Digital Commons Network^™

The Phosphatidylinositol 3-Kinase As A Potential Diagnostic Marker For Beta-Thalassemia And Its Correlation With Hemoglobin Profiles, Duaa K. Mohammed, Layla O. Farhan

Baghdad Science Journal

The erythropoietic dysfunction and iron insufficiency associated with β -Thalassemia (β -TH) underscore the importance of augmenting traditional diagnostic techniques with independent biomarkers, beyond standard panels. This single-center case–control study (n = 120 β -TH major, 55; β -TH intermedia, 25; control, 40) examined whether circulating phosphatidylinositol-3-kinase (PI3K) distinguishes patients from controls and correlates with hemoglobin fractions. The serum PI3K was significantly higher in β -TH (p < 0.001), with excellent discrimination tested in serum (AUC = 0.934; optimal cut-off > 1301 pg/mL; sensitivity 100%, specificity 80%). In a multivariable model, HbA₂% and HbF% were both positively and independently associated with PI3K. These results are biologically consistent with the interaction of erythroid …

Modulate Obesity And Related Metabolic Complications For Yielding Improvements In Ibd Outcomes (Modify-Ibd): Consensus On Obesity And Cardiometabolic Comorbidities In Inflammatory Bowel Disease Using Systematic Reviews And The Rand/Ucla Appropriateness Method, Jalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L. Barnes, Amanda M. Johnson, Andres J. Yarur, Parakkal Deepak

Division of Gastroenterology and Hepatology Faculty Papers

INTRODUCTION: Obesity and related cardiometabolic comorbidities, including hypertension, dyslipidaemia, diabetes, metabolic dysfunction-associated steatotic liver disease and atherosclerotic cardiovascular disease, are increasingly prevalent among individuals with inflammatory bowel disease (IBD). These conditions influence disease activity, therapeutic response, surgical outcomes and overall quality of life, yet evidence remains fragmented. The Modulate Obesity and relateD metabolic complIcations For Yielding improvements in IBD outcomes (MODIFY-IBD) initiative aims to synthesise evidence and generate consensus recommendations to guide practice and future research in this area. This study describes a protocol for a structured evidence synthesis and Research And Development/University of California, Los …

High Temperature High Pressure Extraction Methods, Natalie M. Durdle Miss

Defensive Publications Series

A method is disclosed for accelerating the extraction of flavor volatiles, peptides, and gelatin from animal tissue using high-temperature, high-pressure, non-turbulent conditions to prevent emulsion. The disclosure further details a rapid clarification protocol using mechanically released intracellular proteins to form an aerated, buoyant filtration raft, as well as a cryo-filtration process leveraging a self-assembling gelatin polymer network to separate lipids and hazy proteins from an aqueous phase. These processes are specified for both artisanal culinary production and mass-scale commercial soup, pet food, and protein recovery manufacturing operations.

Accelerated Production Of Culinary Stocks, Natalie M. Durdle Miss

Defensive Publications Series

A method is disclosed for accelerating the extraction of flavor volatiles, peptides, and gelatin from animal tissue using high-temperature, high-pressure, non-turbulent conditions to prevent emulsion. The disclosure further details a rapid clarification protocol using mechanically released intracellular proteins to form an aerated, buoyant filtration raft, as well as a cryo-filtration process leveraging a self-assembling gelatin polymer network to separate lipids and hazy proteins from an aqueous phase.

Dynamic Input Layering To Animate A Virtual Avatar Over A Mobile Video Capture Using Concurrent Front-Camera Tracking, Audio, And Ui Commands, Krzysztof P. Bednarz

Defensive Publications Series

This publication describes a mobile software architecture and method for real-time animation of a virtual avatar over a live or recorded video stream captured from a mobile device. The system concurrently utilises a back-facing for environmental video capture, a front-facing camera for facial tracking, and an audio input for lip synchronisation. A synchronisation and buffering mechanism aligns video, audio, and animation data streams in near real time, ensuring temporally coherent avatar animation over live or recorded video. These heterogeneous inputs are dynamically layered and synchronised to drive a two-dimensional (2D) or three-dimensional (3D) avatar while supporting both local recording and …

Staff Education To Enhance Registered Nurses’ Knowledge And Utilization Of The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (Ciwa-Ar) Tool In An Inpatient Psychiatric Unit, Reign Staron Beri

Walden Dissertations and Doctoral Studies

No abstract provided.

“Big River People”: Human-Nature Interactions In The Mekong And Columbia River Basins, Andrew M. Stone

Forest and Society

The Mekong and Columbia Rivers are a world apart. Yet rivers instantiate and manifest critical ecological relations. This paper draws on qualitative interviews, community dialogues, historical documents, and ceremony-based encounters to examine political practices among "big river people'' in the Mekong and Columbia River basins. It interprets participants' narratives and actions as expressions of ontological politics, i.e., contestation of imposed realities and lifeways. Participants link environmental degradation to violations of relational ethics. Across both study groups, elders and knowledge holders describe ecological and cultural loss as forms of ongoing violence enacted through hydropower development, displacement, and resulting erasure of ways …

Trends In The Management Of Acute Pyogenic Flexor Tenosynovitis Of The Hand: A Comprehensive Analysis., Michael Anderson, Taylor J Manes, Davis Hedbany, Sylvester Okoro, Nithin Gupta, Morgan Turnow, Stephen Berling

Ambulatory and Primary Care Articles

Background Acute pyogenic flexor tenosynovitis (APFT) is typically managed operatively, but there is growing interest in nonoperative treatments using intravenous (IV) antibiotics to reduce surgical complications. Timely intervention is essential, as delayed treatment increases the risk of systemic, life-threatening infections. This study aimed to characterize national trends in the operative management of APFT and to compare mortality and amputation outcomes between operatively and nonoperatively managed patients. Methods A retrospective analysis was conducted using data from the TriNetX United States Collaborative Network from 2015 to 2023. Patients were identified using ICD-10 and CPT codes and categorized into operative and nonoperative cohorts, …

Symmetry And Psychosocial Adaptation To Trauma, Illness And Disability Part I: Views From Physics, Medicine And Psychology, Hanoch Livneh

Leadership, Learning and Counseling Faculty Publications and Presentations

The aim of this two-part paper is to discuss the concept of symmetry and its derivatives, symmetry breaking and asymmetry, and the role they assume in elucidating the structure and processes that underlie psychosocial adaptation to traumatic experiences. To achieve this aim, in Part I, first, a cursory review of symmetry is undertaken as it applies to physics, including conservation laws, the forces of nature, and leading theories of nature. Second, the paper addresses how symmetry is perceived in biology and medicine, including symmetry within biochemical and genetic structures, the human body, and the onset of disease processes. Third, the …

Feminist Necropoetics: The Female Corpse In Oda Sa Wala (2018), Farrah Freibert

Publications

This article explores how Dwein Baltazar’s Oda sa Wala (2018) cultivates themes of collectivity across the life-death divide.

Probiotic Intake Related To Hemoglobin A1c Among U.S. Veterans With Type 2 Diabetes Mellitus, Maryann Martin

Walden Dissertations and Doctoral Studies

No abstract provided.

A Neutrosophic Interpretation Of The Island Rule: From The Tethys Ocean To Urban Gigantism In Freshwater Crabs, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Mathematics Education And Its Contributions To Attention Deficit Hyperactivity Disorder, Randy Zabaleta, Osvaldo Rojas, Beatriz Villarraga, Miguel Cruz, Diana Pérez

Neutrosophic Sets and Systems

No abstract provided.

Injectable, In Situ Forming Peptide Nanofiber Reinforced Composite Hydrogels For Age-Related Macular Degeneration, Shambhavi Bagewadi Ms

Theses and Dissertations

Cell therapy for age-related macular degeneration (AMD) is limited by the absence of a functional substrate such as Bruch’s membrane (BM), which is critical for retinal pigment epithelial (RPE) cell survival and integration. Although preformed substrates have been explored, their implantation can disrupt the fragile retinal architecture, compromise ocular immune privilege and increase infection risk. To address these limitations, an injectable hydrogel capable of forming in situ was developed. The hydrogel consists of thiol-modified hyaluronic acid (HA-SH) and polyvinyl alcohol (PVA). Peptide nanofibers were incorporated to enhance structural reinforcement. Three self-assembling peptides - RADA-16, GAGA and GAGA-YIGSR were designed and …

The Utilization Of Interactive Learning Videos To Improve Critical Thinking In Social Studies Learning Among Grade V Students At Sd Negeri 1 Kota Fajar, Cut Oktanalisa, Lili Kasmini

Jurnal Pendidikan Humaniora

Critical thinking is an essential competency for elementary students because it enables them to interpret information, analyze everyday problems, evaluate reasons, and communicate responsible decisions. In social studies learning, this competency needs to be developed through contextual, dialogic, and visually supported learning experiences. This study investigated the utilization of interactive learning videos to improve the critical thinking skills of Grade V students at SD Negeri 1 Kotafajar. The study employed a qualitative descriptive design supported by quantitative descriptive data. The participants were 30 Grade V students in the 2024/2025 academic year. Data were collected through pretest and posttest tasks, classroom …

Khirbat Khuwweikha (Kafr Kanna): Hiding Complexes From The Roman And Early Byzantine Periods In The Jewish Galilee, Yinon Shivtiel, Dror Barshad, Dina Avshalom-Gorni, Nili Ahipaz, Ruthy Lewis-Bloom, Yonatan Adler, Ram Bouchnick, Yarden Pagelson, Uri Berger

Qadum: Journal of Excavation Reports from Israel

Decades of research on Roman-period hiding complexes in the Galilee have identified 85 such complexes to date. Like the hiding complexes found in Judea, they were used as places of refuge during periods of distress under Roman rule in the country. Extensive archaeological excavations conducted in the hiding complex at Khirbat Khuwweikha, near Kafr Kanna and northwest of Nazareth, have yielded impressive finds, including pottery, glassware, metal items, coins, an ostracon and bones. Such a large quantity of diagnostic finds is rare in Galilean hiding complexes, and the assemblage attests to the use of the complex by Jews during three …

Exploring The Role Of Magnesium Deficiency In Inflammatory Bowel Disease, Victor A. Bob-Yellowe, Shaunte Hadnot, Sonya Bhatia, Anesu K. Murambadoro

MEDI 9331 Scholarly Activities Clinical Years

Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders, including Ulcerative Colitis and Crohn’s disease. As of 2020, it was estimated that IBD significantly impacts the lives of approximately 2.39 million Americans. Magnesium (Mg) is an essential mineral involved in many bodily functions, including immune response and gut health. Recent studies suggest that Magnesium levels may be linked to IBD. Therefore, this review aims to explain how Magnesium might play a role in the development or progression of IBD. Additionally, this article discusses the overall role that Magnesium’s plays in gut health and whether Magnesium supplementation could be …

Clustering And Switching As A Scoring System In Indonesian Three Word Fluency Tests, Heni Gerda Pesau, Gilles Van Luijtelaar

Makara Human Behavior Studies in Asia

The number of correctly produced words is the primary output variable n most verbal fluency tests. The examination of the number of clusters and cluster size achieves a more in-depth analyses of cognitive aspects and processes. We propose a scoring system for phonemic, semantic, and emotion word fluency tests in the Indonesian context. This study aimed to determine the underlying cognitive constructs of the participants, including the clustering and switching indices, using principal component analysis (PCA). A total of 150 participants were included, and the tests were administered online following a previously validated protocol. The three fluency tests loaded different …

Pfas Mixture Composition And Internal Exposure Profiles Shape Biological Responses Under Field-Realistic Exposure, Alan M. Vajda, Jill A. Jenkins, David W. Bertolatus, Denis R. Leblanc, Christopher J. Martyniuk, Zachary R. Hopkins, Andrea K. Tokranov, Abigail R. Dethloff, Joseph C. Tucker, Rainer Lohmann, Larry B. Barber

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) occur as complex mixtures, yet mixture-dependent biological effects under environmentally realistic exposure conditions remain poorly understood. We conducted multiyear (2018, 2019, 2021) continuous-flow, field-based exposures of male fathead minnows (Pimephales promelas) using a low-PFAS reference well (REF; sum of measured PFAS (∑PFAS) 0.1–0.2 μg L^–1) and PFAS-contaminated groundwater from a fire-training area (FTA) at Joint Base Cape Cod, Massachusetts. Dilution treatments enabled separation of concentration and mixture effects. Groundwater from well FTA1 was perfluorooctanesulfonate (PFOS) dominated (∑PFAS 10–31 μg L^–1), whereas groundwater from well FTA2 had higher concentrations and …

Brain Age Prediction In Generalized Anxiety Disorder Using A Convolutional Neural Network, Corey Richier, André Zugman, Anita Harrewijn, Elise M Cardinale, Parmis Khosravi, Moji Aghajani, Willem B Bruin, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Marta Cano, Savannah Gosnell, Ramiro Salas, Andrea P Jackowski, Pedro M Pan, Giovanni A Salum, Karina S Blair, James R Blair, Mohammed R Milad, Katie L Burkhouse, K Luan Phan, Heidi K Schroeder, Jeffrey R Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I Thomopoulos, Jared A Nielsen, Jordan W Smoller, Jair C Soares, Benson Mwangi, Mon-Ju Wu, Giovana B Zunta-Soares, Michal Assaf, Gretchen J Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rebecca B Price, Gisele G Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Brenda Benson, Gabrielle F Freitag, Ellen Leibenluft, Grace V Ringlein, Kathryn Werwath, Hannah Zwiebel, Hans J Grabe, Sandra Van Der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L Balderston, Monique Ernst, Lilianne R Mujica-Parodi, Helena Van Nieuwenhuizen, Hugo D Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Gregory A Fonzo, Martin P Paulus, Murray B Stein, Raquel E Gur, Ruben C Gur, Antonia N Kaczkurkin, Bart Larsen, Theodore D Satterthwaite, Jennifer Harper, Michael T Perino, Chad M Sylvester, Qiongru Yu, Patrick Mcclure, Francisco Pereira, Ulrike Lueken, Dick J Veltman, Paul M Thompson, Nynke A Groenewold, Janna Marie Bas-Hoogendam, Dan J Stein, Nic J A Van Der Wee, Anderson M Winkler, Daniel S Pine, Chelsea K Sawyers

Faculty, Staff and Student Publications

Higher predicted brain age difference has been associated with several psychiatric disorders. Generalized anxiety disorder (GAD) is associated with markers of accelerated aging. In this study, we determined brain predicted age difference (PAD) in individuals with GAD and healthy controls (HC) as well as group differences in PAD variability using voxel-wise structural MRI. The training dataset included 3511 controls, and the testing dataset included 1595 individuals with GAD and 4552 HC from the ENIGMA-Anxiety GAD Working Group. A convolutional neural network model using four input modalities per subject and a model ensemble approach was used to predict brain age. The …

Development Of A Seudati Culture Fusion-Based Digital Flipbook To Strengthen Cultural Literacy And Humanities Learning Outcomes Of Grade V Students, Ainal Mardiah, Lili Kasmini, Siti Mayang Sari, Muhammad Zulhairi Zubairi

Jurnal Pendidikan Humaniora

This study aimed to develop and evaluate a Seudati Culture Fusion-based digital flipbook designed to strengthen cultural literacy and humanities learning outcomes among Grade V elementary school students. The study employed a Research and Development (R&D) design using the ADDIE model, consisting of analysis, design, development, implementation, and evaluation stages. The development process was grounded in the need to provide culturally responsive digital teaching materials that connect classroom learning with local identity, social practices, and students’ lived experiences. The study involved Grade V students, classroom teachers, and expert validators consisting of content, media, and language experts. Data were collected through …

Effects Of Normothermic Hepatic Ischemia–Reperfusion Injury On The Hepatic Disposition Of Arachidonic Acid And Its Cytochrome P450-Generated Metabolites In Rats, Vindhya Edpuganti, Reza Mehvar

Pharmacy Faculty Articles and Research

Purpose

Cytochrome P450 (P450) metabolites of arachidonic acid (AA) are potential therapeutic targets in ischemia–reperfusion (IR) injury, yet their disposition and actions in hepatic IR are unknown. Cellular AA and its P450 metabolites are primarily bound to lipid membranes, resulting in negligible free concentrations. This study investigates how hepatic IR injury impacts the disposition of free AA and its major P450 metabolites in rats.

Methods

Rats underwent 60 min of partial (70%) ischemia or sham surgery, followed by 5 min, 3 h, or 24 h of reperfusion. The effects of IR injury on free concentrations of AA and its major …

A Wildlife Crossing Proposal For Mountain Lions In San Luis Obispo County, Charles Carmichael

Master's Projects and Capstones

California mountain lions are facing threats such as wildlife vehicle-collisions (WVC) and habitat fragmentation from roads that act as barriers to movement. Cuesta Pass in San Luis Obispo County is a stretch of Highway 101 that acts as a barrier and results in WVC for numerous species, including mountain lions. A literature review on predictors for mountain lion usage of wildlife crossings suggests crossing location as an influential variable for predicting whether a crossing will be used. A synthesis on findings from four studies found mountain lions to use underpasses, including culverts, at a combined rate of 0.72 times per …

Cyberspatial Cartographies: Mapping Digital Nationhood Within The California-Punjabi Diaspora., Saihajpratap Singh Bajwa

Master's Theses

This research investigates the phenomenon of digital nationhood, the idea that a new form of community is actively produced through interactions taking place within digital social networks and forums. These spaces function as more than repositories of information or cultural archives; they are living ecosystems in which identity is constructed through mutual encounters among members of a diaspora, where shared references, meanings, and concepts proliferate across multiplex networks. The central questions animating this inquiry are: can a nation exist without a territory, and are these encounters producing what we might conceive of as a digital nation?

The Punjabi people serve …

Adaptive Reuse As Sustainability: Reconciling The Crises Of Functionalism And Environmental Conservation In Copenhagen And San Francisco, Samuel J. Fernandez

Master's Theses

Sustainability is the buzzword for modern global development. In the age of rapidly growing populations, unsustainable building practices, and an ever-present climate crisis, there must be a reorientation in global urban development practices. While experts tend to tout one sustainable initiative as a catch-all solution to the above crises, a multidimensional problem cannot be solved with a one-dimensional approach. In other words, sustainable development can only be achieved through a combination of different practices and approaches. This case study seeks to present adaptive reuse as a viable reaction to the climate crisis, but one that requires a combination of other …

The Feather Of The Quill: How Folklore Shapes Human Relationships With Wildlife, Taylor Breeanne Nelson

Master's Theses

This thesis examines how folklore and cultural phenomena shape human relationships with wildlife, arguing that the stories a society tells about animals are not merely reflective of its values but are constitutive of them. Drawing on narrative research methods sourced from literature and academic journals and interviews with academics, conservationists, and community members, this project examines the role of animal folklore.

I discuss how narratives around wildlife evolved alongside the development of the United States, arguing that the beginnings of mainstream American conservation not only displaced existing communities but also erased the sophisticated human-animal relationships their traditions had long sustained. …

Reviving Revive. Is The Notion Of An Independent Artist An Outdated Concept?, Richard C. Moore Mr

Staff Scholarship - Australia & Dubai

This article published in Spectator Magazine - online - is a reflection on whether or not a cultural policy is a means of controlling the artistic community and whether there is still such a being as an independent Australian artist. It was published as the 2026 submissions for an update to Australia's cultural policy REVIVE -  were closing.

Structure And Diversity Of Play Behavior In Juvenile Belding's Ground Squirrels, Paul O'Driscoll Ii

Master's Theses

Play behavior is ubiquitous among juvenile mammals and can promote motor, social, and cognitive development, providing multiple adaptive benefits to young animals in some cases. The structure of play can be linked to the benefits it confers on individuals. I evaluated the structure of play in juvenile Belding’s ground squirrels (Urocitellus beldingi), a species for which multiple adaptive benefits of play have been identified. I compared juvenile play in U. beldingi to adult sexual and aggressive behavior to determine and classify similarities between juvenile play and adult behavior. I evaluated diversity in the behaviors expressed during play interactions and diversity …

Improving Human-Wildlife Coexistence: An Ecological And Educational Approach To Rewilding Grizzly Bears (Ursus Arctos Horribilis) In California, Amanda C. D. Rosales

Master's Projects and Capstones

Megafauna extinction during the Holocene has been both caused and amplified by climatic changes and human influence. By the last half century, large carnivores were diminished in Europe and the United States, but policies increasingly addressed species decline and their territories expanded. This research examined large carnivore rewilding across the European Union and United States, specifically for rewilding brown bears, Ursus arctos, in historic habitat. Next, case studies for the health status of climate-impacted whitebark pine, Pinus albicaulis, a high energy food for bears, was assessed. Ultimately, research case studies, human perspective surveys, and the California Department of Education content …

Herd Conditions And Food Security: Evidence From Kenya, Kira J. Enriquez

Master's Theses

Food insecurity is worsening across Kenya's Arid and Semi-Arid Lands, where over three million people currently face acute hunger. Among pastoral communities in these regions, livestock are the central productive asset and primary food source. When herds deteriorate, households face falling milk production and the erosion of assets that would otherwise buffer consumption during difficult periods. This paper tests whether livestock body condition and rangeland forage quality predict household food coping behavior, and whether those relationships differ above and below a Micawber-style herd size threshold. Using a panel of 232 pastoralist households surveyed across five ASAL counties between 2021 and …