Digital Commons Network^™

Corchorus Olitorius Exhibits Antiproliferative Potential Supported By Metabolic Profiling And Integrative Biological Analyses, Maha R.A. Abdollah, Salma Sameh, Ahmed Elissawy, Eman Al-Sayed, Rola Labib, Lan Ye, Fang-Rong Chang, Abdel Nasser B. Singab

Pharmacy

Herbal nutraceuticals could be employed as alternative or complementary routes for alleviating cancer. Corchorus olitorius (Malvaceae) was employed traditionally in the management of tumors. The study aimed to investigate the antiproliferative activity of C. olitorius leaves. In vitro cytotoxic and anti-angiogenic activities of C. olitorius were estimated. The bioactive fraction was subjected to in vivo study on BALB/ c female mice using Ehrlich Ascites Carcinoma model. UPLC-ESI-MS/MS analysis was done to determine the phytometabolites followed by in silico studies on the major identified compounds. The bioactive fraction possessed potent in vitro activity against A549 cells with IC50 = 7.8 µg/mL …

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka, Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Everlyn Musanga Nyamar, Rosemary Nabaweesi

Faculty Publications

Background:The COVID-19 pandemic presented many unknowns for pregnant women, with anemia potentially worsening pregnancy outcomes due to multiple factors.

Objective:This review aimed to determine the pooled effect of maternal anemia interventions and associated factors during the pandemic.

Methods:Eligible studies were observational and included reproductive-age women receiving anemia-related interventions during the COVID-19 pandemic. Exclusion criteria comprised non-English publications, reviews, editorials, case reports, studies with insufficient data, sample sizes below 50, and those lacking DOIs. A systematic search of PubMed, Scopus, Embase, Web of Science, and Google Scholar identified articles published between December 2019 and August 2022. Risk of bias was evaluated …

The Micronutrient Gap: Understanding Modern Dietary Shortfalls, Kathy Redfern

School of Biomedical Sciences

Nutrition science is a relatively young discipline, yet our understanding of how diet impactshealth, wellbeing, and performance has grown significantly over the past century. Despite thissurge in research and heightened public awareness, many modern diets in developed nationsare falling short in key micronutrients such as vitamin D, vitamin B12, and folic acid (1). Thesetrends are driven by a range of factors, including rising consumption of ultra-processed foods(UPFs), declining nutrient density in produce, reduced sunlight exposure, and chronic stress.

Effectiveness Of Video-Observed Therapy In The Management Of Tuberculosis: A Multi-Centre Randomised Control Trial In Terengganu, Malaysia, Kartik Kaliyana Sundaram

Student Works (2020-2029)

Introduction: Tuberculosis (TB) remains the leading public health threat. In 2023, an estimated 10.8 million people developed the disease and 1.25 million died, making TB the world’s leading killer from a single treatable infection. In Malaysia, the notification rate of TB is 80.2 per 100,000 population and a rise of 5.5% from the previous year. Since its introduction in the early 1990s, Direct Observed Treatment, Short-course (DOTS) has been the standard of approach for TB treatment. While effective, DOTS is often logistically challenging for both patients and service providers. Daily clinic visits place significant time, travel, and staffing demands on …