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Articles 2041 - 2070 of 10512
Full-Text Articles in Entire DC Network
The Motherhood Penalty On Health: Evidence From China, Ang Sun, Fang Xia, Xuan Zhang
The Motherhood Penalty On Health: Evidence From China, Ang Sun, Fang Xia, Xuan Zhang
Research Collection School Of Economics
Understanding women’s physical and mental well-being following childbirth is critical for informing policies on labor market equity, family support, and fertility. Using event study methods and panel data from China, we document a persistent motherhood penalty in both physical and mental health, whereas the health impacts on fathers are minimal. While mothers experience a temporary reduction in paid work hours, they face a sustained increase in unpaid domestic labor — housework and childcare — resulting in a net increase in total work time. This additional workload likely contributes to deterioration in health. Mothers are also more likely to engage in …
Advancing Medical Education With Lifestyle Medicine: A Comprehensive Program Evaluation Using The Kirkpatrick Framework, Shanna L. Mello
Advancing Medical Education With Lifestyle Medicine: A Comprehensive Program Evaluation Using The Kirkpatrick Framework, Shanna L. Mello
Electronic Theses and Dissertations
This dissertation examined how a U.S. national lifestyle medicine residency curriculum influenced resident learning and practice using a program evaluation paradigm with a convergent mixed methods design guided by Kirkpatrick’s four-level evaluation model. The problem addressed was the persistent gap between evidence for lifestyle interventions and the limited preparation residents receive to deliver lifestyle counseling in routine care. The purpose of the study was to evaluate changes in residents’ reactions, learning, and clinical behaviors and to identify early patient-level signals and the implementation conditions that enabled or constrained behavior change. Quantitative methods analyzed archived pre- and posttraining surveys from 148 …
Southeast Asia Higher Education Changes And Emerging Futures, Muhammad Hali Aprimadya, Lily Kong, Angel Calderon, Hamish Coates
Southeast Asia Higher Education Changes And Emerging Futures, Muhammad Hali Aprimadya, Lily Kong, Angel Calderon, Hamish Coates
Research Collection School of Social Sciences
This paper unpacks recent developments and future directions in Southeast Asian higher education. It takes stock of higher education systems in three selected countries, Australia, Indonesia and Singapore. It sketches these systems, distils several changes around 2024, and discusses emerging directions for education, research and universities. The paper concludes by looking at what is required to catalyse transformations likely to impel future progress.
Hooks For Four-Dimensional Ecology Education (4dee) Teaching With Differing Audiences Of Nonmajors, Sara E. Scanga, Vikki L. Rodgers, Loren B. Byrne, Justin R. St. Juliana, Jon M. Honea, Erica S. Tietjen, George Middendorf
Hooks For Four-Dimensional Ecology Education (4dee) Teaching With Differing Audiences Of Nonmajors, Sara E. Scanga, Vikki L. Rodgers, Loren B. Byrne, Justin R. St. Juliana, Jon M. Honea, Erica S. Tietjen, George Middendorf
Arts & Sciences Faculty Publications
Nonmajors (i.e., undergraduate students not majoring in the natural sciences) constitute a majority of United States college graduates and are a large potential audience for courses with ecology content. However, nonmajors may be unmotivated to learn about ecology because they perceive it to be uninteresting and irrelevant to their everyday lives or career goals. Although the Four-Dimensional Ecology Education (4DEE) framework can be adapted for nonmajors courses as a starting point to improve student engagement, we suggest that nonmajors ecology instructors also use ecology hooks as effective gateways to 4DEE that will motivate and deepen student learning. Selecting and developing …
Perioperative Antibiotic Administration Review: An Analysis Of Outpatient Surgeries At Ohiohealth Doctors Hospital., Rayyan Bhutta, Thomas Shneker, Samantha Currier, Alexander Caskey, Vincent Relli-Dempsey, Matthias Franzen, Samir Patel
Perioperative Antibiotic Administration Review: An Analysis Of Outpatient Surgeries At Ohiohealth Doctors Hospital., Rayyan Bhutta, Thomas Shneker, Samantha Currier, Alexander Caskey, Vincent Relli-Dempsey, Matthias Franzen, Samir Patel
Surgery Articles
INTRODUCTION: A vital part of preventing surgical site infections (SSIs) is perioperative antibiotic prophylaxis. Antibiotics must be administered within a certain window of time, usually 15 to 60 minutes prior to the surgical incision, for them to be effective. The most frequently utilized medication, cefazolin, can be administered quickly by intravenous push (IVP), but other medications, such as vancomycin and clindamycin, need longer infusion times. Antibiotic efficacy declines, and the risk of SSIs is increased when scheduling requirements are not followed. With special focus on time, dosage, and variation by surgery type, this study evaluates adherence to perioperative antibiotic administration …
Tirzepatide For The Maintenance Of Body Weight Reduction: Rationale, Design, And Baseline Characteristics Of Surmount-Maintain, Deborah B Horn, Louis J Aronne, Sean Wharton, Harold E Bays, Elisa Gomez-Valderas, Avigdor D Arad, Palash Sharma, Julia P Dunn, Cagri Senyucel, Clare J Lee
Tirzepatide For The Maintenance Of Body Weight Reduction: Rationale, Design, And Baseline Characteristics Of Surmount-Maintain, Deborah B Horn, Louis J Aronne, Sean Wharton, Harold E Bays, Elisa Gomez-Valderas, Avigdor D Arad, Palash Sharma, Julia P Dunn, Cagri Senyucel, Clare J Lee
Faculty, Staff and Student Publications
Objective: SURMOUNT-MAINTAIN aims to evaluate the efficacy and safety of reducing the tirzepatide dose and/or continuing the maximum tolerated dose (MTD) versus placebo in maintaining body weight (BW) reduction achieved with tirzepatide MTD.
Methods: This Phase 3b, multicenter, randomized, parallel-arm, double-blinded, placebo-controlled, 52-week clinical trial is in progress comparing treatment with once weekly tirzepatide (5 mg and/or MTD of 15 mg or 10 mg) versus placebo in achieving BW reduction maintenance from the initial 60-week open-label weight-loss period on tirzepatide MTD, in adults with obesity (BMI ≥ 30 kg/m2 or ≥ 27 kg/m2 with ≥ 1 obesity-related comorbidity, excluding type …
Calcium Supplementation And The Risk Of Dementia In The Perth Longitudinal Study Of Aging Women: A Post-Hoc Analysis Of A Randomised Clinical Trial For Fracture Prevention, Negar Ghasemifard, Joshua R. Lewis, Simone Radavelli-Bagatini, Simon M. Laws, Blossom C.M. Stephan, Jonathan M. Hodgson, Kun Zhu, Richard L. Prince, Marc Sim
Calcium Supplementation And The Risk Of Dementia In The Perth Longitudinal Study Of Aging Women: A Post-Hoc Analysis Of A Randomised Clinical Trial For Fracture Prevention, Negar Ghasemifard, Joshua R. Lewis, Simone Radavelli-Bagatini, Simon M. Laws, Blossom C.M. Stephan, Jonathan M. Hodgson, Kun Zhu, Richard L. Prince, Marc Sim
Research outputs 2022 to 2026
Background: Concerns have been raised around whether calcium supplements increase dementia risk. This post-hoc analysis of a five-year double-blind, placebo-controlled randomised trial of calcium supplements for primary fracture prevention evaluated the long-term risk for dementia in older women, randomised to either calcium supplements or placebo. Methods: 1460 community-dwelling dementia-free Australian women (≥70 years) were randomised to 1200 mg/day calcium carbonate (n = 730) or placebo (n = 730) for five years and were observed for an additional 9.5 years afterwards. Over 14.5 years, all-cause dementia events (comprising dementia-related hospitalisations and/or deaths) were identified from linked health records. The influence of …
Temporal Eating Patterns And Ultra-Processed Food Consumption Assessed From Mobile Food Records Of Australian Adults, Janelle D. Healy, Satvinder S. Dhaliwal, Christina M. Pollard, Amelia J. Harray, Lauren Blekkenhorst, Fengqing Zhu, Deborah A. Kerr
Temporal Eating Patterns And Ultra-Processed Food Consumption Assessed From Mobile Food Records Of Australian Adults, Janelle D. Healy, Satvinder S. Dhaliwal, Christina M. Pollard, Amelia J. Harray, Lauren Blekkenhorst, Fengqing Zhu, Deborah A. Kerr
Research outputs 2022 to 2026
Background/Objective: Temporal eating patterns and ultra-processed food (UPF) consumption have independently been associated with obesity and non-communicable diseases. Little is known about the temporal patterns of UPF consumption, as data is challenging to collect. Temporal data can be extracted from mobile food records (mFRs). The aim of this study was to identify the temporal eating patterns of those consuming UPFs using an mFR. Methods: A combined sample of 243 young (18–30 years) and 148 older (>30 years) adults completed a 4-day mFR. The time of eating was extracted from the mFR image metadata. UPFs were identified using the NOVA …
Validation Of A Mind Diet Screener In Older Adults, Desarae A. Dempsey, Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, Liana G. Apostolova, David G. Clark, Martin R. Farlow, Sunu Mathew, Sophia Wang, Michelle Quirke, Yolanda Graham-Dotson, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Andrew J. Saykin, Shannon L. Risacher
Validation Of A Mind Diet Screener In Older Adults, Desarae A. Dempsey, Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, Liana G. Apostolova, David G. Clark, Martin R. Farlow, Sunu Mathew, Sophia Wang, Michelle Quirke, Yolanda Graham-Dotson, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Andrew J. Saykin, Shannon L. Risacher
Research outputs 2022 to 2026
Introduction: Higher adherence to the Mediterranean-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) diet has been associated with reduced Alzheimer's disease (AD) risk. This study assessed the validity of a brief 15-item MIND diet screener compared to a comprehensive food frequency questionnaire (FFQ). Methods: The validity of an adapted MIND diet screener relative to the VioScreen FFQ was evaluated in 92 older adults from the Indiana Alzheimer's Disease Research Center (IADRC). Correlation coefficients and tertile-based classification statistics were used, and FFQ nutrient profiles were examined across screener-based MIND diet tertiles. Results: MIND diet scores from the screener …
College Of Nursing Apr 2024 Self-Study Report, Unm Academic Program Review
College Of Nursing Apr 2024 Self-Study Report, Unm Academic Program Review
UNM Academic Program Review
College of Nursing complete an annual academic program review and included in the self-study report for AY2024
Unprecedented Polymicrobial Bacteremia With Nine Microorganisms In A Critically Ill 95% Burn Patient, Alexander Johnson, Julio Nasim, Brian B. Draper, Cindy L. Austin
Unprecedented Polymicrobial Bacteremia With Nine Microorganisms In A Critically Ill 95% Burn Patient, Alexander Johnson, Julio Nasim, Brian B. Draper, Cindy L. Austin
Student Publications
This report describes the case of a 21-year-old male with 95% total body surface area full-thickness burns who developed polymicrobial bacteremia involving nine distinct bacterial species, the highest number of diverse bacterial species documented to simultaneously coexist in a patient’s bloodstream. Despite aggressive surgical, antimicrobial, and multidisciplinary interventions, the patient succumbed to sepsis after 12 days. The case highlights the diagnostic and therapeutic challenges of managing complex infections in burn patients and underscores the critical importance of early detection, prompt treatment, and coordinated care. A literature review of the identified pathogens provides context and reveals notable findings relevant to this …
Exploring Preferences For Interventions To Increase Active School Transportation Among Children And Adolescents In Australia, Anna Gannett, Paula Hooper, Julie Saunders, Gina Trapp
Exploring Preferences For Interventions To Increase Active School Transportation Among Children And Adolescents In Australia, Anna Gannett, Paula Hooper, Julie Saunders, Gina Trapp
Research outputs 2022 to 2026
Introduction: The observed decline in children's active school transport (AST) across numerous countries over recent decades necessitates targeted, multi-level interventions to reverse this trend. However, data on young people's preferred AST interventions is lacking. This study aimed to explore children's preferences for AST interventions and assess differences between AST users and non-users among primary and secondary school students. Methods: In 2023, a cross-sectional survey was conducted in Perth, Western Australia with n = 742 primary school students from 23 schools and n = 412 secondary school students from 9 schools. The survey assessed AST frequency, preferred transport mode, and AST …
A Spanish-Language Adaptation Of The Brief Wisconsin Inventory Of Smoking Dependence Motives Among Mexican And Mexican-American Adults Who Smoke, Yessenia Castro, Jose E. Velasquez, Zully C. Guerra, Tatiana Londoño, John R. Moore, Nazanin M. Heydarian
A Spanish-Language Adaptation Of The Brief Wisconsin Inventory Of Smoking Dependence Motives Among Mexican And Mexican-American Adults Who Smoke, Yessenia Castro, Jose E. Velasquez, Zully C. Guerra, Tatiana Londoño, John R. Moore, Nazanin M. Heydarian
School of Social Work Faculty Publications
Introduction: The smoking pattern of Latino smokers differs from non-Latino white smokers such that physical dependence may not be a strong motivator for smoking among Latinos. Multidimensional measures of dependence may be more useful, but there is a lack of psychometrically sound multidimensional Spanish-language measures. This study evaluated the psychometric properties of a Spanish-language adaptation of the Brief Wisconsin Inventory of Dependence Motives (Brief WISDM) for use among Spanish-speaking Latino smokers in the U.S.
Methods: 287 Spanish-speaking Mexican-origin smokers in the U.S. responded to a revised set of Spanish Brief WISDM items. Confirmatory factor analyses and model trimming procedures were …
The Association Of Cancer-Preventive Lifestyle With Colonoscopy Screening Use In Border Hispanic Adults Along The Texas-Mexico Border, Paul Gerardo Yeh, Audrey C. Choh, Susan P. Fisher-Hoch, Joseph B. Mccormick, David R. Lairson, Belinda M. Reininger
The Association Of Cancer-Preventive Lifestyle With Colonoscopy Screening Use In Border Hispanic Adults Along The Texas-Mexico Border, Paul Gerardo Yeh, Audrey C. Choh, Susan P. Fisher-Hoch, Joseph B. Mccormick, David R. Lairson, Belinda M. Reininger
School of Medicine Publications
Purpose: The relationship between engaging in two domains of cancer-preventive behaviors, lifestyle behaviors and colonoscopy screening, is unknown in Hispanic adults. Accordingly, the study examined the association between lifestyle and colonoscopy screening in Hispanic adults along the Texas–Mexico border, where there is suboptimal colorectal cancer prevention.
Methods: Lifestyle behavior adherence and compliance with colonoscopy screening schedules were assessed using 2013–2023 data from the Cameron County Hispanic Cohorta populationbased sample of Hispanic adults living along the Texas–Mexico border. The 2018 World Cancer Research Fund scoring system characterized healthy lifestyle engagement. Multivariable logistic regression quantified the association between lifestyle behaviors and colonoscopy …
Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi
Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi
Poultry Science Faculty Publications and Presentations
Chronic heat stress (HS) is known to depress feed intake (FI) and growth in broiler chickens, and may alter the gut microbiota and health, however, the amplitude and duration of each (HS and depressed FI) effect on gut microbiota is still unclear. This study aimed to determine the effects of chronic and acute HS on the cecal and ileal microbiota profiles. Broilers were subjected to thermoneutral (TN, 23 degrees C) or chronic cyclic HS (CHS, 8 h/d, 35 degrees C) condition from d29-42, and one group to acute HS (AHS, 2 h, 35 degrees C) at d42. To distinguish between …
Integrating Food Loss And Waste Reduction Policies With Global Dietary Shifts: An Economic Modelling Study, Alessandro Gatto, Maksym Chepeliev
Integrating Food Loss And Waste Reduction Policies With Global Dietary Shifts: An Economic Modelling Study, Alessandro Gatto, Maksym Chepeliev
Department of Agricultural Economics Faculty Publications
Background
Food loss and waste undermine the resilience and sustainability of global food systems, jeopardising progress toward the Sustainable Development Goals (SDGs). Adopting healthier and more sustainable diets could help reduce global food loss and waste, but the potential trade-offs on food loss and waste trends and interactions with standalone reduction policies remain largely unexplored. We aimed to investigate the effects of reducing food loss and waste within the context of a global dietary transition by 2050, shedding light on the synergies and trade-offs between two crucial policy areas for the food systems of the future.Methods
In this economic …Bone Mineral Density Of Willow Ptarmigan (Lagopus Lagopus) As A Potential Taphonomic Factor In Skeletal Part Attrition, Frank J. Dirrigl Jr., Samuel R. Buchanan
Bone Mineral Density Of Willow Ptarmigan (Lagopus Lagopus) As A Potential Taphonomic Factor In Skeletal Part Attrition, Frank J. Dirrigl Jr., Samuel R. Buchanan
School of Integrative Biological & Chemical Sciences Faculty Publications
Agents of taphonomy can bias skeletal parts and the frequency of bones in archaeological sites. An important factor to consider is the possible effect of bone density-mediated attrition on archaeornithological assemblages. We scanned willow ptarmigan (Lagopus lagopus) specimens using a Lunar iDXA and an enCcore small animal body add-on to develop a rank-order scheme based on the volumetric bone mineral density (vBMD) of skeletal parts. Our results identified the tibiotarsus and femur to be the least dense bones, while carpometacarpus, 3rd digit, and coracoid were the densest. This novel scheme allowed us to evaluate a sample of 22 …
Repeated Withdrawal Of A Glpr Agonist Induces Hyperleptinemia And Deteriorates Metabolic Health In Obese Aging Um-Het3 Mice, Nisi Jiang, Jiyuan Yin, Noah Lawrence, Jieyi Meng, Laurence T Maeyens, Ziying Xu, Xin Li, Mbolle Ekane, Ariana Chaudhary, Pengju Cao, Guannan Li, Carolina Solis-Herrera, Yi Zhu, Shangang Zhao
Repeated Withdrawal Of A Glpr Agonist Induces Hyperleptinemia And Deteriorates Metabolic Health In Obese Aging Um-Het3 Mice, Nisi Jiang, Jiyuan Yin, Noah Lawrence, Jieyi Meng, Laurence T Maeyens, Ziying Xu, Xin Li, Mbolle Ekane, Ariana Chaudhary, Pengju Cao, Guannan Li, Carolina Solis-Herrera, Yi Zhu, Shangang Zhao
Children’s Nutrition Research Center Staff Publications
GLP-1-based therapy is highly effective in combating aging-associated metabolic diseases. However, the metabolic effects of frequent withdrawal from this therapy in aged, obese mice have not been previously studied. In this study, aged obese UM-HET3 mice were assigned to three groups: Group 1 received no liraglutide treatment (Lira OFF); Group 2 underwent 3 cycles of treatment followed by withdrawal (Lira ON/OFF); and Group 3 remained on continuous treatment (Lira ON). As expected, mice in Group 3 showed reduced body weight and food intake, along with improved metabolic health. In contrast, mice in Group 2 developed hyperleptinemia and visceral fat expansion, …
Relationship Between Dietary Probiotic Consumption And Cognitive Functioning In Older Adults: A 2011-2014 Nhanes Study, Lauren Weber, J. Gieng, Ashwini Wagle
Relationship Between Dietary Probiotic Consumption And Cognitive Functioning In Older Adults: A 2011-2014 Nhanes Study, Lauren Weber, J. Gieng, Ashwini Wagle
Faculty Research, Scholarly, and Creative Activity
Background
Consumption of probiotics has recently been associated with a reduced risk of cognitive decline due to its anti-inflammatory effect on the brain, via the gut-brain-axis. Current studies with probiotic supplementation indicate that probiotics may play an important role in slowing the rate of cognitive decline and protecting memory. The purpose of this study was to evaluate a potential relationship between cognitive decline and dietary intake of probiotics.
Methods
This study utilized data from NHANES, both 2011-2012 and 2013-2014 cycles. Categorical variables were analyzed using chi-square tests, and continuous variables were analyzed using General Linear Models. Participants (n = 2,689) …
Comparative Analysis Of Mineral Content In Plant-Based Milk Alternatives: Implications For Renal Patient Education, K. Mitchell, A. Widaman, Ashwini Wagle
Comparative Analysis Of Mineral Content In Plant-Based Milk Alternatives: Implications For Renal Patient Education, K. Mitchell, A. Widaman, Ashwini Wagle
Faculty Research, Scholarly, and Creative Activity
The plant-based milk alternative (PBMA) market is expanding rapidly, offering a diverse range of options. However, the mineral composition of PBMA varies significantly across brands and milk types, posing challenges in educating individuals with renal disease. This study aimed to quantify and compare key minerals of concern for renal patients in commercially available PBMA using inductively coupled plasma optical emission spectrometry.
PBMA products available in the San Francisco Bay Area were purchased from chain grocery stores in spring 2023 and early January 2024. A total of 134 unique PBMA products from 28 brands and 11 different milk-alternative sources were analyzed. …
Enhancing Workplace Nutrition: Development Of A Culturally-Tailored Nutrition Intervention Program To Improve Dietary Patterns, Habits, Nutrition Literacy, And Health Outcomes, J. Ryan, S. Agreda, Ashwini Wagle
Enhancing Workplace Nutrition: Development Of A Culturally-Tailored Nutrition Intervention Program To Improve Dietary Patterns, Habits, Nutrition Literacy, And Health Outcomes, J. Ryan, S. Agreda, Ashwini Wagle
Faculty Research, Scholarly, and Creative Activity
Nutrition intervention programs can improve dietary patterns, habits, and health outcomes in communities, but a long-term, integrative approach is essential for success. Barriers such as limited time, resources, lack of cultural sensitivity, and competing priorities hinder their effectiveness. Research highlights the importance of environmental support, particularly from peers and employers, in improving dietary habits and nutrition literacy.
Using the social ecological model framework for food and beverage intake, this program aims to develop a standardized approach to workplace nutrition interventions. The program, approved by the Institutional Review Boards at San Jose State University, will launch in Spring 2025. It incorporates …
Developing Culturally-Tailored Diabetes Friendly And Heart Healthy Recipes For South Asians: Sensory Evaluation And Implications For Dietary Interventions, Ashwini Wagle, S. Starr, N. Goudarzi, G. Molina Martinez
Developing Culturally-Tailored Diabetes Friendly And Heart Healthy Recipes For South Asians: Sensory Evaluation And Implications For Dietary Interventions, Ashwini Wagle, S. Starr, N. Goudarzi, G. Molina Martinez
Faculty Research, Scholarly, and Creative Activity
South Asians have a higher risk of developing type 2 diabetes than manyother racial or ethnic groups. Dietary patterns are a key, modifiable risk factor, and cultural influences strongly shape food choices and lifestyle decisions. Effective, long-term behavior change requires culturally meaningful interventions. This study aimed to develop culturally tailored recipes that comply with the American Diabetes Association (ADA) and American Heart Association (AHA) guidelines.
Recipes were selected from the published South Asian Carbohydrate Counting Tool, created by the researcher, and modified to enhance nutrient composition. Adjustments included ingredient substitutions, reduction or elimination of fat, salt, and sugar, and additions …
Effectiveness And Assessment Of A Culturally-Tailored Carbohydrate Counting Tool For South Asians With Diabetes: A Practitioner’S Evaluation, Ashwini Wagle
Faculty Research, Scholarly, and Creative Activity
South Asians are at a higher risk for type 2 diabetes compared to many other racial and ethnic groups. Dietary patterns play a significant role and are a modifiable risk factor. This study aimed to evaluate a South Asian carbohydrate counting tool developed by the researcher, assessed by Registered Dietitians Nutritionists and Certified Diabetes Care and Education Specialists. Using nutrition communication theory and the transtheoretical model, the tool included a comprehensive list of commonly consumed South Asian foods and sample vegetarian and non-vegetarian meals (1800e2100 kcal). Sixty-five participants received the tool and a training slide deck. A 40-item questionnaire assessed …
Pacap Signalling Network In The Nucleus Accumbens Core Regulates Reinstatement Behaviour In Rat, Samrat Bose, Gregory Simandl, Evan M. Hess, Linghai Kong, Nicholas Raddatz, Brian Maunze, Sujean Choi, David A. Baker
Pacap Signalling Network In The Nucleus Accumbens Core Regulates Reinstatement Behaviour In Rat, Samrat Bose, Gregory Simandl, Evan M. Hess, Linghai Kong, Nicholas Raddatz, Brian Maunze, Sujean Choi, David A. Baker
Biomedical Sciences Faculty Research and Publications
Cocaine use disorder (CUD) lacks FDA-approved treatments, partly due to the difficulty of creating therapeutics that target behaviour-related neural circuits without disrupting signalling throughout the brain. One promising candidate for circuit-selective neuromodulation is pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with pleiotropic behavioural actions whose signalling network spans the gut–brain axis. Here, we investigated the potential existence and function of an endogenous PACAP signalling network within the nucleus accumbens core (NAcc), which is a structure that integrates emotional, cognitive and reward processes underlying behaviour. We found that PACAP and its cognate receptor, PAC1R, are endogenously expressed in the rat NAcc …
Neuroleukemiosis Masquerading As Drug Toxicity In An Adolescent With Refractory Aml, Nia Choi, Deborah Schady, Tim Lotze, Jill Ann Jarrell, Alexandra Rodriguez-Hernandez, Sandra Aziz, Karen K Moeller, Joanna S Yi, Suzanne Woodbury, Andrea N Marcogliese, Zoann E Dreyer, Eric S Schafer
Neuroleukemiosis Masquerading As Drug Toxicity In An Adolescent With Refractory Aml, Nia Choi, Deborah Schady, Tim Lotze, Jill Ann Jarrell, Alexandra Rodriguez-Hernandez, Sandra Aziz, Karen K Moeller, Joanna S Yi, Suzanne Woodbury, Andrea N Marcogliese, Zoann E Dreyer, Eric S Schafer
Faculty, Staff and Students Publications
No abstract provided.
Examining The Relationship Between Dysphagia, Eating-Related Symptoms, And Diet Quality Among Oropharyngeal Cancer Patients During Critical Stages Of Cancer Survivorship: The U-Dine Study, Beatrice Manduchi, Vlad C Sandulache, Ji Yun Tark, Shreela Sharma, Ruosha Li, Emily Roller, Andrew Bevelhimer, Katherine A Hutcheson, Marcia C De Oliveira Otto
Examining The Relationship Between Dysphagia, Eating-Related Symptoms, And Diet Quality Among Oropharyngeal Cancer Patients During Critical Stages Of Cancer Survivorship: The U-Dine Study, Beatrice Manduchi, Vlad C Sandulache, Ji Yun Tark, Shreela Sharma, Ruosha Li, Emily Roller, Andrew Bevelhimer, Katherine A Hutcheson, Marcia C De Oliveira Otto
Faculty, Staff and Students Publications
Background: Diet quality is a modifiable factor impacting treatment outcomes in oropharyngeal cancer (OPC), yet the effect of dysphagia and self-reported eating-related symptoms remains unclear. This study examined their associations with diet quality in OPC patients.
Methods: A cross-sectional analysis was conducted with two parallel cohorts from MD Anderson Cancer Center and Michael E. DeBakey Veterans Affairs Medical Center as part of the Uncovering the Long-Term Impact of OPC and Dysphagia on Dietary Quality and Nutrition Among Cancer Survivors (U-DINE) Study. Participants at varying survivorship stages (prediagnosis, 3-6 and 18+ months posttreatment) were assessed for dysphagia (DIGEST scale) and six …
Prostaglandin E2 As A Mechanistic Biomarker Of Chronic Pancreatitis, Jami L Saloman, Bahiyyah Jefferson, Samuel Han, William E Fisher, Evan L Fogel, Phil A Hart, Liang Li, Walter G Park, Santhi Swaroop Vege, Dhiraj Yadav, Mark D Topazian, Darwin L Conwell
Prostaglandin E2 As A Mechanistic Biomarker Of Chronic Pancreatitis, Jami L Saloman, Bahiyyah Jefferson, Samuel Han, William E Fisher, Evan L Fogel, Phil A Hart, Liang Li, Walter G Park, Santhi Swaroop Vege, Dhiraj Yadav, Mark D Topazian, Darwin L Conwell
Faculty, Staff and Students Publications
Introduction: Chronic pancreatitis (CP) is a disease associated with chronic inflammation, fibrosis, and pain. There is a lack of tools available that facilitate early diagnosis, when intervention could prevent irreversible damage. Pilot data suggested prostaglandin E2 (PGE2) as a candidate biomarker for early CP. PGE2 activates signaling pathways that promote inflammation, pain, and fibrosis.
Methods: We assessed PGE2, metabolites, and downstream targets in pancreatic fluid collected endoscopically 0-10 (n = 110) and 10-20 (n = 111) minutes after intravenous secretin administration. PGE2 and metabolites were measured in plasma (n = 75) and urine (n = 71) from the same subjects. …
Liver-Specific Expression Of Hiv-1 Viral Protein R Causes Hepatic Steatosis And Glucose Intolerance In Male Mice, Neeti Agarwal, Pradip Saha, Claudia E Ramirez Bustamante, Sean M Hartig, Mark A Herman, Ashok Balasubramanyam, Jordan E Lake
Liver-Specific Expression Of Hiv-1 Viral Protein R Causes Hepatic Steatosis And Glucose Intolerance In Male Mice, Neeti Agarwal, Pradip Saha, Claudia E Ramirez Bustamante, Sean M Hartig, Mark A Herman, Ashok Balasubramanyam, Jordan E Lake
Faculty, Staff and Students Publications
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in people with HIV (PWH), with both HIV and antiretroviral therapy contributing to liver damage and glucose intolerance. However, the role of viral proteins derived from reservoirs in this process remains unclear.
Methods: Adeno-associated virus (AAV) constructs encoding a control protein or HIV-1 viral protein R (Vpr) driven by the thyroxine-binding globulin promoter were administered to male mice (n = 5 per group) fed regular chow or a high-fat diet (HFD). Young adult mice underwent intraperitoneal glucose tolerance testing and magnetic resonance imaging, followed by euthanasia. Liver and adipose tissues …
Pfas Exposure And Postoperative Weight Regain In Adolescents After Bariatric Surgery: Findings From The Teen-Labs Study, Brittney O Baumert, Elizabeth Costello, Zhenjiang Li, Justin R Ryder, Thomas Inge, Todd Jenkins, Stephanie Sisley, Stavra A Xanthakos, Douglas I Walker, Nikos Stratakis, Damaskini Valvi, Scott M Bartell, Angela L Slitt, Rohit Kohli, Sarah Rock, Michele A La Merrill, Sandrah P Eckel, Max T Aung, Rob Mcconnell, David V Conti, Lida Chatzi
Pfas Exposure And Postoperative Weight Regain In Adolescents After Bariatric Surgery: Findings From The Teen-Labs Study, Brittney O Baumert, Elizabeth Costello, Zhenjiang Li, Justin R Ryder, Thomas Inge, Todd Jenkins, Stephanie Sisley, Stavra A Xanthakos, Douglas I Walker, Nikos Stratakis, Damaskini Valvi, Scott M Bartell, Angela L Slitt, Rohit Kohli, Sarah Rock, Michele A La Merrill, Sandrah P Eckel, Max T Aung, Rob Mcconnell, David V Conti, Lida Chatzi
Faculty, Staff and Students Publications
Objective: Weight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per- and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfunction, may influence long-term weight trajectories. This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.
Methods: We included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post …
A Narrative Review Of The Ileal Pouch In Pediatric Inflammatory Bowel Disease And Familial Adenomatous Polyposis, Anitta Philip, Allyson Wyatt, Jose R Rodriguez, Brad Pasternak, Lisa Mcmahon, Kalyani Patel, Richard Kellermayer
A Narrative Review Of The Ileal Pouch In Pediatric Inflammatory Bowel Disease And Familial Adenomatous Polyposis, Anitta Philip, Allyson Wyatt, Jose R Rodriguez, Brad Pasternak, Lisa Mcmahon, Kalyani Patel, Richard Kellermayer
Faculty, Staff and Students Publications
Ileal pouch-anal anastomosis is a surgical intervention in patients with medically refractory inflammatory bowel disease and familial adenomatous polyposis syndrome. Reported outcomes in children have been limited by both the retrospective nature and sample size of the investigations. In addition, there is a lack of consensus on surveillance guidelines in this patient population. Delay or lack of surveillance may increase the risk of complications (pouchitis, Crohn's disease-like inflammation, dysplasia, etc.). This narrative review aims to summarize the most recent literature (2013-2023) on short-term, long-term, and quality of life (QoL) outcomes in pediatric ileal pouch (J-pouch) patients. A proposed surveillance guidance …