Digital Commons Network^™

Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s Disease (AD) is the leading cause of dementia, characterised by cognitive and functional impairments that disrupt daily activities. Different clinical modalities such as neuroimaging biomarkers, cognitive assessments, fluid biomarkers and genetic data provide unique and complementary information, contributing to a more comprehensive understanding of disease progression and heterogeneity in disease characteristics. With recent advancements in computational capabilities, particularly in deep learning, multimodal representation learning frameworks aim to integrate diverse clinical modalities into a cohesive framework, capturing the most significant patterns within each modality. Existing data-driven multimodal representation learning frameworks in AD research have two major limitations. First, AD progresses …

Mems 411: The Ez-Push Fsae E-Assisted Pushbar, Ian Snider, Hunter Tate, Erik Lillegard, Maxwell Wrasman

Mechanical Engineering Design Project Class

WashU Racing needs a device that will help them transport their Formula SAE car to and from their garage/paddock during events and testing when the car is unable to move under its own power. Pushing the car is very exhausting and requires at least 2 pairs of people, rotating in and out, to push the car. An electronically assisted push bar would only require two people to push the car and wouldn't experience exhaustion due to pushing the car. This device will function similarly to a shopping cart tug while also functioning as a rear jack for the vehicle that …

Mems 411: Timed Mosquito Egg Container, Daniel Nordquist, Preston Gee, Stephanos Mavrommatis

Mechanical Engineering Design Project Class

To aid in the war against mosquitoes, PHD candidate Lauren Johnson tasked this groups with developing a device to help study egg laying patterns. The goal is to create a device that can cut off access to tea water (an attractive breeding site) at specified time intervals in order to observe the effects of daylight and temperatures on mosquito egg laying behavior.

Mems 411: A Diving Surface Breaker The Jetcycle, Amanda Mclaughlin, Nicholas Harris, Alice Hu, Steven Xiao

Mechanical Engineering Design Project Class

Create a diving surface breaker for the WashU swimming and Diving team.

Challenges To Reproductive Justice: An Ethical Analysis Of Reproductive Technologies And Disparities, Courtney Brenner

Electronic Theses and Dissertations

This dissertation analyzes the Reproductive Justice Framework to describe possible solutions to the ethical challenges related to reproductive healthcare disparities. Various frameworks to support reproductive equity fail to address the challenges marginalized individuals face in accessing reproductive health services. The four ethical principles of autonomy, beneficence, nonmaleficence, and justice serve as foundational tools to support reducing these disparities. This dissertation uses the Reproductive Justice Framework to analyze the unequal distribution of harms among marginalized women. It highlights how access to care, such as Assisted Reproductive Technologies (ART), is disproportionately inaccessible to marginalized women. Then, it discusses the relationship between marginalized …

How Do Expert Forensic Evaluators Do It? A Qualitative Study Exploring Forensic Evaluators’ Lived Experiences Conducting Psychosexual Evaluations Of Sex Offenders With Suspected Autism, Jessica K. Gazzola

Electronic Theses and Dissertations

This qualitative inquiry utilized semi-structured interviews with eight expert forensic evaluators to explore their lived experiences engaging in psychosexual evaluations of sex offenders with a suspected diagnosis of autism. The purpose of this study was to identify current best practices, principles, and challenges faced by forensic evaluators when assessing sex offenders with a suspected diagnosis of autism. The results provide a variety of autism-specific screening tools and assessments used by forensic evaluators in their psychosexual evaluation process. Four emergent themes were developed using a descriptive phenomenological approach and social constructivist framework. These themes encompass forensic evaluators’ role in conducting psychosexual …

College Instructors’ Experiences Of Online English As Second Language (Esl) Teaching And Learning Environments, Jianan Zhou

Electronic Theses and Dissertations

This study investigates college ESL instructors' experiences in teaching online ESL courses. It explores the differences in teaching focus and online modes for teaching speaking, listening, reading, and writing courses. It also investigates how ESL instructors' perceived level of technology competence varies across different online teaching modes and examines how teaching and learner engagement strategies differ depending on the instructional modality. Key findings include the observation that both BICS and CALP were prevalent in online reading courses. Although no significant difference in technology competence between asynchronous and synchronous modes was found, it was shown that instructors used more synchronous modes …

Application Of Peer-Mediated Instruction And Intervention (Pmii) To Enhance Social Interaction Skills In Early Elementary-Level Saudi Students With Autism Spectrum Disorder (Asd) In An Inclusion Setting, Inam Alghamdi

Electronic Theses and Dissertations

In Saudi Arabia, autism spectrum disorder (ASD) is on the rise, and the government is committed to improving nationwide special education services through legislative measures aimed at enhancing the flexibility of inclusion for students with ASD within school settings. However, students with ASD often encounter social challenges, especially in their interactions with peers. This increasing trend underscores the importance of implementing effective strategies to foster the social skills of these students. Evidence-based practice (EBP) is one approach that can assist in delivering services to students with ASD, proving essential for their social development. Nonetheless, limited research has been conducted on …

How Scientists Can Investigate Perception: Phenomenological Foundations For Qualitative Research, Kimberly Tucker

Electronic Theses and Dissertations

While medicine makes visible symptoms of disease, phenomenology provides a different tool for making illness experience visible. Phenomenology offers a tool for a new kind of description and a different kind of knowledge of disease. It holds a unique epistemic power through the descriptions it generates through the application of the transcendental phenomenological method. Husserl’s method, outlined in Ideas I, provides the steps for its implementation in clinical research. This dissertation explores the application of the transcendental phenomenological method as a foundation for research on perception, with the goal of characterizing phenomenological validity as a proper goal of medical epistemology. …

Teaching Video Game As A Leisure Skill To Arab American Children With Autism Spectrum Disorder Using Video Modeling In A School Setting, Lubna Alzayyat

Electronic Theses and Dissertations

Leisure activities are important in assisting individuals with autism spectrum disorder (ASD) to build relationships, learn to behave socially appropriately, and acquire new interests- competences that assist in cultivating positive self-consciousness (Specht et al., 2002; Womack et al., 2011). Statistics indicate that 2.3% of 8-year-old children in the United States are diagnosed with ASD (CDC, 2021). Despite these large numbers and the tremendous benefits of engaging in leisure activities, participation in leisure activities is lower among children with ASD when compared to their typically developing peers (Ratcliff et al., 2018). The situation is worse when compared to children with ASD …

Advancing Continuous Manufacturing: The Role Of Process Analytical Technology In Process Development, Samuel R. Henson

Electronic Theses and Dissertations

The pharmaceutical industry is actively pursuing technologies which improve manufacturing processes with the goal of producing high-quality pharmaceutical products for patients, manifesting in an industry-wide investment in continuous manufacturing (CM). Process analytical technology (PAT) has been recognized for its successful monitoring of critical quality attributes during routine production and is often cited alongside CM due to its ability to make timely, in-line measurements of intermediate materials. Various PAT tools are valuable in process development, particularly as continuous wet granulation processes are developed for use within pharmaceutical manufacturing. This work applied PAT and chemometric modeling during CM process development to enhance …

Wounded And Healing: Licensed Counselors’ Experience With Personal Suicide Loss And The Impact On Clinical Practice, Supervision, And Self-Disclosure, Shannon Strohl

Electronic Theses and Dissertations

This study sought to explore the lived experiences of licensed counselors who experienced personal suicide loss and the impact of their loss on their professional lives. Of particular interest was the impact of the loss on countertransference, professional direction and choices, and self-disclosure with clients and other professionals in the field (e.g., supervisors, professors, and colleagues). The concept of the wounded healer, as described by Zerubavel and Wright (2012), served as the theoretical framework used to understand the participants’ stories. Previous studies have examined the wounded healer among psychologists; however, few studies explored the experience of licensed counselors as wounded …

Method Development Of [3 + 2] Cycloadditions Using Tertiary Amine N-Oxides And Efforts Towards The First Total Synthesis Of Chrysosporazine D, Alexander Cocolas

Electronic Theses and Dissertations

Nitrogen-containing heterocycles are ubiquitous in bioactive molecules, pharmaceutical drugs, and natural products. For this reason, finding new and efficient ways to make such compounds remains a high priority for the organic and medicinal community. Our current endeavors build upon previously established work by our group, where we generated 1,2-diamines by coupling commercially available aldehydes with trimethylamine N-oxide (TMAO) in two steps. This route proved to be effective in generating 20+ novel 1,2-diamines and imidazolidines with a demonstrated ability to undergo transformations. Using this chemistry, we have developed a diastereoselective synthesis of 50+ novel 7-azanorbornanes using tertiary amine N-oxides …

Ethical Considerations In The Diagnosis And Treatment Of Autism Spectrum Disorder, Ferdinand Okafor

Electronic Theses and Dissertations

This dissertation is an ethical response to the ethical issues in the assessment, diagnosis, and treatment of autism. The problems that underlie the discussion are misconception about autism and Autistics. The misconception about autism and Autistics lead to misinterpretation of the neurological functioning, cognition, and the behaviors of Autistics. Consequently, it influences the approach and model of care in the assessment, diagnosis, and treatment of autism. Currently, the analytic approach and biomedical model of disease are applied in the assessment, diagnosis, and treatment of autism. The motive of the analytic approach and biomedical care is to cure autism. The consequence …

Rna Structural-Dynamical Hierarchy: Sars-Cov, Sars-Cov-2, And Delta/Omicron Variant S2m Monomers, Kissing Complexes, And Extended Duplexes, Adam Kensinger

Electronic Theses and Dissertations

The power and promise of ribonucleic acid (RNA) molecules are only beginning to be realized in living organisms and pharmaceutical intervention. Specifically, defining the chemical physics of RNA’s heterogenous structural ensemble and dynamics, which has experienced expansive growth over the last few years, is central to a complete understanding, yet continues to be a significant challenge. A 41-nucleotide hairpin called the stem-loop II motif (s2m), present in the viral genomes of severe acute respiratory syndrome (SARS), SARS-coronavirus-2 (SARS-CoV-2), and the Delta and Omicron variants responsible for the COVID-19 pandemic, is a potential antiviral target due to its high sequence conservation …

Saudi And American Students’ Motivation And Anxiety In Online Collaborative Learning In The United States, Nawal Alqarni

Electronic Theses and Dissertations

This research study aims to explore motivation and anxiety Saudi and American students in online collaborative learning environments through online courses in U.S. universities and how they relate to their academic performance.

The study utilized a quantitative approach for data collection through an online survey of 99 Saudi students and 39 American students who were enrolled in U.S. universities. The results showed that there was no significant difference in motivation scores between undergraduate Saudi students and their American counterparts. Nor was a significant difference observed in motivation scores between graduate Saudi students and graduate American students. The data also indicated …

Efficient Development Of Density-Insensitive Near-Infrared Methods For In-Line Drug Content Monitoring In Continuous Powder Streams, Natasha L. Velez-Silva

Electronic Theses and Dissertations

A well-defined action plan to respond effectively to sudden changes in product demand is critical for preventing drug shortages within the pharmaceutical industry. An effective way to increase the output of a continuous manufacturing (CM) process is through flow rate adjustments. However, robust analytical methods must be in place to ensure consistent analytical performance across varying flow rates. Existing approaches for mitigating the physical effects of flow rate on Near-Infrared (NIR) measurements are often burdensome. Thus, efficient robust modeling strategies that reduce the current calibration burden and ensure model insensitivity to the physical variations in CM systems are needed. In …

Muslim Spirituality As A Foundation In Bioethics For Patient Encounters In Health Care, Sara Rahman

Electronic Theses and Dissertations

Spirituality plays a major role in decision making for individuals with faith-based values. There is often hesitation to discuss the role of faith in healthcare as a core value and coping mechanism. The growing cultural diversity amongst patients and physicians has increased the need to understand eastern religious principles and incorporate them into bioethical guidance. Even as the 2nd largest religion in the world, Islam has not been sufficiently integrated into religious bioethics in western medicine. Muslim populations of patients and physicians are growing, increasing the need for better understanding of how Islamic principles impact healthcare delivery. Although Islamic law …

Design, Synthesis, And Characterization Of Multi-Targeting Pyrrolopyrimidine Antifolates As Potential Single Agent Chemotherapeutic Entities, Tejashree Magdum

Electronic Theses and Dissertations

In cancer chemotherapy, the currently marketed antifolates have two major disadvantages: dose-limiting toxicities to normal tissues and susceptibility to drug resistance. These are due to their major transport by the ubiquitously expressed transporter and mutagenesis in enzymes present in cancer cells. This thesis describes an introduction, background, and research progress in antimetabolites-antifolates designed to multi-target (a) one-carbon metabolism and de novo nucleotide synthesis pathway and (b) target overexpressed transporter in cancer cells for selective tumor-targeting.

Cancer cells transport folate through three transporters: ubiquitously expressed reduced folate carrier (RFC), limitedly expressed proton-coupled folate transporter (PCFT), and folate receptors (FRs). The research …

Daily Associations Between Minority Stressors And Dissociation For Sexual Minority Women And Transgender/Nonbinary Individuals: The Role Of Interpersonal Trauma, Kriti Behari

Theses - ALL

Sexual minority women (SMW), transgender, and/or gender-diverse (TGD) individuals experience interpersonal traumatic stressors (e.g., childhood abuse, sexual violence) at higher rates than their cisgender, heterosexual counterparts. This population also experiences ongoing stressors related to their minoritized sexual and gender identities (e.g., stigma, discrimination). Dissociation has been positively associated with trauma exposure-related factors (e.g., trauma type, chronicity, and severity) as well as identity-related stressors (e.g., stigma, discrimination) for sexual and gender minority people. Some research suggests that experiencing dissociation in response to traumatic stressors can result in individuals responding to non-traumatic chronic stressors with dissociation. However, no study has yet examined …

Tanzania Petroleum Development Corporation (Tpdc) And Its Role In Self-Reliance And Sustainability, Ladislaus Norbeth Tumbu

Theses - ALL

Tanzania possesses significant natural gas reserves, currently estimated at 57.54 trillion cubic feet, with the potential for further discoveries. This thesis examines the socio-economic impacts of Tanzania’s substantial natural gas reserves, focusing specifically on the Tanzania Petroleum Development Corporation (TPDC) and its engagement with the local communities in Mtwara and Lindi. TPDC is the national oil company and owner of all licenses for energy development in the country, wholly owned by the government of Tanzania with all its shares held by the Treasury Registrar. Through comprehensive literature review and field visits to production sites, the study examines TPDC’s management of …

The Influence Of Social Media On Adolescent Mental Health, Sally Diomande

Psychology Student Publications

This paper goes through the difficult relationship between social media use and adolescent mental health, focusing on both the positive and negative impacts. It discusses how social comparison, amplified by social media, can lead to feelings of inadequacy, anxiety, and depression, particularly due to the idealized representations of others lives.The paper also highlights the dangers of cyber-bullying, which exacerbates mental health issues and even leads to suicidal thoughts in some adolescents.

Diagnosing And Treating Adhd In Children, Ellie Renner

Psychology Student Publications

The goal of this paper is to raise awareness for the diagnosis and treatment of ADHD in children. ADHD stands for attention deficit hyperactivity disorder. As a parent, when you have reason to believe your child has ADHD, or they were diagnosed with ADHD, it is important to learn more about the diagnosis and the options for treating your child’s ADHD. This paper will provide you with information to help navigate the diagnosis.

Assembly Of Ppsu-Oligomers, Mariam Nesterov

Student Theses and Dissertations

The development of nanostructures for delivering multiple proteins to targeted antibodies has become a promising avenue in biotechnology, driven by advancements in synthetic polymers like poly(propylene sulfone), PPSU. However, the PPSU polymer faces a major limitation - its high insolubility. To address this challenge, this study investigates whether PPSU oligomers can enhance both the solubility and stability of lysozyme, a model protein that is cost-effective and widely accessible. Using dimer, trimer, tetramer, and hexamer configurations, we analyzed the interactions between PPSU oligomer and lysozyme under varying conditions. Our results show that the dimer and trimer are water soluble (no aggregate …

The Search For Unenumerated Fundamental Rights, Alina Sluzhyvenkova

Student Theses and Dissertations

There are certain rights that are explicitly enumerated in the Constitution, e.g., right to bear arms, right to free speech, right to a speedy and public trial. There are also rights that aren’t specifically written out but are nevertheless enjoyed by people nationwide. Rights that aren’t explicitly mentioned in the Constitution, but which are fundamental to are called the unenumerated rights. Unenumerated rights are just as important and can be derived from natural law, enumerated rights, the Ninth Amendment, precedents, judicial opinions, and substantive due process.

Substantive due process is a principle guaranteed by the Fifth and Fourteenth Amendments, which …

Addressing Over-The-Counter Proton Pump Inhibitor Overuse: Strategies For Pharmacists To Enhance Patient Care, Brenna Hissong, Giang Nguyen, Alexander Defranco, Layla Dials, Jordyn Linfield, Haley Brown, Joshua Honaker, Samantha Mccord, Alaina Kortokrax

Pharmacy and Wellness Review

Proton pump inhibitors (PPIs) are among the most commonly prescribed and widely used medications for the treatment of gastrointestinal (GI) disorders. PPIs irreversibly inhibit the H+/K+-ATPase enzyme, effectively reducing gastric acid secretion and providing sustained relief for acid-related conditions. With the approval of over-the-counter (OTC) PPIs, the number of individuals taking these medications for prolonged periods of time without routine monitoring for the appropriateness of therapy has increased. The overuse of OTC PPIs can be attributed to a number of factors, including ease of access, perceived safety, inadequate understanding of OTC PPI treatment intervals, and a lack of awareness regarding …

Fda Approves Neffy®- First Nasal Spray For Anaphylaxis, Abigail Carter, Penlope Mazivanhanga, Haylee Whyde, Rileigh Rahrig, Ashley Jacob, Anna Spalvieri, Joshua Honaker, Samantha Mccord, Andrew Roecker

Pharmacy and Wellness Review

Between 1.6 and 5.1% of the United States population have experienced anaphylaxis, a severe allergic reaction.1 Anaphylaxis occurs when someone is exposed to an allergen, most commonly foods, medications, and insect venom. Epinephrine is the first-line agent for anaphylaxis treatment, and it is critical to administer this medication immediately after the onset of anaphylactic symptoms to prevent worsening that could lead to death. Epinephrine, more commonly known as EpiPen® or Auvi-Q®, has historically only been available as an intramuscular (IM) injection. Many people are afraid, anxious, or uneducated on how to properly give someone an IM injection, causing anaphylaxis treatment …

Fda Greenlights Early-Stage Trial For Investigational Long Covid Treatment: Phase Ii Evaluation Pending, Arin Wade, Maria Nguyen, Allie Honigford, Kennedy Kosikowski, Minhwan Yang, Rebecca Willier, Joshua Honaker, Samantha Mccord, Theresa Hempleman

Pharmacy and Wellness Review

Long coronavirus disease (COVID) is a condition that affects millions of individuals worldwide. Long COVID manifests as persistent symptoms following acute COVID-19. These symptoms can include, but are not limited to, fatigue, cognitive dysfunction, and chronic inflammation often lasting for months and significantly impairing patients' quality of life. As the number of Long COVID cases continues to rise and major global health organizations begin to standardize Long COVID’s mechanisms and diagnosis, there is an increasing demand for effective treatments that can address its complex nature. While some therapies, such as metformin and hyperbaric oxygen therapy (HBOT) have shown promise in …

Protecting The Integrity Of Sports, Matthew J. Parlow

Seton Hall Law Review

No abstract provided.

Organ-On-A-Chip Platforms For Drug Development, Cellular Toxicity Assessment, And Disease Modelling, Muhammad Maaz Khurram, Göktürk Ci̇nel, Özlem Yeşi̇l Çeli̇ktaş, Erdal Bedi̇r

Turkish Journal of Biology

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, …