Digital Commons Network^™

From Cranes To Clinics: Genomic Epidemiology At The Human-Animal Interface, Sarah Shrum

Biology ETDs

Emerging infectious diseases represent a significant, increasing threat to human life, economic stability, and global security. The One Health framework, which promotes human health and wellness through the understanding that animal, environmental, and human health are interwoven, is critical to understanding pathogen emergence and transmission. This is underscored by the fact that roughly 60% of all human pathogens and 75% of emerging infectious disease are zoonotic, meaning they are transmitted from animals to humans.

The work presented in this dissertation integrates genomic epidemiology, ecological analysis, and One Health Surveillance approaches to characterize cross-species circulation of opportunistic yeast pathogens (Candida …

A Hospital Spiritual Care Volunteer Program: Embodying Vocation And Decreasing Social Isolation And Loneliness In Adults Sixty-Five And Older, Stacy L. Auld

Doctor of Ministry Projects and Theses

Social isolation and loneliness have become familiar terms since the COVID-19 pandemic, but the problem did not start there. We have seen a steady rise in the number of people who face social isolation and loneliness over the past fifty years, and now research shows that this problem is impacting people’s health, especially in adults sixty-five and older. These social diagnoses are being addressed by public policy and in health care settings, but they should also be addressed by United Methodist clergy in their care for their parishioners. Therefore, I am writing this dissertation to my clergy colleagues to raise …

Pneumomlpred: Innovating Pneumonia Management With Guideline Adherence Review And Explainable Machine Learning-Based Mortality Prediction - A Single-Centre Retrospective Study, Kamel A. Samara, Hiba Jawdat Barqawi, Saryia Adra, Batool Aldaher, Drishti D. Kampani, Enad Haddad, Hebah Soudan, Islam Ibrahim Anwar, Mohamad Besher Adi, Omar Hamadi, Yumna Almour, Mohamed Nassef, Zaher Al Aghbari, Eman Abu-Gharbieh

Abington Jefferson Health Papers

Introduction: Community-acquired pneumonia (CAP) is one of the leading causes of death globally. Changing antibiotic resistance profiles, paucity of reliable CAP mortality prediction models, and ageing populations will increase its burden. This study aims to evaluate adherence to CAP management guidelines as well as develop an ML-based mortality prediction model.

Methods: This retrospective, chart review included all CAP cases between 2016 and 2021. Variables collected included patients' demographics, comorbidities, vitals, laboratory, imaging, and culture findings, as well as initial and targeted antibiotic regimens. Data was pre-processed and analysed in python-3. Adherence to the American thoracic society/infectious diseases society of America …

Whiny Women: How Medical Gaslighting Becomes Medical Trauma, Neena Marcus

Honors Projects

Background: The idea of “medical gaslighting” has been present since 1969, but it has increased in popularity in the recent century. Women in particular are at increased risk of being dismissed by their healthcare providers, as throughout history they have been deemed “hysterical” or untrustworthy when recounting their symptoms.

Methods: Articles were compiled from CINAHL Complete, Google Scholar, and the University of Washington library. A total of 33 articles were chosen and reviewed.

Results: Medical gaslighting results in lasting medical trauma, a decreased quality of life and detachment from standard healthcare. Six themes were recurrent in the papers utilized: sexism, …

The Formation Of Indian Health Services Within Imperial And Settler-Colonial Contexts, Jillian E. Grisel

American Studies ETDs

This dissertation examines the Indian Health Services as a Cold War biosecurity apparatus, showing how infectious disease was weaponized to dismantle treaty obligations, reorganize tribal lands into “service areas,” and reclassify Indigenous nations as surveilled populations. Against this carceral health economy, Indigenous nations refused. From the 1969 Alcatraz occupation to the 1976 Puyallup takeover of Cushman Indian Hospital, Native activists reclaimed health facilities as sovereign spaces, insisting that care is not a discretionary service but a treaty right grounded in land and kinship. Methodologically, I combine historical-legal analysis of congressional debates, Public Health Service reports, and IHS data with counter-archives …

Developing A Durable, Memory-Driven, Cspz-Targeting Lyme Disease Vaccine By Rationale Adjuvant Selection\, Miranda Mccarty, Sergio A Hernández, Jill Malfetano, Ana Carolina Leão, Maria Jose Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, Maria Elena Bottazzi, Utpal Pal, Klemen Strle, Wen-Hsiang Chen, Yi-Pin Lin

Faculty, Staff and Students Publications

Rational adjuvant selection is a systematic approach based on adjuvant-mediated immunomodulation to identify safe vaccine regimens that enhance protective immunity. Transmitted through ticks and caused by the bacterium Borrelia burgdorferi (Bb), Lyme disease (LD) is the most common vector-borne disease in the Northern hemisphere. There are no approved human vaccines, making it suitable for testing the concept of rational adjuvant selection. Here, we formulated our previously developed and effective LD vaccine antigen, CspZ-YAC187S, with different adjuvants suitable for human use; we analyzed the immune response by transcriptomics and tested the vaccine efficacy after Bb infection. We identified Alum-CpG and Alum-αGal …

Circulation Of Respiratory Viruses From Air And Human Specimens In A Pre-Kindergarten-12th Grade School District In Kansas City, Mo, Nicole Neeley, Brian Lee, Brittney Fritchmann, Luke Gard, Nibha Sagar, Dithi Banerjee, Anjana Sasidharan, Rangaraj Selvarangan, Olivia Almendares, Hannah L. Kirking, Jennifer Goldman, Jennifer E. Schuster

Research Showcase

Background:

As shown by the SARS-Cov-2 pandemic, respiratory viruses have significant impact to public health, morbidity, and mortality. Large scale viral surveillance within the community can be helpful in monitoring viral spread and disease patterns, but population level testing can be costly and time consuming. Air sampling with respiratory virus testing in community settings may be a potential non-invasive, scalable method to monitor respiratory viruses.

Objectives/Goal:

We performed an ecological analysis to describe the correlation between respiratory virus detections in air and human samples across pre-kindergarten-12^th grade schools to evaluate the potential for air sampling as a tool for …

Genomics And Bioinformatics Student Companion Workbook (First Edition), Na Xu, Tina Hu

Open Educational Resources

This Genomics and Bioinformatics Student Companion Workbook provides an integrated, hands-on introduction to the principles and applications of modern genomics and bioinformatics. Designed for undergraduate students, the workbook guides learners from foundational concepts of genome structure and sequencing technologies to advanced topics including variant analysis, comparative genomics, and multi-omics integration. Emphasizing the interplay between experimental biology and computational analysis, it introduces key analytical tools and biological databases that support genome interpretation and data-driven discovery.

Through a structured progression of chapters, students explore genome organization across diverse biological systems, from prokaryotes and viruses to complex eukaryotic genomes, and examine how genomic …

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

A Tale Of Two Mammals: Tenrec Ecaudatus And Homo Sapiens, Debra Renee Kerr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Most modern mammals maintain stable body temperatures (Tb) ~37ºC and high metabolic rates. Hibernators, like ground squirrels, are homeothermic during the active summer season, but are heterothermic during the hibernation season. During the hibernation season, ground squirrels follow a predictable pattern of torpor bouts interrupted by interbout arousals. Tenrecs are unusual because they are heterothermic and heterometabolic even during the active season. Previously, ground squirrel bile constituents were shown to be predictive of whether a squirrel is in the summer active or winter hibernation season. We found tenrec bile constituents were highly variable and not predictive of seasonal and metabolic …

Impairment And Disability In Mesoamerica: Bioarchaeological Evaluation And Interpretation Of The Maya Of Palenque, Dayanira Lopez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The application of disability theory to the past is of growing interest among bioarchaeologists, both nationally and internationally. However, its application poses greater challenges when considering ancient contexts, such as Mesoamerica. Nonetheless, engagement with disability studies has led to the development of various theoretical frameworks in bioarchaeology, including dis/ability. This model views physical impairment as a fluid state that may exhibit adaptability and resilience rather than a biological deficit. Importantly, it views ability on a spectrum and does not make assumptions about social and cultural perceptions of ability where there is a lack of contextual data. Thus, it is a …

Proceedings Of The 18th Indonesian Occupational Medicine Update (Iomu) 2026 - Occupational Medicine Without Borders: Emerging Risks, Evolving Workforces, And Inclusive Collaboration, Indonesian Association Of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / Perdoki)

Occupational and Environmental Medicine Journal of Indonesia

This Supplemental Issue of the Occupational and Environmental Medicine Journal of Indonesia (OEMJI) compiles the scientific abstracts presented at the 18th Indonesian Occupational Medicine Update (IOMU) 2026, convened in Surabaya, Indonesia, from 15 to 17 May 2026. The IOMU has matured into the most prominent annual scientific platform of the Indonesian occupational medicine community, hosted by the Indonesian Association of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / PERDOKI). Since its inception, the conference has served as a meeting point where clinicians, academics, industrial hygienists, regulators, employers, and worker representatives gather to translate emerging scientific evidence into …

Volume Cxlv, Number 22, May 15, 2026, Lawrence University

The Lawrentian

No abstract provided.

Weighted Blankets: Implementation Of A Quality Improvement Pilot Project In The Neurosciences Intensive Care Unit, Anita Musafar

Doctoral Projects

The weighted blanket quality improvement pilot project was implemented at Stanford Healthcare (SHC) to address the limited number of nonpharmacological interventions available for agitation management in the critical care setting. Patients within the Neurosciences ICU (NSICU) at SHC are clinically complex and uniquely vulnerable to experiencing agitation. The objectives of this initiative were to understand nurses' perceptions surrounding weighted blanket use in the critical care setting and assess whether there was a decrease in Richmond Agitation-Sedation Scale (RASS) scores with this intervention. From September 2025 to December 2025, the nurses within the NSICU implemented the use of weighted blankets for …

Developing A Health Education Program For Adults Reentering The Community After Incarceration, Tiffany Ayame Kinugawa-Larsen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Justice-impacted adults often experience challenges in confidently managing their health due to limited autonomy, disrupted health routines, and limited access to health education during incarceration. Studies have shown that incarcerated adults have a higher likelihood of developing chronic health issues, yet have limited access to resources that promote health and well-being after release from incarceration. Given that health management falls within the scope of occupational therapy (OT), the profession is positioned to promote health and well-being by applying OT principles that emphasize individualized, holistic care tailored to a justice-impacted population during community reintegration. A 5-week health education program grounded in …

Ceftazidime-Avibactam For Multidrug-Resistant Gram-Negative Infections: Outcomes And Timing Of Initiation Across 22 Us Medical Centers, Ashlan J. Kunz Coyne, Chloe Judd, Kristen Lucas, Mohammed Al Musawa, Sean Van Helden, Dana Holger, Ali Althubyani, Christine Yost, Sydney Vandorf, Ryan Mynatt, Wesley D. Kufel, Jillian Hayes, Connor R. Deri, Rebekah H. Wrenn, Cara N. Slaton, Taylor Morrisette, Melisa Davis, M. Gabriela Cabanilla, Elizabeth Shald, Bryan P. White, Joseph Sassine, James Truong, Joshua Rosenberg, Justin Andrade, John Cerenzio, Natalia Medvedeva, David Ha, Taryn A. Eubank, Kevin W. Garey, Mark Biagi, Michaela Todd, S. Lena Kang-Birken, Caleb Rux, Kyle C. Molina, Christopher A. Jankowski, Kimberly C. Claeys, Veena Venugopalan, Michael P. Veve, Carolina Orzol, Mirna Eshaya, Kaylee E. Caniff, Callan Bleick, Michael J. Rybak

Pharmacy Faculty Scholarship

Ceftazidime-avibactam (CAZ-AVI) is a crucial treatment for multidrug-resistant (MDR) gram-negative infections; however, the impact of treatment timing and outcomes in real-world practice remains unclear. This study evaluated CAZ-AVI use across diverse U.S. centers, with emphasis on early initiation. We conducted a retrospective cohort study at 22 U.S. medical centers (2019–2025), including adults with MDR gram-negative infections who received CAZ-AVI ≥ 72 h. The primary outcome was composite clinical success, defined as 30-day survival, absence of microbiological recurrence, and resolution of fever and/or leukocytosis within 72 h of initiation. Early vs late initiation was assessed at 48 h. Classification and regression …

Returning Home: Vocation As A Theological Lens To Foster The Ethiopian Evangelical Church Mekane Yesus’ Holistic Ministry Among Migrant Returnees In Ethiopia, Ebise Dibisa Ayana

Doctor of Philosophy Dissertation

This dissertation examines return migration in Ethiopia, focusing on Ethiopian Domestic Worker Returnees (EDWRs) and the role of the Ethiopian Evangelical Church Mekane Yesus (EECMY) in addressing their holistic needs. Using theological and institutional analysis, the study finds that, although the EECMY affirms holistic ministry as its motto, it lacks clear policies and official statements specifically addressing the spiritual and psychosocial needs of the returnees’.

The research argues that migration and return migration are theological and moral issues that require a holistic response grounded in a Lutheran Theology of Vocation. Such an approach fosters an integrated ministry that attends to …

Evaluation Of Two Bioaerosol Sampling And Analysis Methods For The Collection Of Airborne Bacteria And Viruses, Elizabeth Detrick

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bioaerosols, defined as airborne particles of biological origin, include bacteria, fungi, viruses, and their byproducts. They are ubiquitous in both indoor and outdoor environments and can cause respiratory infections, allergic reactions, and toxin-mediated illnesses. Air sampling plays a vital role in bioaerosol monitoring by enabling the collection and analysis of airborne microorganisms to assess exposure risk and inform mitigation strategies. The objective of this study was to determine the relative collection efficiency of two air samplers, the MD8 Airscan, a filtration sampling method, and the SKC BioSampler, an impingement sampling method. Aerosolization tests were conducted in a controlled test chamber …

Potential Innate And Adaptive Roles Played By Γδ T Cells In A Bacterial Immunization Model, Lee Anne Talbot

Seton Hall University Dissertations and Theses (ETDs)

Francisella tularensis is a highly infectious intracellular bacterium and the causative agent of tularemia, with pulmonary infection resulting in severe disease and high mortality if untreated. While protective immunity to F. tularensis has been largely attributed to CD4⁺ T cell–mediated IFN-γ responses, the contribution of γδ T cells to mucosal immunity and vaccine-induced protection remains poorly defined. The objective of this study was to characterize the role of γδ T cells during primary pulmonary infection with F. tularensis live vaccine strain (LVS) and following intranasal immunization with inactivated F. tularensis (iFt) prior to LVS challenge.

Using a murine intranasal infection …

Quality Improvement (Qi) Project Aimed At Reducing Unnecessary Antibiotic Usage Among Older Adult Patients By Addressing Inappropriate Antibiotic Prescribing In Primary And Long-Term Care Settings, Pamela M. Thomas

Seton Hall University Dissertations and Theses (ETDs)

Antibiotic overuse among older adults remains a significant patient safety and public health concern. Recent national data indicate that approximately 30%–50% of outpatient antibiotic prescriptions may be unnecessary, particularly for viral or self-limiting conditions (Chua et al., 2021). Antimicrobial resistance has been associated with more than 1.27 million deaths globally (Murray et al., 2022). This quality improvement project evaluated a multifaceted antimicrobial stewardship intervention in primary and long-term care settings. Baseline review of 167 antibiotic cases revealed 37.1% were inappropriate or questionable, and 28.7% lacked adequate diagnostic documentation. The intervention incorporated provider education, electronic health record decision-support tools, audit and …

Semi-Rational Strategies For Antifungal Peptide Design, Akilah I. Mateen

Seton Hall University Dissertations and Theses (ETDs)

A recently emerged opportunistic fungi, Candida auris, has been subject to increased scrutiny due to its virulence and rapid geographical spread. Due to the indiscriminate use of antimicrobials as treatments for infectious diseases and as pesticides, the ubiquitous threat of multidrug resistance (MDR) looms large. The lack of progress in antifungal development is of high concern in the treatment of infectious diseases and a rise in fungal resistance highlight the need for updated treatment strategies. This work describes three strategies used to address these concerns:

•  The synthesis of a photosensitizer-membrane-active peptide (PS-MAP) conjugate, Ir-HKII15, that combines the ability of …

How Did A Pandemic Impact Park Usage Among The Older Adult Populations In Memphis, Tn?, Katherine Barlow

Theses and Dissertations

During COVID-19 older adults’ populations were a vulnerable demographic, and through a review of existing literature it was determined that there is limited research about park and outdoor space use during COVID-19 by older adults. This research seeks to address these gaps by examining how a pandemic impacted park usage among the older adult population (age 60+) in Memphis, TN at Shelby Farms Park. This study examines the comparison of park use during (2020-2023) and after (2023-present) COVID-19. A mixed methods approach was employed. Wilcoxon Signed Rank test was run to analyze the survey data and a significant statistical difference. …

Variation In The Sonographic Appearance Of The Liver In Cats With Lymphomatous Hepatic Infiltration., Charlee Sturkie

Theses and Dissertations

Lymphoma is the most diagnosed neoplasm in domestic cats, and abdominal ultrasound is often included as a component of the diagnostic plan. The aim of this study was to determine if changes in sonographic appearance of the liver as well as the presence of free fluid, lymphadenopathy, and splenic abnormalities increase the likelihood of diagnosis of lymphomatous hepatic infiltration in cats diagnosed with lymphoma. Fifty-eight cats were enrolled in this combined retrospective and prospective study, 22 with lymphomatous infiltration in the liver and 36 without. In the current population hypoechogenicity, heterogeneous echotexture, hepatomegaly, and the presence of nodules within the …

Longitudinal Changes In Cognition And Brain Imaging In Persons With Human Immunodeficiency Virus, James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances

2020-Current year OA Pubs

BACKGROUND: As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This study analyzed the effects of aging, HIV serostatus, and viral load on cognition and brain volumes in a large cohort of persons without HIV (PWOH), PWH with undetectable virus (PWHU) (HIV RNA ≤50 copies/mL), and PWH with detectable virus (PHWD) (HIV RNA >50 copies/mL). Cross-sectional and longitudinal data were included.

METHODS: Cognitive composites (NPZ4) and brain volumes were obtained from 259 PWOH, 264 PWHU, and 84 PWHD with a total of …

Stochastic Invasion And Extinction In Environmentally Transmitted Diseases, Mahmudul Bari Hridoy, Lauren M. Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

From Your Pov: Using Narrative-Focused Methodology To Study Psychological Correlates Of Sexual Health Behaviors, Zoë E. Sweaney, Stephanie Afful

The Confluence

How far would you go (or not go) to protect yourself from risky sexual behaviors? Additionally, what influence does our gender identity and socialization have on these decisions? In the current series of studies, a story-driven safe-sex behavioral assessment was developed and administered to participants to assess the relationships amongst psychological indices, personal values, and sexual health. This research confirms the validity of an instrument that queries sensitive data while controlling for social desirability concerns. The applications of this research are especially pertinent to improving upon interpersonal communication, sexual health education, and women’s sexual health advocacy.

How Human Behavior Shapes Epidemic Dynamics, Leah Lejeune, Navid Ghaffarzadegan, Lauren M. Childs, Omar Saucedo

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamics Of A Two-Stage Epidemiological Model With Post-Infection Mortality And Transmission Heterogeneity, B Sagar

Biology and Medicine Through Mathematics Conference

No abstract provided.

Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj, Nattachai Srisawat, Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen

Chulalongkorn Medical Journal

Background: Identification early biomarkers for predicting severe liver dysfunction in severe dengue patients is essential. Currently, there is no any data on circulating microRNAs to predict this important complication.

Objectives: This study aimed to explore the role of circulating microRNAs in prediction severe liver dysfunction in dengue infection by identifying and validating predictive microRNAs via Nanostring and RT-qPCR.

Methods: On the initial day of admission, serum samples were gathered from patients with dengue infection. These patients were monitored for 14 days post-admission to ascertain their final diagnosis. Following the WHO 2009 criteria, participants were categorized into severe liver dysfunction and …

Discharge Rates From Pediatric Emergency Departments Against Medical Advice Can Be Reduced By Improving Service Quality, Sounira Mehri, Josef Finsterer

Saudi Medical Journal

No abstract provided.