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Cyp1b1 Mediates Cigarette Smoke-Induced Lipid Accumulation In Alveolar Type 2 Cells, Yin Zhu, Siddhika Gamare, Francesca Polverino, Caroline A Owen, Payaningal R Somanath, Xiaoyun Wang, Duo Zhang

Faculty, Staff and Students Publications

Alterations in lipid profiles have been shown in patients with chronic obstructive pulmonary disease (COPD), but the underlying molecular mechanisms remain unclear. In this study, we aimed to investigate the role of cytochrome P450 family-1 subfamily B member 1 (CYP1B1) in cigarette smoke (CS)-induced lipid accumulation in alveolar type II epithelial (AT2) cells. We observed a steady increase in CYP1B1 protein levels in AT2 cells from COPD patients. Additionally, CS exposure induced CYP1B1 expression in AT2 cells of murine lungs. In vitro, treatment with cigarette smoke extract (CSE) not only upregulated CYP1B1 expression but also triggered lipid accumulation in AT2-like …

Sickle Cell Disease: A Story Of Injustice And Neglect, Nosakhare Edogun, Rosalyn Marar, Jasmine R. Marcelin

Graduate Medical Education Research Journal

N/A

A Case Of Kikuchi-Fujimoto Disease In Texas, United States, Divya Chandramohan, Moyosore Awabajo-Otesanya, Deepak Chandramohan, James C. Saca

Graduate Medical Education Research Journal

Kikuchi-Fujimoto disease (KFD) commonly presents with lymphadenopathy, with a third of cases presenting with fevers. It is seen in young female patients of Asian descent, with Taiwan accounting for most of the reported cases. It is imperative to consider KFD in an individual presenting with fever and lymphadenopathy. While it might not be common in the United States, there is an increasing number of cases being reported. Histologic features in KFD are unique, and a lymph node biopsy determines the diagnosis. We outline a case of KFD in the United States and describe histologic details that resulted in the diagnosis.

Project #099: Reducing Anesthetic Greenhouse Gas Emissions Across Henry Ford Hospitals, Joshua Goldblatt, Kimberly A. Finch, Mary Jarzebowski, Terry A. Ellis

Quality Expo 2025

No abstract provided.

Project #080: Optimizing Neonatal Outcomes: Improving Early Hiv Detection And Intervention In Newborns. A Quality Improvement Initiative., Faryal Durrani, Eric J. Mcgrath, Indira Brar, Eileen M. Pokriefka, Uzma Shah

Quality Expo 2025

No abstract provided.

Project #068: Thinking Like An Infection Prevention Expert: Creating An Automated Report To Aid Frontline Staff In The Reduction Of Clostridioides Difficile Infections, Sarah Prascius, Alex K. Wells, Wendy Raffin, Gabe Smith, Ann M. Collier, Amanda Renard, Tricia Stein

Quality Expo 2025

No abstract provided.

Project #157: Improving Central Line Necessity Documentation: A Quality Improvement Project, Meghan Smith

Quality Expo 2025

No abstract provided.

Whole-Blood Cellular Responses: A Promising Indicator Of Sars-Cov-2 Immunity Compared To Serology, Lucas M. Zhou, Elizabeth H. Duncan, Rupsa C. Boelig, Margaret Costanzo, Jeffrey R. Currier, Elke S. Bergmann-Leitner

Department of Obstetrics and Gynecology Faculty Papers

Background: Currently available immunological tests for SARS-CoV-2 assess only antibody responses. Despite the growing evidence that T cells play a crucial role in protection, especially against emerging viral variants, no routine test is available to determine T cell immunity. The prognostic value of SARS-CoV-2-specific antibodies for determining whether individuals are immune and protected against disease remains uncertain. This is in part due to the following: (a) specificity and limitations such as the sensitivity of antibody tests, and (b) the lack of correlation between antibody titers (quantity) and the antiviral function of antibodies (quality). Approximately a quarter of SARS-CoV-2-infected patients with …

Educating Correctional Nurses On The Use Of A Mindfulness Program To Reduce Work Stress, Victoria Ngozi Emelogu

Walden Dissertations and Doctoral Studies

Correctional nurses deliver care in environments marked by violent incidents, chronic understaffing, and moral distress. These conditions heighten occupational stress, jeopardize patient safety, and accelerate staff turnover, yet few U.S. jails provide evidence-based training in rapid self-regulation strategies. The purpose of this staff education project was to evaluate whether a 2-week curriculum could increase correctional nurses’ knowledge, attitudes, and self-reported skills (KAS) for on-shift mindfulness use. Pender’s health promotion model framed the intervention, Bloom’s taxonomy and Kirkpatrick’s evaluation model informed learning objectives and outcome levels. Five correctional nurses at a large urban jail completed an anonymous 10‑item KAS survey before …

The Function Of Di-Methyl Fumarate In Immunobiochemical And Hematological Changes In Individuals Infected With Entamoeba Histolytica, Saif Mohammed Algebory, Zainab Ali Hussein, Sarah Suliman Mohammed, Alaa Ihsan Saymeh, Hayder Kareem Algabri

Hilla University College Journal For Medical Science

Background: Amebiasis can cause a number of symptoms, from infections that are passed on when someone touches something infected to serious illness.

Objectives: role of DMF on reducing Entamoeba histolytica (E. histolytica) infection.

Materials and Methods: The study involved patients supplying E. histolytica-related symptoms. Diagnoses were confirmed using stool samples, and 10 mL of venous blood was obtained for antioxidant and immunological investigation. Groups: Control (uninfected patients), Normal medication (infected patients on normal medication), and Combination (infected patients getting standard treatment with DMF).

Results: Group 2 and 3 had lower red blood cell and haemoglobin levels than group …

When To Tap: Complex Febrile Seizure With Atypical Course As Early Presentation Of Hsv-1 Meningoencephalitis, Isabella Comsa, Sindhu H. Manjunath, Elise Gross, Rawad Obeid, Graham Krasan

Conference Presentation Abstracts

Introduction: Febrile seizures have a prevalence of 2-5% among children ages 6-60 months. Less than 1% of complex febrile seizures without meningeal signs are associated with bacterial or viral meningitis. Current literature supports limiting routine lumbar puncture in this population. We present a case of Herpes Simplex Virus (HSV) encephalitis presenting with complex febrile seizure, who progressed to cerebritis requiring decompressive craniectomy, and discuss indications for further diagnostic evaluation.

Case Description: 2-year-old male with a history of simple febrile seizure presenting with a 10 minute tonic-clonic seizure with right-sided gaze deviation. He had tactile fever and low energy at home …

Acute Care Of Patients With Moderate Respiratory Distress: Recommendations From An American College Of Emergency Physicians Expert Panel., Christopher W Baugh, Jim F Neuenschwander, Jesslyn Lenox, Jennifer Hoh, Kara Ward, Sara Muramoto, John Casey, Antonio Anzueto, Hajirah Ishaq, Jared Mount, Peter M Deblieux

Ambulatory and Primary Care Articles

INTRODUCTION: Patients with respiratory distress are frequently encountered in the emergency department (ED). Efforts to assess, initiate treatments, and stabilize these patients require a systematic and rapid response. Emergency physicians need a comprehensive and efficient approach for evaluating, treating, and managing patients presenting to the ED with moderate respiratory distress.

METHODS: The American College of Emergency Physicians convened an expert panel of academic and community emergency physicians, critical care specialists, respiratory therapists, hospitalists, and pharmacists to develop and subsequently disseminate consensus recommendations regarding the diagnosis and treatment of patients with moderate respiratory distress presenting to the ED.

RESULTS: A digital …

Dilemmas And Prospects Of Infectious Disease Prevention In Long-Term Care: A Qualitative Study, Po-Jen Kung, Ching-Min Chen, Nancy Reynolds

International Nursing Research Congress (INRC)

Aim: To explore the experiences of long-term care workers in preventing emerging infectious diseases, the challenges they faced during the pandemic, and how they were addressed.

Design: This study used an exploratory qualitative research design.

Methods: The study involved various long-term care institutions across Taiwan. Twelve interviewees, including four nurses, four nursing assistants, and four managers, were recruited via purposive sampling. All interviewees worked in the sector during the COVID-19 pandemic, were actively involved in clinical care or institutional management, and were proficient in Mandarin. In-depth interviews were conducted face-to-face between July and August 2024, and data …

Pandemic Prevention Competencies Of Long-Term Care Institution Workers: A National Survey In Taiwan, Po-Jen Kung, Ching-Min Chen, Katherine Ornstein

International Nursing Research Congress (INRC)

Aim: To assess the self-perceived pandemic prevention competencies of health and care workers in Taiwan’s long-term care institutions and identified key factors influencing these competencies.

Methods: A cross-sectional online survey was conducted from June to July 2024 using stratified proportional sampling of health and care workers (nursing and nursing assistants) from various types of long-term care institutions (assisted living facilities, residential care homes and nursing homes). Participants were actively employed during the survey, involved in COVID-19 prevention efforts, and proficient in reading traditional Chinese. Data on pandemic prevention competencies were collected, using the Emerging Infectious Disease Prevention Competencies …

Developing And Validating An Emerging Infectious Disease Prevention Competencies Scale, Po-Jen Kung, Ching-Min Chen

International Nursing Research Congress (INRC)

Aim: To develop an instrument and evaluate its psychometric properties for emerging infectious disease assessing prevention competencies among health and care workers in long-term care institutions.

Design: A cross-sectional, descriptive design utilizing both qualitative and quantitative methods was employed.

Methods: The scale was developed according to scale development guidelines in two phases, namely the scale development phase and scale testing phase, with the staff of long-term care institutions as the study population and their workplaces as the sampling unit.

Results: The scale comprises 27 items across three dimensions: 14 items pertaining to professional role performance, 7 items addressing workplace resources, …

Health And Care Workers’ Roles In Infectious Disease Prevention In Long-Term Care: A Scoping Review, Po-Jen Kung, Ching-Min Chen, Yi-Yuan Cheng

International Nursing Research Congress (INRC)

Aim: To describe how health and care workers contribute to the prevention of emerging infectious diseases in long-term care facilities.

Design: A scoping review.

Methods: A systematic search of literature dating from 2002 to 2022 was conducted in the following databases: EMBASE, Medline (Ovid), Cochrane Library, CINAHL Plus with Full Text (EBSCOhost), Web of Science, and AgeLine. Studies were selected if they focused on health and care workers in long-term care facilities, offered a perspective on the prevention of emerging infectious diseases or infection prevention and control, and were original qualitative or quantitative studies in English. Data were extracted, cross-checked …

Native Hawaiian Culturally Appropriate Substance Use Disorders Formative Program Evaluation, Kelly J. Penn

Walden Dissertations and Doctoral Studies

Substance use disorders (SUDs) disproportionately affects Native Hawaiians, yet conventional treatments often overlook the cultural, spiritual, and relational foundations of well-being for Native Hawaiians. This gap represents a human services problem, as it perpetuates health disparities, limits recovery, and slows social change within Native Hawaiian communities. The purpose of this qualitative single case study was to identify culturally relevant components for an SUD treatment program tailored to Native Hawaiians. The research question guiding this study was, what are culturally appropriate components for a SUD program for Native Hawaiians. The Nā Pou Kihi framework grounded the exploration of Indigenous approaches to …

The Path To A Green Transition: Just And Inclusive, Nour Elden Tarek Anwr Abd Elshafy

COP30

This paper explores the opportunities and challenges in achieving Just Transition in the agricultural sector, focusing on the critical areas of Climate investments in the field of training and public awareness, policy formulation, and promoting Inclusive sustainable livelihoods for the most affected groups, namely people with disabilities. It highlights the current gaps in Climate investments, the need for inclusive and effective policies, and the importance of ways to achieve just integration to reduce Poverty and unemployment rates. The paper proposes actionable solutions to align financial investments, policy frameworks, and Comprehensive practices with the Paris Agreement goals and Glasgow talks (COP26), …

Driving Climate Mitigation And Health Equity In Rapid Test Diagnostics (Rdts): A Sustainable Biodegradable Patch Solution, Sarah Abozeid

COP30

Total energy-related CO2 emissions increased by 0.8% in 2024, hitting an all-time high of 37.8 Gt CO2, driven primarily by energy, transport, and industrial sectors. The healthcare sector, often overlooked in mitigation discussions, contributes 4.4% of total global GHG emissions, a footprint exceeding that of many countries. Disposal of petroleum-based plastics—especially through incineration—emits approximately 2.7 tonnes of CO2 equivalent (CO2e) per tonne of plastic burnt. Production itself accounts for around 2.5 tonnes CO2 per tonne of

plastic, making the combined lifecycle emissions significant when including end- of-life incineration or decomposition. Around 16,000 tonnes of plastics are

produced globally for rapid …

Engl 102-H05: Intro To Research Writing - Honors, Drew Ciccolo

Humanities Syllabi

No abstract provided.

Engl 102-H01: Intro To Research Writing - Honors, Johanna Deane

Humanities Syllabi

No abstract provided.

Engl 102-H07: Intro To Research Writing - Honors, Jake Slovis

Humanities Syllabi

No abstract provided.

Hss 404-039: Senior Seminar - Medicine And Globalization, Gareth Edel

Humanities Syllabi

No abstract provided.

Hospital And Temporal Variations In Limitations Of Care Among Hospitalized Patients With Covid-19: A Virus Registry Retrospective Cohort Study, Nathan Mesfin, Nitesh Kumar Jain, Anwar Khedr, Hisham Mushtaq, Abbas B. Jama, Noura Attallah, Esraa Hassan, Benjamin Langworthy, Nicholas Ingraham, Juan Pablo Domecq Garces, Thoyaja Koritala, Donna Lee Armaignac, Nicholas Eugene Perkins, Katherine Belden, Vishakha Kumar, Karen Boman, Devang K. Sanghavi, Vikas Bansal, Rahul Kashyap, Rodrigo Cartin-Ceba, Abigail La Nou, Allan J. Walkey, R. Adams Dudley, Syed Anjum Khan

Division of Infectious Diseases and Environmental Medicine Faculty Papers

INTRODUCTION: Life-support limits (i.e., code status), the first step in the continuum of palliation and end-of-life (EoL) care, stem from decisions made by patients and their providers to align care near the EoL with patients' wishes. The pandemic created health care strain that may have influenced life-support limitation practices among patients with serious COVID-19. In this study, we examine variations in life-support limitations (do-not-resuscitate, DNR; do-not-intubate, DNI) depending on the hospital and period of hospitalization.

METHODS: We included all adults admitted to a hospital in the United States with COVID-19 from January 2020 to December 2021 using the VIRUS registry. …

The Relationship Between Nursing Faculty Sense Of Belonging And Faculty Intent To Stay, Heather M. Bowers

Doctoral Dissertations and Projects

The purpose of this quantitative causal-comparative and correlational study was to evaluate the relationship between workplace sense of belonging and intent to stay in the current nursing faculty role among full-time nursing faculty. The shortage of nursing faculty impacts the ability to prepare the next generation of nurses needed to meet worldwide nursing demands. Strategies to effectively recruit and retain nursing faculty are important considering the current shortage and increasing retirements of nursing faculty. While sense of belonging has been studied for student retention and studies are beginning to explore the importance of workplace belonging, the impact of organizational sense …

The Covid-19 Pandemic And College Students' Experiences: A Phenomenological Study, Mervin L. Davis

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore and comprehend the lived experiences of college students at North Carolinian colleges and universities during the interruption and transitions of studies amid the COVID-19 pandemic. This research used qualitative inquiry design and employed Schlossberg’s transition theory to guide the study. Schlossberg’s transition theory correlates with this research and phenomenological exploration because it underscores the varying abilities and incapacities of students to persist through their studies during challenging circumstances. The setting for this research was North Carolinian higher education institutions within Mecklenburg County which boast 17 colleges and universities within a 50-mile …

Edge Percolation Centrality: A New Measure To Quantify The Influence Of Edges During Percolation In Networks, Christina Durón, Hannah Kravitz, Moysey Brio

Mathematics and Statistics Faculty Publications and Presentations

Numerous centrality measures exist to quantify the influence of edges within a network, with edge betweenness being one of the more well-known measures. However, such measures are inadequate in network percolation scenarios (e.g., the transmission of a disease over a transportation network of highways) as they fail to consider the changing percolation states of edges over time. This paper addresses this limitation by extending percolation centrality, a measure originally developed to evaluate the influence of vertices during a percolation process (i.e., a dynamic spread of a contagion) in the network, to the edge level. The proposed measure, edge percolation centrality, …

Health And Climate At Cop29: Advancing Integration And Bridging Research Gaps, Rupa R Patel, Yevheniia Varyvoda, Hiba Baroud, Philip J Landrigan, Aminata Kilungo

2020-Current year OA Pubs

Climate and health science is a rapidly growing, interdisciplinary field and holds importance during intergovernmental climate adaptation and mitigation policy negotiations. The 29th session of the Conference of the Parties (COP) to the United Nations Framework Convention on Climate Change (UNFCCC) convened stakeholders for negotiations and scientific discourse. This viewpoint presents insights gained by the authors' participation at COP29 focused on health and climate. The authors analyze the evolving integration of health into the UNFCCC process, dissect the contributions and the role of the Research and Independent Non‑Governmental Organizations (RINGOs), a constituency to achieve this endeavor, and identify the key …

Purulent Pericarditis: Treating A Medically-Complex Patient With Intrapericardial Antibiotics, Meryem Guler, Sudheshna Vemula, Matthew Hart, Josh Wiener, Darius Farzad, Mark Decaro, Gregary D. Marhefka, Devin Weber, John W.C. Entwistle, Jacqueline Urtecho

Division of Cardiology Faculty Papers

OBJECTIVE: Purulent pericarditis is a rare, lethal complication of a bacterial pericardial infection. This case report outlines the protocol for instilling intrapericardial antibiotics for methicillin-sensitive Staphylococcus aureus (MSSA) pericarditis without fibrinolytics in a 51-year-old man.

KEY STEPS: An appropriately sized percutaneous pericardial drain was placed. Then, a 3-day course of intrapericardial infusions of 50 mL vancomycin was begun. Drainage of all accessible fluid was performed before each infusion. The daily infusions each had an 8-hour dwell time. The prior drainage protocol continued after each infusion.

POTENTIAL PITFALLS: Strict dosage and infusion length management are required to prevent direct toxicity. Potential …

Covid-19 Infection Prevention And Control Guidelines Of Philippine Physical Therapy Association (Ppta) And Rehabilitation Department Of Select Hospitals In The Philippines: Impact On Infection Trend, Ghiester Marc T. Estrellado, Venize Edanne F. Montecillo, Cristina Faye C. Panopio, Alexandra Marie V. Amistoso, Raymond M. Tosoc

Philippine Journal of Physical Therapy

Introduction: There is a paucity of evidence supporting the need for setting up hospital COVID-19 infection prevention and control (IPC) guidelines for Physical Therapists (PTs) that meet global standards. This study aimed to determine the consistency of IPC guidelines among different rehabilitation departments of hospitals within Region IV-A and the Philippine Physical Therapy Association’s (PPTA) recommendations with the World Health Organization’s (WHO) IPC guidance document. It also compared the hospitals’ consistency scores with the trend of infected PTs per month.

Methods: In this descriptive cross-sectional survey, an online checklist was developed and validated to examine the consistency of the IPC …