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A New Genus Of Horn-Like Tetrigids (Orthoptera: Caelifera: Tetrigidae) From South America, Daniela Santos Martins Silva, Marcelo Ribeiro Pereira

Insecta Mundi

A new pygmy unicorn genus, Brazitettix Silva, new genus, and two new species, Brazitettix roraimae Silva, new species and Brazitettix paulista Silva, new species (Orthoptera: Caelifera: Tetrigidae) are described in Brazil. This new genus is a unique tetrigid taxon in the American continent due a notched-long and elevated head projection. The morphology of this taxon resembles Rostella Hancock, 1913 and Dravidacris Bhaskar and Kasalo, 2022 that are currently comprised into Cleostratini, an artificial group that contains biogeographic distant taxa with distinct morphological head projection.

Resumen

Un nuevo género de tetrígidos, Brazitettix Silva, nuevo género, y dos nuevas especies, …

Improvement And Evaluation Of Multiple Imputation By Heckman's One-Step Mle For Binary Mnar Outcomes And Various Types Of Mar Covariates, Xin W. Shore

Mathematics & Statistics ETDs

Missing data is inevitable in clinical epidemiology. It becomes one of the major challenges in the analyses and can potentially undermine the validity of results and conclusions. Although methods for handling missing data with mechanisms of missing completely at random (MCAR) or missing at random (MAR) have been widely researched, methods adapted for the missing not at random (MNAR) mechanism are less studied. Galimard et al. (2018) have derived a method to use multiple imputation by Heckman's One-Step ML Estimation for binary MNAR outcome and continuous MAR covariates (MIHEml). This dissertation focuses on updating MIHEml in terms of …

Perceived Naturalness Biases Objective Behavior In Both Trivial And Meaningful Contexts, Brian P. Meier, Eric Noreen, Michael Fellman, Courtney Lappas, Li-Jun Ji

Psychology Faculty Publications

Research shows that perceived naturalness can bias beliefs about the positivity of items such as food, human talent, and vaccines. Yet, this research focuses on self-reports, which leaves open the implications it has for behavior. In four studies (N = 492), this research team tested if perceived naturalness impacts trivial and meaningful behaviors. Participants were asked to consume a purported natural/synthetic performance drink (Study 1), test a purported natural/synthetic drug that would be injected (Study 2), eat chocolate containing a purported natural/synthetic cocoa described as causing stomach discomfort (Study 3), or choose a sticker purportedly made with natural/synthetic ink …

2024-09-13 Minutes & Appendices, Longwood University

Board of Visitors Meeting Minutes 1964-

No abstract provided.

2024 September 13 - Board Of Trustees Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

The Diamond, September 13, 2024, Dordt University

Dordt Diamond

• Front Page: The Restoration of Rock Valley Christian School; Sioux County Area Schools Lock Down after Threat, Dordt Sends out Safety Alert; Dordt Football Record Holder Levi Jungling Named New Offensive Coordinator
• News: No More Hardees or Taco Johns - Now What?; Defender Feud Replaces Freshman Talent Show; Out with the Old In with the New - Updates to the Grille; Brazilians React to X Ban, Proxy War with Musk; East Campus Building Housing Sophomore Girls; Professor De Waal Creates a Positive Learning Environment in Her Home; Men's and Women's Cross Country Ranked #1 in GPAC Preseason Poll; …

An Analytical Approach For Simulating Effects Of Avalanches On Mountain Goat Population Dynamics: Implications For Management And Conservation, Kevin White, Taal Levi, Eran Hood, Gabriel J. Wolken, Erich H. Peitzsch, Yves Bühler, Katreen Wikstrom Jones, Chris T. Darimont

Faculty, Staff, and Students

Mountain environments with snow avalanche hazard cover about 6% of Earth’s land area and occur on all continents. Whereas human risks associated with avalanche hazard have been widely studied, little is known about how avalanche activity affects population dynamics in mountain wildlife. Globally, 32 species of mountain ungulates across 70 countries occupy avalanche-prone terrain. Avalanches comprise the leading cause of mortality in coastal Alaskan mountain goats (mean = 36%, range = 23 - 65%, depending on area), and disproportionately remove prime-aged individuals from populations. The implications of such rates and patterns of mortality on population growth rate are likely to …

The Roles Of Ninik Mamak On The Victory Of Mahyeldi And Audy In The 2020 Election In Agam Regency, West Sumatera., Kintan Aghna Khaira, Makmun Wahid, Moh. Arief Rakhman, Rio Yusri Maulana

Jurnal Wacana Politik

This article analyzes the influence of ninik mamak (traditional leaders) on the victory of Governor Mahyeldi and Vice Governor Audy in the 2020 West Sumatra Governor Election in the Agam District. The influence of ninik mamak in shaping public perception can be observed in the political contestation during the West Sumatra gubernatorial election on December 9, 2020. The research aims to analyze how the influence of ninik mamak contributed to the success of the Mahyeldi and Audy pair and to identify the factors that enabled Mahyeldi and Audy to mobilize ninik mamak in the 2020 gubernatorial election in Agam, West …

Alphafold2 Modeling And Molecular Dynamics Simulations Of The Conformational Ensembles For The Sars-Cov-2 Spike Omicron Jn.1, Kp.2 And Kp.3 Variants: Mutational Profiling Of Binding Energetics Reveals Epistatic Drivers Of The Ace2 Affinity And Escape Hotspots Of Antibody Resistance, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

AlphaFold2-based atomistic predictions of structures and conformational ensembles of the SARS-CoV-2 spike complexes with the host receptor ACE2 for the most dominant Omicron variants JN.1, KP.1, KP.2 and KP.3 to examine the mechanisms underlying the role of convergent evolution hotspots in balancing ACE2 binding and antibody evasion. Using the ensemble-based mutational scanning of the spike protein residues and computations of binding affinities, we identified binding energy hotspots and characterized the molecular basis underlying epistatic couplings between convergent mutational hotspots. The results suggested the existence of epistatic interactions between convergent mutational sites at L455, F456, Q493 positions that protect and restore …

2024 September 13 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Spatially Fractionated Grid Radiation Potentiates Immune-Mediated Tumor Control, Rebecca A Bekker, Nina Obertopp, Gage Redler, José Penagaricano, Jimmy J Caudell, Kosj Yamoah, Shari Pilon-Thomas, Eduardo G Moros, Heiko Enderling

Faculty, Staff and Student Publications

Background: Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor beds, or immune deserts with low levels of infiltration. The pre-treatment immune make-up of the TIME is associated with treatment outcome; immunologically inflamed tumors generally exhibit better responses to radio- and immunotherapy than non-inflamed tumors. However, radiotherapy is known to induce opposing immunological consequences, resulting in both immunostimulatory and inhibitory responses. In fact, it is thought that the radiation-induced tumoricidal immune response is curtailed by subsequent applications of radiation. It is thus conceivable that spatially fractionated radiotherapy (SFRT), administered through …

Minimally Invasive Therapies For Knee Osteoarthritis, Uchenna Osuala, Megan H Goh, Arian Mansur, John B Smirniotopoulos, Arielle Scott, Christine Vassell, Bardia Yousefi, Neil K Jain, Alan A Sag, Allison Lax, Kevin W Park, Alexander Kheradi, Marc Sapoval, Jafar Golzarian, Peiman Habibollahi, Osman Ahmed, Shamar Young, Nariman Nezami

Faculty, Staff and Student Publications

Knee osteoarthritis (KOA) is a musculoskeletal disorder characterized by articular cartilage degeneration and chronic inflammation, affecting one in five people over 40 years old. The purpose of this study was to provide an overview of traditional and novel minimally invasive treatment options and role of artificial intelligence (AI) to streamline the diagnostic process of KOA. This literature review provides insights into the mechanisms of action, efficacy, complications, technical approaches, and recommendations to intra-articular injections (corticosteroids, hyaluronic acid, and plate rich plasma), genicular artery embolization (GAE), and genicular nerve ablation (GNA). Overall, there is mixed evidence to support the efficacy of …

Systematics Of The Rhinolophus Landeri Complex, With Evidence For 3 Additional Afrotropical Bat Species, Bruce D. Patterson, Terrence C. Demos, Laura Torrent, Amanda L. Grunwald, Cecilia Montauban, Julian C. Kerbis Peterhans, Molly M. Mcdonough, Carl W. Dick, Michael Bartonjo, M. Corrie Schoeman, Multiple Additional Authors

Biology Faculty Publications and Presentations

Roughly a third of all horseshoe bat species (Rhinolophidae: Rhinolophus) are found in Africa, where a recent continent-wide genetic survey suggested the presence of both undescribed and apparently invalid species. Here, we focus on the R. landeri species complex and the recent elevation of R. lobatus Peters, 1852, to species rank. That action created ambiguity in the taxonomy of East African members of the group—are both R. landeri Martin, 1838, and R. lobatus sympatric in East Africa or is another, unnamed species present there? Here, we refine genetic, morphological, and behavioral characterizations of R. landeri and its erstwhile synonyms with …

A Correspondence Between Deep Boltzmann Machines And P-Adic Statistical Field Theories, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

There is a strong interest in studying the correspondence between Euclidean quantum fields and neural networks. This correspondence takes different forms depending on the type of networks considered. In this work, we study this correspondence in the case of deep Boltzmann machines (DBMs) having a tree-like topology. We use p-adic numbers to encode this type of topology. A p-adic continuous DBM is a statistical field theory (SFT) defined by an energy functional on the space of square-integrable functions defined on a p-adic N-dimensional ball. The energy functionals are non-local, meaning they depend on the interaction of all the neurons forming …

Impact And Characterization Of Serial Structural Variations Across Humans And Great Apes, Wolfram Höps, Tobias Rausch, Michael Jendrusch, Jan O Korbel, Fritz J Sedlazeck

Faculty, Staff and Students Publications

Modern sequencing technology enables the systematic detection of complex structural variation (SV) across genomes. However, extensive DNA rearrangements arising through a series of mutations, a phenomenon we refer to as serial SV (sSV), remain underexplored, posing a challenge for SV discovery. Here, we present NAHRwhals ( https://github.com/WHops/NAHRwhals ), a method to infer repeat-mediated series of SVs in long-read genomic assemblies. Applying NAHRwhals to haplotype-resolved human genomes from 28 individuals reveals 37 sSV loci of various length and complexity. These sSVs explain otherwise cryptic variation in medically relevant regions such as the TPSAB1 gene, 8p23.1, 22q11 and Sotos syndrome regions. Comparisons …

Enhancing Cardiomyocyte Resilience To Ischemia-Reperfusion Injury: The Therapeutic Potential Of An Indole-Peptide-Tempo Conjugate (Iptc), Shanshan Hou, Xin Yan, Xiang Gao, Steffen Jockusch, K. Michael Gibson, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Ischemia/reperfusion (I/R) injury leads to apoptosis and extensive cellular and mitochondrial damage, triggered by the early generation and subsequent accumulation of mitochondrial reactive oxygen species (mtROS). This condition not only contributes to the pathology of I/R injury itself but is also implicated in a variety of other diseases, especially within the cardiovascular domain. Addressing mitochondrial oxidative stress thus emerges as a critical therapeutic target. In this context, our study introduces an indole-peptide-tempo conjugate (IPTC), a compound designed with dual functionalities: antioxidative properties and the ability to modulate autophagy. Our findings reveal that IPTC effectively shields H9C2 cardiomyocytes against hypoxia/reoxygenation (H/R) …

Metallophytes As Guardians Of Highly Harsh Environments – Comprehensive Insights Into Silene Vulgaris Tolerance To Metals, Konrad Bąk, Maksymilian Adamczyk, Jagoda Matyjek, Anna Rusaczonek, Wojciech Borucki, Alina Wiszniewska, Ewa Muszyńska

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Harnessing The Potential Of Extremophyte Sea Aster For Environmental Challenges, Maksymilian Adamczyk, Konrad Bąk, Anna Rusaczonek, Aleksandra Koźmińska, Ewa Muszyńska, Alina Wiszniewska

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Assessing Extreme Environments: Is Diplotaxis Muralis A Key Species For The Phytomanagement Of Mercury-Contaminated Soils?, Csaba Timár, Maria Anastasia Abrudan, Mihaela Gălean, Dorina Podar

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

The Impact Of Temperature And Humidity On The Transcriptome Of Symbiochloris Reticulata In Relation To Lobaria Pulmonaria’S Genepools, Ioana Violeta Ardelean, Christoph Scheidegger, Mihai Miclaus

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Insights Into Past Extreme Environments Through Ancient Biomolecules, Ioana Nicoleta Meleg, Magdalena Năpăruş-Aljancic, Yuichi Naito, Hervé Bocherens, Axel Barlow

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Onsite Microbial Analyses In One Of The Most Remote Quartzite Subterranean Environment On Earth: Imawarì Yeuta On Venezuelan Tepuis, Martina Cappelletti

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Targeting Ribosome Biogenesis Is A Novel Approach For The Management Of Pancreatic Cancer, Mudassier Ahmad, Haider Ahsan, Carlos Perez, Muhammad Bangash, Andrew Massey, Emmanuel Anning, Manish Tripathi, Dae Kim, Subhash C. Chauhan, Bilal Bin Hafeez

Research Colloquium

Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related deaths in the United States with limited therapeutic options available. Gemcitabine, a deoxycytidine nucleoside analog is currently considered the most effective therapy for PanCa. However, it shows only a marginal survival benefit of six months. Aberrant ribosome biogenesis occurs in most tumor types. We observed that PanCa cells are addicted to ribosome biogenesis, which supports their highly aggressive metastatic phenotypes. Thus, strategically targeting ribosome biogenesis process could be one of the ideal strategies for the prevention and treatment of PanCa. In this study, we elucidated the molecular mechanisms of POLR1A …

Shining Light On The Invisible: Fluorescent Detection Of Reactive Oxygen Species, Alex Zuo

Research Colloquium

Background

Reactive oxygen species (ROS) play an important role in cell signaling and homeostasis. However, overproduction of ROS leads to oxidative stress, as well as other related diseases, including cancer, neurodegenerative diseases, and cardiovascular disorders. Conventional ROS detection methods are limited by their low sensitivity and low specificity in real-time measurements. Fluorescent probes can offer valuable tools to detect ROS in biological systems. This study is focused on the detection of ROS formation during hypoxia and reoxygenation.

Methods

We used fluorescence detection techniques to study ROS in isolated rodent skeletal muscle models, which were exposed to alternating hyperoxia and hypoxia. …

The Use Of Social Media For Organisational Learning: A Systematic Review Of Literature, Harry Moongela, Marie Hattingh

African Conference on Information Systems and Technology

Social media (categorised as Web 2.0 platforms) has been reported to significantly impact and improve organisational learning (OL), but there seems to be a lack of systematic literature reviews (SLR) covering the use of social media to facilitate OL. Thus, this article conducted a SLR for both social media and OL by presenting the significant concepts, models and frameworks from literature. A total number of 48 articles were found for the analysis method and the findings reveal important concepts such as types of OL, levels of OL and frameworks incorporating both social media and OL. The results also show that …

Obsessive Compulsive Disorder And Other Specified Anxiety Disorder In An 8-Year-Old Post-Respiratory Infection: A Case Report, Michael Tran, Alcides Amador, Sofia Camacho Bermudez

Research Colloquium

Background: This case report presents the diagnosis and management of Obsessive Compulsive Disorder (OCD) and Other Specified Anxiety Disorders in an 8-year-old male. The importance lies in the development of psychiatric symptoms after multiple respiratory infections and the subsequent diagnosis of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). It highlights a potential connection between infections and psychiatric manifestations in pediatric patients. PANDAS is an immune-mediated neuropsychiatric disorder that occurs after a Group A Strep (GAS) infection, characterized by the sudden onset or worsening of obsessive-compulsive disorder and tic disorder. While pathophysiology is not fully understood, evidence indicates that …

Investigating Therapeutic Activity Of Br-Ormeloxifene (Br-Orm) Against Cervical Cancer, Mohammed Sikander, Shabnam Malik, John Apraku, Sonam Kumari, Parvez Khan, Daniel Zubieta, Hassan Mandil, Aditya Ganju, Bhavin Chauhan, Maria C. Bell, Man Mohan Singh, Sheema Khan, Murali Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash Chauhan

Research Colloquium

Aberrant activation of β-catenin signaling is strongly associated with cancer proliferation, invasion, migration, and metastasis, thus small molecules that can inhibit this pathway might have great clinical significance. Our molecular modeling studies suggest that Ormeloxifene (ORM), a triphenylethylene molecule docks with β-catenin, and its brominated analogue (Br-ORM) bind more effectively with relatively less energy (-7.6 kcal/mol) to the active site of β-catenin as compared to parent ORM. Herein, we report the synthesis and characterization of a Br-ORM by NMR and FTIR, as well as its anti-cancer potential in cervical cancer models in vitro and in vivo. Br-ORM treatment effectively …

Tc-Ptp-Mediated Regulation Of P38 Mapk Signaling Pathway Promotes Uvb-Induced Apoptosis In Skin, Lindsey Shim, Jose Delgado, Bilal B. Hafeez, Dae Joon Kim

Research Colloquium

Background: T-cell protein tyrosine phosphatase (TC-PTP) is a non-receptor PTP that has been shown to have various roles in signaling pathways. Our previous studies have demonstrated that the TC-PTP deficiency in the epidermis can exacerbate hyperplastic response by inducing epidermal cell proliferation in response to tumor promoter TPA or UVB exposure. This implies that TC-PTP plays a tumor-suppressive role in the epidermis and provides protection against UVB radiation, which is well known to contribute to skin cancer development. The p38 mitogen- activated protein kinase (MAPK) is one of serine/threonine kinases that are activated through environmental stress including UVB. It has …

Can Zinc Reduce The Disease Burden Of Diabetes Mellitus?, Ronald Shaju, Rahnuma Ahmad, Mohammed S. Razzaque

Research Colloquium

Background: Diabetes mellitus is a prevalent chronic metabolic disorder characterized by hyperglycemia. Traditionally, this disease is managed with medication and dietary modifications. However, recent studies have shown the potential role of zinc in diabetes management. We explained the complex interplay between zinc deficiency, impaired glucose metabolism, and the progression of diabetes to elucidate the potential therapeutic benefits of zinc supplementation.

Methods: A comprehensive literature search using databases such as Google Scholar, PubMed, and Scopus was conducted to identify relevant studies published between November 2023 and February 2024. Keywords such as ‘zinc in diabetes mellitus,’ ‘zinc supplementation,’ ‘zinc deficiency,’ and ‘diabetic …

New Insights Into The Mechanisms Of Skeletal Muscle Atrophy In Copd, Justin D. Mills, Hiram L. Garcia, Alex Zuo

Research Colloquium

Background: In 2020, it was estimated that there were over 480 million cases of chronic obstructive pulmonary disease (COPD) worldwide. Up to 40% of COPD patients suffer from certain degrees of muscle atrophy. The severity of this muscle atrophy is normally correlated with an increased mortality rate among these patients. The goal of this study is to underline the causes of muscle atrophy/dysfunction in the COPD population and to investigate treatment options.

Methods: We conducted an extensive literature review using the PubMed database, mainly focusing on publications from 2013 to 2024. Our objective was to identify the biological mechanisms underlying …