Digital Commons Network^™

Regulation Of Glut5 Expression And Fructose Uptake By Heat Stress And Pro-Inflammatory Cytokines In Enterocytes, Landri Shope, Gretchka Mair

Liberty University Research Week

Diabetes is an escalating global health concern, affecting 11.1% of the adult population worldwide, with over 90% of cases classified as type 2 diabetes mellitus (T2DM) (Facts & Figures., n.d.). T2DM is characterized by chronic fasting hyperglycemia and is increasingly associated with alterations in the gut microbiome. This study tests the hypothesis that heat stress, a gut dysbiosis-associated stressor, will upregulate the fructose transporter GLUT5 in enterocytes. Increased GLUT5 expression may enhance intestinal fructose uptake, thereby contributing to worsened glycemic control in T2DM. While the mechanism linking inflammation and impaired glucose homeostasis remains elusive, emerging evidence supports strong associations among …

The 3-D Apparatus Of Local Ticks: A New Insight Into The Mechanism Of Sensing Hosts And Their Storage Of Pathogens, Sara Grant, Tristan Davis, Maggie Milhorne, Zipporah Nedlock, Jonathan Marks, Alan L. Gillen

Liberty University Research Week

No abstract provided.

Production, Isolation And Characterization Of Novel Peroxidases From Cucurbita Family, Rahel Mamo

Liberty University Research Week

Peroxidases are found throughout nature and are valuable biocatalysts due to their versatility in catalyzing oxidative reactions using hydrogen peroxide as a co-substrate. The peroxidase from horseradish root is widely used in diagnostics and synthetic applications, however, plant peroxidases from other plant sources remain underexplored. Recently, a peroxidase from the skin of Cucurbita maxima (PKS) was isolated and demonstrated promising biocatalytic properties related to the decomposition of a wide variety of fluorinated aromatic compounds. Purification and characterization of this enzyme revealed a protein sequence that was similar to the well characterized HRP, with some key amino acid substitutions. A second …

Investigating The Natural Communities And Flora Of Candler’S Mountain, Lydia Harris, Cyrus Harris, Tyler Knick

Liberty University Research Week

Candler’s Mountain is home to a variety of natural communities and flora. With more than 1200 vascular plant species documented in Campbell County, the identification and growing historical record of local flora will support short and long-term recognition of the importance of biodiverse natural communities in central Virginia. This project seeks to (1) document flora diversity in this region, (2) further establish an herbarium teaching and research collection of representative species, and (3) advance our understanding of the flora in relation to natural communities. Identified ecological groups and community types are based upon the Virginia Department of Conservation and Recreation …

Characterizing B1 B-Cells In Zebrafish (Danio Rerio), Alyssa Canelo, Victoria Pacheco

Liberty University Research Week

This project tests the hypothesis that developing antibodies specific to zebrafish CD5 and IgM will enable the reliable identification and characterization of B1 B-cells in zebrafish. B1 B-cells play a critical role in autoimmunity across species, yet their functions remain poorly characterized in zebrafish (Danio rerio). Zebrafish are widely used as a developmental and immunological model organism due to their genetic similarity to humans as well as their transparent embryos. The lack of species-specific antibodies has hindered the study of B1 B-cells in zebrafish.

This project seeks to develop and validate antibodies against zebrafish CD5 and IgM. This will be …

Characterizing Novel Peroxidase Activity Through Enzyme Kinetics And Equilibrium Binding, Marika Yelle

Liberty University Research Week

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants, motivating the exploration of peroxidases as potential bioremediation catalysts. This study spectroscopically characterized three peroxidases, with a focus on Pumpkin Skin Peroxidase (PKS). Initial characterization assessed PKS equilibrium binding with various ligands to determine dissociation constants (Kd) for each ligand-enzyme interaction. To characterize PKS catalytic activity, guaiacol oxidation was monitored, with parallel KF trials modelled by Michaelis-Menten kinetics, revealing fluoride-induced increases in Km and Vmax, consistent with an inhibitory effect on substrate binding and catalytic turnover. These findings provide insight into the function of PKS and its potential for environmentally relevant …

Morphological Evaluation Of Cadaveric Tissues Integrity Using Histology Staining, Jumana Rizk, Levon Shukrian, Maria Mendoza Lopez, Shanice Rerrie

Liberty University Research Week

The transition from gross anatomical dissection to microscopic evaluation is essential for a comprehensive understanding of human biology. While systemic anatomy reveals the macroscopic organization of the body, histology provides insight into cellular structure and tissue integrity. This study aimed to bridge these disciplines through histological assessment of cadaveric tissues. Our objective was to determine whether tissue samples after prolonged fixation could be processed and stained to meet standards for histology education. Tissue samples of the cerebral cortex, renal cortex, liver lobe, and skeletal muscle were obtained from two cadaveric donors, one male and one female. Tissues were processed, embedded …

Spectroscopic Characterization Of Pfas Ligands Binding To Novel Plant Peroxidases, Vladimir Bogatov

Liberty University Research Week

No abstract provided.

Elephant's Toothpaste: A Statistical Investigation Of The Yeast-Catalyzed Decomposition Of Hydrogen Peroxide, Annaliese Defelice

Liberty University Research Week

Catalase is the main enzyme in yeast that catalyzes the popular “elephant’s toothpaste” reaction. Elephant’s toothpaste reactions often proceed using an iodide or yeast catalyst, but iodine is favored for ease of quantitative analysis. There remains little statistical data on the yeast-catalyzed hydrogen decomposition reaction. The relationship between reagent amounts and reaction rate was measured by manipulating reagent quantity while maintaining other variables. The results were graphed and fitted for linearity, indicating the relative relationship between each reagent and the overall reaction rate. There were strong positive correlations between yeast and hydrogen peroxide concentrations and reaction rate. Augmenting the volume …

Investigating Nutritionally Derived Treatments For Metabolic Disease: Enterolactone And Its Effect On Glp-1 And Pyy Secretion, Aidan Clancy

Liberty University Research Week

Gut-derived hormones such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) play essential roles in maintaining glucose homeostasis and appetite regulation. These hormones are primarily secreted by enteroendocrine L cells in response to nutrient signaling in the gut. Emerging evidence suggests that polyphenolic compounds and their metabolites may influence gut hormone secretion. Enterolactone (ENL), a microbial metabolite of the dietary lignan, matairesinol, is of particular interest due to its reported anti-diabetic properties. In this study, we propose to test whether ENL can modulate the secretion of GLP-1 and PYY in L cells in vitro, thereby identifying a potential mechanism by …

Bacterial Purification Of Hat Enzymes From Cryptococcus Neoformans: Esa1 And Gcn5 Purification, Manasi Joshi, Andrew Wisley

Liberty University Research Week

Gene expression in eukaryotes is tightly regulated by post-translational modifications. Histone acetylation is an epigenetic modification associated with increased transcription. The putative histone acetyltransferase (HAT) in the fungus Cryptococcus neoformans, Something About Silencing 3 (SAS3), has been a novel research target due to its potential role in virulence that causes nearly 112,000 to 625,000 annual deaths worldwide through cryptococcal meningitis. Although SAS3 homologs acetylate core histone 3 in mammalian organisms, recombinant SAS3 has not yet demonstrated HAT activity. Previously, an established human HAT p300 was used as a positive control to validate enzymatic conditions for HAT assays. However, using known …

Offspring Cognitive And Neurobiological Outcomes Influenced By Maternal Dietary Patterns, Emma Whatley, Abigail Frommack, Karina Long, Sarah Nelson

Liberty University Research Week

The impact of maternal diet on offspring neurodevelopment is a relatively new field, and its areas of focus are vast. The field is predominantly studied and understood through the impacts of an unhealthy diet, the maternal Western diet (WD), but there is very little research on healthy diets like the maternal Mediterranean diet (MD). The general healthiness of the diet and some limited research support that this diet could have beneficial impacts on offspring. This research aims to explore the impacts of a maternal MD on adult offspring. We hypothesize that the maternal MD will enhancing cognitive performance in learning, …

Impacts Of Maternal Diet On Offspring Affective Behavior And Brain Morphology, Abigail Frommack, Emma Whatley, Karina Long, Sarah Nelson

Liberty University Research Week

The field of maternal dietary impacts on offspring neurodevelopment has been established over the past 30 years, and since its establishment it has grown rapidly. The research shows that maternal diet significantly impacts offspring neurodevelopment, with those effects lasting until adulthood. Most research in this field focuses on the detrimental impacts of a Western Diet (WD), but little research exists on the beneficial impacts of a healthy diet. This research aims to close that gap by assessing a healthy diet and its impact on adult offspring. We hypothesize that a maternal Mediterranean diet (MD) will have positive impacts on the …

Analysis Of The Effects Of Phytocannabinoids Cannabichromene (Cbc), Cannabidiol (Cbd), And Cannabigerol (Cbg) On The Enzyme Faah, Rachel Duncan

Liberty University Research Week

No abstract provided.

Histological Quality Of Fresh And Pre-Fixed Tissue, Rebekah Satalino, Andrew Hodges, Bright Danso, Gretchka Mair, Kingsley Ampong

Liberty University Research Week

The quality of a tissue sample used for histological analysis robustly influences the accuracy of scientific results and diagnostic interpretation. For fresh tissue samples, the duration between termination and fixation is a major determinant for tissue quality going forward as fixation halts tissue degradation. The condition of the fixed tissue before subsequent processing can have a pronounced effect on staining characteristics and cellular component integrity as examined under the microscope. However, while fresh tissue is frequently considered best, many institutions may only have access to pre-fixed tissue for training or research purposes. The aim of this research is to compare …

Impacts Of Interspecific Competition On Stress And Body Condition In A Montane Salamander (Plethodon Hubrichti), Jason Porter, Allison Carmen

Liberty University Research Week

No abstract provided.

Quantifying Biogenic Amines In Anaerobic Porcine Liver Decomposition For Improved Pmi Estimation Using Gc/Ms, Shanice Rerrie, Faith Ekoh

Liberty University Research Week

Postmortem interval (PMI) estimation remains a central challenge in forensic science, particularly during the early stages of decomposition. Quantifying biochemical changes during tissue breakdown has emerged as a promising approach to improve accuracy in PMI determination. This study expands on earlier research that quantified the biogenic amines cadaverine (CAD), putrescine (PUT), and methylamine (MEA), which result from bacterial amino acid decarboxylation during decomposition. It specifically examines how these compounds form under anaerobic conditions over a prolonged 30-day period. Porcine liver, serving as a human tissue analog, was decomposed in sealed anaerobic chambers. Tissue samples were collected at regular intervals, homogenized, …

Examining Carroll’S Alice In Wonderland And Through The Looking Glass, And What Alice Found There: A Christian Calling To Spiritual Childhood, Kristen Hess

Liberty University Research Week

"Examining Carroll’s Alice in Wonderland and Through the Looking Glass, and What Alice Found There: A Christian Calling to Spiritual Childhood" dives into the positive and negative childlike habits that Alice, a representative of children and childhood, embodies and how Christians should identify and emulate her positive childlike behaviors in order to best fulfill their roles as spiritual children of God. Because Christians are children of God according to Romans 8:16, it is vital for Christians, like children, to understand the world around them, learn about themselves and others, and enjoy physical and mental play and recreation. Lewis Carroll found …

Paws And Predictions: Interpreting Intraspecific Cat Social Interactions Through Facial Signals, Levi Neal, Lauren Scott, Gosia Zobel, Brittany Florkiewicz

People and Animals: The International Journal of Research and Practice

There has been limited research on humans’ ability to perceive and predict social interactions among cats using facial signals. This area is crucial to explore since conflicts between cats often cause significant stress for their guardians. By evaluating individuals’ skills in understanding cat interactions, researchers can develop tools to help guardians predict affiliative and nonaffiliative behaviors, leading to effective intervention strategies for multicat households. We distributed a survey to individuals subscribed to the Companion Animals New Zealand newsletter to assess cat guardians’ effectiveness in perceiving and predicting various social interactions among cats. We hypothesized that guardians with one or more …

Real World Fertility: From Participatory Research To Clinical Trial, Belinda Tan, Azure Grant, Ayla Barmmer

Oxford ICSB

Nutritional supplements are widely popular for female reproductive health, but their ingredients are typically studied in isolation in the laboratory. Finished products make claims based on these isolated studies, creating a gap in which impact of multi-nutrient formulas in the real world are not investigated, largely due to high research costs. Decentralized clinical research methods are modernizing clinical trials, leading to affordable, efficient evidence generation in large representative populations. Utilizing a decentralized research platform, we tested the hypothesis that specific supplement protocols would be associated with improved female health and fertility in a real world cohort. We present a novel …

2026 Acssc Program, Acssc Planning Committee

Annual Celebration for Student Scholarship and Creativity

No abstract provided.

Frankincense (Boswellia Spp.) Essential Oils: Chemistry-Driven Authentication, Chemotype Discovery, And Sustainability Insights Across My Published Studies, Prabodh Satyal

Oxford ICSB

Frankincense, which comes from the oleo-gum resins of Boswellia species, is one of the most important botanicals in global trade. However, its essential oils often face issues like variations in chemical makeup, mislabeling, and adulteration. This presentation summarizes findings from ten peer-reviewed studies conducted between 2016 and 2023. These studies create a chemistry-based framework for authenticating frankincense and ensuring sustainable sourcing.  Research on various Boswellia species, including B. sacra, B. carteri, B. papyrifera, B. frereana, B. occulta, B. ogadensis, and B. rivae, shows strong patterns in volatile profiles at both the species and tree levels. This supports distinguishing between species …

Using Path Analysis To Examine The Psychological Well-Being Model For U.S. College Students, Pi-Ming Yeh, Cheng-Huei Chiao, Gavin Waters

Epsilon Sigma at-Large Research Conference

Background: College students’ psychological well-being and mental health issues are very important in this society. Little is known about a comprehensive psychological well-being model for college students.

Purpose: The purpose of this study was using Path Analysis to examine the Development of Personality and Psychological Well-Being Model among US college students.

Methods: This was a cross sectional, descriptive design. The 481 participants were recruited from nursing and business college students in the United States. After IRB approval, the trained researchers explained this study to college students. After agreeing to participate, they signed an informed consent form. Upon completion of a …

Smart Wearable Plasma Healing Patch With Adaptive Electronic Control And Integrated Biosensors, Zainab Hussam Al-Araji

Engineering and Technology Journal

Traditional healthcare for chronic wounds and Cold Atmospheric Plasma (CAP) treatments relies on passive dressings and large-volume stationary equipment operating with open-loop systems, which severely limits their use and confines it to specialized clinical environments. To address the lack of active thermal safety mechanisms in mobile devices, this research proposes a wearable smart plasma patch equipped with a closed-loop adaptive electronic control system to ensure safe patient care and treatment at home. The smart patch integrates real-time analog biosensors to continuously monitor skin temperature and relative humidity. An algorithm running on a microcontroller dynamically adjusts the high-voltage plasma parameters using …

Pokok·Pokok Pikiran Mengenai Pengaturan Persaingan Sehat Dalam Dunia Usaha, A. Zen Umar Purba

Jurnal Hukum & Pembangunan

Abstract

Spring 2026 Excellence In Research And Creative Inquiry And Incite Award Ceremony, Office Of Student Research, Longwood University

Spring Showcase for Research and Creative Inquiry

No abstract provided.

Morphometric-Based Biomass Distribution And Carbon Sequestration Capabilities Of Native Perennial Plants In An Extremely Arid Environment In Eastern Saudi Arabia, Mohamed I. Alzarah, Mohammed M. Elgarawany, Majed A. Alotaibi

Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture

Understanding ecosystem functioning, the processes of land degradation, and the potential for climate mitigation in hyper-arid environments requires quantifying biomass, carbon sequestration, and the structural characteristics of desert vegetation. This study was done In a hyper-arid habitat such as the location of west of Al-Ahsa International Airport in Eastern Saudi Arabia to study the integrates morphometric characterization, non-destructive biomass modeling, physiological assessment, and carbon stock estimation for native perennial plant communities. Twelve dominant perennial species were assessed across a 5.5 ha site using systematic random sampling. Plant height (cm), canopy volume (m³), basal diameter, projected canopy cover (%), …

A Harmonious Legal System: True Justice Through Modernized Platonic Marxism, Cian R. Batarla

Departmental Honors & Graduate Capstone Projects

The Marxist theory of the law is underdeveloped compared to the rest of Marx and Engels works. This can be chalked up to legal systems merely being part of the superstructure, by which the ruling class use to maintain power. In this essay I push back on this notion that the rule of law can be dismissed, arguing that if Marx's true community is to be as such then the addition of a just legal system is not an issue. However, Marx's true community on its own is not enough to satisfy the inclusion of a legal system. Thus necessitating …

Improving Electrochemical Measurements And Informing Future Reprocessing Of Advanced Nuclear Fuels, J. Marvin Torrie

Theses and Dissertations

This research promotes the application of molten salts through developing analytical tools in electroanalytical studies and in the data analysis of vapor pressure data. The electrochemical community lacks standardized, stable, and repeatable reference electrode designs which threaten the reliability of measured thermophysical properties and repeatability of published studies. This work confirms the application of a saturated reference electrode design for molten chlorides systems that outperforms traditional Ag+/Ag reference electrodes. In the field of thermal physical property measurements, vapor pressure data for chloride salts are diffused throughout the literature, uncertainty quantification is absent or limited, and all previous studies rely on …

Spring 2026 Student Showcase For Research & Creative Inquiry Program, Office Of Student Research, Longwood University

Spring Showcase for Research and Creative Inquiry

No abstract provided.