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Systematic Perturbations Of Setd2, Nsd1, Nsd2, Nsd3, And Ash1l Reveal Their Distinct Contributions To H3k36 Methylation, Gerry A Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N Vitorino, Joanna M Gongora, Benjamin A Garcia, Chao Lu, Jacek Majewski

2020-Current year OA Pubs

BACKGROUND: Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development and disease, how the molecular agents collectively shape the H3K36me landscape is unclear.

RESULTS: We use mouse mesenchymal stem cells to perturb the H3K36me methyltransferases (K36MTs) and infer the activities of the five most prominent enzymes: SETD2, NSD1, NSD2, NSD3, and ASH1L. We find that H3K36me2 is the most abundant of the three methylation states and is predominantly deposited at intergenic regions by NSD1, and partly by NSD2. In contrast, H3K36me1/3 are most …

Sestrin 2 As A New Biomarker In Obesity And Diabetes Mellitus: A New Key Player In The Metabolic Regulation, Shashank M Patil, Jayanthi M K, Ramith Ramu

International Journal of Health and Allied Sciences

The global health crisis of diabetes linked to obesity necessitates innovative biomarkers for early diagnosis and targeted treatment. This study explores the pivotal role of sestrins, evolutionarily conserved proteins, in the intricate interplay between obesity and diabetes. Highlighting their significance as regulators of metabolic balance, stress response, and cellular homeostasis, particularly sestrin 2 (SESN2), the study delves into their impact on oxidative stress, insulin sensitivity, and inflammatory responses. Recent studies have highlighted the dysregulation of sestrins in obesity and diabetes mellitus, suggesting their potential as diagnostic markers and therapeutic targets. Examining the molecular processes involving AMP-activated protein kinase (AMPK) and …

Curating And Validating Universally Applicable Primers For Efficient Its2-Based Dna Barcoding Across Plant Taxa, Ajay R Bhat, Subrahmanya Hegde, Supriya S Kammar, Mb Muthamma, Gaurav Mudgal, Prashanth Babu H, Rajulu Charukesi, Thotegowdanapalya C Mohan

International Journal of Health and Allied Sciences

Abstract: Rapid and accurate identification of plant species increasingly seeks to employ molecular techniques. The ITS2 region is highly regarded in DNA barcoding due to its short length and ease of sequencing, making it an ideal candidate for species identification

Epitope Identification Of Rabies Virus Nucleoprotein Using Immunoinformatics Approach, Kavitha G. Manjunatha, Chandrahasa Chethana, Akhila D. Sannejal, Mohammad Shueb, Devananda Devegowda, Shashanka K. Prasad, Deepak S. Pinto, Shrikrishna Isloor

International Journal of Health and Allied Sciences

Abstract

Background

Rabies is a deadly and preventable disease. The nucleoprotein of rabies virus has been found to have group-specific antigenic determinants. The rabies virus nucleoprotein can shield dogs and mice from the lethal infection. Early diagnosis of rabies is crucial for the prevention of rabies.

Methods

In this study, B-cell epitopes of the nucleoprotein gene of the rabies virus were identified, and the characteristics of the epitopes were analyzed using various bioinformatics tools, such as the immune epitope database's Bepipred Major Histocompatibility Complex II (IEDB MHC II) prediction tool, NetCTL 1.2, Vaxijen v20, AllerTOP v2.0 server.

Results

Fourteen epitopes …

Harnessing Nature's Power Of Azolla Pinnata Superfood With Biofertilizers For A Sustainable Future, Khalander Bibi, Sushma Shree Krishnappa, Charan Kumar Kachintaya, Shankramma Kalikeri, Lingaraju Honnuru Gurusiddappa

International Journal of Health and Allied Sciences

Azolla pinnata, a rapidly growing floating aquatic fern, flourishes in freshwater bodies throughout India. It forms clusters in marshes, drains, and rice fields, doubling its biomass every 1.9 days. Azolla, known for its versatility, is used in food, medicinal, water purification, biofertilizers, and livestock feed. Its use in animal diets improves live weight, protein efficiency, and feed conversion rates. Azolla has pharmaceutical benefits in addition to agricultural, including antioxidant and immunological stimulation, as well as hepatoprotective properties. It also plays an important part in phytoremediation and bioremediation. Azolla's potential extends to biofuel production, making it a promising feedstock for sustainable …

Vol. 32, No. 4-8 - Whole No. 173, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 9 - Whole No. 168, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 8 - Whole No. 167, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 7 - Whole No. 166, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 5 - Whole No. 164, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 3 - Whole No. 162, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 2 - Whole No. 161, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Ligand Directed Signalling In Therapeutics, Julia Shield

Discussions

No abstract provided.

[Discussions] Vol. 16 Iss. 1

Discussions

No abstract provided.

Disemboweling Binaries: How Medical Texts And Gothic Fiction Propagate Deviance Through The Damaged Brain, Hailey Q. Barab

Discussions

No abstract provided.

The Problem With Direct Collateral Review, Jaden M. Lessnick

Pepperdine Law Review

Federal habeas review of state convictions is sharply circumscribed for a reason: Granting the writ of habeas corpus disrupts the federalism and finality interests that lie at the heart of state sovereignty over criminal law. Both the Antiterrorism and Effective Death Penalty Act (AEDPA) and the Supreme Court’s equitable bars to relief reflect the structural dangers inherent in collateral review of state convictions. Given the increasing unavailability of federal habeas relief, state prisoners have turned to another vehicle for collateral federal review, one that bypasses AEDPA’s demanding standard: direct review of state post-conviction proceedings. And regrettably, the Court has entertained …

Index To Volume 69

Merrill-Palmer Quarterly: A Peer Relations Journal

Index to Volume 69

Spartan Daily, October 9, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 163, Issue 20

Association Between Psychopharmacotherapy And Postpartum Hemorrhage, Frank Ian Jackson, Insaf Kouba, Natalie Meirowitz, Nathan A. Keller, Luis A. Bracero, Matthew J. Blitz

Specialty Medicine Faculty Publications

Background: Prior studies evaluating the relationship between psychopharmacotherapy (PPT), and postpartum hemorrhage (PPH) have yielded inconsistent findings. Clarifying this potential relationship is important for effective counseling and risk stratification.
Objectives: Our primary objective was to evaluate the association between prenatal exposure to PPT (any drug class) and the occurrence of PPH requiring transfusion of packed red blood cells (PPH+pRBC) after systematically adjusting for known hemorrhage risk factors at the time of admission for delivery. Secondary objectives were to evaluate the association between individual PPT drug classes and PPH+pRBC, and the association between treatment intensity of mental health condition and PPH+pRBC. …

No. 06: Enhancing Rural-Urban Linkages Through Food Remittances, Elizabeth Opiyo Onyango, Jonathan Crush, Samuel Owuor

Migration and Food Security (MiFOOD) Network

In many rapidly urbanizing African countries, food remittances from rural to urban areas play a vital role in maintaining rural-urban linkages. In Nairobi, Kenya, half of all households, regardless of migration status, receive food remittances from rural areas. Contrary to conventional beliefs, these food transfers are not solely linked to migration or poverty. Instead, they appear to be a long-standing, integral part of urban household resilience, especially for better-off households. As urbanization intensifies, policymakers should recognize the role of food remittances in ensuring food security for both migrants and non-migrant households. This brief explores key challenges such as economic inequality, …

October 9, 2024 (Vol. 109, No. 7), Daily Eastern News

Daily Eastern News: 2024-2025

No abstract provided.

October 9, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Sustainable Aquaculture And Youth Membership, Stephen Hughes

Sustainability Research & Practice Seminar Presentations

Dr. Steven Hughes of Cheyney University discusses Sustainable Aquaculture and Youth Mentorship

The Lumberjack, October 09, 2024

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Navigating Entry: The Role Of Exposure And Career Fit Negotiation In Women’S Pathways To Policing In The United States, Samantha S. Clinkinbeard, Rachael Rief, Trisha Rhodes, Lexi Goodijohn

Criminology and Criminal Justice Faculty Publications

Women’s engagement in policing in the United States and other countries has not reached its potential. We interviewed 47 women in law enforcement to learn about their pathways into policing. Two primary themes emerged: career discovery through exposure and negotiating career fit. Exposure through interactions with role models, hands-on experiences, and media portrayals, provided a peek into policing. The assessment and negotiation of career “fit” in our study was an ongoing, dynamic process. As participants faced questions about their own characteristics, values, and belonging, exposure in the form of role models and experiences helped them navigate career fit concerns. Implications …

Farm Waste Can Filter Microplastics In Runoff, Prevent Pollution, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Using treated plant waste as a filter reduced the presence of harmful microplastics in agricultural runoff by more than 92%, according to a new study authored by a University of Mississippi research team.

Palimbiosis, Leila Walker

Publications and Research

How does one begin to talk about the end? Contemporary artistic and literary responses to climate change frequently invoke Romantic traditions, in part because many theorists attribute our current crisis to historical developments in the Romantic period, but also as means of representing how climate change collapses the familiar orderliness of time. This essay is about the narrative forms that emerge when our place of safety is revealed to be as unstable as melting permafrost. It centers on Mary Shelley’s 1825 essay about a frozen Englishman reanimated during that especially warm summer. I read Shelley’s essay anachronistically alongside contemporary climate …

The South China Sea Arbitration After Eight Years: Its Implications For Jurisprudence And Third Parties, Yoshifumi Tanaka

International Law Studies

Even though eight years have passed since the issuance of the South China Sea arbitral award between the Republic of the Philippines and the People’s Republic of China, China has repeatedly claimed that the South China Sea arbitral award is null and void. Thus a question arises with regard to the legal consequences of the award in international law and international relations. The aim of this article is to consider this question by analyzing the impacts of the South China Sea arbitral award from three viewpoints: The impacts on the jurisdiction of an adjudicative body with regard to mixed disputes …

A Virtual In Vivo Dissection And Analysis Of Socioaffective Symptoms Related To Cerebellum-Midbrain Reward Circuitry In Humans, Linda J. Hoffman, Jula M. Foley, Josiah K. Leong, Holly Sullivan-Toole, Blake L. Elliot, Ingrid R. Olson

Psychological Science Faculty Publications and Presentations

Emerging research in nonhuman animals implicates cerebellar projections to the ventral tegmental area (VTA) in appetitive behaviors, but these circuits have not been characterized in humans. Here, we mapped cerebello-VTA white matter connectivity in a cohort of men and women using probabilistic tractography on diffusion imaging data from the Human Connectome Project. We uncovered the topographical organization of these connections by separately tracking from parcels of cerebellar lobule VI, crus I/II, vermis, paravermis, and cerebrocerebellum. Results revealed that connections between the cerebellum and VTA predominantly originate in the right cerebellar hemisphere, interposed nucleus, and paravermal cortex and terminate mostly ipsilaterally. …

A Unique Advantage Of A 24-Hour Surgical Delay In Autologous Breast Reconstruction, Devin M. Melancon, Daniel Yoo, Zachary Stern-Buchbinder, Samantha Morin, Hugo St. Hilaire, Robert J. Allen

School of Medicine Faculty Publications

Summary: The surgical delay technique can be used effectively in autologous breast reconstruction when there is unfavorable flap vascular anatomy or when the reconstruction necessitates a larger volume of donor tissue to obtain optimal results. The length of time between surgically delaying the flap to pedicle division and inset of the flap often varies based on surgeon preference but is typically approximately a week or longer. The authors present a case in which a 24-hour surgical delay was successfully used to augment deep inferior epigastric perforator flaps for autologous reconstruction. This technique is beneficial as it does not allow time …