Digital Commons Network^™

Beyond The Label Campaign: An Integrated Marketing And Communications Campaign To Educate And Empower Low-Income Communities In The Southern United States, Erica Napuli

Honors Program: Senior Projects (Public)

The Beyond the Label campaign is an Integrated Marketing Communications (IMC) initiative designed to educate and empower low-income consumers about food additives, labeling regulations and the impact of making educated food choices on long-term health. This campaign is based on research on current U.S. food labeling and regulations, health risks associated with current ingredients and additives approved through regulations, the disproportionate impact of food policy on low-income communities with a focus on the Southern U.S., as well as further exploration of strategies for multi-channel marketing for targeted audiences. This project proposes a hypothetical partnership with the Environmental Working Group (EWG). …

Nebraska's Preparedness For A Growing Diverse Aging Population: A Survey Of Area Agencies On Aging, Vince Barger

Honors Program: Senior Projects (Public)

This paper aims to examine the current efforts of Nebraska’s Area Agencies on Aging (AAAs) to serve a growing diverse population of older adults (United States Census Bureau, 2023). This project is comprised of a survey created to gauge the thoughts and opinions of Nebraska AAA employees supplemented by a comprehensive literature review. The findings of the literature review indicate the need for an understanding of the importance of diversity and how it affects individual life experiences. The survey revealed that the AAAs are already making changes to reflect the population shift that is currently happening, such as specific programs …

Evolution And Strengths Of School Lunch Programs In The United States And Japan, Sarah Ritterling

Honors Program: Senior Projects (Public)

School lunches around the world perform a vital role in children’s nutritional needs and overall health. These nutritional programs provide a chance for children to learn how to create a balanced meal and about the production and serving of food. However, many countries, including the United States and Japan, have taken different approaches to meet these goals, influenced by the needs of children and communities over time. The United States provides support, funding, and nutritional standards through the National School Lunch Program. Japan promotes the Basic Act of Shokuiku (food and nutrition education) within society and outlines goals for schools …

Gut Feeling: A Holistic Digital Tool For Managing Irritable Bowel Syndrome And Food Sensitivities, Hailey M. Olberding

Honors Program: Senior Projects (Public)

Irritable Bowel Syndrome (IBS) and food intolerances are increasingly prevalent chronic gastrointestinal (GI) conditions that significantly impair quality of life. While the low-Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) diet has demonstrated success in symptom management, current digital tools fail to offer integrated, user-friendly platforms that holistically track contributing health factors. Gut Feeling is a mobile app (Appendix 1) and complementary website (Appendix 2) developed to fill this gap. By incorporating symptom logging, food intake tracking and complementary database, stress and sleep monitoring, and trend analysis, this platform empowers users to better understand their bodies and manage GI symptoms proactively. …

Conagra Brands Strategic Audit, Ashley R. Nierman

Honors Program: Senior Projects (Public)

The goal of this paper is to present a comprehensive strategic audit of Conagra Brands, Inc., a major company in the consumer-packaged foods industry. The audit evaluates the external environment of Conagra, including a PESTEL analysis and Porter’s Five Forces analysis. Various industry factors that affect Conagra’s operations are taken into consideration. It will also explain the internal environment of Conagra using tools such as a SWOT analysis, financial performance review, and strategy explanation. Key areas of focus include shifting demands, including consumers’ desire for more healthy and sustainable food options, recent political and economic factors, competitive advantages of Conagra, …

Participant Personal Characteristics And Adherence To Oral Capsules: A Secondary Analysis Of A Randomized Placebo-Controlled Trial Of Antenatal Probiotics, Lisa Hanson, Kathlyn Albert, Emily Malloy, Maharaj Singh, Mikala Kallay, Ava Brandt, Courtney Morris, Diana Kleber, Marie Forgie

College of Nursing Faculty Research and Publications

Background

Adherence to study interventions is critical to the conduct of randomized controlled trials (RCTs). The relationships between participant characteristics and intervention adherence are understudied in pregnant populations. The purpose of this study was to conduct a secondary analysis of adherence to study capsules in a double-masked, placebo-controlled RCT of a probiotic intervention to reduce antenatal Group B Streptococcus colonization, in relationship to participant characteristics.

Methods

We analyzed the relationship between capsule adherence rates and demographic characteristics among 81 RCT participants. Categorical variables were reported using counts and percentages, and continuous variables were expressed as means along with their standard …

Lefitolimod In Combination With Ipilimumab In Patients With Advanced Solid Tumors: A Phase I Trial, Mirella Nardo, Mohamed A Gouda, Matthew J Reilley, Amadeo B Biter, Joann Lim, Stacie A Bean, Ly M Nguyen, Priya R Bhosale, Casey R Ager, Coline A Couillault, Sarina A Piha-Paul, Siqing Fu, Apostolia M Tsimberidou, Timothy A Yap, Aung Naing, Jordi Rodon, Vivek Subbiah, Daniel D Karp, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

Introduction: TLR9 agonists are immunomodulators that have been of interest for combined use with cancer immunotherapy. TLR9 agonists, such as lefitolimod (MGN1703), significantly increased Th1 response in preclinical models and have demonstrated efficacy in early clinical trials. This trial assessed the safety and preliminary efficacy of the combination of lefitolimod and ipilimumab in patients with advanced solid tumors.

Methods: This was a single-center, open-label, investigator-initiated phase I trial conducted at The University of Texas MD Anderson Cancer Center. Patients received leftolimod either subcutaneously (at escalating doses of 15-120 mg) or intratumorally (at the maximum feasible dose) in combination with ipilimumab …

Trends In And Factors Associated With Science Achievement Among Fourth Graders In Saudi Arabia: A Secondary Analysis Of Timss Data, Reda Massawe

Theses and Dissertations

This secondary analysis examined trends and factors associated with science achievement among fourth-grade students in Saudi Arabia using data from the Trends in International Mathematics and Science Study (TIMSS). Between 2007 and 2019, Saudi students consistently scored below the international average in science, with female students outperforming males by more than 30 points. The study addressed two issues: (1) reasons behind Saudi students’ underperformance and (2) limited research on contributing factors. TIMSS data from 2011, 2015, and 2019 were analyzed using descriptive, correlational, and regression methods. While trends across the years were explored, only 2019 data were used for detailed …

Risky Genes: The Impact Of Social Determinants Of Health On Dna Methylation In Indigenous Communities, Ella Martin

Celebrating Scholarship and Creativity Day (2018-)

Epigenetics is the study of molecular modifications to DNA structure that do not impact the sequence of the DNA itself. This biological study works to link health outcomes later in life with environmental interactions that affect our genetic predispositions. These complex factors can greatly impact longevity and quality of life. DNA methylation is one type of epigenetic mark that happens through natural biological processes. However, this marking has been shown to be detrimental to the process of aging and can be accelerated by harmful exposures such as stress, substance-use, or chemicals in the environment. Exposure to these compounds is exasperated …

Gonadotropin-Releasing Hormone Ii And Its Receptor: Novel Regulators Of Semen Quality And Follicular Function In Swine, Caitlin Elizabeth Ross

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Pigs are the only mammalian livestock species encoding functional proteins for the second form of gonadotropin-releasing hormone (GnRH-II) and its receptor (GnRHR-II). In the first study, GnRHR-II localized to developing germ cells and the connecting piece of ejaculated spermatozoa. Concurrently, GnRH-II was most abundantly produced in the testis compared with other reproductive tract organs and was present within seminal plasma. Moreover, treatment of extended semen with GnRHR-II analogues altered sperm motility, morphology, and kinematics. For remaining studies, we utilized a swine line with ubiquitous knockdown of GnRHR-II (GnRHR-II KD) developed in our laboratory. The second study demonstrated that circulating GnRH-II …

Understanding Dimensional Stability Of Polymer Surgical Mesh, Simeon J. Mckelvey

All Dissertations

Polymer surgical mesh is a biomedical implant that has revolutionized the repair of the abdominal wall and pelvic floor. Each year, over 1.6 million Americans undergo surgical procedures using polymer surgical mesh to treat conditions where internal organs protrude through weakened tissues. This material is used in approximately 90% of hernia repairs, 80% of stress urinary incontinence procedures, and 30% of pelvic organ prolapse surgeries.

Despite this widespread use of polymer surgical mesh, post-implantation complications have prompted regulatory investigation and scrutiny. These complications stem from the mesh's behavior within the human body, including wrinkling, contraction, and loss of fixation, which …

Ceramic Membrane Evaluation Via Automated Filtration Systems For Water Treatment And Resource Recovery, Weiming Qi

All Dissertations

Membranes are an advanced and mature water and wastewater treatment technology. Membrane fouling is a key difficulty for all membrane filtration processes, leading to significant attention in the literature over the years. A common problem in laboratory-scale membrane research is that the testing methods in the laboratory are often quite different than industrial applications due to the limitations of manual experimental setups. An automated membrane filtration apparatus was built in the lab to solve this problem by allowing long-term filtration, frequent backwash and CIP, and high-accuracy operation. The filtration system achieves different cleaning strategies for both theoretical research and practical …

Bridging The Gap In Rural Education: Exploring Solutions For Enhanced College And Career Preparedness Among Secondary School Students, Patricia Moultrie-Goldsmith

All Dissertations

This study investigates how to improve college and career readiness (CCR) among high school students in rural areas. The study focuses on creating effective strategies that cater specifically to the unique needs of rural students. Using a blend of both quantitative and qualitative research methods, the study examines the effectiveness of specific interventions designed to raise students' readiness for college and careers.

The interventions tested include teaching methods and increased engagement with students. These were developed to tackle the common challenges that hinder educational outcomes in rural settings, such as limited access to advanced courses and extracurricular activities.

Findings from …

Identification And Characterization Of Intermediate Phenotypes To Decipher Genetic Architecture Of Stalk Lodging Resistance In Maize (Zea Mays L.), Bharath Kunduru

All Dissertations

Maize is a key contributor to global food security and incurs severe yield losses due to stalk lodging, the permanent displacement of plants from an upright growth habit due to mechanical damage to the stem (stalk). Stalk lodging resistance, an indicator of the stalk ability to resist lodging, is a complex trait and determined by several structural, geometric, and material properties of stalks, collectively referred to as intermediate phenotypes, whose identity and genetic framework are poorly understood. Therefore, progress in resolving the genetic architecture of stalk lodging resistance was impeded by a lack of standardized phenotyping methodologies and a poor …

Biochar And Manure Levels: Impact On Selected Soil Hydro-Physical Parameters And Sorghum Canopy Temperature, Catana Faison

All Theses

Climate-smart agriculture (CSA) enhances crop yields and maintains healthy soils while also contributing to strategies that mitigate climate change. One of the main aspects of CSA is its impact on soil and environmental conditions, such as structural stability, moisture retention, temperature regulation, and canopy development, which are fundamental to sustainable crop production and land management. Soil organic amendments, e.g., biochar, and chicken and dairy manure applications, substantially improve soil hydrological properties and structure. This thesis reports on the impact of three organic amendment types and rates on selected soil hydrological and physical properties, including water holding capacity, heat capacity, aggregate …

Racial Disparity And Environmental Influences On Perinatal Health In Jefferson County, Kentucky., Felicia A Pugh

Electronic Theses and Dissertations

Background: Severe maternal morbidity (SMM) risk has tripled over the past 30 years. Adverse infant birth outcomes in the U.S. have also increased with substantial Black-White disparities. Objectives: This work compares the frequency of adverse maternal and infant birth outcomes by maternal race (Black vs White) and examines associations between maternal ambient heavy metal exposures and birth outcomes in Jefferson County, Kentucky, 2017-2022. Methods: Jefferson County inpatient hospital delivery and birth certificate records of self-identified Black or White birthing parents were used. Incidence of SMM, stillbirth, preterm birth (PTB), and small for gestational age (SGA) with 95% confidence intervals (CI) …

Welfare Federalism And Immigrant Inclusion: How State Ideology, Democracy, And Public Opinion Shape Social Policy, Emily Daniel

Honors Theses

This thesis explores the variation in immigrant access to state-level social welfare programs in the United States from 1997 to 2023, focusing on the influence of state ideology, democratic performance, and public opinion. In the wake of the 1996 Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA), which curtailed federal welfare access for many immigrants and shifted authority to the states, significant disparities emerged in how states approached immigrant inclusion. This study examines eight states—four historic immigrant destinations and four “new growth” states—with varied political climates and demographic changes. Using a legislative output index, moral language analysis of state media …

Implications Of Acetylation And Phosphorylation On Metabolic Enzymes, Nour Fatema

Graduate Theses and Dissertations

All living things depend on glycolysis and the TCA cycle for energy production and metabolic control. Post-translational modifications (PTMs) such as acetylation and phosphorylation, which can change enzyme activity, substrate binding, and overall metabolic balance, tightly regulate these pathways. Diseases like cancer and metabolic problems are associated with disruptions in these alterations.

Serine phosphorylation and lysine acetylation are two of the many PTMs that are evolutionarily conserved processes that alter protein function. Previously thought to be a static histone alteration, acetylation is now understood to be a dynamic regulator of metabolic enzymes that modifies contacts, charge, and conformation. In response …

Developing Custom Fertilizer Strategies Recirculating Hydroponic Systems, Joshua Bryan Tebow

Graduate Theses and Dissertations

Hydroponic systems recirculate nutrient solution to reduce the amount of water used in leafy green production. However, the rootzone of the nutrient solution is complex and influenced by interacting factors such as plant uptake demand, irrigation water quality, supplied fertilizer salts and nutrient concentrations, environmental conditions, and injection of mineral acids/bases to control solution pH. A common strategy for managing nutrients in commercial production is to select a hydroponic solution formulation (i.e. recipe) to supply and maintain a target pH and electrical conductivity (EC) in the recirculating solution over time by automatic injection of mineral acids/bases and concentrated fertilizer stock …

Fixed-Time Artificial Insemination Protocols Using Pre-Synchronization In Suckled Beef Cows, Wyatt Eugene Weber

Graduate Theses and Dissertations

Adoption of artificial insemination by beef producers has been limited within the United States. Estrous synchronization (ES) for fixed-time artificial insemination (FTAI) has been one of the most effective ways to implement artificial insemination into beef production systems, but its efficiency has primarily been restrained by the dependency on the effectiveness of the initial gonadotropin releasing hormone (GnRH) injection in many FTAI protocols. The hypotheses of these studies were to determine practical methods of pre-synchronization to improve current FTAI protocols, ultimately increasing beef herd reproductive performance. The objective was to evaluate the use of prostaglandin F2α (PGF) and progesterone (P4) …

Bacterial Chondronecrosis With Osteomyelitis In Broiler Chickens: Experimental Lameness And Additive Probiotic Treatments, Amanda Anthney

Graduate Theses and Dissertations

With the global population already surpassing 8.2 billion and expected to reach 9.7 billion by 2050, the poultry industry has seen a surge in demand due to its unmatched efficiency and affordability for consumers across the globe. Selective breeding and quality nutrition developments since the industry's commercialization have allowed producers to grow broilers up to 7 pounds by market age. While this extraordinarily efficient process has allowed quality poultry products to be available worldwide, the modern-day broiler has developed a multitude of musculoskeletal issues. Due to the lack of integral skeletal development to match the rapid production of muscle tissue, …

Bacterial Chondronecrosis With Osteomyelitis In Broilers: Etiology And Selected Mitigation Measures, Khawla Saud Alharbi

Graduate Theses and Dissertations

Bacterial chondronecrosis with osteomyelitis (BCO) is the predominant cause of lameness in broiler chickens. It mainly impacts broiler production and animal welfare, causing substantial financial losses accounting for 1- 2% due to bird condemnations at the marketing age. Remediating BCO lameness disease demands investigating its causes using appropriate models and evaluating preventive measures, such as enhancing epithelial tissue health and tight junction integrity in the digestive and respiratory tract, strengthening immune functions, and improving bone strength. Therefore, the objectives of this dissertation were to 1) study predisposing factors for BCO lameness by investigating the effects of deoxynivalenol (DON) and fumonisin …

Reformation To Transformation : Power Of Pulpit Preaching In The Reformation Era, Transforming Believers To Be Like Christ And Making A Missional Impact On Their Community, Stanly John Varghese

ATS Dissertations

No abstract provided.

Parkinson’S Disease Pathophysiology And Comparative Analysis Of The Efficacy Between Subthalamic Nucleus And Globus Pallidus Interna Deep Brain Stimulation: A Student’S Perspective, Peter C. Solimando Ii

Anthropology

Parkinson’s Disease (PD) is becoming an increasingly common neurodegenerative disease across the world, presenting with both debilitating motor and non-motor symptoms that progressively worsen throughout the course of the disease. Prominent motor symptoms include tremors, bradykinesia, muscle rigidity, and postural/gait instabilities, while common non-motor symptoms include fatigue, pain, autonomic dysfunction (i.e., bowel and bladder dysfunction), mood disorders, and dementia. The advent of modern medical management of PD has introduced several different medications, the most popular being levodopa, that have shown success in reducing the severity of motor symptoms, particularly in the early stages of the disease. Throughout disease progression, however, …

Targeting Discrepancies In Linear Growth Measurements In The Neonatal Intensive Care Unit Through Nursing Interventions: A Quality Improvement Initiative, Gail Snyder, Rebekah Wilkinson, Raina Evans, Meagan Owen, Akram Yazdani, Covi Tibe, Catherine Perez, Lindsay F Holzapfel

Faculty, Staff and Student Publications

Objective: Accurate length measurements are essential for infants to identify growth deficiencies and adjust nutrition accordingly. The gold standard for length measurement in infants is using a length board with two people to obtain an accurate clinical assessment. We aimed to improve the number of measurements with the desired minimal difference, defined as a discrepancy ≤1 cm between nurse and audit measurements, in our center. Our secondary aim was to increase and maintain the number of length boards available.

Methods: This quality improvement (QI) study used a before-and-after intervention comparison design in a single-level IV neonatal intensive care unit between …

Enteral Nutritional Practices In Extremely Preterm Infants: A Survey Of U.S. Nicus, Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas

Faculty, Staff and Student Publications

No abstract provided.

First Step To Environmentally Sustainable Endoscopy Practice: A Prospective Study Of Minimizing Multiple Device Use During Screening Colonoscopy At A Large Tertiary Center, Prateek S Harne, Vaishali Harne, Asad Rehman, Nirav Thosani, Madhav Desai

Faculty, Staff and Student Publications

The healthcare sector generates 8% of greenhouse gas emissions in the USA, of which gastrointestinal (GI) endoscopy is the third largest contributor. Single-use tools are a major contributor to modifiable waste generation during GI endoscopy. Through a quality improvement initiative, we aimed to reduce endoscopy waste by urging gastroenterologists to be mindful of tools used during polypectomies by avoiding using multiple tools.We discussed green endoscopy initiatives in monthly journal club and business meetings. Over 14 weeks, 210 patients were included in the pre-intervention group and 112 in the post-intervention group.At baseline, 34% of colonoscopies required no intervention, 32% required one …

Comparing The Efficacy And Safety Of Glp-1 Receptor Agonists Versus Gastric Bypass Surgery In The Treatment Of Obesity And Type 2 Diabetes, Abir Oliver

Physician Assistant Scholarly Project Papers

Obesity and type 2 diabetes are interconnected global health challenges, contributing significantly to morbidity, mortality, and healthcare costs. This literature review compares the efficacy, safety, and applicability of glucagon-like peptide-1 (GLP-1) receptor agonists and bariatric surgery as treatment options. A literature search with defined inclusion and exclusion criteria was conducted using PubMed and EBSCOhost from May to July 2024, resulting in 14 randomized controlled trials for evaluation. This literature review supports the efficacy of both GLP-1 receptor agonists, particularly semaglutide, and bariatric surgery as effective interventions for weight loss and glycemic control in patients with obesity and type 2 diabetes. …

Interdisciplinary Collaboration: The Impact Of Curriculum Support Through Museum/Education Partnerships In Rural Communities, Erin Gentry

Electronic Theses and Dissertations

Museum education is a dynamic field, and often an underutilized or nonexistent resource in the educational sphere of rural communities. Within the current system of rural K-12 schools, a local museum can serve as both educational enrichment and entertainment/reward. The author’s research explores how museums in rural communities can actively collaborate with schools through a fusion of art and science using an interdisciplinary curriculum model to provide educational support and enrichment to both students and teachers. This research focused on high school students enrolled in a Title 1 charter school located within a rural district in east Texas. The author …

Risk Analysis Index For Estimation Of 30-Day Postoperative Mortality In Hip Fractures., Nithin K Gupta, Hikmat R Chmait, Vikram Gill, Morgan Turnow, Taylor Manes, Benjamin C Taylor, Jack W Weick, Christian Bowers

Surgery Articles

IMPORTANCE: Hip fractures present a substantial public health challenge, with projections of more than 500 000 per year by 2040. As such, frailty indices such as the Revised Risk Analysis Index (RAI) and the Modified Five-Item Frailty Index (mFI-5) have been recently investigated as metrics for preoperative risk stratification for these patients.

OBJECTIVE: To understand the accuracy of frailty, as measured by the RAI and the mFI-5, for estimating 30-day mortality following surgically managed hip fractures.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cross-sectional analysis used the American College of Surgeons' National Surgical Quality Improvement database. Patients aged 65 years old …