among the most productive and valuable ecosystems, providing critical services such as shoreline protection, fisheries support, and carbon sequestration. Despite their ecological and economic significance, mangrove forests continue to decline at an alarming rate due to land conversion for aquaculture, urban expansion, overharvesting, and climate-related impacts. Although national and community-based conservation programs exist in the Philippines, many of these efforts have struggled due to limited public participation and a lack of insight into how local communities perceive and value mangrove ecosystems. This study surveyed 503 residents living near the Katunggan Coastal Ecopark in Mindanao Island, Philippines, to …

Redd+ Projects And Their Impact On Household Incomes In Indonesian Borneo, Sandy Nofyanza, Zahra Avia, Colas Chervier, Agus Muhamad Maulana

Forest and Society

In Indonesia, early Reducing Emissions from Deforestation and Forest Degradation (REDD+) projects, established in the early 2010s, were required to self-fund through carbon credit sales or donor aid while supporting local livelihoods. This paper examines the impact of REDD+ projects on both agricultural and overall household incomes (i.e., from all economic activities, including agriculture). We hypothesize that the agricultural incomes of REDD+ participating households (or treated households) would decrease as REDD+ forbids forest clearance, but this loss would be offset by a subsequent rise in overall household income as REDD+ encourages income diversification. Additionally, we assess whether REDD+ implementation has …

Pantun As A Medium For Environmental Education And Ecological-Political Activism By Customary Institutions In Haruku Island, Diah Meutia Harum, Sabara Sabara, Helmina Kastanya, Devi Fauziyah Ma'rifat, Selvone Christin Pattiserlihun, Andi Alfian, Vikry Reinaldo Paais

Forest and Society

This research aims to examine the ecological values and political practice contained in pantun, particularly that used by the kewang, a customary or adat institution in Haruku Village, Central Maluku. In Haruku, pantun is used as a medium of enviromental education and ecological activism for the community, specifically the young generation. This study is expected to contribute to the reconstruction of a more eco-friendly civilization of the Archipelago by streamlining the potential of local traditions in promoting sustainability andconservation Haruku Village, in this study, becomes a role model and best practice of utilizing kewang as a customary institution, …

Impacts Of Urbanization On The Use Of Soil Amendments By Rice Farmers Along A Rural-Urban Continuum In Northeast Thailand, Sujitra Yodda, Suwit Laohasiriwong, Phrueksa Lawongsa, Tanabhat-Sakorn Sukitprapanon, A. Terry Rambo

Forest and Society

This study investigated the impact of urbanization on use of soil amendment by rice farmers in three villages along a rural–urban continuum in Northeast Thailand. It shows how urbanization influences their use of types and quantities of soil amendments. Data were collected by interviewing 150 farmers, focusing on types, quantities, sources, costs, and perceived effects of nine different amendments, including rice straw, chemical fertilizers, manures, and green manure. Results revealed significant declines in organic amendment use as villages become more urbanized, with rural farmers employing more diverse and greater quantities of organic amendments while periurban and urban farmers predominantly rely …

Comparative Transcriptomic Analysis Of Mouse Macrophages Infected With Live Attenuated Vaccine Strains Of Mycobacterium Tuberculosis, Raja Veerapandian, Barbara Yang, Areanna Carmona, Melina J. Sedano, Victoria Reid, Rodrigo Jimenez, Jessica Chacon, Chinnaswamy Jagannath, Enrique I. Ramos, Shrikanth Gadad, Subramanian Dhandayuthapani

School of Medicine Publications

The BCG vaccine has been used against tuberculosis (TB) for over a hundred years; however, it does not protect adults from pulmonary TB. To develop alternative vaccines against TB, we generated Mycobacterium tuberculosis H37Rv (Mtb)-derived vaccine strains by rationally deleting key virulent genes, resulting in single (SKO; ΔfbpA), double (DKO; ΔfbpA-ΔsapM), triple (TKO-D; ΔfbpA-ΔsapM-ΔdosR and TKO-Z; ΔfbpA-ΔsapM-Δzmp1), and quadruple (QKO; ΔfbpA-ΔsapM-Δzmp1-dosR) strains. To understand how macrophages, the host cells that defend against infection and process antigens for presentation to immune cells, respond to these vaccine strains, we performed transcriptomic analyses of mouse bone marrow-derived macrophages …

Single-Nucleotide Resolution Epitranscriptomic Profiling Uncovers Dynamic M6a Regulation In Bovine Preimplantation Development, Rajan Iyyappan, Yichi Niu, Ming Hao, Kinga Pajdzik, Noah R Rakestraw, Piyush K Jain, Chuan He, Chenghang Zong, Zongliang Jiang

Faculty, Staff and Students Publications

RNA N6-methyladenosine (m6A) plays a crucial role in regulating gene expression during early embryonic development. However, the m6A dynamics at single-nucleotide resolution in preimplantation development remain uncharacterized, and the functional significance of site specific m6A modifications in key developmental regulators is largely unknown. Here, using SAC-seq, a single-base resolution, antibody-independent m6A profiling method, we generate the first comprehensive m6A landscape in bovine oocytes and preimplantation embryos. We identify a previously uncharacterized m6A site in RPL12 transcript that is essential for embryonic development. Loss of m6A at this site leads to reduced protein synthesis, disrupted expression of translation-related genes, and …

Global Diversity Of Soil-Transmitted Helminths Reveals Population-Biased Genetic Variation That Impacts Diagnostic Targets, Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara Sr Ajjampur, Roy M Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R Caro, David Chaima, Rubén O Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L Houlder, Moudachirou Ibikounlé, Timothy P Jenkins, Khumbo Kalua, Eyrun F Kjetland, Alejandro J Krolewiecki, Bruno Levecke, Adrian Jf Luty, Andrew S Macdonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R Odiere, Charfudin Sacoor, Judd L Walson, Steven A Williams, Stefan Witek-Mcmanus, D Timothy J Littlewood, Cinzia Cantacessi, Stephen R Doyle

Faculty, Staff and Students Publications

Soil-transmitted helminths (STHs) are intestinal parasites that affect over a billion people worldwide. STH control relies on microscopy-based diagnostics to monitor parasite prevalence and enable post-treatment surveillance; however, molecular diagnostics are rapidly being developed due to increased sensitivity, particularly in low-STH-prevalence settings. The genetic diversity of helminths and its potential impact on molecular diagnostics remain unclear. Using low-coverage genome sequencing, we assess the genetics of STHs within worm, faecal, and purified egg samples from 27 countries, identifying differences in the genetic connectivity and diversity of STH-positive samples across regions and cryptic diversity between closely related human- and pig-infective species. We …

Assessment Of Incisive Canal Morphology And Position In A Sample Of Egyptian Population: A Cone Beam Computed Tomography Study, Sherif Shafik

Dentistry

ABSTRACT Several studies have highlighted the diversity in the anatomy of the incisive canal. Evaluation of incisive canal as well as its approximation to the maxillary incisor root is crucial before orthodontic treatment, implant placement and other surgical procedures in the anterior maxillary area. Cone beam computed tomography (CBCT) provides detailed three-dimensional information and have been used to evaluate the nasopalatine region with high accuracy along with relative safety due to low radiation exposure. Aim: The study aimed to provide analysis of the nasopalatine canal anatomy using cone-beam computed tomography (CBCT) in a sample of the Egyptian population. Materials & …

Assessment Of Incisive Canal Morphology And Position In A Sample Of Egyptian Population: A Cone Beam Computed Tomography Study., Caroline Maged Massieh, Hisham Mohamed El Sheikh, Magdy Fouad Youakim, Sherif Shafik El Bahnasy

Dentistry

Several studies have highlighted the diversity in the anatomy of the incisive canal. Evaluation of incisive canal as well as its approximation to the maxillary incisor root is crucial before orthodontic treatment, implant placement and other surgical procedures in the anterior maxillary area. Cone beam computed tomography (CBCT) provides detailed three-dimensional information and have been used to evaluate the nasopalatine region with high accuracy along with relative safety due to low radiation exposure. Aim: The study aimed to provide analysis of the nasopalatine canal anatomy using cone-beam computed tomography (CBCT) in a sample of the Egyptian population. Materials & methods: …

Blunted Cd40-Responsive Enhancer Activation In Crebbp-Mutant Lymphomas Can Be Restored By Enforced Cd4 T-Cell Engagement, Haopeng Yang, Wenchao Zhang, Vida Ravanmehr, Guiling Cui, Kevin Bowman, Ruidong Chen, Jared M Henderson, Shyanne Lockman, Estela Rojas, Ashley Wilson, Sydney Parsons, Ariel Mechaly, Leslie Regad, Ahmed Haouz, Christopher R Flowers, Sattva Neelapu, Loretta Nastoupil, R Eric Davis, Qing Deng, Fernando Rodrigues-Lima, Michael R Green

Faculty, Staff and Student Publications

The CREBBP lysine acetyltransferase (KAT) is frequently mutated in follicular lymphoma and diffuse large B-cell lymphoma and has been studied using gene knockout in murine and human cells. However, most CREBBP mutations encode amino acid substitutions within the catalytic KAT domain (CREBBP KAT-PM) that retain an inactive protein and have not been extensively characterized. Using CRISPR gene editing and extensive epigenomic characterization of lymphoma cell lines, we found that CREBBP KAT-PM lead to unloading of CREBBP from chromatin, loss of enhancer acetylation, and prevention of EP300 compensation. These enhancers were enriched for those that are dynamically loaded by CREBBP in …

The Impact Of Genetic Ancestry On Survival Outcomes In Pediatric Rhabdomyosarcoma: A Report From The Children’S Oncology Group, Ekene A Onwuka, Christina L Magyar, Bailey A Martin-Giacalone, Michael E Scheurer, Deborah A Marquez-Do, Mark Zobeck, Elizabeth G Atkinson, Erin R Rudzinski, Michael A Arnold, Donald A Barkauskas, David Hall, Javed Khan, Jack F Shern, Paul Scheet, Brian Crompton, Corinne M Linardic, Douglas S Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Chad D Huff, Melissa A Richard, Philip J Lupo

Faculty, Staff and Student Publications

Emerging evidence suggests genetic ancestry may influence childhood cancer outcomes, but its impact on pediatric rhabdomyosarcoma (RMS) is unknown. We explored genetic ancestry's impact on survival among children with RMS. This multi-center observational cohort study is a secondary analysis of previously collected biobanking, genomic, and clinical data. The study included 920 individuals with newly diagnosed RMS under 40 years of age enrolled from 2005 to 2017 under the COG soft tissue sarcoma biobanking protocol D9902. The primary endpoints were (1) event-free survival (EFS), defined as the time from study enrollment to tumor recurrence/progression, secondary malignancy, or death from any cause; …