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Articles 2461 - 2490 of 23007
Full-Text Articles in Entire DC Network
Targeting Tomm40 And Tomm22 To Rescue Statin-Impaired Mitochondrial Function, Dynamics, And Mitophagy In Skeletal Myotubes, Neil V Yang, Sean Rogers, Rachel Guerra, Justin Y Chao, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss
Targeting Tomm40 And Tomm22 To Rescue Statin-Impaired Mitochondrial Function, Dynamics, And Mitophagy In Skeletal Myotubes, Neil V Yang, Sean Rogers, Rachel Guerra, Justin Y Chao, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss
2020-Current year OA Pubs
Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well-tolerated, statins can induce myopathy, a major cause of non-adherence to treatment. Impaired mitochondrial function has been implicated in the development of statin-induced myopathy, but the underlying mechanism remains unclear. We have shown that simvastatin downregulates the transcription of
Lair1 Prevents Excess Inflammatory Tissue Damage In Staphylococcus Aureus Skin Infection And Cutaneous T-Cell Lymphoma, Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton
Lair1 Prevents Excess Inflammatory Tissue Damage In Staphylococcus Aureus Skin Infection And Cutaneous T-Cell Lymphoma, Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton
2020-Current year OA Pubs
Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the underlying mechanisms remain unclear. We have previously identified high levels of LAIR2, a decoy protein for the inhibitory receptor LAIR1, in advanced CTCL. Mice lack a LAIR2 homolog, so we used Lair1 knock-out (KO) mice to model LAIR2 overexpression. In a model of S. aureus skin infection, Lair1 KO mice had significantly larger abscesses and areas of dermonecrosis compared to WT despite similar bacterial burdens. Lair1 KO exhibited a pattern of increased inflammatory responses in infection and sterile …
Development Of Artificial Intelligence-Based Learning Media Using Powtoon Animation With A Joyful Learning Approach To Support Ppl Activities For Pre-Service Ppg Students, Zihan Novita Sari, Evania Yafie, Muhammad Alfan, Qorry Armen Gemael, Paundra Wangsa Fajar Kusuma
Development Of Artificial Intelligence-Based Learning Media Using Powtoon Animation With A Joyful Learning Approach To Support Ppl Activities For Pre-Service Ppg Students, Zihan Novita Sari, Evania Yafie, Muhammad Alfan, Qorry Armen Gemael, Paundra Wangsa Fajar Kusuma
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan
Although Artificial Intelligence (AI) has the potential to create adaptive and engaging instructional media, its application in the teaching practicum of pre-service teacher education students remains suboptimal. During field teaching practice, most pre-service teachers still rely on conventional methods and non-interactive media, resulting in learning that is teacher-centered, less engaging, and unable to accommodate diverse student needs. This condition leads to limited student participation, low classroom interaction, and ineffective delivery of material. Therefore, the development of AI-based learning media is necessary to support more interactive, personalized, and meaningful teaching practices aligned with 21st-century learning demands. This study aims to develop …
An Unusual Case Of Common Terns Nesting On A Rooftop In Ontario And An Attempt To Relocate The Colony, David J. Moore, Jeffrey N. Costa, Alexis L. Stupich
An Unusual Case Of Common Terns Nesting On A Rooftop In Ontario And An Attempt To Relocate The Colony, David J. Moore, Jeffrey N. Costa, Alexis L. Stupich
Ontario Birds
A variety of gull and tern species have adapted to urban environments by nesting on rooftops and other human-made structures. Previous reports of Common Terns (Sterna hirundo) breeding on rooftops have generally involved small numbers of nests (≤25). Here, we report an occurrence of an unusually large number of Common Terns nesting on a rooftop in Port Credit, Ontario, in 2013. A complete survey of the roof was conducted on 31 May, when 1,011 Common Tern nests were counted. A similar number of breeding pairs used this roof in 2014, but the site was largely abandoned by 2015, due to …
Full Issue, Ontario Field Ornithologists
The Breeding Status Of American White Pelicans In The Canadian Waters Of The Laurentian Great Lakes, David J. Moore, Sara C. Pereira De Souza, Maya Da Silva, D.V. Chip Weseloh
The Breeding Status Of American White Pelicans In The Canadian Waters Of The Laurentian Great Lakes, David J. Moore, Sara C. Pereira De Souza, Maya Da Silva, D.V. Chip Weseloh
Ontario Birds
No abstract provided.
Full Issue, Ontario Field Ornithologists
Is The Double-Crested Cormorant A Likely Disperser Of The Japanese Chaff-Flower To The Lake Erie Islands, Ontario?, Ronald I. Orenstein
Is The Double-Crested Cormorant A Likely Disperser Of The Japanese Chaff-Flower To The Lake Erie Islands, Ontario?, Ronald I. Orenstein
Ontario Birds
No abstract provided.
Distinguished Ornithologist 2022: Erica Nol, Douglas C. Tozer
Distinguished Ornithologist 2022: Erica Nol, Douglas C. Tozer
Ontario Birds
No abstract provided.
The University Of Guelph’S Arboretum Winter Bird Count, 1980-2022, Brandon P.M. Edwards, Alan P. Watson, Chris G. Earley
The University Of Guelph’S Arboretum Winter Bird Count, 1980-2022, Brandon P.M. Edwards, Alan P. Watson, Chris G. Earley
Ontario Birds
No abstract provided.
Loafing And Sleeping Behaviour Of Trumpeter Swans, Harry G. Lumsden, Gerry Markhoff, Gary Lane, Allan Scott
Loafing And Sleeping Behaviour Of Trumpeter Swans, Harry G. Lumsden, Gerry Markhoff, Gary Lane, Allan Scott
Ontario Birds
An observational study of loafing and sleeping behaviour of Trumpeter Swans was conducted in southern Ontario throughout the year in 2018 and 2019. Like other birds, these swans have the ability to close down one brain hemisphere at a time during rest, which is indicated by eye closure. We quantified rates of closure of eyes during sleeping bouts for both breeding and non-breeding swans. Single eye closure varied in frequency, duration and in terms of which hemisphere was shut down. Increasing duration of eye closure over time indicated an increased sense of security with surrounding in one mated pair. Proportion …
Reliability And Validity Of A Modified Version Of The Consumer Assessment Of Healthcare Providers And Systems (Cahps®) Clinician And Group Visit Survey 4.0 (Beta) For Ambulatory Behavioral Health Care, Jessica K. Jeffrey, Ron D. Hays, Randi Hissom, Mark Grossman, Samuel A. Skootsky
Reliability And Validity Of A Modified Version Of The Consumer Assessment Of Healthcare Providers And Systems (Cahps®) Clinician And Group Visit Survey 4.0 (Beta) For Ambulatory Behavioral Health Care, Jessica K. Jeffrey, Ron D. Hays, Randi Hissom, Mark Grossman, Samuel A. Skootsky
Patient Experience Journal
Patient experience is a fundamental indicator of healthcare quality. A patient experience survey that assesses telemedicine and in-person ambulatory behavioral health care is needed. This study aims to adapt the CAHPS Clinician and Group Visit Survey 4.0 (beta) to assess adult patient experience with ambulatory behavioral health services and its reliability and validity. Seven behavioral health subject matter experts (psychiatrists, therapists with master’s degrees, and primary care physicians) at an integrated delivery system aligned with an academic institution provided input to select a subset of items and make minor wording adjustments to the CAHPS survey. The adapted survey was administered …
Enhancing System-Level Quality Improvement Through Patient-Inclusive Teamwork: A Review, Shaik Mohiuddin
Enhancing System-Level Quality Improvement Through Patient-Inclusive Teamwork: A Review, Shaik Mohiuddin
Patient Experience Journal
Engaging patients in quality improvement (QI) initiatives offers significant advantages, including increased patient satisfaction, improved outcomes, and the integration of creative insights from patient perspectives. This review synthesizes findings from 14 peer-reviewed articles retrieved from PubMed and Google Scholar, focusing on patient-inclusive teamwork in healthcare settings. Despite the recognized benefits, patient involvement remains limited due to cultural and professional barriers, logistical challenges, and the need for structured training programs. The review contrasts conventional provider-centered approaches with patient-centered models, emphasizing the importance of policy reform, organizational culture change, and supportive training to enhance patient engagement. Traditional QI strategies often overlook patient …
“Better Than Any Medicine:” Understanding How Therapy Dogs Support Patients Presenting With Mental Health And Substance Use Concerns In An Emergency Department Setting, Alexandria R. Pavelich, Colleen A. Dell, James Stempien, Holly Mckenzie, Aimee Hozack, Jane Smith, Alexis Rowsell, Janet Gunderson, Elizabeth Pease
“Better Than Any Medicine:” Understanding How Therapy Dogs Support Patients Presenting With Mental Health And Substance Use Concerns In An Emergency Department Setting, Alexandria R. Pavelich, Colleen A. Dell, James Stempien, Holly Mckenzie, Aimee Hozack, Jane Smith, Alexis Rowsell, Janet Gunderson, Elizabeth Pease
Patient Experience Journal
In Canada, emergency departments have a large number of patients with mental health and substance use concerns passing through their doors. Our research aim was to assess the impact that therapy dog visits may have for patients presenting with mental health and/or substance use concerns to an emergency department based in Saskatoon, Saskatchewan. Working alongside an active patient advisory group and community-based therapy dog program volunteers, our mixed method approach utilizing ethnography, surveys, and interviews showed that therapy dog visitation had a beneficial impact on both patients and staff, thus improving the overall patient experience. Our study displays how the …
Impact Of Non-Pharmacological Interventions On Patient Experience, Opioid Use, And Healthcare Utilization In Adult Cardiac Surgery: A Randomized Controlled Mixed Methods Trial, Julie R. Piazza, Alexander A. Brescia, Jessica N. Jenkins, Alexander J. Ivacko, Xiaoting Wu, Sara M. Jafri, Christopher J. Varlamos, James C. Piazza, Lindsay K. Heering, Stefanie L. Peters, Molly Dwyer-White, Bailey H. Brown, Faraz N. Longi, Katelyn P. Monaghan, Frederick W. Bauer, Varun G. Kathawate, Melissa C. Webster, Amanda M. Kasperek, Nickole L. Garvey, Claudia Schwenzer, Kiran H. Lagisetty, Michelle Riba, Donald S. Likosky, Jennifer F. Waljee, Nicholas H. Osborne, Mary E. Byrnes, G. Michael Deeb
Impact Of Non-Pharmacological Interventions On Patient Experience, Opioid Use, And Healthcare Utilization In Adult Cardiac Surgery: A Randomized Controlled Mixed Methods Trial, Julie R. Piazza, Alexander A. Brescia, Jessica N. Jenkins, Alexander J. Ivacko, Xiaoting Wu, Sara M. Jafri, Christopher J. Varlamos, James C. Piazza, Lindsay K. Heering, Stefanie L. Peters, Molly Dwyer-White, Bailey H. Brown, Faraz N. Longi, Katelyn P. Monaghan, Frederick W. Bauer, Varun G. Kathawate, Melissa C. Webster, Amanda M. Kasperek, Nickole L. Garvey, Claudia Schwenzer, Kiran H. Lagisetty, Michelle Riba, Donald S. Likosky, Jennifer F. Waljee, Nicholas H. Osborne, Mary E. Byrnes, G. Michael Deeb
Patient Experience Journal
Non-pharmacological techniques designed to reduce anxiety, pain, and healthcare utilization have shown effectiveness in pediatric and non-surgical adult populations; however, their application has not been widely evaluated among adult surgical patients. This study randomized opioid-naive adults undergoing first-time, elective cardiac surgery to receive either targeted interventions from a trained “comfort coach” or usual care. The primary outcome assessed was healthcare utilization, specifically measured as the number of days at home within the first 30 days post-surgery. Secondary outcomes included postoperative opioid use and patient-reported outcomes, collected via validated surveys. Additionally, 50 participants in the intervention group completed semi-structured qualitative interviews …
Cv: Christina Jeslis (Nursing), Christina Jeslis
Cv: Christina Jeslis (Nursing), Christina Jeslis
Nursing Department Faculty Curricula Vitae
No abstract provided.
Bluefish (Pomatomus Saltatrix) Neurocranium, Courtney R. Schober, Alyssa Olmeda, David W. Kerstetter
Bluefish (Pomatomus Saltatrix) Neurocranium, Courtney R. Schober, Alyssa Olmeda, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
The Parthenon, November 12, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan
The Parthenon, November 12, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan
The Parthenon
No abstract provided.
Sustainability As Global Citizenship: Creating High-Impact Learning Experiences In The Honors College, Timothy Jussaume Dr.
Sustainability As Global Citizenship: Creating High-Impact Learning Experiences In The Honors College, Timothy Jussaume Dr.
Sustainability Research & Practice Seminar Presentations
Dr. Timothy Jussaume, Honors College, presents "Sustainability as Globl Citizenship: Creating High-Impact Learning Experiences in the Honors College."
Exploring The Vitronectin Binding Affinity And Cell Viability Effect Of Small Molecule Metabolites From Medicinal Plants For Neuroblastoma, Stephenie C. A Alaribe, Sofia Granados-Aparici, Akolade R. Oladipupo, Isaac Vieco-Marti, Blessing E. Titilayo, Gordon Allen, Rosa Noguera
Exploring The Vitronectin Binding Affinity And Cell Viability Effect Of Small Molecule Metabolites From Medicinal Plants For Neuroblastoma, Stephenie C. A Alaribe, Sofia Granados-Aparici, Akolade R. Oladipupo, Isaac Vieco-Marti, Blessing E. Titilayo, Gordon Allen, Rosa Noguera
Pharmaceutical Sciences and Research
High-risk neuroblastoma (HR-NB) is an aggressive form of childhood cancer with a five-year survival rate of less than 50%, underscoring the need for more efficacious and less toxic treatments. The glycoprotein vitronectin (VN) has been linked to poor prognosis in patients with HR-NB, thus inhibitors of VN function represent a promising avenue for molecular mechanotherapy. This study investigated the binding affinity between the somatomedin B (SMB) domain of VN and natural compounds from the medicinal plant, Olax subscorpioidea, targeting the plasminogen activator inhibitor-1 (PAI-1). The therapeutic potential of α-amyrin (AMY), lupeol (LUP), and olax chalcone A (olax CHA) was tested …
The College Voice, Vol. 62, No. 4 [November 12, 2025], Connecticut College
The College Voice, Vol. 62, No. 4 [November 12, 2025], Connecticut College
2025-2026
No abstract provided.
Dairy And Food Science Student Newsletter, November 12, 2025, Department Of Dairy And Food Science
Dairy And Food Science Student Newsletter, November 12, 2025, Department Of Dairy And Food Science
Dairy and Food Science Student Newsletter
No abstract provided.
Apoe-Targeted Therapeutics For Alzheimer’S Disease, Hussein N. Yassine, Cristelle Hugo, Bernadette O’Donovan, Isaiah O. Stephens, Lance A. Johnson, Gregory Cole, Julia Tcw, Jan Johansson, Kassandra Kisler, Ornit Chiba-Falek
Apoe-Targeted Therapeutics For Alzheimer’S Disease, Hussein N. Yassine, Cristelle Hugo, Bernadette O’Donovan, Isaiah O. Stephens, Lance A. Johnson, Gregory Cole, Julia Tcw, Jan Johansson, Kassandra Kisler, Ornit Chiba-Falek
Physiology Faculty Publications
Apolipoprotein E (APOE) is the major lipid transport protein in the brain. Produced primarily by astrocytes and microglia, it delivers cholesterol and other lipids for membrane repair, synaptic maintenance, and immune regulation. Through interactions with specific lipid receptors, APOE maintains neuronal and vascular health. The APOE ε4 allele (APOE4), carried by approximately one-quarter of the population, has an altered protein conformation, which reduces lipid transport efficiency and modifies receptor binding. These changes disrupt lipid homeostasis, increase risk of chronic unresolved neuroinflammation and vascular inflammation, and cause breakdown of the blood–brain barrier (BBB), thus increasing neuronal vulnerability to disease pathology and …
Multilevel Influence Of Sustainability Leaders In Business Systems, Alwen Jose Apid, Mendiola Teng-Calleja
Multilevel Influence Of Sustainability Leaders In Business Systems, Alwen Jose Apid, Mendiola Teng-Calleja
Journal of Management for Global Sustainability
Existing studies that point to the various influences of sustainability leaders on individuals, organizations, and external stakeholders remain fragmented. Using Bronfenbrenner’s Ecological Systems Theory, this study aimed for a deep examination of leaders’ experiences as they built layers of influence through their sustainability initiatives and efforts. The study employed a reflexive qualitative approach in gathering and analyzing data from semi-structured interviews with five sustainability managers working in listed fast-moving consumer goods companies. The results suggested evident patterns of sustainability-promoting actions among the leaders that reflect alignment with environmental, social, and governance (ESG) standards. Strategies toward effective leadership influence include grounding …
Brotherhood: Black Male Perception On The Impact Of Mentorship, Berinda Hollis-Sapp
Brotherhood: Black Male Perception On The Impact Of Mentorship, Berinda Hollis-Sapp
Walden Dissertations and Doctoral Studies
During the adolescent stage of development, identity is a foundational aspect of one’s development, and its absence leads to a negative outcome, characterized by role confusion. Positive interventions are necessary to develop a strong sense of self. The purpose of this generic qualitative project was to explore the perspectives of black males and the impact of mentorship on their identity during adolescence. The theoretical framework chosen for this study was Erikson’s identity versus role confusion, the fifth stage of his psychosocial development theory. Based on this concept, the research supported the idea that adolescent Black males should participate in culturally …
User Interface And Watchstation Improvements Required For Multi-Vehicle Usv Operations, Val Schmidt, Joshua Bergeron
User Interface And Watchstation Improvements Required For Multi-Vehicle Usv Operations, Val Schmidt, Joshua Bergeron
Faculty Publications
In October 2024, the University of New Hampshire and NOAA’s Uncrewed Systems Office embarked on a mapping mission in the Gulf of Maine, simultaneously operating two DriX Un-crewed Surface Vehicles. Goals of the project were focused on testing hypotheses related to concepts of operation, including the safety of operations, cognitive loading of operators, management of vehicle endurance, vehicle logistics, maintenance and field support, refueling and a host of others.
Systematic And Scoping Reviews: What They Are, Why They Matter, And How To Do Them Right, Sharon Duffy Mlis, Rowan Marye Mlis, Lsu Health Libraries
Systematic And Scoping Reviews: What They Are, Why They Matter, And How To Do Them Right, Sharon Duffy Mlis, Rowan Marye Mlis, Lsu Health Libraries
Library Instruction
Curious about evidence synthesis? This session offers a practical introduction to literature reviews and explains their role in evidence-based scholarship. You’ll learn the types of research questions they address and the structured six-step process for conducting them effectively. Recorded session from the information session that took place on November 12, 2025.
Maternal Overnutrition And Nutritional Challenge In Adulthood Cause Long-Term Gut Dysbiosis In Oryctolagus Cuniculus En [Póster] 7th International Conference And Exhibition On Functional Foods, Erika Navarrete, Juan Pablo Ochoa-Romo, Lucía Carolina Cano, Sofía Morán-Ramos, Ivette Caldelas
Maternal Overnutrition And Nutritional Challenge In Adulthood Cause Long-Term Gut Dysbiosis In Oryctolagus Cuniculus En [Póster] 7th International Conference And Exhibition On Functional Foods, Erika Navarrete, Juan Pablo Ochoa-Romo, Lucía Carolina Cano, Sofía Morán-Ramos, Ivette Caldelas
Congresos y Conferencias
No abstract provided.