Digital Commons Network^™

Meeting Essential And Quality Of Life Needs Of Rural Older Mainers Through The Community Connector Pilot, Kimberly I. Snow Mhsa, Mary Lou Ciolfi Jd, Ms, Patricia Oh Phd, Msw

All Maine Rural Health Research Center Publications

Rural America is aging rapidly and experiencing health and population declines. Older age counties - those in which more than 20% of the population are age 65 or older - are overwhelmingly in rural locations. While some rural locations in Maine are destinations for retirees due to the beauty of the natural environment, those communities face housing, healthcare, and service access challenges and environmental pressures. Maine’s recent Statewide Needs Assessment for our State Plan on Aging identified many essential and quality of life unmet needs and preferences of older Mainers, including the many older adults living in rural areas. A …

Washington University Magazine, August 2025

Washington University Magazine

No abstract provided.

Association Of Sarcopenic Obesity With Cognitive Dysfunction: A Systematic Review And Meta-Analysis, Qi Wu, Siye Xie, Jinhong Ying

Neurosciences

ABSTRACT Objectives: To evaluate the association between sarcopenic obesity and cognitive dysfunction. Changes in human body composition may be linked to the development of cognitive dysfunction. Sarcopenic obesity, characterized by excessive fat accumulation and reduced muscle mass, is implicated in various adverse health outcomes. Methods: We conducted a systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science, Embase, CINAHL, CNKI, Sinomed, Wanfang, and VIP databases were searched for studies examining the link between sarcopenic obesity and cognitive dysfunction. The process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Eight studies, comprising 87,520 participants …

Comment On: Median Nerve Conduction Parameters Can Vary Between Different Arm Positions Due To Altered Vascular, Mechanical, And Functional Properties

Neurosciences

No abstract provided.

College Student Health Outcomes Through The Lens Of Social Class And Possible Interventions, Ann Mary Thomas

LEAD Scholars Academy Showcase

Social class is a key determinant of college student health that is often overlooked. This project explores how students from low socioeconomic status (SES) backgrounds face unique barriers to physical and mental well-being, including financial strain, food and housing insecurity, limited access to healthcare, and chronic stress. These inequities contribute to disparities in sleep, nutrition, mental health, and academic performance.

While universities have implemented general health initiatives, many fail to address the specific needs of low-SES students. Through an analysis of existing programs and systemic gaps, this research highlights the urgent need for targeted, inclusive, and sustainable solutions.

Promoting health …

Hostos Community College Academic Bulletin 2024-2025, Hostos Community College

College Bulletins

This is the official college catalog for 2024-2025. It contains course descriptions as well as information on degree programs, college resources and services, financial aid, admissions, and the academic calendar.

Weight Stigma In Physical And Occupational Therapy: A Scoping Review, Jason Brumitt

Faculty Publications - College of Physical Therapy

Background: Weight stigma describes the negative attitudes held toward people with obesity. Weight bias stereotypes have been previously reported in physicians, physician assistants, nurses, registered dieticians, psychologists, and students enrolled in healthcare professional education programs. Physical and occupational therapists (PTs and OTs) are healthcare providers who evaluate and treat individuals across their lifespan. A PT or an OT who harbors weight bias may create an environment where the patient may fail to optimize their rehabilitation recovery. The first purpose of this scoping review was to identify the prevalence of weight bias in PT and OT clinicians and students. The second …

Bs Public Health Community Health, Public Health

Program Revisions/Additions

No abstract provided.

Toll-Like Receptor Signaling In Neurons Modulates C. Elegans Feeding Behavior In A Hunger State-Dependent Manner, Neel Patel, Joseph Rios, Retwika Ganguly, Cindy Mutafoglu, Nour Shalash, Karla Gallardo, Malak Saleh, John Chahine, Emily Kopecky, Gursimran Gujral, Kamya Shah, Christos Suriano

Department of Biology Faculty Scholarship and Creative Works

Animals face the risk of encountering pathogenic microbes while foraging for resources. Assessing the risk of nutrition vs. infection can result in the behavioral regulation of immune processes. Behavioral immunity in the nematode roundworm Caenorhabditis elegans (C. elegans) is regulated, in part, by the innate immune molecule TOL-1: a homolog of vertebrate Toll-like Receptor (TLR) proteins that influences C. elegans pathogen avoidance behaviors by promoting the development of CO2-detecting chemosensory neurons. While TOL-1′s role in pathogen avoidance is well established, its role in an opposing behavior – foraging – has not been examined. In addition to pathogenic bacteria, preferred food …

Underrepresented Medical Students: Perceptions Of Academic Persistence And Successful Completion Of Medical School, Nicholas Dakota Bibbs

Electronic Theses and Dissertations

Less than one percent of the United States population’s workforce are physicians. The road to becoming a medical doctor is long, complex, and taxing. Individuals desiring to become physicians must have large amounts of grit, persistence, patience, and a hard work ethic just to get to medical school. The students who are accepted into medical school come from various backgrounds with differing degrees of access to resources and opportunities to prepare them before and during their medical education. Studies show that students who are categorized as underrepresented in medicine often face the most challenges to achieving academic success. Understanding what …

The Influence Of Pressure, Intensity, And Amount Of Muscle Mass Exercised On Changes In Muscle Size, Strength, And Endurance: A Methodological Investigation, Ryo Kataoka

Electronic Theses and Dissertations

Purpose: To 1) examine the effects of low-load submaximal resistance exercise with blood flow restriction (BFR) on muscle size, strength, cross-education, and local muscular endurance while accounting for proximity to failure under restriction, and 2) determine whether changes in muscle size and strength differ based on the amount of muscle recruited during the exercise bout.

Methods: A total of 177 (18–35 years) participants were randomly assigned to one of five groups: unilateral low-load submaximal elbow flexion exercise 1) with BFR (LL+BFR, n=35), 2) without BFR (i.e., matched for a % of repetition-to-failure under restriction) (LL, n=37), 3) to failure (LL-Failure, …

Exploring The Links Among Brain Iron Accumulation, Cognitive Performance, And Dietary Intake In Older Adults: A Longitudinal Mri Study, Valentinos Zachariou, Colleen A. Pappas, Christopher E. Bauer, Elayna R. Seago, Brian T. Gold

Neurology Faculty Publications

This study evaluated longitudinal brain iron accumulation in older adults, its association with cognition, and the role of specific nutrients in mitigating iron accumulation. MRI-based, quantitative susceptibility mapping estimates of brain iron concentration were acquired from seventy-two healthy older adults (47 women, ages 60–86) at a baseline timepoint (TP1) and a follow-up timepoint (TP2) 2.5–3.0 years later. Dietary intake was evaluated at baseline using a validated questionnaire. Cognitive performance was assessed at TP2 using the uniform data set (Version 3) neuropsychological tests of episodic memory (MEM) and executive function (EF). Voxel-wise, linear mixed-effects models, adjusted for longitudinal gray matter volume …

The Massai People And Wealth: A Stewardship Of Totality, Youssry Guirguis

Journal of Adventist Mission Studies

The concept of wealth among the Massai people differs significantly from the traditional understanding in contemporary societies. To the Massai people wealth is not measured by money as commonly perceived by people today, but rather exhibits itself by land, social status, and livestock. This article examines a few terms used by the Massai people to define the idea of wealth in order to comprehend their unique cultural dimensions. Terms that are related to wealth will be investigated, such as “land” (enkop), “red God” (enkai Nanyokie), “black God” (enkai Narok), “cattle” (inkishu), “goats and sheep,” “wealth” (emali), and “dowry” (Inkishu/ Olpisiai). …

Circulating Molecular Drivers Of Bone Remodeling In Pancreatitis, Rachel L. Hill, Dhiraj Yadav, Phil A. Hart, David C. Whitcomb, Kristen J. Mcquerry, Kelsey N. Karnik, Kimberly M. Stello, Darwin L. Conwell, Madhumathi Rao

Internal Medicine Faculty Publications

INTRODUCTION: 

Pancreatitis-associated osteopathy is a clinically significant but mechanistically underexplored complication of pancreatic disease. We aimed to characterize stage-specific alterations in bone remodeling biomarkers across the spectrum of disease: recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP).

METHODS: 

In a cross-sectional analysis of North American Pancreatitis Study 2 participants, we measured serum mechanistic (sclerostin, dickkopf-1, receptor activator of nuclear factor κβ ligand, and osteoprotegerin), hormonal (fibroblast growth factor 23, insulin, and leptin), and modulatory (osteopontin, oncostatin, and osteoactivin) markers in controls (n = 30), RAP (n = 40), and CP (n = 40) using a multiplex assay. Group differences were …

A Unique Inflammaging Profile Generated By T Cells From People With Obesity Is Metformin Resistant, S. Santacruz‑Calvo, S. Saraswat, Gabriella Kalantar, E. Zukowski, H. Marszalkowski, Aida Javidan, F. Gholamrezaeinejad, L. P. Bharath, P. A. Kern, X. D. Zhang, Barbara S. Nikolajczyk

Pharmacology and Nutritional Sciences Faculty Publications

The alarmingly high prevalence of obesity in older adults coupled with the negative health effects of chronic inflammation in both obesity and aging highlight the importance of studies investigating the impacts of obesity on age-related inflammation. Since shifts in peripheral T-cell metabolism and function drive systemic inflammation in both obesity and aging, we hypothesize that obesity impacts the Th17-dominated inflammaging profile we identified in lean subjects and thus modifies the anti-inflammatory effects of geroprotective drugs like metformin. New cytokine profiling data showed that CD4+ T cells from older people with obesity generate a profile that specifically excludes Th17 cytokines. Metformin …

Bilirubin Hepatic And Intestinal Transport And Catabolism: Physiology, Pathophysiology, And Benefits, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Terry D. Hinds, Jr., Wang-Hsin Lee

Pharmacology and Nutritional Sciences Faculty Publications

Bilirubin, a metabolite derived from heme degradation, has traditionally been regarded as a waste product and a marker of liver injury. However, increasing evidence suggests that bilirubin also functions as a hormone, and reduced levels are associated with metabolic dysfunction. Studies have shown a strong association between low circulating bilirubin levels and an increased risk of metabolic disorders and cardiovascular disease. To advance bilirubin-based treatment strategies, it is essential to elucidate the mechanisms underlying bilirubin transport and metabolism. Therefore, we provide an in-depth discussion of bilirubin production and its subsequent fates, with a particular focus on the transport between the …

Cd47: An Immunoregulatory Nexus In Liver And Gastrointestinal Disorders, Josephine Otuagomah, Alana Newcomb, Taesik Gwag, Shuxia Wang

Pharmacology and Nutritional Sciences Faculty Publications

Cluster of differentiation 47 (CD47) is a widely expressed transmembrane protein that serves as a critical immunoregulatory checkpoint in both homeostatic and pathological conditions of the digestive system. It interacts with signal regulatory protein alpha to send a ‘do not eat me’ signal, thereby preventing phagocytosis and shaping immune responses. Beyond immunity, CD47 also influences cell death, growth and metabolism through interactions with integrins and thrombospondin-1. Recent studies implicate CD47 as a central nexus in the pathogenesis of diverse liver and gastrointestinal disorders, including metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, inflammatory bowel disease, liver ischaemia-reperfusion injury, drug-induced liver …

Gut Microbiome, Neuroinflammation, And Fetal Alcohol Spectrum Disorders: Insights From Rodent Models, Abdulrahman M. Busayli, Wenhua Xu, Ghaidaa A. Raffah, Gang Chen

Pharmacology and Nutritional Sciences Faculty Publications

Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, considerable attention has been focused on the influence of gut microbiome on brain development through the gut–brain axis. Changes in the gut microbiome resulting from ethanol exposure may contribute to the pathology of FASD, potentially involving neuroinflammation. This literature review summarizes the existing research and primary animal studies on the impact of early ethanol exposure on the gut microbiome, neuroinflammation, brain development, …

Calcineurin/Nfat Inhibitors Maintain Cognition In A Preclinical Prevention Study In An Aging Canine Model Of Alzheimer Disease, Lorena Sordo, Margo F. Ubele, Kathy Boaz, Jennifer L. Mefford, Erin Dehnart Jones, Katie L. Mccarty, Hollie Y. Van Rooyen, Jeffrey R. Smiley, Stasia A. Bembenek Bailey, Jessica A. Perpich, Beverly Meacham, David K. Powell, Frederick Bresch, Jacob W. Crump, Michael J. Phelan, Jessica A. Noche, Craig E. Stark, László G. Puskás, Christopher M. Norris, Elizabeth Head

Pharmacology and Nutritional Sciences Faculty Publications

Brain signaling of calcineurin (CN) and nuclear factor of activated T-cells (NFAT) transcription factor increases in Alzheimer disease (AD) and is associated with synaptic loss, neurodegeneration, neuroinflammation, amyloid-β (Aβ) production, and cognitive decline. CN/NFAT inhibitors ameliorate these neuropathologies in mouse models of AD. Further, chronic use of tacrolimus in transplant patients reduces risk of AD. Beagles naturally develop Aβ plaques and cognitive dysfunction. We evaluated the impact of FDA-approved CN inhibitor, tacrolimus, and experimental NFAT inhibitor, Q134R, on cognitive outcomes during a three-year prevention study in 37 middle-aged beagles. While beagles treated with CN/NFAT inhibitors showed differences in the pattern …

Ceramide Homeostasis In Hepatic Lipid Droplets, Leobarda Robles-Martinez, Kylie H. Morin, Mariana Nikolova‑Karakashian

Physiology Faculty Publications

Almost all eukaryotic cells have the capacity to form lipid droplets (LDs) in conditions of excess energy. Traditionally thought to be just inert fat reservoirs, LDs have recently emerged as important metabolic regulators of cellular stress response that buffer excess free fats and protect cells from lipotoxicity. Ceramide is a bioactive lipid that accumulates in metabolic tissues during fat oversupply. Emerging evidence suggests that sphingolipids and sphingolipid-metabolizing enzymes are found in the LDs and affect LD biogenesis and functions. This article aims to summarize the evidence, delineate some plausible functions of ceramide in hepatic LD biogenesis, and illustrate some of …

Impact Of Fast Advancement And Early Fortification Of Enteral Feedings In Preterm Infants, A Retrospective, Observational Study., Enrique Gomez-Pomar, Holly Clarke, Jamie Adams

Pediatrics Faculty Publications

UNLABELLED: We aimed to evaluate the outcomes and growth of preterm infants at a Neonatal Intensive Care Unit that focuses on early initiation, fast advancement, and early fortification of enteral feeds.

METHODS: Retrospective study conducted at a community hospital level III NICU. Extensive feeding data and outcomes were collected by utilizing a NutritionIQ software application, NICUtrition®. Infants born between 26- and 34-weeks gestational age were included, whereas infants with congenital defects, deceased or with incomplete data were excluded. Frequency and descriptive statistical analysis were conducted using chi-square and Fisher's exact test. Unadjusted odds ratios were computed for categorical variables and …

Mental Health Literacy: What’S The Value Of Youth Engagement In Intervention Development?, Teresa Johnson

Electronic Theses and Dissertations

Background: One in five youth experience a mental health challenge each year (CDC, 2021). Mental Health Literacy (MHL) is vital for addressing this crisis as it involves the knowledge, attitudes, and skills necessary to promote mental well-being, understand mental health conditions, and seek appropriate help. MHL interventions for adolescents have been developed; however, recent reviews indicate research is needed in school settings with community input. Youth Participatory Action Research (YPAR) places youth as co-researchers in intervention development. This methodology aligns with Bartholomew’s Intervention Mapping (IM) framework, which ensures interventions are theoretically grounded. Utilizing these two frameworks, this study aimed to …

Opportunity Restored: Using Creative Measures To Provide Students With Academic Advancement Opportunities Lost During Covid-19, Randal Clint Jordan

Electronic Theses and Dissertations

This mixed-methods action research study examines the Fast Track and Graduation Path (FTGP) programs—equity-focused interventions developed to offer opportunity to students who experienced academic disruption during COVID-19 emergency schooling (Creswell & Plano Clark, 2018). The programs targeted students retained due to socioeconomic status, learned helplessness, or the technology learning gap, rather than a lack of ability or low prior performance (Jenson, 2013; Maier & Seligman, 1976; Bower, 2019). FTGP provided structured academic pathways, daily facilitation, technology-based instruction, and character education to rebuild learner confidence and achievement (Reimer & Hill, 2022).

Quantitative data from the Edgenuity© learning platform revealed the program’s …

Interaction Between Riluzole Treatment And Dietary Glycemic Index In The Disease Progression Of Amyotrophic Lateral Sclerosis, Ikjae Lee, Hiroshi Mitsumoto, Seonjoo Lee, Edward J. Kasarskis, Michael Rosenbaum, Pam Factor-Litvak, Jeri W. Nieves

Neurology Faculty Publications

Objective: We examined whether riluzole treatment modifies the associations between the dietary glycemic index (GI) and load (GL) and disease progression in amyotrophic lateral sclerosis (ALS).

Methods: Sporadic ALS patients in the Multicenter Cohort Study of Oxidative Stress who completed a baseline food frequency questionnaire were included (n = 304). Interactions between baseline riluzole treatment and GI/GL on functional decline and tracheostomy-free survival were examined using linear regression and Cox proportional hazard models adjusted for covariates. Age, sex, disease duration, diagnostic certainty, body mass index, bulbar onset, revised ALS functional rating scale (ALSFRS-r) total score, and forced vital capacity, from …

Bones And Brains: The Association Between Osteoporosis And Depression, Mason Taylor

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: Osteoporosis and depression are two public health problems that are increasing in prevalence. Previous studies have found a positive association between the two variables in women and men and women together, but there is a gap when looking at men. Therefore, it was important to investigate the odds of depression in men, women, and men and women together to make comparisons by sex.

Methods: 1,602 participants aged 65 and older were included in the study from the National Health and Nutrition Examination Survey (NHANES) 2017 – March 2020 Pre-Pandemic dataset. One unadjusted and seven adjusted models were created for …

How Sleep Disorders And Sleep Duration Impact Memory, Alexandria J. Sims

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

INTRODUCTION: Sleep duration and sleep disorders can cause changes in memory function as populations age. Previous studies have shown that disordered sleep is associated with increased risk of cognitive dysfunction and long and short sleep durations can cause memory impairment. This study studies aims to find if there is an association between sleep disorders and sleep duration and the impacts on memory.

METHODS: In this study, 3,478 participants aged 60 year and older from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 dataset were included in adjusted and unadjusted models, comparing the sleep disorders and sleep duration exposures to …

Environmental And Behavioral Determinants Of Congenital Defects: An Ecologic Study In Kentucky, Amelia G. Floyd

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Congenital defects are a significant contributor to infant morbidity and mortality. The multifactorial etiology of such defects presents complex challenges for public health. This ecologic study investigates the association between environmental and behavioral exposures and congenital defects rates at the county level in Kentucky from 2010 to 2019. The Kentucky Department for Public Health, Office of Vital Statistics, provided all relevant defect data. County-level exposure data was collected from multiple sources.

Descriptive and geospatial analyses revealed substantial geographic variability, with notable high defect rates in northeastern Kentucky. Negative binomial regression models identified behavioral and socioeconomic factors to be the strongest …

Prevalence Of Covid-19 Associated Xerostomia, Taste And Smelldisturbances Over 3 Years In An Egyptian Sample: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Asmaa Abou-Bakr

Dentistry

Aim: Although xerostomia, smell, and taste dysfunctions are prominent signs of COVID-19 infection, long-term data regarding their prevalence and recovery rates is scarce. Accordingly, this study aimed to evaluate the frequency and persistence of xerostomia, taste, and smell disturbances in COVID-19 survivors over 3 years in an Egyptian sample. Methods: This cross-sectional study used an online questionnaire to assess the oral symptoms ofxerostomia, which include altered taste and smell. Data was collected from 826 patients recovered from COVID-19. Results: Xerostomia was the most frequent finding affecting 73.6% of the studied sample, followed bysmell disturbances affecting 67.8%, and altered taste reported …

Protective Effects Of Nigella Sativa Against Acrylamide-Induced Toxicity In Submandibular Salivary Glands Of Albino Rats: A Histological And Molecular Study, Salma Awad Taghyan, Elham Fathy Mahmoud, Rasha Mohamed Taha, Mohamed Shamel

Dentistry

No abstract provided.

Augmenting The Posterior Mandible Using Xeno Grafts: A Randomized Clinical Trial, Moataz Bahaa Dr., Amr Amin Ghanem Prof, Mohamed Sobhy Dr., Karim Abdelmohsen Prof

Dentistry

Aim: To assess the vertical height gain in atrophic posterior mandible using different forms of xenograft through an interpositional bone grafting procedure (sandwich technique). Materials and methods: Patient were separated into two groups, Group A (Study Group): received augmentation through the use of an organic bovine bone particulate. Group B (Control Group): received augmentation through the application of an organic bovine bone block. This study was conducted on 16 patients suffering from posterior mandibular partial edentulism with an inadequate bone height enough for favorable implant placement. The alveolar vertical dimension measured ranges from or equal to 5-8 mm from roof …