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2025

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Editorial: Enhancing Nutrient Profile, Safety, And Sustainability With Fermentation Technology, Oluwafemi Ayodeji Adebo, John Gieng, Xi Feng Jan 2025

Editorial: Enhancing Nutrient Profile, Safety, And Sustainability With Fermentation Technology, Oluwafemi Ayodeji Adebo, John Gieng, Xi Feng

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

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Butyrate Attenuates High-Fat Diet Induced Glomerulopathy Through Gpr43-Sirt3 Pathway, Ying Shi, Lin Xing, Ruoyi Zheng, Xin Luo, Fangzhi Yue, Xingwei Xiang, Anqi Qiu, Junyan Xie, Ryan D. Russell, Dongmei Zhang Jan 2025

Butyrate Attenuates High-Fat Diet Induced Glomerulopathy Through Gpr43-Sirt3 Pathway, Ying Shi, Lin Xing, Ruoyi Zheng, Xin Luo, Fangzhi Yue, Xingwei Xiang, Anqi Qiu, Junyan Xie, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

The incidence of obesity related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut-kidney axis theory, beneficial effects of butyrate, one of short-chain fatty acids produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with high-fat diet (HFD) feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocytes injury, oxidative stress, and mitochondria function were evaluated in mice kidney and validated …

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