Digital Commons Network^™

Severe Acute Malnutrtion Among Children Under Five In South Sudan, Rhoda Elia Iburu Kenyi

Capstone Experience: Master of Public Health

Severe acute malnutrition (SAM) is a life-threatening condition characterized by severe wasting. The World Health Organization defines SAM as a low weight-for-height Z-score (WHZ) less than -3 standard deviation (SD) from the median growth standard or the presence of edema of both feet and/or mid-upper arm circumference (MUAC) less than 115mm. SAM is a significant public health concern affecting children under five in developing countries, with South Sudan being one of the most severely affected regions. Persistent food insecurity, weak healthcare systems, and ongoing conflict contribute to the high SAM prevalence in the region, where political, religious, and social divisions, …

Active Shooter And Radiological Contamination Full-Scale Exercise, Elise M. Lowe

Capstone Experience: Master of Public Health

Planning and conducting exercises in rural settings highlights the unique features and challenges of emergency preparedness in rural America. Exercise designers must employ creative solutions to plan for player/controller contingencies, limited resources, and patient management across large geographical areas. This paper outlines the process by which a full-scale mass casualty exercise was conducted in a small Wyoming town. It analyzes some of the major problems encountered in rural exercise development and the solutions employed. The focus is on the success and failures of the exercise design based on direct observation/participation, hotwash forms, the after-action review, and direct feedback from participants. …

The Weaponization Of Medicine In Arkansas Prison Farms, 1960s-1970s, Grace E. Marr

History Undergraduate Honors Theses

The Arkansas State Penitentiary provides a case study for medical care in prisons during a transformational period. Isolation and state non-involvement in Arkansas allowed the creation of an independent culture in which harrowing abuses flourished. Medical providers could be prisoners themselves, operating the hospital and blood bank creating a complicated hierarchy. By examining medical provisions at the Cummins and Tucker Prison Farms during the 1960s to 1970s, this thesis reveals a system where the lines between treatment and torture and medical practitioner and imprisoned were blurred.

The Narrative Effects Of Cure On Representations Of Disability In The Medical Procedural And Body Horror Genres, Will Schuessler

FCRH Honors Program Theses

In disability studies, “cure” can refer both to literal cures and to the cultural belief that disabilities are problems with the body that can and should be solved through these medical interventions. In recent years, disability scholars have written about this topic of cure critically, but an academic media analysis approach to cure has yet to be taken, despite the prevalence of narratives where disabled characters are cured. This thesis explores how cure shapes disabled stories that are told through film and television, by viewing a sample of over 50 films and 70 episodes of television focused on disabled characters …

Genomic Diversity Of Salmonella Enterica Serotype Braenderup In New York State, Nicole Zac Soligno

Biological Sciences

The Gram-negative Salmonella enterica (family Enterobacteriaceae) is a common foodborne pathogen mainly isolated from foods of animal origin. Salmonella can be transmitted to humans, causing diverse symptoms, from self-limiting gastrointestinal diseases to more fatal typhoid fever. The young, elderly, and Individuals with weakened immune systems are especially at risk from salmonellosis. Salmonella is a concern to public health and the food industry throughout the world, and its severity depends largely on its serotype, a classification based on the unique combination of surface antigens. In this study, I aimed to elucidate the population structure and antimicrobial resistance determinants of S. enterica …

Serological Evaluation For Leptospirosis On Samples Received By The Connecticut Veterinary Medical Diagnostic Laboratory (Cvmdl), Hayden R. Samuels

Honors Scholar Theses

Leptospirosis is a globally distributed zoonotic disease caused by pathogenic species of Leptospira, motile spirochetes capable of infecting humans and animals. Transmission typically occurs through contact with water or soil contaminated by the urine of reservoirs or infected animals. Although leptospirosis is considered a neglected tropical disease, its geographic range is expanding due to climate change and urbanization. Surveillance remains limited in many regions, especially in the United States. This study aimed to assess the seroprevalence and serovar diversity of Leptospira exposure in a variety of domestic and wild animals submitted to the Connecticut Veterinary Medical Diagnostic Laboratory (CVMDL). …

Increasing Accessibility And Enhancing Value Of Two University Small Vertebrate Collections Through Digitization And Online Database Publication, Chloe Smotherman

Masters Theses and Doctoral Dissertations

Natural history collections (NHCs) are widely considered to be an exceptionally valuable resource and a critical foundation for research. Of the thousands of collections maintained today, the majority are considered small with a local or taxonomic focus. Collaboration among smaller NHCs through online publication contributes a largely underutilized resource for collections-based research. Past digitization efforts have resulted in the mobilization of collections data that enhance their preexisting value without significant additional costs. With this project I digitized and published the mammal collection (2,525 records) and, separately, the ornithology collection (403 records). Upon publication these records are the only mammal and …

Mathematical Model For Tripledemic Disease (Covid-19, Rsv, And Influenza), Foster Opoku

Masters Theses and Doctoral Dissertations

The concurrent circulation of COVID-19, Influenza (Flu), and Respiratory Syncytial Virus (RSV), collectively termed the ”Tripledemic,” poses substantial public health challenges due to their overlapping transmission patterns and compounded healthcare demands. The discovery of COVID-19 vaccines such as Moderna (mRNA-1273, Spikevax) and Johnson & Johnson’s, among other vaccines, has reduced COVID-19 cases but has not completely eradicated the disease. In the 2022-2023 season, the world witnessed a ”tripledemic” of Flu, COVID-19, and RSV. We propose Susceptible-Infectious-Recovered (SIR) and SusceptibleExposed-Infectious-Recovered (SEIR) mathematical models to estimate transmission rates, compute the basic reproduction number, forecast infections, and analyze seasonal variations and comparative transmission …

Implementing And Evaluating An Ai-Powered Visual Decision Support System To Improve Antibiotic Usage Among Physicians With A Built-In Early Warning System, Akua Sekyiwaa Osei-Nkwantabisa

Theses and Dissertations

The widespread misuse and excessive prescription of antibiotics have played a pivotal role in the emergence and proliferation of antibiotic-resistant bacteria, posing a critical global public health crisis. Addressing this challenge necessitates innovative solutions that enhance antimicrobial stewardship. This study presents the development and implementation of a visual decision support system designed to monitor and optimize antibiotic usage among healthcare providers. The proposed system integrates advanced machine learning algorithms with real-time data analytics to provide a dynamic, evidence-based decision support tool. Specifically, a neural network model was developed after evaluating multiple machine learning approaches, including Random Forest, Logistic Regression and …

The Infected Diabetic Foot: Bacteraemia And Endocarditis Complicating Moderate And Severe Foot Infections, Mario C Reyes, Arthur N Tarricone, Mathew J Sideman, Michael C Siah, Bijan Najafi, Edgar J G Peters, Lawrence A Lavery

Center on Aging Staff Publications

To identify the incidence of blood stream infections (BSIs) and endocarditis in patients with diabetic foot infections (DFIs), risk factors and clinical outcomes. A post hoc analysis of 280 patients using pooled patient level data from three RTCs. Blood cultures were drawn at time of admission for DFI. Deep intraoperative cultures were obtained from infected foot wounds. Data from the 12-month follow-up were used to determine clinical outcomes. 77.1% (N = 216) had blood cultures of which 15.7% (n = 34) had BSI. One patient (3.3%) had endocarditis. Risk factors for BSI included Charcot Neuroarthropathy history (20.6% vs. 7.1%, p …

Redefining Borders: Mexico, Texas, And The Border Crisis, Emily Maria Zaragoza

Architecture Theses

This thesis explores how humane design can improve the migrant detention experience at the U.S. – Mexico border. Located in Eagle Pass, Texas, the project addresses the ongoing border crisis by proposing a new kind of entrance point. This border crossing will prioritize dignity, safety, and support for both migrants and government staff. Through circular floor plans, natural materials, natural light, and shared outdoor spaces the design challenges the typical cold nature of detention centers. Rather than focusing on politics, the project aims to redefine how we design for migrants, how we think about them, and how we take care …

The Importance Of Voice: American Indian Experiences With Their Healthcare, James Zimmer

Doctor of Social Work Capstone Projects

American Indians and Alaskan Natives (AIAN) have faced inequity and discrimination since colonization. Specifically, within the healthcare system, AIAN individuals have experienced maltreatment, poor quality services, and the dismissal of cultural and personal practices. Health disparities among this population have led to the highest prevalence in many chronic disease categories nationwide (Laffey et al., 2021). A qualitative study with nine respondents was conducted using virtual interviews. Respondents were recruited through healthcare agencies and snowball sampling. Interviews focused on the experiences of American Indians in the Midwest United States with their primary care provider or in a hospital within the last …

Home For The Brave: Housing Program, Amanda Jabr

Capstone Projects and Master's Theses

Veteran homelessness remains a critical issue across the United States. Since 1996, the Veterans Transition Center (VTC) of Monterey County has been at the forefront of addressing this crisis by providing comprehensive services, housing, therapy, addiction recovery, job training, healthcare, and support for families and pets to homeless and formerly incarcerated veterans. Guided by its mission of “Veterans Supporting Veterans,” VTC has achieved a notable 0% recidivism rate among program participants. This project evaluated the effectiveness of VTC’s housing program through a survey of 40 alumni veterans. The findings indicate that the majority of respondents found the program effective, credited …

The Multigenerational Impact Of Mass Incarceration On Families In Southern California, Adelle G. Phillips

Electronic Theses, Projects, and Dissertations

Mass incarceration has been a serious social issue in the United States, affecting directly and indirectly millions of individuals and families, particularly those with minority backgrounds. The generational impact of this social issue is significant. This study aimed to explore the perspectives of individuals on the multigenerational impact of mass incarceration on their families. Using convenience and snowball sampling techniques, this mixed-methods study surveyed residents of Southern California who have been affected by incarceration, either personally or through a family member (n = 63). Descriptive statistics demonstrate that the vast majority of the participants (92.1%) reported a moderate to very …

Differential Diagnosis Of Oral Ulcerations: A Case Report, Richard Nguyen, Kaitlin Carlson, Meredith Clark, Amy Burleson, Brenda S Bohaty, Robin Onikul, Neena Patel, Jenna Sparks

Posters

The diagnosis of oral lesions in children can be challenging as it can be an unspecified symptom of several diseases. Differential diagnoses can range from infectious diseases of childhood, inflammations, nutritional deficiencies, and chronic diseases. Because of this, children with oral ulcers may be treated by different specialists such as pediatric dentists and pediatricians. The purpose of this poster is to report the case of a twenty-one-month-old female patient who presented to Children’s Mercy Hospital Kansas City Emergency Department with chief concern for acute onset of intraoral oral ulcers, extraoral blisters near the lower lip, and fetid oral odor. Patient …

Assessing The Relationship Between The Incidence Of Campylobacteriosis And Ecological Risk Factors In Tennessee, Emmanuel Angmorteh Mensah

Electronic Theses and Dissertations

Background: Campylobacteriosis although is the leading causes of bacterial diarrheal illnesses, have not gained prominent awareness and there are gaps in the understanding of transmission routes for sporadic, non-outbreak cases and their risk factors at the communal level to humans. This study, therefore, aimed to identify the campylobacteriosis risk factors and risk perception from the existing literature in the United States, determine the incidence and ecological risk factors for campylobacteriosis zip code level in Tennessee, and to perform spatiotemporal analysis of campylobacteriosis incidence cases in Tennessee.

Method: To achieve the first aim, a scoping review was conducted to synthesize …

Measles, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Impact Of Temperature And Microbial Infection On The Honey Bee Hemocytes, Michael E. Oeth

Master's Theses

Introduction

Honey bees (Apis mellifera) rely on hemocytes for immunity, wound healing, and hemolymph homeostasis. While 32°C reflects optimal hive conditions, suboptimal temperatures (22°C) and stressors like pathogens (Varroa destructor, bacteria) or pesticides impair hemocyte function. Using clodronate liposomes (CLD) to deplete hemocytes, we assessed how immune suppression interacts with these stressors.

Methods

Newly emerged (5-day-old) and older (15-day-old) bees were assigned to: CLD, control liposomes (LP), PBS, injection wound, or no treatment. Cohorts were exposed to 32°C (optimal) or 22°C (stressful for non-immunosuppressed bees). Fifteen-day-old bees were challenged with Escherichia coli or Staphylococcus aureus. Survival, hemolymph volume, and hemocyte …

Network-Based Attacks In Cloud Computing In 2020-2024, Yaswanth Sai Manikanta Anguluri

Electronic Theses, Projects, and Dissertations

As the use of cloud technologies has increased in the past five years, the number of network attacks is also increasing. During 2020 to 2024, there are lot of changes in cloud technologies which led to various network attacks in the cloud computing environments from 2020 to 2024. This study investigates the evolution of network-based attacks in cloud environments from 2020 to 2024. Data was collected from Kaggle website to analyze the trends of the evolution of network-based attacks. The research questions are: (Q1) How do the trends change in network-based attack from 2020 to 2024 and why? (Q2) Which …

Assessing Bioterrorism Preparedness In Indonesia: Challenges And Strategic Frameworks For National Security, Toni Toni, Haliansyah Haliansyah

Journal of Terrorism Studies

Bioterrorism represents a growing global threat, necessitating robust preparedness frameworks to safeguard national security. This study aims to assess Indonesia's bioterrorism preparedness by identifying key challenges and proposing strategic frameworks for improvement. Using Structural Equation Modeling (SEM), this quantitative research examines the relationship between Government Capacity (independent variable), Crisis Management Effectiveness (intervening variable), and National Security Preparedness (dependent variable). A structured survey was distributed to key stakeholders, including public health officials, security experts, and policymakers, yielding 100 valid responses. Data analysis through SEM revealed that Government Capacity significantly influences Crisis Management Effectiveness, which in turn positively impacts National Security Preparedness. …

The Roles Of Rnt1 And Putative Endoribonucleases In Eukaryotic Mrna Degradation, Lee-Ann Notice-Sarpaning

Dissertations and Theses (Open Access)

Endoribonucleases initiate degradation by cleaving RNAs internally. Mutations in these enzymes have been shown to cause diseases such as cancer, developmental disorders, and neurodegenerative diseases. Yet, eukaryotic endoribonucleases have not been well studied, especially with regard to their role in nuclear mRNA degradation. Rnt1 is a Saccharomyces cerevisiae (budding yeast) nuclear endoribonuclease and homolog of human Drosha with well-characterized roles in the processing of ncRNAs. The enzyme recognizes and cleaves double-stranded RNA stems containing a terminal tetraloop with an AGNN consensus sequence. However, the scope and consequence of its function in mRNA degradation has heretofore been unclear. Previous studies have …

Leveraging Innate Immune Sensors To Generate Durable Anti-Glioma Adaptive Immune Responses, Spencer Lea

Dissertations and Theses (Open Access)

Glioblastoma is an aggressive primary brain malignancy harboring a tumor microenvironment that is mostly devoid of T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired phagocytosis and antigen presentation and are inadequate for triggering the subsequent immune activating signals needed for anti-tumor adaptive effector responses. Glioblastoma tumors can further restrict phagocytosis and subsequent tumor antigen presentation by the upregulation of the antiphagocytic “don’t eat me” ligand CD47. Here we tested whether activation of multiple conserved innate immune pathways could initiate proinflammatory conversion of suppressive myeloid populations, activation …

Immune Landscape Of Early Liver Metastatic Lesions In A Novel Immunocompetent Murine Colorectal Cancer Metastasis Model, Alaa Mohamed

Dissertations and Theses (Open Access)

Colorectal cancer minimal residual disease (MRD) represents a major clinical problem for colorectal cancer patients, with failure rates of surgery and adjuvant chemotherapy between 5% to 40% depending on stage of disease. In our study, we simulated MRD using genetically engineered organoids with precise somatic editing of APC and TP53, creating a murine model that mimics human liver metastatic colorectal cancer. By implementing a meticulously timed experimental metastatic model, we could detect microscopic tumor lesions. Through genomic and transcriptomic analyses, we pinpointed the importance of macrophages, particularly those expressing high levels of CSF1R, in these microscopic metastatic focal lesions. We …

Impact Of Tumor Cell Expressed Cd38 On Metastasis And Immune Evasion In Breast Cancer, Tanvi Visal

Dissertations and Theses (Open Access)

Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer subtype. The epithelial-to-mesenchymal transition (EMT) of cancer cells is a key feature of the metastatic cascade and is not a binary process but often generates malignant cells with both epithelial (E) and mesenchymal (M) traits known as hybrid EM cells. Recent studies highlight the enhanced metastatic potential of the hybrid EM cells. However, molecular insights and targetable vulnerabilities within hybrid EM remain elusive. We discovered that hybrid EM murine tumors are enriched in CD38, an immunesuppressive molecule associated with worse clinical outcomes in liquid malignancies but relatively understudied in solid …

Exploring Veto Activity: Dnam-1-Cd155 Axis In Overcoming Nk Cell-Mediated Allo-Rejection And Applications For Car-T Cell Therapy, Wei-Hsin Liu

Dissertations and Theses (Open Access)

As Miller et al. defined veto activity, it enables cells to target host cytotoxic T lymphocyte (CTL) precursors specific to veto cells' antigens, selectively eliminating anti- donor T cell clones without inducing rejection. By leveraging this unique immune property, two key research aims were proposed: “Exploration of the Impact of Veto Activity on Natural Killer (NK) Cell-Mediated Allo-rejection” and “Development of Off-the- shelf Chimeric Antigen Receptor (CAR)-T Therapy: Engineering Anti-Viral Veto CD8+ T Cells”. As demonstrated in our previous research, in a murine model with mild conditioning, anti-third-party central memory CD8+ veto T cells (veto Tcm) can prevent T cell- …

Harnessing The Immunomodulatory Potential Of Radiofrequency Ablation To Improve Therapeutic Outcomes In Pancreatic Ductal Adenocarcinoma, Bhumi Maniyar

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDAC) continues to rank among the most lethal cancers with poor prognosis. PDAC is characterized by a thick desmoplastic stroma, severe immunological suppression, and resistance tostandard treatments. The need for innovative therapeutic approaches is highlighted by the tumor microenvironment's (TME) critical role in promoting disease development and reducing the effectiveness oftreatment. A promising locoregional treatment that can induce tumor necrosis and modify the TME is endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA). However, there is still minimal understanding around its wider impact on stromal remodeling and immunological activation. This study investigates the immunomodulatory effects of RFA combined with neoadjuvant …

Exploring The Immunologic Consequences Of Atrx Deficiency In Glioma, Benjamin Whitfield

Dissertations and Theses (Open Access)

ATRX is a key chromatin regulator that is frequently mutated across multiple cancer types. One of the most common ATRX-mutated tumor types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic regulation at a cell level; however, less is known about the impact of ATRX mutation on immune signaling. Furthermore, little is known about the interaction of ATRX loss with gain-of-function mutations in IDH. In this paper we set out to explore the impact of ATRX loss on immune signaling in gliomas, both in the context …

Stat3, Nf-Κb, And Estrogen Receptor Beta: The Balance Of Inflammation In K-Ras Mutant Lung Adenocarcinoma, Michael J. Clowers

Dissertations and Theses (Open Access)

K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. This network is underpinned by interaction and coordination of two inflammatory pathways: signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). The balance of these transcription factors determines the degree of anti- vs. pro-tumor immunity, and a skewing towards STAT3 is known to promote tumor development and a pro-tumor TIME. It is also …

Mhc Class I Tyrosine Phosphorylation Site Y320 Augments Cd8+ T Cell Priming, Effector Function, And Memory Response, Yimo Sun, Gregory A Lizee, Yitao Tang, Priscilla Ortiz, R Eric Davis

Dissertations and Theses (Open Access)

The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K^b had reduced capacity to generate K^b-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at least in part) to defects in endolysosomal trafficking of H-2K^b and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether there are additional, post-presentation dependencies on Y320 for T-cell priming. We engineered both human- and mouse-derived antigen-presenting cells (APCs) to express either wild-type MHC-I or variants of …

Investigating Metabolic And Mitochondrial Adaptations Triggered By Blood Flow During The Endothelial-To-Hematopoietic Transition, Paulina Horton

Dissertations and Theses (Open Access)

Hematopoietic stem cell (HSC) transplant is the standard of care for many hematologic diseases. However, many patients cannot benefit from this potentially curative treatment because they cannot find a suitable donor, contributing to a high level of unmet need. Recently, bona fide HSCs capable of robust engraftment and differentiation have been generated from iPSCs utilizing wall shear stress (WSS) to help promote HSC generation. However, the mechanisms through which WSS regulates hematopoiesis remain poorly understood. Scientists, therefore, continue to look for the mechanotransduction pathways that promote hematopoiesis, and key answers may lie in examining the role of extrinsic factors that …