Digital Commons Network^™

A 3d Co-Culture Model Of Senescent Cell Burden And Salivary Gland Fibrosis, Stephen Rose

Electronic Theses & Dissertations (2024 - present)

Patients with head and neck cancer often suffer collateral radiation damage to the salivary glands, leading to fibrosis. Histological examinations indicate that radiation encourages fibrosis by promoting cellular changes leading to both senescent and myofibroblast phenotypes, coupled with a significant loss of regenerative and acinar cells. Chronic hypofunction remains a primary concern, even with modified radiation approaches to sparing salivary glands. Current treatments primarily offer symptomatic relief without rectifying irreversible glandular tissue damage. This limitation arises, in part, from a deficiency in predictive preclinical models to study this multifaceted problem.

We introduce a 3D in vitro microtissue model to address …

Stable Oxygen Isotope Variability As A Proxy For Large-Scale Dynamics Of The South American Summer Monsoon, Rebecca Orrison

Electronic Theses & Dissertations (2024 - present)

Terrestrial archives of oxygen isotope records are particularly important for the study of South American hydrology, where hydroclimate observations over the historical period are sparse and often not long enough to characterize multidecadal to centennial-scale changes. Knowledge of such low-frequency changes is critically important for interpreting and constraining projections of future change and detecting the emergence of forced change beyond the envelope of natural variability. This dissertation focuses on the past, present, and future of South American tropical and subtropical climate, with an emphasis on the mature phase of the monsoon season (December, January, and February; DJF) using oxygen isotopes …

Understanding Teacher Behavior And Its Influence On Student On-Task Behavior, Jennifer Birchler

Electronic Theses & Dissertations (2024 - present)

Student behavior in the classroom is a significant predictor of student outcomes and teacher satisfaction. But, teachers report classroom management to be challenging. Finding simple, cost-effective methods of improving student behavior in the classroom can vastly improve long-term success for students. This study seeks to better understand how class size relates to teacher praise and movement, and how these teacher behaviors relate to student on-task behavior. Previous research suggests on-task behavior improves with more teacher praise and movement in the classroom. The current study used data collected using the Bx Management Tool as part of the Osage County Fall 2019 …

Testing An Integrated Dual Diathesis-Threat Model Of Authoritarianism, Brendan Gallagher

Electronic Theses & Dissertations (2024 - present)

The Dual Diathesis-Threat Model of Authoritarianism proposes parallel motivational pathways by which similar personality features could predispose liberals and conservatives to different forms of authoritarianism. Specifically, the model posits that cognitive rigidity serves as a shared dispositional ‘diathesis’ of right- and left-wing authoritarianism ‘activated’ by distinct threats. For cognitively rigid conservatives, threats of change (i.e., threats to cohesion/conventions, cultural shifts) were expected to enhance the embrace of RWA; while for cognitively rigid liberals, threats to change (i.e., oppression, inequities, barriers to social progress) were predicted to promote LWA. Two studies examined this premise. In Study One, American citizens (N …

The Effect Of Presenting Concerns On Providers’ Assessment Of Patients' Suicide Risk, Alexandria Brunkow

Electronic Theses & Dissertations (2024 - present)

Objective: Suicide is the 10^th leading cause of death in the U.S. with nearly 50,000 people per year dying by suicide. Public health approaches to suicide prevention focus on screening people in primary and mental health care settings and offering treatment to those who screen positive. Research shows that mental health providers may not recognize risk factors for suicide and miss opportunities to screen patients who may be at risk. Providers’ mental representations of suicide risk may be influencing their perception of patient risk and contributing to low screening rates. This study used an experimental vignette case design to …

Sparse Representation Learning For Temporal Networks, Maxwell Mcneil

Electronic Theses & Dissertations (2024 - present)

Temporal networks arise in many domains including activity of social network users, sensor network readings over time, and time course gene expression within the interaction network of a model organism. Data of this type contains a wealth of prior information such as the connectivity among nodes (e.g., a friendship graph), and prior knowledge of expected temporal patterns (e.g., periodicity). Modeling these temporal and network patterns jointly is essential for state-of-the-art performance in temporal network data analysis and mining. Sparse dictionary encoding is one modeling approach for such underlying patterns. However, most classical approaches consider only one dimension of the data …

Examining Downshear Reformation In Tropical Cyclones, Nathalie Rivera Torres

Electronic Theses & Dissertations (2024 - present)

The development of a new low-level circulation center in tropical cyclones, known as downshear reformation, can lead to sudden changes in storm structure and intensity, representing a challenge in forecasting tropical cyclones. This phenomenon is commonly observed in weak tropical cyclones (e.g., tropical depressions, tropical storms) experiencing moderate to strong vertical wind shear (> 5 m s-1), when the vertical wind shear organizes convection in the downshear region of the tropical cyclone, and lower-tropospheric vorticity is generated within the intense convection. Downshear reformation has been proposed as a mechanism for intensification, sometimes rapidly, in tropical cyclones under unfavorable environmental wind …

Understanding Local And Large-Scale Drivers Of Rainfall Variability And Change Over The Hawaiian Islands Region, Katrina Fandrich

Electronic Theses & Dissertations (2024 - present)

Hawaiian rainfall variability is strongly influenced by anthropogenic climate change and natural variability (e.g., Pacific Decadal Oscillation (PDO), Pacific North American (PNA) pattern, El Niño–Southern Oscillation (ENSO)). For local decision-makers and resource managers, understanding the drivers of rainfall variability and change in Hawai‘i is crucial for climate adaptation and mitigation planning. Previous studies have applied statistical and dynamical downscaling to produce high-resolution rainfall projections for the Hawaiian Islands region. However, to date, downscaling has only been used to investigate the influence of anthropogenic forcing on late-century rainfall projections for the Hawaiian Islands. For regions like Hawai’i, that are highly vulnerable …

A Combinatorial Model For Affine Demazure Crystals Of Levels Zero And One, Samuel Spellman

Electronic Theses & Dissertations (2024 - present)

The symmetric and non-symmetric Macdonald polynomials are special families of orthogonal polynomials with parameters q and t. They are indexed by dominant, (resp. arbitrary) weights associated to a root system and generalize several well-known polynomials such as the Schur polynomials, Jack polynomials, Hall-Littlewood polynomials, etc. There are two well-known combinatorial models for computing these polynomials: a tableau model in type A, due to Haglund, Haiman and Loehr, and a type-independent model due to Ram and Yip, based on alcove walks.

Crystals bases are an important construction encoding information about Lie algebra representations. It turns out that there is an interesting …

Deconstructing Whiteness In Teacher Education, Allison Karcher

Electronic Theses & Dissertations (2024 - present)

This study sets out to understand how five teacher educators deconstruct whiteness in their courses and how their institutions support or hinder their work. Undergirding the study is the silence of whiteness residing in education and the urgency to notice, name, and disrupt it (Kohli et. al, 2021; Sleeter, 2017). The racial demographics in K-12 is 80% White for educators, and 54% students of color (National Center for Education Statistics, 2021). Therefore, most educators are teaching from experiences or identities that differ than their students. Since teaching is a personal endeavor, bringing our identities and experiences into the classroom, (Ahmed, …

The Transdiagnostic Role And Measurement Of Cognitive Inflexibility Across Understudied Eating Disorder Groups: A Multi-Method Investigation, Mckenzie Miller

Electronic Theses & Dissertations (2024 - present)

Cognitive inflexibility is an established transdiagnostic executive function deficit that maintains a wide array of psychiatric conditions. Eating disorders (ED) are serious, life-threatening conditions that remain underdiagnosed and understudied across diverse demographic groups. There is growing evidence for a role of cognitive inflexibility in driving hallmark ED symptoms, particularly in anorexia nervosa. Treatments targeting cognitive inflexibility may improve the currently poor outcomes of these conditions. To date, the role of cognitive inflexibility remains to be examined across demographically and diagnostically diverse ED groups. The first two studies presented here examine associations between cognitive inflexibility and symptom presentation in two relatively …

A Foundation For Transformative Learning Practices In Higher Education, Michelle Meyer

Electronic Theses & Dissertations (2024 - present)

Higher education institutions in the United States have an ongoing rhetoric of claiming that they offer students educational experiences that build skills and prepare them for a career. However, reports from employers and students indicate that many schools are struggling to do so, and research imperative skills like critical thinking have wide construct definitions that can be difficult for institutions to work with. Transformative learning theory (TLT) is a theoretical practice and pedagogy that could support institutions by providing both a pedagogical foundation of what should occur in a classroom and a series of steps for what transformative learning looks …

Understanding How Laypeople Perceive Sexual Harassment Claims From "Non-Typical" Claimants, Jennifer Mezzapelle

Electronic Theses & Dissertations (2024 - present)

Over the past four decades, scholars have generated a wealth of knowledge on the topic of sexual harassment. However, in much of this research, findings may have resulted from participants assuming that the target in question was a “typical” sexual harassment victim (i.e., a White, straight, cisgender woman who is traditionally feminine and conventionally attractive; Kaiser et al., 2022). As a result, the generalizability of this research is inherently limited, as it may not accurately reflect how sexual harassment is perceived when it is aimed at a person who does not possess the attributes typically associated with sexual harassment targets. …

Remediating Fibrosis To Restore Salivary Gland Function, Jennifer Morrissey

Electronic Theses & Dissertations (2024 - present)

Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. In the case of persistent injury or autoimmunity, as in Sjogren’s Disease, the ECM persists. Fibrosis can be studied in multiple animal models. Our lab has published the use of a mouse submandibular salivary gland partial resection model. In this procedure 40% of the left distal tip of the submandibular salivary gland (SMG) is excised. This leads to a chronic sustained fibrotic response in a localized region. The use of the non-obese diabetic mouse (NOD) has …

School-Based Grief Interventions For Childhood Bereavement: A Systematic Review, Louise M. Olson

Electronic Theses & Dissertations (2024 - present)

Childhood bereavement is a critical national issue in the United States. Children and adolescents who experience the death of a significant person, such as a parent or sibling, are predisposed to a variety of negative risk factors and long-term implications across several domains, including academic and social-emotional functioning. Schools are in the unique position to offer free, accessible mental health services to grieving students. As such, it is vital that school mental health professionals have access to information about evidence- and school-based grief interventions. The current study is a systematic review of school-based grief interventions for students who have experienced …

The Effect Of Learning Environment And Student Groupings On Math Skill Mastery, Erin Marr

Electronic Theses & Dissertations (2024 - present)

This study was designed to evaluate the impact of instructional group size and composition on student progress within a classwide math intervention. In terms of group size, groupings of greater than and less than 10 students were compared. In terms of group composition, homogeneous and heterogeneous groups were compared, defined by grouping the classes with standard deviations of student performance within the upper quartile (heterogeneous) and lower quartile (homogeneous) on a pre-intervention measure. The outcome measure used to evaluate student progress was the number of trials required for students to reach mastery on a specific skill within the 16-skill intervention …

Compassion Cartography: Mapping The Psychological Landscape Of Altruistic Equity And Effectiveness, Kyle Fiore Law

Electronic Theses & Dissertations (2024 - present)

Psychologists and philosophers have often championed deliberative reasoning over empathy as a better approach to overcoming parochial biases and guiding altruistic equity and effectiveness. Advocates of the effective altruism (EA) philosophy even advise philanthropists to downregulate empathic responses to maximize the impact of their donations. However, recent research reveals that extraordinary altruists (XAs), such as those who donate organs to strangers, are driven primarily by empathy. This dissertation explores whether empathy necessarily impedes altruistic equity (impartial regard for others’ welfare) and effectiveness (prioritizing impact), revealing a more nuanced reality that challenges this perspective. Across two phases of research involving three …

The Shifting Suns: A New Understanding Of The Five Suns Story Of The Mexica Empire And 16th Century Colonial Mexico, Heungtae Yang

Electronic Theses & Dissertations (2024 - present)

In this dissertation, I study the Mexica creation story commonly known as the Five Suns Story (Abbreviation: FSS) to explain the coexistence of multiple texts of FSS, the evolution of FSS from 1400 to 1600, and its multiple functions in multiple cultural spheres of the Mexica society. In contrast to previous studies up to the 1990s, whose main goals were to cite the Five Suns Story as part of a larger research topics, reconstruct a pure pre-Columbian version of the story, and analyze specific aspects of its symbolism, I conduct an intensive study of the FSS that brings together multiple …

Building Engaged Audiences: The Influence Of Multimedia-Inclusive Posts On Online Engagement Breadth And Depth For Arts And Culture Nonprofit Organizations, Sabrina Jeffcoat

Electronic Theses & Dissertations (2024 - present)

In recent years, broad access to digital communication tools provided by the “tech boom” has forced arts and culture nonprofit organizations (ACNPO) to transition to social media and mobile applications to engage audiences. While various approaches focus on building breadth (i.e. recirculation of content) and depth (i.e. replies) of engagement, ACNPO use multimedia to spur discussion and dissemination of their mission. Dependent on individual donors who generally give in small amounts, ACNPO are reliant on effective and visual social media campaigns to drive virality and broaden marketing appeal. Yet questions remain whether the presence of multimedia-inclusive posts (MIP) generates broader …

Evaluating The Impact Of Instruction Mode And Experience On Meditation Intentions And Outcomes In Self-Taught Meditators And Mindfulness-Based Stress Reduction Completers, Leah Howard

Electronic Theses & Dissertations (2024 - present)

Objectives: The widespread availability of mindfulness-based practices has led to growing concern about the potential for misuse, namely the use of such practices as a control-based strategy rather than in an acceptance-based manner consistent with research. Thus, the present study aimed to elucidate factors (e.g., mode of instruction, meditation experience, psychological [in]flexibility [PF/PI]) that may relate to intentions guiding meditation use. Methods: Self-taught (ST) and Mindfulness-Based Stress Reduction (MBSR) meditators (N = 122, Mage = 46.54, SDage = 16.49, 65.6% Female) completed a battery of measures assessing meditation intentions (control- or acceptance-based), meditation experience (in months), PF/PI, psychological distress, …

Innovative Solutions In Medical Diagnostics, Seafood Industry, Environmental, And Forensic Applications Through Integrating Raman Spectroscopy And Machine Learning, Luis Perez Almodovar

Electronic Theses & Dissertations (2024 - present)

There is an urgent need for rapid and on-site analytical methods to address various environmental and forensic challenges. This dissertation explores the application of Raman spectroscopy combined with machine learning for three critical areas: evaluating perfluoroalkyl or polyfluoroalkyl substances (PFAS) exposure in wildlife, authenticating tuna species in the seafood industry, identifying body fluids at crime scenes, and medical diagnostics.

First, Raman spectroscopy and support vector machine discriminant analysis (SVMDA) were employed to detect PFAS levels in the blood plasma of smallmouth bass from two different tributaries, rivers, or streams that flow into larger bodies of water. The method achieved 100% …

Advancements In Forensic Analysis: Development Of Mass Spectrometric And Chemometric Approaches For The Identification Of Synthetic New Psychoactive Substances And Plant Materials, Mónica Ventura

Electronic Theses & Dissertations (2024 - present)

While forensic science is a well-established discipline, a number of federal agencies have highlighted challenges that continue to plague the field and the extent to which these challenges remain unaddressed. Examples are the illegal trade of wildlife timber and the drug epidemic. Characterization of these materials requires nuanced method development for compound determination, matrix material-specific protocols, and heavy use of expensive consumables. The application of a technique such as direct analysis in real time – high-resolution mass spectrometry (DART-HRMS) provides the opportunity to circumvent many of the challenges presented by conventional methods. In general, little to no sample preparation is …

Assessment Of Spatial Distribution Patterns And Infestation Risk Over Time Of Spotted Lanterfly (Lycorma Delicatula) In New York State, Alanna Richman

Electronic Theses & Dissertations (2024 - present)

Spotted Lanternfly (Lycorma delicatula) is an invasive treehopper native to Asia. It was first introduced to Pennsylvania in 2014, and as of 2020 it has expanded to New York state. Their preferred host tree is the invasive tree of heaven (Ailanthus altissima), but they will feed on over 173 different plants worldwide. Preferred host species in New York state include agricultural vegetation such as grape vines and fruit trees. Positive Spotted Lanternfly site data collected by the New York Department of Agriculture and Markets and iMapInvasives were analyzed using ArcGIS Pro to assess spatial distribution patterns. …

A Descriptive Analysis Of Depressive Symptoms And Body Image By Race/Ethnicity And Nativity Status Among Adolescents, Radhika Prasad

Electronic Theses & Dissertations (2024 - present)

Previous research on the immigrant health paradox among children and adolescents show a mental health advantage yet it is unclear if this applies in a similar magnitude to females (Fillion et al., 2018; Zarei et al., 2023). Immigrants may be exposed to stressors related to immigration and acculturation. Some research suggests that females respond more to stress through internalizing symptoms relative to males (Hall-Lande et al., 2007; Adkins et al., 2009). Given these gender differences in stress response, female immigrants may be particularly vulnerable to the psychological consequences of immigration related stressors. The immigrant health paradox has also overlooked subjective …

"Not Trans Enough": A Qualitative Inquiry Of Non-Binary Individuals' Experiences Of Transphobia Within The Lgbtq+ Community, Alyssa Lombardi

Electronic Theses & Dissertations (2024 - present)

Transphobia has been well-documented to have detrimental impacts on the lives of transgender individuals. However, research typically has not focused on the experience of non-binary individuals, and particularly even less so on their experiences of within-group discrimination. This study used Interpretative Phenomenological Analysis to understand both the experience and expression of transphobia toward non-binary people from within the LGBTQ+ community. Twelve interviews were conducted with six non-binary individuals ranging in age from 23 to 33. Each interview was analyzed and coded, resulting in four superordinate themes: The Experience of Enbyphobia, The Impact of Enbyphobia, The Expression of Enbyphobia, and The …

The Study Of Ribosome-Amplified Metabolism, Rambo, Effect In Vitro And In Live Cells, Jianchao Yu

Electronic Theses & Dissertations (2024 - present)

Quinary interactions arise due to the extreme macromolecular crowding inside live cells. Quinary interactions affect intracellular protein stability, activity, and homeostasis. Ribosomes, traditionally known for their role in protein synthesis, have been found to engage in quinary interactions with metabolic enzymes, modulating their activity and thereby revealing a potential regulatory role for ribosomes in cellular metabolism. This phenomenon, termed the Ribosome-Amplified MetaBOlism (RAMBO) effect, was investigated in this dissertation through a series of in vitro and in vivo studies using primarily Nuclear Magnetic Resonance (NMR) spectroscopy.

Firstly, an NMR-based direct enzyme assay compatible with ribosome was developed and validated using …

Stabilizing Bulk Lead-Free Tin Halide Perovskites, William Rice

Electronic Theses & Dissertations (2024 - present)

Tin halide perovskites are a growing candidate in the semiconducting materials field due to their band gap, and ability to be doped (specifically p-type doped). Halide perovskites are sensitive to light and air which causes the degradation of the material from its preferred cubic perovskite lattice. This thesis introduces a way of stabilizing bulk CsSnCl3 through the Goldschmidt tolerance factor. It will also introduce potential new ways to p-type dope halide perovskites. We attempted to p-type dope our halide perovskite by substitutional, interstitial, and vacancy doping to increase the carrier concentration to compete with current perovskites. During our trials of …

Developing Cellular Systems To Elucidate Rna Structural Dynamics Of Cag Expansion Transcripts In Spinocerebellar Ataxias, Victoria Demeo

Electronic Theses & Dissertations (2024 - present)

Spinocerebellar ataxias (SCAs) are a diverse group of over 40 genetically heterogeneous neurodegenerative disorders, many of which are caused by a trinucleotide CAG repeat expansion in the coding region of specific genes. These expansions lead to the production of polyglutamine (polyQ) tracts that interfere with normal protein function, triggering cellular dysfunction and contributing to disease pathogenesis. The most well-known of these SCAs, such as SCA1, SCA2, and SCA3, exhibit progressive neurodegeneration, yet the precise mechanisms through which these mutations cause disease remain poorly understood.

A significant challenge in studying CAG repeat expansion disorders lies in the complexity of the disease …

“A True Tower Of Babel”: Nation, Race, And Gender In The French Foreign Legion, 1831 To 1854, Nicholas Michael Charnley

Electronic Theses & Dissertations (2024 - present)

The French Foreign Legion, part of the July Monarchy’s 1831 expansion of the Army of Africa, sought to create a non-French force entirely deployable outside of the metropole. The creation of the expatriate corps intended to solve two of France’s most pressing problems at the time: an excess of foreign migrants at home, and a dearth of French soldiers abroad. The Paris government hoped to attract recruits from its considerable non-national male population, particularly political exiles and migrant workers fleeing Europe’s 1830 revolutionary wave. Initially intended as a temporary expedient for the homeland’s demographic crisis, the expatriate fighting force grew …

Dishes Of Yesteryear: Memories, Stories, And Representations Of The Past Within Food Media, Diana Willis Bottomley

Electronic Theses & Dissertations (2024 - present)

In 1963, Julia Child revolutionized cooking television. Child’s The French Chef, which ran for ten years on the Boston public television station, WGBH, changed how American’s viewed, produced, and consumed food. And in the sixty years since Child’s debut, food media has grown in scope and popularity, increasingly altering how we communicate identity in and through food and foodways. In this dissertation, I examine the relation between food, media, and memory, with particular attention to: how the past moderates the connection between food and identity; how food media produce a sense of place integral to identity; and how food …