Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 2491 - 2520 of 23007

Full-Text Articles in Entire DC Network

The Bg News November 12, 2025, Bowling Green State University Nov 2025

The Bg News November 12, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 12, 2025. Volume 105-Issue 11.


Integrating Heritage Assets Into Peatland Restoration: Finding, Assessing And Valuing The Palaeoenvironmental Archive, Heather Davies, Ralph Fyfe Nov 2025

Integrating Heritage Assets Into Peatland Restoration: Finding, Assessing And Valuing The Palaeoenvironmental Archive, Heather Davies, Ralph Fyfe

School of Geography, Earth and Environmental Sciences

Peatland restoration projects aim to improve the delivery of ecosystem services. Cultural heritage and Historic Environment assets are usually identified as co-beneficiaries of restoration but are not commonly well-integrated at the planning or design stages. This paper considers the heritage value of upland peatlands and methods for integrating these values in ecosystem services approaches. Taking Exmoor National Park as a case study, an extensive walkover survey identified 119 small mires and assessed their cultural heritage asset potential. Many were not previously recognised as part of the Historic Environment potential of the upland. A novel valuation system based on proximity of …


The Gut Microbiome As A Modulator Of Traumatic Brain Injury Pathology And Symptoms, Cole Vonder Haar, Marta Celorrio, Kris M Martens, Stuart H Friess, Sonia Villapol, Randal J Urban, Richard Pyles, Richelle Mychasiuk, Dennis Simon, Amanda Dave Nov 2025

The Gut Microbiome As A Modulator Of Traumatic Brain Injury Pathology And Symptoms, Cole Vonder Haar, Marta Celorrio, Kris M Martens, Stuart H Friess, Sonia Villapol, Randal J Urban, Richard Pyles, Richelle Mychasiuk, Dennis Simon, Amanda Dave

2020-Current year OA Pubs

Traumatic brain injuries (TBIs) affect millions annually, leading to devastating neurobehavioral consequences and increasing risk for neurodegenerative and psychiatric diseases. However, therapies are lacking. Starting in 2018, dysbiosis of the gut microbiome was identified as an acute, and potentially chronic, pathology originating from TBI. Recent studies established that the microbiome contributes to the evolution of TBI pathology and functional impairments. The gut microbiome is the collection of microorganisms that inhabit the stomach through colon and is indicated as a contributor to myriad neurological and psychiatric conditions. This makes it an intriguing target to understand in the context of TBI. Thus, …


Dendritic Inhibition Effects In Memory Retrieval Of A Neuromorphic Microcircuit Model Of The Rat Hippocampus, Nikolaos Andreakos, Vassilis Cutsuridis Nov 2025

Dendritic Inhibition Effects In Memory Retrieval Of A Neuromorphic Microcircuit Model Of The Rat Hippocampus, Nikolaos Andreakos, Vassilis Cutsuridis

School of Engineering, Computing and Mathematics

Background: Studies have shown that input comparison in the hippocampus between the Schaffer collateral (SC) input in apical dendrites and the perforant path (PP) input in the apical tufts dramatically changes the activity of pyramidal cells (PCs). Equally, dendritic inhibition was shown to control PC activity by minimizing the depolarizing signals in their dendritic trees, controlling the synaptic integration time window, and ensuring temporal firing precision. Objectives: We computationally investigated the diverse roles of inhibitory synapses on the PC dendritic arbors of a CA1 microcircuit model in mnemonic retrieval during the co-occurrence of SC and PP inputs. Results: Our study …


Presidents, Opinions, And Independent Officers, Jed Handelsman Shugerman Nov 2025

Presidents, Opinions, And Independent Officers, Jed Handelsman Shugerman

Faculty Scholarship

The Opinions in Writing Clause is a persistent textual problem for the claim that Article II implies an indefeasible removal power: If the Framers believed they had given the president an unconditional removal power, why would they also specify a lesser power merely to ask for opinions? New historical research confirms this textual problem was also contextual: early state constitutions, the Ratification debates, and the First Congress indicate that the Opinions Clause’s original public meaning signaled independence of department heads, or at least the possibility of congressional requirements like good cause.

Legal scholars have already shown that the texts of …


Low Mutation Rate But High Male-Bias In The Germline Of A Short-Lived Opossum, Yadira Peña-García, Richard J Wang, Muthuswamy Raveendran, R Alan Harris, Paul B Samollow, Jeffrey Rogers, Matthew W Hahn Nov 2025

Low Mutation Rate But High Male-Bias In The Germline Of A Short-Lived Opossum, Yadira Peña-García, Richard J Wang, Muthuswamy Raveendran, R Alan Harris, Paul B Samollow, Jeffrey Rogers, Matthew W Hahn

Faculty, Staff and Students Publications

Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these factors are still unclear. One approach to distinguishing between alternative mechanisms is to study species that reproduce at very young ages, as competing hypotheses make different predictions about patterns of mutation in these organisms. Here, we study the germline mutation rate in the gray short-tailed opossum, Monodelphis domestica, a laboratory model species that becomes reproductively mature at less than 6 mo of age. Whole-genome sequencing of 22 trios reveals one of the lowest mutation rates per generation …


Slc35g3 Is A Udp-N-Acetylglucosamine Transporter For Sperm Glycoprotein Formation And Underpins Male Fertility In Mice, Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M Matzuk, Masahito Ikawa Nov 2025

Slc35g3 Is A Udp-N-Acetylglucosamine Transporter For Sperm Glycoprotein Formation And Underpins Male Fertility In Mice, Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Despite the recognized importance of glycans in biological phenomena, their complex roles in spermatogenesis and sperm function remain unclear. SLC35G3, a 10-transmembrane protein specifically found in early round spermatids, belongs to the sugar-nucleotide transporter family, indicating its involvement in glycan formation. In this study, we found that Slc35g3 knockout male mice were sterile due to impaired sperm functions in uterotubal junction passage, zona pellucida binding, and oocyte fusion. Mouse SLC35G3 has UDP-GlcNAc transporter activity, and its ablation caused abnormal processing of the sperm plasma membrane and acrosome membrane proteins. Reported human SLC35G3 mutations (F267L and T179HfsTer27) diminished the UDP-GlcNAc transporter …


Unraveling The Lullabies Of Learning: Exploring The Role Of Individual Components Of Infant-Directed Speech In Language Learning, Stephanie L. Lopez Nov 2025

Unraveling The Lullabies Of Learning: Exploring The Role Of Individual Components Of Infant-Directed Speech In Language Learning, Stephanie L. Lopez

LSU Doctoral Dissertations

Children learn language more effectively from infant-directed speech (IDS) than adult-directed speech (ADS). Three experiments were run (a pilot and two full experiments) testing the effects of pitch and pitch variability on segmenting a target word out of the speech stream and then associating it to an object. Visual prosody via eyebrow movements and lip contours were added as additional cues after the Pilot Study. Additional factors included after the Pilot Study were shortened sentences from 10 syllables each to seven syllables each, shortened target words from three syllables to two syllables, consistent syllable onset of target words, and two …


Host Cysteine Proteases Promote The Severity Of Catheter-Associated Urinary Tract Infection And Kidney Fibrosis, Wei Xu, Jian Chen, Lisa K Mclellan, Ana L Flores-Mireles, David A Hunstad, Michael G Caparon Nov 2025

Host Cysteine Proteases Promote The Severity Of Catheter-Associated Urinary Tract Infection And Kidney Fibrosis, Wei Xu, Jian Chen, Lisa K Mclellan, Ana L Flores-Mireles, David A Hunstad, Michael G Caparon

2020-Current year OA Pubs

UNLABELLED: The bacterium

IMPORTANCE: Catheter-associated urinary tract infections (CAUTIs) are the most prevalent healthcare-associated infection globally, with


Morphometric And Meristic Analysis Of Labeo Coubie In Esa-Odo Water Reservoir, Esa-Odo, Osun State Nigeria, Olugbemi V. Ekundare, Funmilayo B. Oyekanmi, Mahmud Sanni, Azeez Aransi, Dorcas O. Owolabi Nov 2025

Morphometric And Meristic Analysis Of Labeo Coubie In Esa-Odo Water Reservoir, Esa-Odo, Osun State Nigeria, Olugbemi V. Ekundare, Funmilayo B. Oyekanmi, Mahmud Sanni, Azeez Aransi, Dorcas O. Owolabi

Tanzania Journal of Science

One of the common species of family Cyprinidae found in Nigeria and West Africa is Labeo coubie. They are of commercial importance in West Africa. This study embarked on the assessment of the length- weight relationship, condition factor, morphometrics and meristic characteristics of L. coubie from Esa-Odo water reservoir, Esa-Odo, Osun State Nigeria. A total of 135 (65 males and 70 females) individual L. coubie collected from fishermen were subjected to morphometric and meristic analysis. Results showed 4.90, 5.46 and 5.24 as the b value for male, female and combined sexes respectively, describing positive allometric growth for all the fish …


On The Indispensability Of Natural Law On The Moral Theory Of The State, David W. Bolton Nov 2025

On The Indispensability Of Natural Law On The Moral Theory Of The State, David W. Bolton

Liberty University Journal of Statesmanship & Public Policy

Natural Law is widely regarded as a set of universal moral standards in which the acknowledgement of the differences between right and wrong are inherent in people, not created by society or lawmakers. It is based on the consistent nature of man as opposed to varying cultural standards and is unchanged by time or circumstance. Many thinkers throughout history have offered their educated opinions on the matter of Natural Law and the moral theory of the State. The Social Contract theory of the Modern Secular thinkers of the 17th century was considered a break with classical and traditional Christian …


Automatic Gui Generation Based On Layered Queries For Interaction With Ai, Raviteja Govindaraju, Ramprasad Sedouram Nov 2025

Automatic Gui Generation Based On Layered Queries For Interaction With Ai, Raviteja Govindaraju, Ramprasad Sedouram

Defensive Publications Series

Conversational interface (UI) for artificial intelligence (AI) assistants typically uses text or speech and, as such, presents some cognitive load. The UI can be unintuitive for complex queries, leading to frustratingly long to-and-fro conversations. For sophisticated tasks, the UI can lack expressivity, forcing users to use long text prompts over multiple conversational turns. This disclosure describes techniques that enhance and simplify interactions with AI assistants using automatically generated graphical elements that enable a user to manipulate and weigh particular parameters in their input queries. Two modes of user input are defined - text mode and graphical mode - with easy …


Dual-Spectrum Multi-Layer Holographic Projection System With Shadow-Based Positional Sensing For Interactive Spatial Computing, Lorenzo Lbn Bernardini Nov 2025

Dual-Spectrum Multi-Layer Holographic Projection System With Shadow-Based Positional Sensing For Interactive Spatial Computing, Lorenzo Lbn Bernardini

Defensive Publications Series

The present invention discloses a revolutionary dual-spectrum multi-layer holographic projection system that fundamentally redefines the paradigm of human-computer spa- tial interaction by eliminating the necessity of wearable apparatus while simultaneously enabling tactile manipulation of volumetrically-rendered virtual objects. The system achieves this through an innovative architectural decoupling wherein visible-spectrum multi-projector arrays generate stratified holographic imagery across multiple depth planes, while a parallel infrared sensing subsystem performs continuous shadow-pattern analysis to extract precise three-dimensional positional information of the user within the interac- tion volume. This spectral bifurcation resolves the fundamental paradox inherent in prior art wherein projection and sensing mechanisms interfere through …


Edgar Wright’S The World’S End: What Really Matters?, Sophie Guthrie Nov 2025

Edgar Wright’S The World’S End: What Really Matters?, Sophie Guthrie

Episteme

No abstract provided.


Unearthing The Undead Prejudice: How ‘Feminist Science’ Creates A More Empirically Accurate Scientific Framework By Revealing The Inherent Bias In All Investigate Methodologies, Horatio Holloway Nov 2025

Unearthing The Undead Prejudice: How ‘Feminist Science’ Creates A More Empirically Accurate Scientific Framework By Revealing The Inherent Bias In All Investigate Methodologies, Horatio Holloway

Episteme

No abstract provided.


The Structuralist Semiotics Of Hidden Places, Alexander Shin Nov 2025

The Structuralist Semiotics Of Hidden Places, Alexander Shin

Episteme

No abstract provided.


Superintelligence And The Burden Of Intelligence: A Zapffean Critique Of Ai, James (Xiaolong) Wang Nov 2025

Superintelligence And The Burden Of Intelligence: A Zapffean Critique Of Ai, James (Xiaolong) Wang

Episteme

No abstract provided.


Episteme Vol. 36 Nov 2025

Episteme Vol. 36

Episteme

No abstract provided.


Cv: Philip Blankenship (Behavioral Neuroscience), Philip Blankenship Nov 2025

Cv: Philip Blankenship (Behavioral Neuroscience), Philip Blankenship

Psychology Department Faculty Curricula Vitae

No abstract provided.


Anonymity And Social Pressure: A Sociological Analysis Of Lolcows On Kiwifarms, Mary R. Smith Nov 2025

Anonymity And Social Pressure: A Sociological Analysis Of Lolcows On Kiwifarms, Mary R. Smith

Honors Theses

This research assesses the website KiwiFarms using a mixed-methods approach, including content analysis and descriptive statistics, to determine whether demographic factors, such as weight, disability, and sexuality, influence an individual’s susceptibility to online trolling for others' entertainment.

The study found that most disproportionately targeted group was found to be overweight females. Meanwhile, Kiwi Farms users were found to be predominantly male, aged 18-24, and reside in the United States. The study's results indicate that the expressions of anomie on KiwiFarms are predominantly disciplinary, suggesting that KiwiFarms users mainly focus their criticism on rule violations rather than targeting individuals based on …


The State Of Our Streams: A Land Trust's Approach To Monitoring The Health Of Three Headwater Streams, Lauren Mcgrath Nov 2025

The State Of Our Streams: A Land Trust's Approach To Monitoring The Health Of Three Headwater Streams, Lauren Mcgrath

Sustainability Research & Practice Seminar Presentations

Lauren McGrath, Director of Watershed Protection Program, Willistown Conservation Trust, presents "The State of Our Streams: a land trust's approach to monitoring the health of three headwater streams."


Heritage-Based City Branding Case Study Of Fayoum City, Menna Mounir, Sameir Hammad Nov 2025

Heritage-Based City Branding Case Study Of Fayoum City, Menna Mounir, Sameir Hammad

Mansoura Engineering Journal

Uniqueness and distinction have become fundamental requirements in promoting and branding cities. Influencing people's perceptions is best achieved by reinforcing the city's identity. This identity is the main component that can transform any ‘space’ into a ‘place’. Promoting a city should extend to highlighting the Heritage, landscape, religious sites, pathways, cuisine, inhabitants, activities, and personal experiences. These elements collectively express the city spirit and enrich visitors’ experience.

This study aims to enhance the image of heritage-based cities by exploring the potential for city branding and leveraging heritage to boost the national economy.

Fayoum was selected as a case study for …


Cardiac Sr-Mitochondria Contacts-Impact On Cardiac Physiology And Mitochondrial Fitness, Celia Fernandez-Sanz, Shey-Shing Sheu, Sergio De La Fuente Nov 2025

Cardiac Sr-Mitochondria Contacts-Impact On Cardiac Physiology And Mitochondrial Fitness, Celia Fernandez-Sanz, Shey-Shing Sheu, Sergio De La Fuente

Center for Translational Medicine Faculty Papers

In adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structures that regulate various physiological processes, including lipid exchange, calcium (Ca2+) communication, control of excitation-contraction bioenergetics coupling, and reactive oxygen species (ROS) production. Over the years, several scientific studies have reported the accumulation of diverse proteins within these SR-mitochondria close contacts. Some proteins strategically accumulate in these areas to enhance their function, such as the mitochondrial Ca2+ uniporter, while others …


Epigenetic Landscape In Lysosomal Storage Disorders: Mechanisms And Modulation, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu Nov 2025

Epigenetic Landscape In Lysosomal Storage Disorders: Mechanisms And Modulation, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) are rare substrate-accumulating diseases primarily characterized by mutations in genes encoding proteins involved in lysosomal function, most of which have enzymatic activity. Resulting lysosomal dysfunction leads to the overaccumulation of non- or partially degraded substrates. While it is true that enzyme deficiency is the primary cause of LSDs, the epigenetic alterations in DNA methylation, miRNA expression, and histone modifications appear to be critical mechanisms involved in the pathogenesis of LSDs. As epigenetic marks are, in most cases, reversible, their study becomes vital to developing strategies aimed at reversing epigenome alterations. Although classical therapeutic alternatives aim to …


Postmortem Vitreous Humor As An Alternative Matrix To Peripheral Blood For Benzodiazepine Detection, Sara Bussey Nov 2025

Postmortem Vitreous Humor As An Alternative Matrix To Peripheral Blood For Benzodiazepine Detection, Sara Bussey

Honors Theses

Benzodiazepines are commonly prescribed secondary drugs of abuse that cause Central Nervous System depression through the neurotransmitter gamma aminobutyric acid. While not commonly fatal on their own, benzodiazepines have a minor risk for physical dependence and abuse. They also can have cumulative effects with other medications that can lead to overdose situations; thus, they are considered secondary drugs of abuse. While peripheral blood is considered the standard for xenobiotic detection in postmortem forensic toxicology, it is important to consider the validity of alternative matrices that could be analyzed in the event that blood was not available due to circumstances like …


Exploring Counselor Perspectives On The Role Of Ecotherapy In Mental Health Treatment: A Qualitative Study, Kimberly Seid Nov 2025

Exploring Counselor Perspectives On The Role Of Ecotherapy In Mental Health Treatment: A Qualitative Study, Kimberly Seid

Walden Dissertations and Doctoral Studies

This grounded qualitative study explored the common themes of ecotherapy in practice. The research problem was the limited understanding of how counselors implement ecotherapy in clinical practice, hindering the field’s ability to fully integrate nature-based approaches into mental health treatment. The purpose of this grounded theory study was to explore counselor perspectives on ecotherapy using the biophilia hypothesis and Swarbrick’s wellness model. The research questions focused on how licensed mental health counselors understood, implemented, and evaluated the impact of ecotherapy. Qualitative data were collected through an online survey with open-ended questions from 15 licensed counselors across the United States who …


Spartan Daily, November 11, 2025, San Jose State University, School Of Journalism And Mass Communications Nov 2025

Spartan Daily, November 11, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 34


Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon Nov 2025

Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon

Faculty, Staff and Student Publications

Toll-like receptor (TLR) agonists, as potent immunostimulatory adjuvants, play a critical role in linking the innate and adaptive immune responses. However, their antitumor effects as cancer immunotherapeutic agents have been limited. Here, we report our finding that manganese ion (Mn2+) potentiates various TLR agonists, leading to robust activation of the TLR pathway and the stimulator of interferon genes (STING) pathway among innate immune cells. In particular, we have observed robust antitumor efficacy after intratumoral administration of a TLR3 agonist and Mn2+. To achieve systemic codelivery of TLR3 agonist and Mn2+, we have developed a low-molecular-weight poly(inosinic:cytidylic acid)-Mn2+ coordination lipid nanoparticle …


The Ontological Is Political, The Philosophical Discussion Group Nov 2025

The Ontological Is Political, The Philosophical Discussion Group

The Philosopher's Stone

  • The Ontological is Political


Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju Nov 2025

Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju

Faculty, Staff and Student Publications

Hepatic ischemia-reperfusion injury (H-IRI) is a critical complication in liver surgery and liver transplantation, contributing to graft dysfunction and poor clinical outcomes. When hepatocyte protective mechanisms are insufficient to counteract energy depletion and oxidative stress during ischemia, cell death occurs. Tissue damage during H-IRI leads to the release of damage-associated molecular patterns (DAMPs), which recruit and activate immune cells such as neutrophils and monocytes, orchestrating the initiation, progression, and eventual resolution of sterile inflammation. Extended criteria donor (ECD) livers, particularly steatotic ones, are more vulnerable to H-IRI, leading to poorer outcomes and limiting expansion of the donor pool. However, the …