Spartan Daily, November 11, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 34

Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon

Faculty, Staff and Student Publications

Toll-like receptor (TLR) agonists, as potent immunostimulatory adjuvants, play a critical role in linking the innate and adaptive immune responses. However, their antitumor effects as cancer immunotherapeutic agents have been limited. Here, we report our finding that manganese ion (Mn2+) potentiates various TLR agonists, leading to robust activation of the TLR pathway and the stimulator of interferon genes (STING) pathway among innate immune cells. In particular, we have observed robust antitumor efficacy after intratumoral administration of a TLR3 agonist and Mn2+. To achieve systemic codelivery of TLR3 agonist and Mn2+, we have developed a low-molecular-weight poly(inosinic:cytidylic acid)-Mn2+ coordination lipid nanoparticle …

The Ontological Is Political, The Philosophical Discussion Group

The Philosopher's Stone

• The Ontological is Political

Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju

Faculty, Staff and Student Publications

Hepatic ischemia-reperfusion injury (H-IRI) is a critical complication in liver surgery and liver transplantation, contributing to graft dysfunction and poor clinical outcomes. When hepatocyte protective mechanisms are insufficient to counteract energy depletion and oxidative stress during ischemia, cell death occurs. Tissue damage during H-IRI leads to the release of damage-associated molecular patterns (DAMPs), which recruit and activate immune cells such as neutrophils and monocytes, orchestrating the initiation, progression, and eventual resolution of sterile inflammation. Extended criteria donor (ECD) livers, particularly steatotic ones, are more vulnerable to H-IRI, leading to poorer outcomes and limiting expansion of the donor pool. However, the …

Bridging Reason And Perception: Searching For The Arguments Of Ptolemaïs Of Cyrene In Works On Music Theory From The Italian Renaissance, Sean Robert Denby

Electronic Theses and Dissertations Archive

Ptolemaïs of Cyrene is the earliest known female music theorist from antiquity. Her lost work, Pythagorean Elements of Music, is a substantive addition to the debate on the differences in approaches to reason and perception in harmonic science from Pythagorean and Aristoxenian doctrines. It only survives in three quotations in Porphyry of Tyre’s Commentary on Ptolemy’s Harmonics, a work known and used by humanists and music theorists alike in the Italian Renaissance. Considering that numerous individuals in Renaissance Italy—in particular, Franchino Gaffurio, Gioseffo Zarlino, and Vincenzo Galilei—had access to Porphyry’s Commentary, it is a mystery as to why she does …

Cgas-Agonistic Spherical Nucleic Acids Reprogram The Glioblastoma Immune Microenvironment And Promote Antitumor Immunity, Akanksha S Mahajan, Corey Dussold, Seunghyun Kim, Rachel Jarvis, Lisa A Hurley, Serena Tommasini-Ghelfi, Jungsoo Park, Connor M Forsyth, Bin Zhang, Jason Miska, Amy B Heimberger, Chad A Mirkin, Alexander H Stegh

2020-Current year OA Pubs

The cyclic GMP-AMP synthase-Stimulator of Interferon Genes (cGAS-STING) pathway is an important DNA-sensing mechanism that increases T cell trafficking and activation in tumors and reverses the immunosuppressive phenotype of myeloid cells. Therefore, direct STING targeting using synthetic cyclic dinucleotides (CDNs) is an attractive strategy for treating lymphocyte-depleted and myeloid cell-enriched tumors, such as glioblastoma (GBM). However, inadequate bioavailability and poor cellular accumulation limit the clinical development of CDNs, particularly for noninvasive administration strategies. Spherical nucleic acids (SNAs) have emerged as promising modular constructs for creating therapeutic lead compounds for many diseases, including different forms of cancer. Here, we report the …

Preclinical Efficacy Of Tasquinimod-Based Combinations In Advanced Myeloproliferative Neoplasms In Blastic Phase, Warren Fiskus, Lucia Masarova, Christopher P Mill, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Taghi Manshouri, Andrew Dunbar, Surbhi Sharma, Tapan M Kadia, Courtney D Dinardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Xiaoping Su, Raajit K Rampal, Marie Törngren, Kapil N Bhalla

Faculty, Staff and Students Publications

The alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. A8 and A9 are secreted into the extracellular space and plasma, in which they interact with Toll-like receptor 4, receptor for advanced glycation end products, and CD33. In these studies, we determined the preclinical efficacy of tasquinimod (TQ) against advanced myeloproliferative neoplasm (MPN) cell lines and patient-derived (PD) CD34+ blastic phase (BP; >5% blasts in the peripheral blood) MPN cells. TQ induced loss of viability in cell lines and PD MPN-BP cells, but not in normal CD34+ progenitor cells. In TQ-treated PD …

From Sensibility To Critical Engagement: Sympathy, Animality, And Subjecthood In Wollstonecraft’S Maria And Vindication, Yingnan Shang

Comparative Woman

This paper examines Mary Wollstonecraft’s strategic use of sentimental animal tropes alongside rationalist critique in Maria, or The Wrongs of Woman (1798) and A Vindication of the Rights of Woman (1792), arguing that she mobilizes sensibility not as an end in itself, but as a pedagogical instrument within a broader project of aesthetic education—one intended to move readers from affective sympathy toward political and philosophical judgment. Focusing in particular on animal metaphors—especially in the character of Jemima, who repeatedly figures herself as a domesticated and brutalized creature—I trace how Wollstonecraft employs tropes of animality to illuminate the processes by which …

Driving Together: The Necessity Of A Comprehensive Federal Response For The Success Of Autonomous Vehicles, Timothy Buff

Fordham Intellectual Property, Media and Entertainment Law Journal

Today’s world is full of promising yet controversial new technologies. Large Language Models (LLMs), such as OpenAI’s ChatGPT, have both promised fantastic results and generated a range of critiques. Quantum computing claims to be able to complete computations that would take traditional computers, even supercomputers, longer than the lifespan of the universe to complete. With such advancements, the future dreamed of in science fiction stories of the twentieth century seems to be becoming reality. Autonomous Vehicles (AVs) are another notable technology, which promise to ultimately remove any human responsibility, and hence any human error, from the process of driving a …

The Rider (2025-11-10), Daniela Martinez Salazar

The Rider Archives

Vol. 11, No. 11

Bonita - Euthynnus Alletteratus Neurocranium, Daniella M. Acosta Reyes, Matthew Mcmanus, Morgan Michalek, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Correcting Class Imbalance Through Synthetic Training Data And 3d Modeling For Carabid Pitfall Trap Sampling, Blair Mirka

Geography ETDs

Crowdsourced biodiversity data provide an accessible foundation for large-scale ecological monitoring, but class imbalance limits automated species identification, particularly for rare taxa. This research explores the use of synthetic training data generated from 3D models of carabid beetle museum specimens to improve detection and classification performance for underrepresented species in crowdsourced datasets. High-resolution 3D models were created to simulate variation in lighting, orientation, and background. These synthetic images were incorporated into convolutional neural network training datasets at varying synthetic-to-real ratios to assess their impact on classification accuracy. Models were evaluated using controlled pitfall-trap imagery to examine the influence of scene …

A Prodrug Strategy For Sustained Release Of Lactic Acid From Silicone Elastomer Vaginal Rings., Yahya H. Dallal Bashi, Xinyu Zhao, Clare F. Mccoy, Narender Kumar, Natalia Teleshova, Dolores J. Lamb, José A. Fernández Romero, Abigail Meyer, Patrick Barnable, Meropi Aravantinou, Osaretin E. Asowata, Melissa A. White, Alexander J. Travis, Lisa B. Haddad, Xin Shen, Vicky-Leigh Young, Peter Boyd, R Karl Malcolm

Manuscripts, Articles, Book Chapters and Other Papers

Lactic acid is the most abundant organic weak acid in the healthy human vagina and plays a pivotal role in maintaining an acidic vaginal environment protective against exogenous bacteria and viruses. However, in dysbiotic or non-optimal vaginal environments, significantly decreased concentrations of lactobacilli result in reduced lactic acid production, increased vaginal pH, and enhanced risk of sexually transmitted infections (including human immunodeficiency virus), and bacterial vaginosis. Various gel-based products are marketed to administer lactic acid vaginally for the treatment of bacterial vaginosis and non-hormonal contraception, and there is interest in developing vaginal ring products for sustained/controlled release of lactic acid. …

Tales From The Crypt: Margaret Thatcher's Industrial Policy And Its Afterlife, James Silverwood, Richard Woodward

Research Outputs: 2025-Present

No abstract provided.

The Echo: November 10, 2025, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Chain Continuity & Multi-Master Keyframe Coverage- Two Methods For Edit-Ready Ai Filmmaking, John Trevino

Theatre Faculty Publications

Current AI video models generate short clips with inconsistent visual details across shots, preventing traditional film editing. A character may change clothing, lighting may shift, and spatial relationships may drift between angles—all of which break cinematic continuity (Bordwell, Thompson, & Smith, 2020). This paper formalizes Chain Continuity, a reproducible four-step method that eliminates these discontinuities by separating camera construction from performance generation. The method requires locking a single Master Key Frame taken from the first frame of the Master Shot, building all other camera angles as static Setup Frames derived only from that first-frame key, and then generating performances solely …

Nanofiber-Enabled Rapid And Non-Destructive Sensors For Meat Quality And Shelf-Life Monitoring: A Review, Karna Ramachandraiah, Elizabeth M. Martin, Alya Limayem

Food Science Faculty Publications and Presentations

The meat industry faces significant economic losses and environmental impacts due to spoilage and waste, much of which results from inadequate, delayed, or inefficient quality assessment. Traditional methods used for assessing meat quality are often time-consuming, labor-intensive, and lack the ability to provide real-time information, making them insufficient for modern supply chains that demand safety, freshness, and minimal waste. Recent advances in nanotechnology position nanofibers (NFs) as promising materials for addressing these challenges through smart sensing and active packaging. NFs, characterized by their high surface-to-volume ratio, tunable porosity, and small diameter, enable superior encapsulation and immobilization of sensing agents. These …

Spots, Stripes, And Strains: A Case Report Of Multidrug-Resistant Salmonella Newport In Exotic Felids, Brianna L S Stenger, Daniel R. Evans, Sarah J. Gefroh, Alyssa Breuer, Heidi L. Pecoraro, Kelli J. Maddock

APC Fund Awardees

Background

Shedding of Salmonella is not unusual in captive exotic animals; however, few cases link Salmonella to chronic disease or death of exotic felids.

Case Summary

We report a multidrug-resistant (MDR) Salmonella enterica serovar Newport, persisting strain REPJJP01, isolated from exotic felids from two separate regional zoos and potentially contributing to the death of a snow leopard (Panthera uncia) and a Pallas’s cat (Otocolobus manul). REPJJP01 strains of S. Newport are a recurring cause of human enteric disease outbreaks associated with travel to Mexico and beef products.

Conclusion

This case highlights the value of genotypic and phenotypic techniques to identify …

Genome-Wide Crispr Screens Identify Critical Targets To Enhance Car-Nk Cell Antitumor Potency, Alexander Biederstädt, Rafet Basar, Jeong-Min Park, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Merve Dede, John Watts, Sunil Acharya, Donghai Xiong, Bin Liu, May Daher, Hind Rafei, Pinaki Banerjee, Ping Li, Sanjida Islam, Huihui Fan, Mayra Shanley, Jingling Jin, Bijender Kumar, Vernikka Woods, Paul Lin, Silvia Tiberti, Ana Karen Nunez Cortes, Xin Ru Jiang, Inci Biederstädt, Patrick Zhang, Ye Li, Seema Rawal, Enli Liu, Luis Muniz-Feliciano, Gary M Deyter, Elizabeth J Shpall, Natalie Wall Fowlkes, Ken Chen, Katayoun Rezvani

Faculty, Staff and Student Publications

Adoptive cell therapy using engineered natural killer (NK) cells is a promising approach for cancer treatment, with targeted gene editing offering the potential to further enhance their therapeutic efficacy. However, the spectrum of actionable genetic targets to overcome tumor and microenvironment-mediated immunosuppression remains largely unexplored. We performed multiple genome-wide CRISPR screens in primary human NK cells and identified critical checkpoints regulating resistance to immunosuppressive pressures. Ablation of MED12, ARIH2, and CCNC significantly improved NK cell antitumor activity against multiple treatment-refractory human cancers in vitro and in vivo. CRISPR editing augmented both innate and CAR-mediated NK cell function, associated with enhanced …

“You’Re Getting A Little Big For This”: Fat Characters In Disney Animated Films, Rachel Casey, Grace Brenner

Faculty and Staff Scholarship

To further develop the literature regarding representations of larger bodies in popular culture, this quantitative content analysis describes demographic and stereotypic depictions of fat characters in all 54 Disney animated films theatrically released from 1937 to 2023. The 124 identified fat characters were most commonly depicted as sidekicks of the protagonist (n = 38, 30.65%), with only four (3.23%) depicted as protagonists. Demographically, fat characters were most frequently male (n = 95, 76.61%), white (n = 92, 74.19%), middle aged (n = 57, 46.00%), and of lower social class (n = 50, 40.32%). Compared to …

Design And Implementation Of Home Energy Management System (Hems) In Smart Grid Through Demand Side Management (Dsm), Nirmala Jegadeesan Ms

Theses and Dissertations

The rising global energy demand, combined with environmental concerns and the depletion of conventional energy sources, has driven the need for the development of smarter and more sustainable energy systems. This research focuses on Home Energy Management System (HEMS) using soft computing techniques to optimize load scheduling, enhance energy efficiency, and integrate Renewable Energy Sources (RES) such as solar and battery storage. The primary goal is to balance supply and demand, reduce peak loads, and minimize energy costs while ensuring consumer comfort and system reliability.

Smart grids provide enhanced capabilities compared to conventional grids by enabling bidirectional flows of energy …

Development Of A Targeted Bioprotac Degrader Selective For Misfolded Sod1, Christen G Chisholm, Rachael Bartlett, Mikayla L Brown, Emma-Jayne Proctor, Natalie E Farrawell, Jody Gorman, Fabien Delerue, Lars M Ittner, Kara L Vine-Perrow, Heath Ecroyd, Neil R Cashman, Darren N Saunders, Luke Mcalary, Jeremy S Lum, Justin J Yerbury

Faculty, Staff and Student Publications

The accumulation of misfolded proteins underlies a broad range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Due to their dynamic nature, these misfolded proteins have proven challenging to target therapeutically. Here, we specifically target misfolded disease variants of the ALS-associated protein superoxide dismutase 1 (SOD1), using a biological proteolysis targeting chimera (BioPROTAC) composed of a SOD1-specific intrabody and an E3 ubiquitin ligase. Screening of intrabodies and E3 ligases for optimal BioPROTAC construction reveals a candidate capable of degrading multiple disease variants of SOD1, preventing their aggregation in cells. Using CRISPR/Cas9 technology to develop a BioPROTAC transgenic mouse line, we …

Tackling The Burden Of Envenomation In Africa: Advances, Challenges, And Strategic Priorities For Enhanced Diagnosis And Treatment, Khawla Ammouch, Nihal Mesmoudi, Noureddine Hammani, Jacob Galan, Abdellah Moustaghfir, Reto Stöcklin, Naoual Oukkache

Human Genetics Publications

Venomous animal envenomation remains a significant but neglected public health problem worldwide, with an estimated 5.4 million cases and up to 138,000 deaths annually. The burden is particularly acute in tropical and subtropical regions, especially sub-Saharan Africa, where rural and vulnerable populations face limited access to effective antivenoms and healthcare. Despite this, comprehensive data on envenomation incidence, clinical management, and outcomes remain scarce, hampering efforts to develop effective prevention and treatment strategies. This review synthesizes current knowledge on venomous animal diversity, epidemiology, and clinical manifestations globally, with a focus on Africa’s unique challenges. We examine critical gaps in antivenom production, …

Chimes: November 10, 2025, Calvin University

Chimes

Trinity Christian College closes, teach-out program to offer students a place at Calvin by Ashley Hamons & Ian Tjoelker

Vice President for Enrollment Strategy Lauren Jensen to step down by Ian Tjoelker

Third annual FAST conference held at Calvin by Ian Tjoelker

Federal government shutdown the longest in US history: How is Calvin holding up? by Ian Tjoelker & Joe Toly

Remembering the wreck of the Edmund Fitzgerald by Maya Oeverman

The Resonance Of Desire: A Sonic Exploration And Guide To Recreating Disney’S Signature ‘I Want’ Songs, Aiyanna E. Riley

Electronic Theses and Dissertations

This thesis explores the sonic architecture of Disney’s Renaissance-era “I Want” songs and develops a framework for recreating their signature production style. This study analyzes how vocal timbre, microphone choices, layering, stereo placement, and mixing strategies contribute to the immersive qualities that define the Disney sound. Drawing from historical accounts, interviews with industry professionals, and technical literature, the thesis documents production practices unexamined in scholarly work. Inspired by David Gibson’s The Art of Mixing, my analyses prioritize spatial and textural qualities in Disney mixes, highlighting how sound design shapes narrative impact. The study culminates in two original compositions modeled …

E-Pocket Book Of Angiosperms Diversity Of Ghimbo Pomuan Sacred Forest To Improve Students’ Species Literacy And Plant Awareness, Hikmah Hidayah, Siti Zubaidah, Frida Kunti Setiowati

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Students' low species literacy and limited awareness of plant diversity highlight the need for contextualised learning media based on local plant resources. This study aims to develop, assess the feasibility, and evaluate the effectiveness of an e-pocket book on Angiospermae diversity in Ghimbo Pomuan Sacred Forest, Kampar, Riau, Indonesia, as an innovative learning tool for higher education. This e-pocket book was developed using the Lee & Owens multimedia development model, which includes the stages of analysis, design, development, implementation, and evaluation. The feasibility test results showed that this e-pocket book was rated as very valid with an average score of …

Effectiveness Of An Outcomes-Based Education Module In Electrochemistry For Engineering Students, Reden E. Nolasco

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study investigated the effectiveness of an Outcomes-Based Education (OBE) module in electrochemistry for engineering students. Students' conceptual knowledge and problem-solving abilities were assessed using a quasi-experimental design that included pre-and post-tests. The experimental group used the OBE module, while the control group received traditional instruction. Statistical tests, including t-tests and correlation analysis, established the module's impact. The post-test scores of the experimental group differed significantly from those of the control group. Faculty and student assessments verified the module's effectiveness in content quality, instructional approach, and learning effectiveness. The study concludes that OBE instructional materials improve learning outcomes and suggest …

Fostering Student Enthusiasm In Ecoprint Pounding As An Environment-Based Learning Technique, Livia Sugiastutih, Arina Restian, Kuncahyono Kuncahyono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The lack of learning interest and environmental awareness among students poses a particular challenge in the school learning process. This study introduces ecoprint pounding as an alternative environment-based learning medium that is not only educational, but also enjoyable and contextual. The research employed a descriptive qualitative approach with a participatory method. The research subjects were elementary school students who were directly involved in the ecoprint-making process, starting from selecting leaves to printing patterns on fabric using the pounding technique. The findings indicate that this activity was effective in increasing students’ enthusiasm and engagement in learning. Additionally, students appeared more creative, …

Virtual Reality-Based Learning Performance In Civil Engineering Education, Tri Kuncoro, Dwi Siswahyudi, Jehad A.H Hammad

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The focus of this research is the design and implementation of VR based learning media for building construction classes and exam ining its efficacy on how it helps the students comprehensively grasp the concepts taught in those classes us-on. It is however important to note that two major misconceptions regarding virtual reality that persons may hold are that students act like passive observers in a virtual environment and un-derstand theory without practice or visual representation. This is the reason why VR is the chosen option. The development processes used were needs analysis design development testing and evaluation. The end product …

The Impact Of Religiosity On The Morality Of Islamic Education Students, Tri Yaumil Falikah, Zalik Nuryana, Anaas Tri Ridlo Dina Yuliana, Shazia Malik

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Religiosity is an important aspect in shaping student morale, especially for Islamic Education (IE) students who are future educators. The purpose of the study was to look for the influence of religiosity on the morale of Islamic Religious Education students at Universitas Ahmad Dahlan. This research is a quantitative study with the population of IE students from 2019 to 2021 amounting to 699 students. The technique of taking sample uses the Slovin formula, namely as many as 90 students who were taken randomly (random sampling). The primary data collection tool used is a 4-scale Likert scale questionnaire. The instruments were …