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2024

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Sloshing Analysis Of An Isothermal Fluid In A Cylindrical Tank For Cryogenic Tank Design Using Smoothed Particle Hydrodynamics, Dillon Freeman Dec 2024

Sloshing Analysis Of An Isothermal Fluid In A Cylindrical Tank For Cryogenic Tank Design Using Smoothed Particle Hydrodynamics, Dillon Freeman

The Plymouth Student Scientist

This paper investigates the capability of Smoothed Particle Hydrodynamics to model the free surface sloshing response of an isothermal fluid in a cylindrical geometry. Eleven frequencies for two horizontal driving amplitudes (0.5 mm & 2.0 mm) were validated against experimental results and the influence of the starting direction of the tanks acceleration on the steady state response was investigated. The SPH results reproduced the overall behaviour of the experimental data closely over the range of frequencies tested, but produced higher amplitudes with greater variance in the region of the tanks natural frequency. Furthermore good symmetry was observed between sidewalls for …


Circle Of Security Parenting; A Qualitative Investigation Into The Perceived Long-Term Impact On Parenting In Plymouth, United Kingdom, Rebecca Cartwright Dec 2024

Circle Of Security Parenting; A Qualitative Investigation Into The Perceived Long-Term Impact On Parenting In Plymouth, United Kingdom, Rebecca Cartwright

The Plymouth Student Scientist

Parenting is a unique experience for every family and improving this experience for both the child and the parent has long-term benefits for giving the child the best opportunities for the future. Attachment has been noted as a factor which improves a child's development and other areas of their life with a lasting effect into adulthood. An example of interventions used to improve parent-child relationships are parenting courses. Circle of Security Parenting is an 8-week parenting course designed to support attachment by encouraging a group of between four and six parents to reflect on their own childhood and subsequently their …


Changes In Reef Fish Assemblage And Coral Reef Community In A Newly Established Marine Protected Area, Skye Neal Dec 2024

Changes In Reef Fish Assemblage And Coral Reef Community In A Newly Established Marine Protected Area, Skye Neal

The Plymouth Student Scientist

Coral reef ecosystems are vital to sustaining marine biodiversity and provide invaluable resources to coastal communities. However, coral reefs across the globe are exposed to harmful local and global anthropogenic pressures that can lead to the mortality of key reef-building corals, consequently disrupting ecosystem functioning. Preserving biodiversity of coral reef systems continues to be a challenging topic in conservation. Marine Protected Areas (MPAs) are a globally recognised spatial management tool, designed to protect marine species and habitats from anthropogenic induced stressors. Here, using a long-term dataset collected over the last ten years from the unique coral reef system of Banco …


Investigating Climate Change And Nutrient Pollution Effects On Drupella Rugosa Coral Reef Destruction In Koh-Tao, Thailand, Beatrice Canteri Dec 2024

Investigating Climate Change And Nutrient Pollution Effects On Drupella Rugosa Coral Reef Destruction In Koh-Tao, Thailand, Beatrice Canteri

The Plymouth Student Scientist

The introduction and proliferation of invasive species in coral reef ecosystems play a pivotal role as significant contributors to ecological disturbance. These invasive species pose specific threats to the delicate equilibrium of coral reef health by disrupting nutrient cycling, modifying community structure, applying selective pressure on essential coral species, leading to ecosystem degradation. Embarking on an exploration of ecological intricacies, this study focuses on the invasive coral-feeding snail Drupella rugosa in Koh Tao and aims to explore how environmental variables affect its abundance. Although prior research elucidated the impacts of environmental stressors on coral reef degradation, methodological limitations and gaps …


An Exploratory Analysis Of Within And Between-Testlet Local Item Dependence In A Medical School Admission Situational Judgment Test Using Exploratory Structural Equation Modeling, Ester Sampson Dec 2024

An Exploratory Analysis Of Within And Between-Testlet Local Item Dependence In A Medical School Admission Situational Judgment Test Using Exploratory Structural Equation Modeling, Ester Sampson

Theses and Dissertations

To use a Cronbach's alpha coefficient or IRT methods on measuring instruments, both unidimensionality and local item dependence (LID) conditions need to be met. Moreover, LID can potentially introduce an unintended additional dimension into the test at the expense of the constructs of interest. Situational judgment tests use testlet structures, and thus likely present degrees of LID. We explored the latent structure and degrees of local item dependence in a situational judgment test (SJT) used by a Western United States medical school (WMS) for admission purposes. I used a fully deidentified data set from a group of 560 examinees who …


Quantifying Interpretation Reproducibility In Vision Transformer Models With Tavac., Yue Zhao, Dylan Agyemang, Yang Liu, J Matthew Mahoney, Sheng Li Dec 2024

Quantifying Interpretation Reproducibility In Vision Transformer Models With Tavac., Yue Zhao, Dylan Agyemang, Yang Liu, J Matthew Mahoney, Sheng Li

Faculty Research 2024

Deep learning algorithms can extract meaningful diagnostic features from biomedical images, promising improved patient care in digital pathology. Vision Transformer (ViT) models capture long-range spatial relationships and offer robust prediction power and better interpretability for image classification tasks than convolutional neural network models. However, limited annotated biomedical imaging datasets can cause ViT models to overfit, leading to false predictions due to random noise. To address this, we introduce Training Attention and Validation Attention Consistency (TAVAC), a metric for evaluating ViT model overfitting and quantifying interpretation reproducibility. By comparing high-attention regions between training and testing, we tested TAVAC on four public …


Enhancing Orthodontic Retraction: A Randomized Controlled Trial On Injectable Platelet-Rich Fibrin's Impact On Tooth Movement, Gabriel Eisenhuth, Sebastian Eisenhuth Dec 2024

Enhancing Orthodontic Retraction: A Randomized Controlled Trial On Injectable Platelet-Rich Fibrin's Impact On Tooth Movement, Gabriel Eisenhuth, Sebastian Eisenhuth

Annual Research Symposium

Introduction: Accelerated orthodontics aims to shorten treatment duration while improving patient comfort. Injectable platelet-rich fibrin (i-PRF) has been proposed to enhance orthodontic tooth movement (OTM) by stimulating bone remodeling. This study evaluates the effect of i-PRF on space closure rates, anchor loss, and salivary biomarkers (ALP, AST, and LDH) during orthodontic retraction.

Materials and Methods: Twenty-four participants requiring extractions and space closure were divided into two groups (n = 12 each). Group A (experimental) received i-PRF, while Group B (control) did not. Space closure, anchor loss, and salivary enzyme activity were measured at T0 (baseline), T1 (3 weeks), T2 (6 …


Exploring The Benefits Of Feature Selection Based On Bat Algorithm And Deep Learning In Brain Cancer Diagnosis, Noor Fawzi Shafiq Dec 2024

Exploring The Benefits Of Feature Selection Based On Bat Algorithm And Deep Learning In Brain Cancer Diagnosis, Noor Fawzi Shafiq

Al-Esraa University College Journal for Engineering Sciences

Brain cancer is considered one of the most dangerous types that must be treated as soon as possible. Therefore, it is necessary to detect brain cancer in its early stages to enhance the diagnosis of the condition. This study proposes to combine the bat algorithm (BA) with deep learning methods to identify and classify brain tumors in medical images accurately.

In this paper, the bat algorithm was used to select distinctive features from the input brain images. The Bat Algorithm (BA) is a metaheuristic optimization algorithm that mimics the echolocation behavior of bats. It efficiently explores the feature space to …


Toward Effective Interfaith Relations Between Christianity And Indigenous African Religious Tradition In The Obolo Context In Nigeria – A Decolonial Theological Approach, Jerome Etenduk Dec 2024

Toward Effective Interfaith Relations Between Christianity And Indigenous African Religious Tradition In The Obolo Context In Nigeria – A Decolonial Theological Approach, Jerome Etenduk

Electronic Theses and Dissertations

This study focuses on the need for effective interfaith relations between Christianity and the Indigenous African Religious Tradition (IART) in a post-colonial Obolo context in Nigeria. It explores a history of complex religious crises in Obolo and identifies that Eurocentric/colonial theological imagination constitutes a significant reason for the problematic interfaith relations in Obolo. The dominant Eurocentric/colonial theology is founded on the theoretical framework that assumes that Europe (and America) is the hubris of knowledge. It negates and discounts the knowledge systems of other people. To know, they must learn from Europe and America. In this way, European missionaries to Obolo …


Increasing Awareness Of The Effectiveness Of Occupational Therapy In Cancer Rehabilitation, Aaliyah Parson, Zeida Gutierrez Dec 2024

Increasing Awareness Of The Effectiveness Of Occupational Therapy In Cancer Rehabilitation, Aaliyah Parson, Zeida Gutierrez

Fall 2024 OTD Capstone Symposium

Many cancer survivors are faced with functional limitations when engaging in meaningful occupations due to side effects such as anxiety, pain, fatigue, weakness, nausea, etc. from receiving cancer treatments which can impact their quality of life. Occupational therapy has a significant role in supportive care for cancer survivors by providing occupation-based interventions that focus on maximizing function and mitigating functional decline. However, occupational therapy is underutilized in cancer care due to patients' lack of awareness of the role of OT and how it can improve quality of life after receiving cancer treatment. Therefore, this capstone project took place in Tallahassee, …


Relationship Of Emotional Intelligence To Workplace Stress And Burnout In Behavior Analysts, Elia Santos Dec 2024

Relationship Of Emotional Intelligence To Workplace Stress And Burnout In Behavior Analysts, Elia Santos

Student Dissertations

The experience of stress leading to burnout is at an all-time high in the field of behavior analysis. Increasing job demands for board-certified behavior analysts (BCBA) put newly minted BCBAs at a higher risk of burnout. The problem is that BCBAs only receive technical and clinical training to become certified. Yet, their emotional intelligence (EI), which is associated with stress and burnout, had never been examined. The purpose of this quantitative, associational study was to investigate the relationships between EI, workplace stress, and burnout in BCBAs. The theoretical framework for this study was based on Goleman’s (1995) theory of EI. …


Advancing Healthcare Through The Integration Of Digital Twins Technology: Personalized Medicine’S Next Frontier, Sharmin Attaran, Mohsen Attaran Dec 2024

Advancing Healthcare Through The Integration Of Digital Twins Technology: Personalized Medicine’S Next Frontier, Sharmin Attaran, Mohsen Attaran

Marketing Department Faculty Journal Articles

The use of Digital Twin technology has been expanding rapidly, and projections indicate that it will continue to proliferate across various applications, use cases, and industries, including healthcare. In recent years, the healthcare sector has seen an acceleration in digital transformation. This fast-paced change offers both opportunities and risks, especially with emerging technologies like digital twins, which are relatively untested and still in the early stages of adoption in medical care. This paper aims to conduct a literature review to explore how digital twins facilitate intelligent automation in healthcare. It defines the concept, traces the technology’s evolution and development, reviews …


Optimizing Wind Wing Wall Ventilation In High-Rise Buildings Within Dense Urban Hot And Humid Climate., Arushi Bhatia Dec 2024

Optimizing Wind Wing Wall Ventilation In High-Rise Buildings Within Dense Urban Hot And Humid Climate., Arushi Bhatia

Theses

This study investigates how wing walls can increase natural ventilation in high-rise structures, particularly in hot, humid locations such as Mumbai, India. Using wind flow simulations and computational fluid dynamics (CFD) modeling, the study investigates how wind direction and the installation of wing walls affect airflow throughout the building. The study examines four scenarios, each analyzing how airflow varies when a building is located near surrounding structures of differing heights. It uses comprehensive CFD simulations to assess how alternative wing wall depth design can affect ventilation, as well as how wall-to-window ratio variation can contribute to airflows. Following these simulations, …


From Factories To Homes: A Comparative Analysis Of Adaptive Reuse In New England Industrial Buildings For Multi-Family Residential Conversion, Jeremy Weeden Dec 2024

From Factories To Homes: A Comparative Analysis Of Adaptive Reuse In New England Industrial Buildings For Multi-Family Residential Conversion, Jeremy Weeden

Theses

The adaptive reuse of industrial buildings offers a promising path toward sustainable urban development, particularly in New England. This study investigates the feasibility and energy efficiency of converting an older, unused industrial building into a multi-family residential structure by evaluating three distinct wall assemblies that preserves the exterior brick facade: existing structural brick, a typical adapted wall assembly with interior 2x4 wood construction, and a high-efficiency adapted wall assembly with an additional interior 2x6 wood construction. Through a detailed case study analysis focusing on the building’s core and shell, this research aims to identify the most effective wall assembly for …


Comparative Analysis Of Earth-Bermed And Conventional; Single-Family, Residential Homes In The Hudson Valley Region, Beacon, New York, Michael G. Patchen Dec 2024

Comparative Analysis Of Earth-Bermed And Conventional; Single-Family, Residential Homes In The Hudson Valley Region, Beacon, New York, Michael G. Patchen

Theses

This thesis is a comparative analysis of the environmental sustainability between two similar square-foot, single-family residential homes constructed as a bermed shelter and the conventional wood frame in the Hudson Valley Region, Beacon, New York. The research will focus on the two designs' embodied carbon, cost, and energy use. To quantify the environmental impact of these two construction methods, an in-depth understanding of the diverse host climate is necessary. Climate data and the results from the experiments are collected by performing life cycle, cost, and energy analysis, providing insights into the environmental implications of residential construction methods. The methodology will …


Kenneth Konias, Jr. V. Pennsylvania Department Of Corrections Dec 2024

Kenneth Konias, Jr. V. Pennsylvania Department Of Corrections

2024 Decisions

USDC for the Western District of Pennsylvania


Information Management Plan – Delivery Team, Robert Moore Dec 2024

Information Management Plan – Delivery Team, Robert Moore

Tools

Information Management Plan – Delivery Team is a support in a spreadsheet format that contains a number of delivery team (tenderers) templates that ISO 19650 recommend the delivery team (tenderers) should consider when responding to a tender to deliver a project for an Asset.

Build Digital has created Industry templates to allow organisations work in accordance with ISO 19650. These templates start to address the information requirements in the ISO 19650 series of standards. The templates are also in accordance with CEN-TR17654-2021” Guideline for the implementation of Exchange Information Requirements (EIR) and BIM Execution Plans (BEP) on European level based …


Effects On Maternal And Pregnancy Outcomes Of First-Trimester Malaria Infection Among Nulliparous Women From Kenya, Zambia, And The Democratic Republic Of The Congo, Sequoia I. Leuba, Daniel Westreich, Carl L. Bose, Andrew F. Olshan, Steve M. Taylor, Antoinette Tshefu, Adrien Lokangaka, Waldemar A. Carlo, Elwyn Chomba, Musaku Mwenechanya, Edward A. Liechty, Sherri L. Bucher, Osayame A. Ekhaguere, Fabian Esamai, Paul Nyongesa, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Janet L. Moore, Tracy L. Nolen, Jennifer Hemingway-Foday, Elizabeth M. Mcclure, Marion Koso-Thomas, Richard Derman, Matthew Hoffman, Steven R. Meshnick, Melissa Bauserman Dec 2024

Effects On Maternal And Pregnancy Outcomes Of First-Trimester Malaria Infection Among Nulliparous Women From Kenya, Zambia, And The Democratic Republic Of The Congo, Sequoia I. Leuba, Daniel Westreich, Carl L. Bose, Andrew F. Olshan, Steve M. Taylor, Antoinette Tshefu, Adrien Lokangaka, Waldemar A. Carlo, Elwyn Chomba, Musaku Mwenechanya, Edward A. Liechty, Sherri L. Bucher, Osayame A. Ekhaguere, Fabian Esamai, Paul Nyongesa, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Janet L. Moore, Tracy L. Nolen, Jennifer Hemingway-Foday, Elizabeth M. Mcclure, Marion Koso-Thomas, Richard Derman, Matthew Hoffman, Steven R. Meshnick, Melissa Bauserman

Department of Medicine Faculty Papers

BACKGROUND: Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.

METHODS: In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.

RESULTS: Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth …


Synthesis And Characterization Of Novel Diffusible Signal Factor Analogs For Antibiofilm Properties, Elisabeth Rachel Wiley Dec 2024

Synthesis And Characterization Of Novel Diffusible Signal Factor Analogs For Antibiofilm Properties, Elisabeth Rachel Wiley

Electronic Theses and Dissertations Archive

Biofilms are composed of biomolecules, bacteria, and sometimes fungi and are considered the leading cause of antibiotic resistance. Biofilm formation and dispersion is regulated in part by signaling molecules called diffusible signal factors (DSF) through a process termed quorum sensing. However, the mechanism of action behind quorum sensing remains poorly understood. Chapter 1 focuses on the structure activity relationship (SAR) of DSF. DSF are medium chain fatty acids with an alkene at the C2-C3 carbon position. Tail length, branching, and cis/trans configuration all significantly affect antibiofilm action; these affects are also microbe specific. The chapter concludes with a discussion on …


A Conversation With Justice Brett Kavanaugh, Brett M. Kavanaugh, J. Joel Alicea Dec 2024

A Conversation With Justice Brett Kavanaugh, Brett M. Kavanaugh, J. Joel Alicea

Catholic University Law Review

On Thursday, September 26th, 2024, the Center for the Constitution and the Catholic Intellectual Tradition at The Catholic University of America hosted a conversation between Justice Brett M. Kavanaugh and Professor J. Joel Alicea. This was the inaugural event of the new Center. The conversation covered topics such as constitutional interpretation, the separation of powers, religious liberty, and the Catholic intellectual tradition. This is a transcript of the conversation, and the text appears substantially as it was delivered. The video of the event may be found at this link: https://www.youtube.com/watch?v=2sKvSwzkmqo.


The Illusory Coverage Doctrine Is Not A Doctrine At All (But It Should Be), Shannon W. Conway Dec 2024

The Illusory Coverage Doctrine Is Not A Doctrine At All (But It Should Be), Shannon W. Conway

Catholic University Law Review

The Illusory Coverage Doctrine, if it ever becomes a true legal doctrine, has the potential to be an incredibly useful tool in insurance law. But courts around the country take very different approaches to the doctrine, ranging from one end of the spectrum—a hard-nosed “pro-insurer” stance where coverage is not illusory so long as a policy provides any coverage—to the other—a muscular “pro-policyholder” public policy approach that requires coverage even if some other exclusion might have prevented coverage under the applicable policy. And along the spectrum are various other iterations, contributing to the complete lack of certainty or consistency about …


Ud In The News Dec. 13-20, University Of Dayton Dec 2024

Ud In The News Dec. 13-20, University Of Dayton

News Releases

Faculty contributed to New America, Catholic World Report and The Chronicle of Higher Education. Local media featured onMain, the McIntosh scholarship winner, graduation and University of Dayton Research Institute expertise.


Cover And Contents Dec 2024

Cover And Contents

Turkish Journal of Biology

No abstract provided.


Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir Dec 2024

Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir

Turkish Journal of Biology

Background/Aim: Sugarcane mosaic virus (SCMV; genus Potyvirus and family Potyviridae), poses a significant threat to global sugarcane cultivars, including those in Pakistan. The aim of this study was to develop a rapid and effective diagnostic tool for detection of SCMV, enabling timely implementation of control measures to mitigate potential yield losses.Materials and Methods: The study focused on the in silico analysis; physicochemical properties, immunogenicity and subcellular localization of the SCMV coat protein (CP). The SCMV coat protein (CP) gene was synthesized, cloned and expressed in Escherichia coli. The recombinant fusion coat protein (rFCP-SCMV) was purified and used to generate polyclonal …


Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n Dec 2024

Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Background: Melanoma arises from the uncontrolled multiplication of melanocytes, posing an escalating global health concern. Despite early detection and surgical removal being crucial, metastatic melanoma poses treatment challenges, with limited options like chemotherapy and immunotherapy. All-trans retinoic acid (ATRA), a natural metabolite of vitamin A, has shown promise in melanoma treatment by inducing differentiation, apoptosis, growth arrest, and immune modulation. However, ATRA treatment alone can lead to resistance and relapse. Sphingomyelin (SM) also plays a role in inhibiting melanoma progression by apoptotic cell death.Objective: This study investigated combinational anticancer effects of ATRA and SM on in vitro B16F10 melanoma cells.Method: …


Religion In Public Schools: Constitutional Revolution In Action, Noah R. Feldman Dec 2024

Religion In Public Schools: Constitutional Revolution In Action, Noah R. Feldman

University of Cincinnati Law Review

No abstract provided.


Is Hipaa Dead? How Recent Developments In Ftc Section 5 Enforcement May Impact Traditional Notions Of Health Privacy, Brian Patrick Dec 2024

Is Hipaa Dead? How Recent Developments In Ftc Section 5 Enforcement May Impact Traditional Notions Of Health Privacy, Brian Patrick

University of Cincinnati Law Review

No abstract provided.


Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar Dec 2024

Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s Disease (AD) is the leading cause of dementia, characterised by cognitive and functional impairments that disrupt daily activities. Different clinical modalities such as neuroimaging biomarkers, cognitive assessments, fluid biomarkers and genetic data provide unique and complementary information, contributing to a more comprehensive understanding of disease progression and heterogeneity in disease characteristics. With recent advancements in computational capabilities, particularly in deep learning, multimodal representation learning frameworks aim to integrate diverse clinical modalities into a cohesive framework, capturing the most significant patterns within each modality. Existing data-driven multimodal representation learning frameworks in AD research have two major limitations. First, AD progresses …


Defining The Chondrocyte “Mechanome”: How Mechanosensitive Ion Channels Trpv4 And Piezo1 Drive Changes In Gene Expression To Affect Cell Behavior And Cartilage Health, Daniel Raymond Palmer Dec 2024

Defining The Chondrocyte “Mechanome”: How Mechanosensitive Ion Channels Trpv4 And Piezo1 Drive Changes In Gene Expression To Affect Cell Behavior And Cartilage Health, Daniel Raymond Palmer

McKelvey School of Engineering Graduate Student Theses & Dissertations

Chondrocytes, the only native cell population of cartilage, utilize mechanosensitive transmembrane ion channels to sense mechanical forces. Transient Receptor Potential Vanilloid 4 (TRPV4) is activated by physiologic levels of load (resulting in ~10% tissue deformation) while PIEZO1 is activated by supraphysiologic levels of load (resulting in >50% tissue deformation). TRPV4 activation promotes the expression of a limited number of chondrogenic genes and the production of vital cartilaginous matrix proteins, while PIEZO1 activation drives cell death and senescence, cytoskeletal weakening, and production of catabolic mediators, which contribute to the development of osteoarthritis (OA). However, the path connecting activation of these channels …


Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta Dec 2024

Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta

McKelvey School of Engineering Graduate Student Theses & Dissertations

Deep learning driven computational methods have profoundly impacted medical imaging by advancing feature extraction, and by establishing a critical foundation for downstream image analysis and interpretation. Co-clinical trials are an emerging area of investigation in which a clinical trial is coupled with a corresponding preclinical study to inform the corresponding clinical trial to enhance translational accuracy and therapeutic development. Within this framework, quantitative imaging and pathology plays a fundamental role in both clinical and preclinical arms of co-clinical trials. Quantitative imaging enables enabling identification and validation of imaging biomarkers which are leveraged to predict therapeutic response, characterize disease phenotypes, and …