Digital Commons Network^™

Characterization Of Tick Exoproteins Interacting With Anaplasma Phagocytophilum, Yilei Qin

Public Health Theses

Anaplasma phagocytophilum (Ap) is an Ixodes-transmitted obligate intracellular bacterium thatinfects neutrophils and causes human granulocytic anaplasmosis. Ap alternates between an infectious dense-cored (DC) form and a replicative reticulate cell (RC) form, and successful transmission depends on coordinated interactions at the vector–pathogen interface. Tick extracellular and secreted proteins (the tick exoproteome) likely contribute to Ap survival and transmission, yet many proposed tick factors remain computationally annotated with limited experimental validation. In this thesis, I prioritize candidate tick exoproteins, identified from yeast- display screens using whole Ap organisms, and evaluate them using a two-step validation strategy. First, I quantify tissue-specific expression of …

Invasive Pneumococcal Disease: Outcomes And Vaccine Effectiveness By Risk Profiles Among A Pediatric Cohort From 2002 – 2025, Keyner Rojas

Public Health Theses

AbstractBackground: Invasive pneumococcal disease (IPD) remains a significant cause of morbidity and mortality among children globally, despite the widespread use of protein conjugate vaccines (PCVs). While the introduction and implementation of these vaccines have drastically reduced the incidence of vaccine-type invasive disease, shifts in circulating serotypes raise concerns of serotype replacement. Methods: This study is a retrospective observational study of pediatric IPD cases in Massachusetts from 2002 – 2025. Over the course of these 23 years, the Massachusetts Department of Public Health has operated an enhanced population-based, statewide surveillance system for IPD. Isolates of Streptococcus pneumoniae from normally sterile sites …

Vibriosis In Connecticut: Case Trends And Seasonality, 1997–2024, Lisa Michelle Stutzman

Public Health Theses

Vibrio bacteria species, including V. vulnificus and V. parahaemolyticus, cause vibriosis, which can present as gastrointestinal illnesses, wound infections, or septicemia. In the United States the geographical range of these infections is growing, with the northward expansion of Vibrio along the Atlantic coast highlights the importance of understanding trends in vibriosis in Connecticut. This analysis is based on surveillance data from the Connecticut Emerging Infections Program from January 1, 1997–December 31, 2024. Analyses were restricted to culture-confirmed cases to ensure consistent case definitions and conducted on data aggregated to the state level. Descriptive statistics were used to characterize trends in …

Effectiveness Of The Release Of Wmel Wolbachia-Infected Aedes Aegypti Mosquitoes On The Incidence Of Chikungunya In Campo Grande, Brazil, Vivienne Zhong Ying Su

Public Health Theses

Chikungunya is a mosquito-borne arboviral disease primarily transmitted by Aedes aegypti and Aedes albopictus that is rapidly emerging in new geographical settings because of climate change, viral adaptation, and globalization. Brazil has experienced the significant expansion of chikungunya over the past decade and has adopted novel vector control interventions, including Wolbachia-based population replacement, as part of its public health response. While the effectiveness of wMel Wolbachia on dengue incidence has been demonstrated across multiple settings, evidence on its effect on chikungunya risk remains limited. Large-scale releases of wMel-infected Aedes aegypti mosquitoes were implemented in the city of Campo Grande, Brazil …

Redefining Hospital-Acquired Rsv: Epidemiologic Burden And Probabilistic Classification In A Large Health System, Anna Trinh

Public Health Theses

Healthcare acquired respiratory syncytial virus (HA RSV) is an important but under recognized infection in adult patients. Current surveillance definitions classify RSV as healthcare acquired when a positive test occurs ≥48–72 hours after admission, despite a broad incubation period of 2–8 days which would allow community acquired infections to present several days into hospitalization. This thesis has two aims: (1) to describe the epidemiology of adult HA RSV cases in the Yale New Haven Health System (YNHHS) from 2021–2025, and (2) to develop an incubation period-based probabilistic model to assess the plausibility of each HA RSV classification. Among 2,905 laboratory-confirmed …

Influenza-Associated Hospitalizations And Socioeconomic Status In Southern Connecticut, 2022-2025, Allison Traiger

Public Health Theses

Background: Influenza is a common respiratory illness in the United States responsible for hundreds of thousands of influenza-associated hospitalizations each year. To implement effective preventative interventions, it is crucial to understand which populations are most at risk of severe illness and hospitalization. Prior studies have found that increased rates of poverty and crowding are associated with increased rates of hospitalization.Methods: This study explores the connection between neighborhood poverty, crowding, and influenza-associated hospitalization through the connection of hospitalized influenza cases with their census tract-level socioeconomic indicators. Addresses of hospitalized cases were geocoded and linked to data on poverty and crowding from …

Asymptomatic Tb Duration And Transmission Models, Zhichao Zhou

Public Health Theses

Tuberculosis (TB) transmission is sustained in part by asymptomatic disease states that limit the effectiveness of passive case finding interventions that rely on symptom-based diagnosis. Here we develop a transmission model that represents the duration of asymptomatic disease with a gamma-distributed waiting time. By chaining multiple asymptomatic sub-states, we find that the gamma-distributed model provides a better fit to the observed distribution of the duration of asymptomatic disease than a simple one-state model which imposes an assumption of an exponentially-distributed duration of asymptomatic disease. Comparing the fitted gamma-distributed model and the simple model, we quantify how assumptions about the distribution …

Hiv Screenings In Dental Settings Feasibility, Challenges And Opportunities, Leander Nguyen, Melissa Yap, Ezzard Rolle Dds, Alison Newgard Dds

The New York State Dental Journal

Integrating human immunodeficiency virus (HIV) screening into dental settings presents a valuable opportunity to enhance early detection and reduce transmission rates. Dentists regularly interact with at-risk populations and can use rapid oral fluid tests, which are noninvasive and reliable. Studies show that both dental professionals and patients are generally receptive to this practice, though barriers remain, including cost, provider training and concerns about scope of practice. Implementing structured education, clear protocols and interprofessional collaboration can support widespread adoption. Overall, dental HIV screening holds promise as a feasible and impactful public health intervention.

Gut And Blood Diversity Microbiota Of Tilapia (Oreochromis Niloticus) Reared In Aquaponic Systems: A Scoping Review, Ang´Elica Adiaç˜Ao Jossefa, Leonildo Dos Anjo Viagem, Brunno Da Silva Cerozi Brunno Da Silva Cerozi, Sebastian Wilson Chenyambuga Sebastian Wilson Chenyambuga Chenyambuga

All Rsif Scholars' Publications

Tilapia is commonly integrated with vegetables in aquaponics systems, where complex microbial interactions may have important implications for food safety. This scoping review examines the current evidence on the microbiota diversity of tilapia reared in aquaponics systems, analyzes its potential influence on food safety, and highlight direction for future research. The review followed the Preferred Reporting Items for Systematic Re- views and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and included studies pub- lished between 2000 and 2025, retrieved from five scientific databases, including Google Scholar, Web of Science, Science Direct, PubMed, and Wiley Online Library. Only three studies met …

Widowed And Wounded? Exploring The Health Impacts Of Adverse Childhood Experiences In Later Life Widowhood, Sierra Wickline

UNF Graduate Theses and Dissertations

Losing a spouse is considered one of the most stressful life events that disproportionately affect older individuals. Exposure to traumatic events at an early age can change the body’s response to subsequent stressors across the lifespan. These physical changes often impact people’s health. Utilizing data from the Health and Retirement Study, the current study aimed to investigate the link between: adverse childhood experiences (ACEs) and three indicators of health: inflammation (i.e., c-reactive protein [CRP], reflecting immune functioning), as well as self-reported depressive symptoms and physical health, among people who have lost a spouse. Participants included 97 widowed individuals aged 68 …

Social Support, Trauma And Neurophysiological Stress, Devon S. Glicken

UNF Graduate Theses and Dissertations

Traumatic life experiences and the prolonged effects of stress can negatively impact an individual’s mental and physical health. Hyperreactivity to acute stressors can often be seen in individuals with anxiety, depression, and suicidal ideations, conditions commonly observed with endocrine dysfunction. How do traumatic experiences, particularly experiences related to military affiliation, influence stress responses and feelings of burdensomeness and thwarted belongingness? This study predicted (1) that military-affiliated individuals (and those with PTSD symptomology and high perceived life stress) will have heightened neurophysiological responses to minor levels of acute stress compared to individuals without military-affiliations (and those without PTSD symptomology or high …

Studies Towards Chemical Synthesis Of Homogeneous Prion Glycoprotein, Baotong Tian

Electronic Theses & Dissertations (2024 - present)

Prion diseases are fatal neurodegenerative disorders initiated by conformational misfolding of the prion protein (PrP), which generates pathogenic conformers that propagate via templated conversion and accumulate as aggregates. Glycosylation can modulate the PrP folding energy landscape, thereby biasing folding trajectories and the distribution of resulting conformational states. Bank vole PrP contains two N-linked glycosylation sites, and disentangling the contributions of site occupancy versus glycan structure requires homogeneous, site-defined glycoforms. In contrast, biosynthetic expression typically produces heterogeneous glycoform ensembles due to multistep Golgi processing, precluding independent control of glycan identity at each site. Here we report a chemical synthesis strategy of …

Human Vaccine Hesitancy Spillover In The Field Of Veterinary Medicine: A Systematic Narrative Review Of Impacts And Veterinary Responses, Allison Schimpf

HEAL Project Outputs

Human vaccine hesitancy spillover in the veterinary field is a relatively new concept that has gained traction since the COVID-19 pandemic. Concerns about vaccine safety have increased among pet owners leading to questions about the potential impacts of reduced vaccination and how veterinarians can address these attitudes. A systematic search strategy following PRISMA 2020 guidelines was used with 3 different databases to collect peer-reviewed research articles from 2022 until now. The initial search yielded 376 articles for review and 11 were included after screening. Articles were analyzed using a narrative review format. Results showed that pet owners are more vaccine …

Assessing Sandfly & Mosquito Abundance, Richness, And Diversity In Villaflora, Ecuador: Linking Disease Vectors To Disease Risk, Carlia Rose Lopez

Student Scholarship

No abstract provided.

Effects Of Desiccation On Invasive Faucet Snail (Bithynia Tentaculata) And Trematode Survival, Elise Marie Jordahl

Graduate Research Theses & Dissertations

Parasitism is one of the most common and diverse life history strategies, yet relatively little is known about the role of parasites as invasive species. Invasive species, which present one of the greatest threats to biodiversity, often need to overcome adverse environmental conditions as they establish and spread in new habitats. Invasive parasites are subject to these same conditions, though the effects may be mediated through their hosts. Here, I use an invasive snail and its trematode parasites to quantify the effects of desiccation on survival to better understand how processes of invasion play out in host-parasite systems. The faucet …

The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee

Graduate Theses/Dissertations

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional mechanism mediated by ADAR enzymes that can alter RNA sequence, protein function, and gene regulation. Because ADAR1 is upregulated during inflammation and plays a critical role in innate immunity, previous studies investigated the effects of acute inflammation on RNA editing in male and female mice. Lipopolysaccharide (LPS) was used to induce inflammation, and RNA editing levels were examined in the heart, brain, and skeletal muscle. While editing levels in the heart and brain remained unchanged, skeletal muscle exhibited tissue- and sex-specific differences in editing. In this thesis, LPS treatment affected selective editing, increasing …

Adapting A Smartphone-Based Auricular Point Acupressure Self-Management Program For Rural Chronic Musculoskeletal Pain: Qualitative Study, Jungkyung Min, Peiyin Hung, Jane N Bolin, Rupsikha Bora, Sarah Pace, Patricia Pitones, Hulin Wu, Jennifer Kawi

Faculty, Staff and Student Publications

Background: Chronic musculoskeletal pain is more prevalent in rural areas where access to pain interventions, including complementary approaches like Auricular Point Acupressure (APA), remains limited. APA is a non-invasive, needle-free approach, and its smartphone-based self-management delivery model has not been optimized for rural contexts.

Objectives: To explore the perspectives of rural partners on adapting a smartphone-based Auricular Point Acupressure-Self-Management (APA-SM) program to better meet rural needs. Study objectives were to: (1) refine the APA-SM program for rural adults, (2) identify implementation barriers, (3) understand practice workflows and engagement, and (4) identify strategies to integrate the APA-SM program into rural pain …

Using “Big Data” And Non-Linear Machine Learning To Infer Groundwater Contamination Mechanisms Across A Spatially Extensive, Geologically Heterogeneous Region, Ioan Petculescu, Anna Majury, R. Stephen Brown, Kevin Mcdermott, Paul Hynds

Research Outputs: 2025-Present

Groundwater accounts for approximately 98% of available freshwater, with >2 billion people relying on it as a primary drinking water source. Notwithstanding its importance, specific groundwater quality parameters - namely microbial concentrations and non-Escherichia coli coliforms (NEC) - remain understudied. The current study sought to address this gap by modelling three distinct Contamination Indices (CI) corresponding to E. coli concentration, NEC concentration, and the NEC:E. coli concentration ratio. CIs were developed for south Ontario (115,693 km²) using ∼1 million samples from ∼290,000 wells collected between 2010 and 2021. To permit modelling, CIs were linked to 50 subregion-specific variables …

A Case Of Delayed Cutaneous Manifestation Of Mrsa Bacteremia In A Hemodialysis Patient, Ndukeabasi Nze, Jenna Alkhatib, Morgan Caradonna, Soumyadeep Bag, Alan Baggett

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster

Mapping Historical Neighborhoods With Geospatial Viewshed Buffers, James B. Townsend

Dissertations, Master's Theses and Master's Reports

The concept of neighborhood has been long studied with little agreement beyond the notion that neighborhoods are somewhat self-contained areas within a wider urban environment. Despite the lack of a finite definition, there is wide agreement of the importance of studying population dynamics at the neighborhood scale. Many attempts have been made to spatially define, measure, and quantify contemporary neighborhoods, but less attention has been given to methods to spatially define historical neighborhoods. In this paper, we utilize a historical spatial data infrastructure for the city of London, Ontario to develop a viewshed methodology that recognizes that ‘neighborhood’ is unique …

When Fever And Thrombocytopenia Are Not Infectious: A Case Of Vitamin B12 Deficiency Mimicking Tropical Fever, Ram Arvind Viswanathan Dr

Digital Journal of Clinical Medicine

Vitamin B12 deficiency is classically associated with megaloblastic anaemia and neurological manifestations; however, atypical presentations continue to pose diagnostic challenges. Fever in association with thrombocytopenia often prompts evaluation for infectious aetiologies such as dengue, malaria, or sepsis, particularly in tropical settings. We report a case of vitamin B12 deficiency presenting with pyrexia and isolated thrombocytopenia, initially suspected to be an infectious illness. Extensive evaluation failed to reveal an infective cause, and subsequent haematological workup demonstrated megaloblastic changes with low serum vitamin B12 levels. Remarkably, the patient showed rapid defervescence and normalisation of platelet counts following parenteral vitamin B12 therapy. This …

Comorbid Psychosis In The General Population, Mariam Sankoh

Theses and Dissertations

Psychosis is a complex psychiatric phenotype characterized by substantial heterogeneity in symptom presentation, psychosis diagnosis, comorbidity patterns, and genetic architecture across diverse populations in the general population. Despite advances in psychiatric epidemiology and genomics, important gaps remain in understanding how psychosis symptoms and psychosis-related diagnoses manifest across racial and ethnic groups and how evolutionary genomic factors may contribute to disease risk and cross-ancestry genetic prediction. This dissertation, Characterizing Comorbidity in Psychosis in the General Population, integrates epidemiological, psychometric, and evolutionary genetic approaches to examine psychosis across diverse populations.

Aim 1 examined racial and ethnic differences in psychosis comorbidity patterns …

Tuberculosis In Jim Crow Virginia, 1900-1972, Elizabeth Dooley

Theses and Dissertations

Tuberculosis (TB) was a major public health concern in the United States, especially in the first half of the twentieth century. Transmission and treatment of the disease, which is spread between humans through close contact, was complicated by racial segregation laws in the South known as Jim Crow laws. Virginia subscribed to these laws, which played a role in how and where Black Virginians with TB could be treated. Segregated treatment facilities with an inadequate number of beds for the number of infected people and deaths in the state added to these complications of disease control and plan for eradication. …

Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam

Graduate Research Theses & Dissertations

Paper spray mass spectrometry (PS-MS) is a novel ambient ionization method that allows chemical and biological samples to be rapidly analyzed with little preparation being required. In this paper, PS-MS was set up and streamlined as an acetylcholinesterase (AChE)-monitoring platform in addition to screening an existing and newly produced AChE-inhibitors. The detection of the substrate, acetylcholine (m/z 146), and the AChE catalysis product, choline (m/z 104) was performed without applying chromatographic separation or derivatization to the dried paper substrates. Assay conditions were optimized in a systematic way, to develop a robust MS-compatible enzymatic workflow.

Calibration curves for both, acetylcholine and …

Building The Infection Prevention Workforce: Development, Implementation And Evaluation Of Texas Epidemic Public Health Institute Infection Prevention And Control 300 Series, Kayla E Ruch, Janelle Rios

Faculty, Staff and Student Publications

Background: The Texas Epidemic Public Health Institute (TEPHI) was established to strengthen infectious disease preparedness across Texas. The Infection Prevention and Control (IPC) 300 Series represents the third year of a multi-tiered educational initiative designed to provide free, accessible, evidence-based IPC training and continuing education credits for the healthcare workforce.

Methods: Registration and attendance data were collected through Zoom™ and Microsoft Teams™. Knowledge assessments, post-module surveys, and mid- and end-of-series evaluations were administered through QuestionPro™. Module content was informed by guidance from APIC, CDC, CMS, and OSHA. Descriptive statistics and the Kirkpatrick Model of Training Evaluation were used to assess …

Understanding Practices Of Lactation And Infant Feeding Together With Women With Hiv: The Uplift Observational Study Protocol, Christiana Smith, Emily Anne Barr, Karen Hampanda, Mark Trumbull, Hulin Wu, Jennifer Mckinney, Sarah Buisson, Carly Hoffmann, Ciarra Brown, Angela B Hutchinson, K Rivet Amico, Ifeyinwa V Asiodu, Elizabeth J Mcfarland, Margaret A Lampe, Preetam A Cholli, Olga Varechtchouk, Allahna Esber, Athena P Kourtis, Lisa Abuogi

Faculty, Staff and Student Publications

Introduction: There is a limited understanding of infant feeding decisions, practices, and outcomes for women living with HIV (WLHIV) and their infants since U.S. guidelines were updated in 2023 to support breastfeeding for virally suppressed women on antiretroviral treatment.

Methods and analysis: The Understanding Practices of Lactation and Infant Feeding Together with women with HIV (UPLIFT) study is a convergent mixed-methods, multisite, observational study designed to address key knowledge gaps. Twelve US sites will begin enrollment in early 2026 to accomplish three core activities (CA). In CA1, we explore infant feeding decision-making and experiences via in-depth interviews with pregnant/postpartum WLHIV …

Enhancing Surgical Safety, Sarah Moxon

IdeaFest 2026

Surgical site infections (SSIs) account for 20% of hospital-acquired infections, increasing patients’ risk of disability and mortality and raising costs for hospitals. This quality improvement project, using the Model for Evidence-Based Practice Change, aims to reduce SSIs at a rural hospital by 20% within one year. Engaging key players, proven strategies will be implemented, including preoperative nasal decolonization, reducing operating room traffic, and using an SSI risk tool. These strategies will be evaluated through electronic medical record (EMR) documentation audits, tracking door openings, nasal swab cultures, and surveys assessing the SSI risk tool’s impact on clinical decision-making.

Skin Tone Inclusive Assessment To Reduce Missed Pressure Injuries, Sheena May Viste

IdeaFest 2026

Patients with high‑melanin skin are at increased risk of developing pressure injuries and experiencing more severe progression because early signs are frequently missed. This disparity is attributed to delayed PI recognition because standard visual skin assessments are biased toward light skin and fail to identify early tissue damage (Black et al., 2023; LaFond et al., 2025). Implementing the Skin Assessment for Dark Skin (SADS) technique—use of halogen light and multisensory palpation—during assessments helps nurses identify early pressure injury indicators. The overarching goal is to reduce diagnostic delays by using tools such as Skin Assessment for Dark Skin (SADS) to support …

Pestilent Air, Contagious Evil: Infectious Disease In Early Modern Poland, Danielle Marie Airola

Graduate Student Theses, Dissertations, & Professional Papers

The individuals buried in the cemetery of Czysty Square and the population of the vanished village of Gać lived and died during the early modern period in what is now modern-day Poland. Epidemics broke out repeatedly during this time, and the skeletal remains of several individuals buried in Czysty Square’s cemetery display pathological changes suggestive of infectious disease. These non-specific morphological changes created a need for DNA testing to search for pathogens associated with these lesions. In contrast, Gać’s population declined over time until the village’s abandonment. This has led to a hypothesis of an epidemic having contributed to the …

N Y State Dent J January 2026

The New York State Dental Journal

In the January 2026 issue, the reader will find the following feature articles:

• No Need to Travel the Road to Licensure Renewal Alone
• IPS Subperiosteal Implant for the Maxilla and Mandible
• Amyloidoma of the Palate
• Titanium Hypersensitivity as Possible Cause of Dental Implant Failures

This issue includes regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.