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Articles 4111 - 4140 of 30680
Full-Text Articles in Entire DC Network
Winonan, Winona State University
Winonan, Winona State University
The Winonan - 2020s
This issue of the Winonan, the Winona State University student newspaper, was published on October 9, 2024.
Effects Of Supplementing Rumen-Protected Methionine And Lysine On Milk Yield And Milk Composition In Dairy Cows, Imene Kerbache, Samir Souames, Amel Haddoum, Nedjoua Lakhdara, Nassim Moula
Effects Of Supplementing Rumen-Protected Methionine And Lysine On Milk Yield And Milk Composition In Dairy Cows, Imene Kerbache, Samir Souames, Amel Haddoum, Nedjoua Lakhdara, Nassim Moula
Turkish Journal of Veterinary & Animal Sciences
The use of “health-food additives” has gained significant attention within the dairy sector, with a focus on enhancing the nutritional intake of dairy cows to improve their productivity and reproductive performance. This study aims at examining the impact of rumen-protected methionine (Met) and lysine (Lys) supplementation on production and reproductive parameters in a sample of 100 dairy cows, comprising 32 primiparous and 68 multiparous cows with an average of 5.24±2.31 years. The cows’ average milk production was determined to be 24.9±7.40 kg/day. The cows were divided into two groups, one receiving Met/Lys supplementation and the other serving as a control …
Monitoring Cow Behavior Based On Lying, Standing, Eating, And Ruminating Recognition Using Yolov8, Ali Saifudin, Sri Pantja Madyawati, Imam Yuadi, Rimayanti Rimayanti, Imam Mustofa, Riries Rulaningtyas, Teddy Surya Gunawan, Adnan Rahmat Anom Besari
Monitoring Cow Behavior Based On Lying, Standing, Eating, And Ruminating Recognition Using Yolov8, Ali Saifudin, Sri Pantja Madyawati, Imam Yuadi, Rimayanti Rimayanti, Imam Mustofa, Riries Rulaningtyas, Teddy Surya Gunawan, Adnan Rahmat Anom Besari
Turkish Journal of Veterinary & Animal Sciences
Cow behavior is a crucial indicator for monitoring health, reproductive status, and welfare in livestock management. However, methods that rely on wearable devices often face significant challenges, including high costs, maintenance difficulties, and potential impacts on animal welfare. To address these limitations, this study explored the potential of using YOLOv8, a cutting-edge computer vision model, for non-invasive monitoring of cow behavior. The research methodology involved four key steps: data collection, preliminary data processing, model training, and validation. The findings revealed that YOLOv8 is capable of accurately detecting and localizing key cow behaviors—lying, standing, eating, and ruminating—achieving a mean average precision …
Cover And Contents
Turkish Journal of Veterinary & Animal Sciences
No abstract provided.
Investigation Of The Acaricidal Efficacy, Tolerance And Residue Levels Of Thymol-Containing Gelatin-Based Hydrogel Developed For Varroosis Control, Onur Demi̇r, Ali̇ Bi̇lgi̇li̇, Mehli̇ka Pulat
Investigation Of The Acaricidal Efficacy, Tolerance And Residue Levels Of Thymol-Containing Gelatin-Based Hydrogel Developed For Varroosis Control, Onur Demi̇r, Ali̇ Bi̇lgi̇li̇, Mehli̇ka Pulat
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the acaricidal efficacy, tolerability of the target species and residue levels of a thymol-containing gelatin-based hydrogel developed as a controlled release system for varroosis control. The study was carried out on naturally infested honey bee colonies and compared with those of the negative control and positive control groups. The acaricidal efficacy (%) of the negative control, positive control and hydrogel was 21.93 ± 2.87, 81.09 ± 2.30 and 70.32 ± 2.05, respectively. For the tolerability controls, the average number of dead bees per colony was determined to be 60.80 ± 8.01, 297.40 …
An Innovative Approach: Introducing Novel Sheep Paternity Testing Panels, Onur Yilmaz, İbrahi̇m Cemal, Nezi̇h Ata, Orhan Karaca
An Innovative Approach: Introducing Novel Sheep Paternity Testing Panels, Onur Yilmaz, İbrahi̇m Cemal, Nezi̇h Ata, Orhan Karaca
Turkish Journal of Veterinary & Animal Sciences
The aim of this research was to create various microsatellite paternity test panels that are efficient, cost-effective, simple, and accessible for paternity assessments within the Eşme sheep breed in Western Anatolia. The study included 2432 animals from sixteen farms, consisting of 147 rams and 2285 lambs. 17 microsatellite markers were utilized in the study to develop these test panels, prioritizing markers with high polymorphic information content (PIC) and probability of exclusion (PE) values. By combining markers with varying PIC and PE values, 16 distinct paternity test panels were established. The study revealed mean values for various parameters of the microsatellites …
Brief Of 20 Professors Of Law And Public Knowledge As Amici Curiae In Support Of Affirmance, Charles Duan, Rachel Bamberger
Brief Of 20 Professors Of Law And Public Knowledge As Amici Curiae In Support Of Affirmance, Charles Duan, Rachel Bamberger
Amicus Briefs & Court Filings
In Carroll Shelby Licensing v. Halicki, the U.S. Court of Appeals considers whether a car in a film is a "character" for purposes of copyright law. Character copyright protection has proven to be an especially difficult area of the law, and courts and commentators have struggled with the proper boundaries of such protection and whether characters are independently protectable works at all. This brief presents a novel legal argument for resolving the scope of character copyright, at least in the context of inanimate objects in creative works such as cars. While the case law and commentary has to date focused …
Office Of Research, Economic Engagement And Outreach Update, October 9, 2024, Office Of Research, Economic Engagement And Outreach
Office Of Research, Economic Engagement And Outreach Update, October 9, 2024, Office Of Research, Economic Engagement And Outreach
Office of Research, Economic Engagement and Outreach
No abstract provided.
Sexual Dimorphism And Divergent Evolutionary Pathways In Primate Cranial Biomechanics: Insights From A Theoretical Morphology Framework, Z. Jack Tseng, Claire E. Terhune
Sexual Dimorphism And Divergent Evolutionary Pathways In Primate Cranial Biomechanics: Insights From A Theoretical Morphology Framework, Z. Jack Tseng, Claire E. Terhune
Anthropology Faculty Publications and Presentations
he mammalian order Primates is known for widespread sexual dimorphism in size and phenotype. Despite repeated speculation that primate sexual size dimorphism either facilitates or is in part driven by functional differences in how males and females interact with their environments, few studies have directly assessed the influence of sexual dimorphism on performance traits. Here, we use a theoretical morphology framework to show that sexual dimorphism in primate crania is associated with divergent biomechanical performance traits. The degree of dimorphism is a significant covariate in biomechanical trait divergence between sexes. Males exhibit less efficient but stiffer cranial shapes and significant …
The Pilling Process: Significance Quest, Self-Verification, And Fusion In Online Incel Forums, Gregory J. Rousis
The Pilling Process: Significance Quest, Self-Verification, And Fusion In Online Incel Forums, Gregory J. Rousis
USF Tampa Graduate Theses and Dissertations
Incels (short for “involuntary celibates) are an online community of men who blame women for their reputed sexual and romantic failures. The misogyny of their worldview, called the blackpill, has inspired multiple instances of real-world violence against women. Alarmingly, we know little about the temporal processes whereby an incel goes from joining an online community to becoming deeply aligned (i.e., “fused”) with the group. This project sought to address this by scraping incels’ most popular web forum and using text analysis to identify psychological mechanisms that could be responsible for incels’ fusion. The resulting dataset consisted of 1,097,841 unique discussion …
Oregon State Rank Assessment For Catlow Tui Chub (Siphateles Bicolor Ssp. 2), Jesse Laney
Oregon State Rank Assessment For Catlow Tui Chub (Siphateles Bicolor Ssp. 2), Jesse Laney
Institute for Natural Resources Publications
Oregon state conservation status assessment for Catlow tui chub (Siphateles bicolor ssp. 2) using NatureServe methodology, 2024.
Oregon State Rank Assessment For Sheldon Tui Chub (Siphateles Bicolor Eurysoma), Eleanor P. Gaines
Oregon State Rank Assessment For Sheldon Tui Chub (Siphateles Bicolor Eurysoma), Eleanor P. Gaines
Institute for Natural Resources Publications
Oregon state conservation status assessment for Sheldon tui chub (Siphateles bicolor eurysoma) using NatureServe methodology, 2024.
Employing Multi-Omics Analyses To Understand Changes During Kidney Development In Perinatal Interleukin-6 Animal Model., Ganesh Panzade, Tarak Srivastava, Daniel P. Heruth, Mohammad Rezaiekhaligh, Jianping Zhou, Zhen Lyu, Mukut Sharma, Trupti Joshi
Employing Multi-Omics Analyses To Understand Changes During Kidney Development In Perinatal Interleukin-6 Animal Model., Ganesh Panzade, Tarak Srivastava, Daniel P. Heruth, Mohammad Rezaiekhaligh, Jianping Zhou, Zhen Lyu, Mukut Sharma, Trupti Joshi
Manuscripts, Articles, Book Chapters and Other Papers
Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. Maternal obesity during pregnancy is linked to systemic inflammation and elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6). In our previous work, we demonstrated that increased maternal IL-6 during gestation impacts intrauterine development in mice. We hypothesized that IL-6-induced inflammation alters gene expression in the developing fetus. To test this, pregnant mice were administered IL-6 or saline during mid-gestation. Newborn mouse kidneys were analyzed using mRNA-seq, miRNA-seq and whole-genome bisulfite-seq (WGBS). A multi-omics approach was employed to quantify mRNA gene expression, miRNA expression and DNA methylation, using …
Status Epilepticus A Risk Factor For Sudden Unexpected Death In Epilepsy (Sudep): A Scoping Review And Narrative Synthesis, Rohit Shankar, Zygimantas Puras, Saffron Richardson, Lance Watkins
Status Epilepticus A Risk Factor For Sudden Unexpected Death In Epilepsy (Sudep): A Scoping Review And Narrative Synthesis, Rohit Shankar, Zygimantas Puras, Saffron Richardson, Lance Watkins
Peninsula Medical School
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among people withepilepsy (PWE). Risk factors such as increased seizure frequency, drug-resistant epilepsy, and early epilepsy onsetare well recognised. However, little evidence of the role of seizure severity, specifically Status Epilepticus (SE) onSUDEP risk exists.Objective: To identify mechanisms, risk factors and clinical characteristics overlap between SE and SUDEP.Methods: A scoping review using the PRISMA-ScR model was performed by two reviewers using suitable searchterms. The PubMed Advanced Search tool along with the ancestry method was utilised to identify suitable articles published between 06/1992 and 05/2023. Quantitative, qualitative and …
Symposium: What Does The Microbiome Tell Us About Prevention And Treatment Of Ad/Adrd?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett
Symposium: What Does The Microbiome Tell Us About Prevention And Treatment Of Ad/Adrd?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett
2020-Current year OA Pubs
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.
A Review Of Biomass-Based Natural Coagulants For Water Pollution Remediation: Impact Of Properties And Coagulation Operational Parameters, Nur Faizzah Husna Mohammad Ali, Megat Ahmad Kamal Megat Hanafiah, Sabiha Hanim Saleh, Mohd Tajudin Mohd Ali, Shariff Ibrahim
A Review Of Biomass-Based Natural Coagulants For Water Pollution Remediation: Impact Of Properties And Coagulation Operational Parameters, Nur Faizzah Husna Mohammad Ali, Megat Ahmad Kamal Megat Hanafiah, Sabiha Hanim Saleh, Mohd Tajudin Mohd Ali, Shariff Ibrahim
AUIQ Complementary Biological System
The rapid growth of cities, industries, and population has made tackling water scarcity increasingly challenging as the global demand for clean drinking water continues to rise. Consequently, extensive research in water and wastewater treatment, specifically focusing on the coagulation process, has ensued. Coagulation plays a critical role in water treatment, and its effectiveness depends on the type of coagulant used. However, the widespread use of chemical coagulants raises concerns for the environment and public health. Consequently, there has been growing interest in exploring natural alternatives derived from plants and animals. This review examines how the properties of natural coagulants, as …
Vol. 28, No. 12 - Whole No. 138, David Bratman
Vol. 28, No. 12 - Whole No. 138, David Bratman
Mythprint
Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.
Vol. 28, No. 7 - Whole No. 133, David Bratman
Vol. 28, No. 7 - Whole No. 133, David Bratman
Mythprint
Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.
Mutations And Antibiotic Resistance In Mycobacterium Tuberculosis, Ryan M. Johnson, Bodhi Brady, Nicklaus Busse, Connor Beckman, Hunter Gloden, Joseph Glasrud, Zachary Smith, Hari P. Nepal, Madhav P. Nepal
Mutations And Antibiotic Resistance In Mycobacterium Tuberculosis, Ryan M. Johnson, Bodhi Brady, Nicklaus Busse, Connor Beckman, Hunter Gloden, Joseph Glasrud, Zachary Smith, Hari P. Nepal, Madhav P. Nepal
Life Science Reports
Mycobacterium tuberculosis (MTB) is a bacterium known to target, infect, and destroy lung cells as well as connective tissues within the body. This bacterium is prevalent worldwide and has infected over a quarter of the current world population, becoming one of the most successful pathogens in history. Due to its extreme transmission rates as an airborne pathogen, MTB strains have been treated with antibiotics such as rifampicin and isoniazid, which inhibit bacterial infection in the human body. These first-round drugs remained as successful mechanisms for slowing and killing the pathogen, notably through rifampicin's inhibition of RNA-polymerase and isoniazid’s ability to …
Participatory Community Action Research In Homeless Shelters: Withstanding The Pandemic And Flourishing Beyond It With New Interventions, Kathryn E. Hurley, Roger N. Reeb, Sarah M. Clark, Tia N. Turner, Greg Elvers
Participatory Community Action Research In Homeless Shelters: Withstanding The Pandemic And Flourishing Beyond It With New Interventions, Kathryn E. Hurley, Roger N. Reeb, Sarah M. Clark, Tia N. Turner, Greg Elvers
Research and Reflection on Learning and Teaching in Higher Education
This article tells the story of a long-term (12-year-old) and ongoing participatory community action research in homeless shelters – the Behavioral Activation Research Project in Homeless Shelters (the project), which represents a long-term collaboration between Roger N. Reeb, PhD (Professor of Psychology) and St. Vincent de Paul (Dayton, Ohio). The first section of this article provides a grand overall description of the project, summarizes past research, and explains how we sustained the project during the COVID-19 pandemic. To demonstrate the project’s ongoing nature, the second section reports an honors thesis completed within the context of the project, accompanied by a …
An Interview With Harry “Murf” Mccloy, Harry (Murf) Mccloy
An Interview With Harry “Murf” Mccloy, Harry (Murf) Mccloy
The Journal of Conventional Weapons Destruction
Harry “Murf” McCloy, is a retired US Marine Colonel who transitioned from military service to become a pivotal figure in humanitarian demining with PM/WRA in the US Department of State. Heading the US State Department’s first demining program in Bosnia and Herzegovina in 1996, McCloy became the State Department’s Senior Demining Advisor in 1998, holding this position until his retirement in 2007. He continues to work parttime in the Office of Weapons Removal and Abatement and has played a crucial role in the strategic oversight and execution of mine action programs across forty-six countries, significantly enhancing safety and establishing essential …
Spartan Daily, October 8, 2024, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, October 8, 2024, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2024
Volume 163, Issue 19
Crocodylian Diversity During The Early Eocene Climatic Optimum In The Golden Valley Formation Of North Dakota, U.S.A., Adam P. Cossette, David Tarailo
Crocodylian Diversity During The Early Eocene Climatic Optimum In The Golden Valley Formation Of North Dakota, U.S.A., Adam P. Cossette, David Tarailo
Biological Sciences Faculty Publications
Rich bone beds from the lower Eocene strata of the Golden Valley Formation of Stark County, North Dakota reveal a speciose sympatric crocodylian fauna. However, analyses demonstrate limited phylogenetic diversity among these co-occurring taxa, and of the four species known for the locality, three are alligatorids and one is a crocodyloid. Phylogenetic hypotheses recover Chrysochampsa mylnarskii as a late lived member of Brachychampsini—a stem-based clade including Brachychampsa montana and all alligatorids more closely related to it than to Caiman crocodilus or Alligator mississippiensis—and a new genus and species, Ahdeskatanka russlanddeutsche groups with species of Allognathosuchus. The crocodylians, partitioned by body …
Transition Living Program (Tlp), Kaleb Crenshaw, Monica Himes
Transition Living Program (Tlp), Kaleb Crenshaw, Monica Himes
Justice Festival at Morehead State University
A PowerPoint presentation, titled "Transitional Living Program (TLP)," given by Kaleb Crenshaw and Monica Himes at the Justice Festival held on the campus of Morehead State University on October 8, 2024.
Ai And Future-Making: Design, Biases, And Human-Plant Interactions, Maliheh Ghajargar
Ai And Future-Making: Design, Biases, And Human-Plant Interactions, Maliheh Ghajargar
Art Faculty Articles and Research
Design researchers and practitioners are turning to generative AI (genAI) to support activities such as ideation and concept development in pursuit of preferred futures. At the same time, genAI is known to have biases, which prompts questions about how these biases might adversely affect design practices. In the domain of sustainable HCI, with its recent trends in human-nature interactions and more-than-human design, the question can be further refined into whether and how genAI biases might perpetuate anthropocentric biases that these practices are increasingly seeking to confront. In the present research, we conducted three workshops, focusing on genAI for human-plant interactions; …
"The Words We Do Not Yet Have." A Creative Inquiry Into Human-Plant Relationships, Maliheh Ghajargar
"The Words We Do Not Yet Have." A Creative Inquiry Into Human-Plant Relationships, Maliheh Ghajargar
Art Faculty Articles and Research
Climate change, loss of plant biodiversity, and ocean pollution signal the drastic changes in our ecology that call us to attend to the needs of more than human forms of life on Earth. Sustainable design and HCI research are responding to this call by offering methods and approaches to design more sustainable products and systems and recently, more than human design is building momentum. This agenda seeks to reform traditional design processes by decentering the creative agency of the dominant socio-economical group of humans and foregrounding those of diverse Others. In this paper, I focus on plants as a nonhuman …
Aspect-Ratio-Dependent Heat Transport By Baroclinic Acoustic Streaming, Jacques Abdul Massih, Remil Mushthaq, Guillaume Michel, Gregory P. Chini
Aspect-Ratio-Dependent Heat Transport By Baroclinic Acoustic Streaming, Jacques Abdul Massih, Remil Mushthaq, Guillaume Michel, Gregory P. Chini
Faculty Publications
Standing acoustic waves have been known to generate Eulerian time-mean ‘streaming’ flows at least since the seminal investigation of Lord Rayleigh in the 1880s. Nevertheless, a recent body of numerical and experimental evidence has shown that inhomogeneities in the ambient density distribution lead to much faster flows than arise in classical Rayleigh streaming. The emergence of these unusually strong flows creates new opportunities to enhance heat transfer in systems in which convective cooling cannot otherwise be easily achieved. To assess this possibility, a theoretical study of acoustic streaming in an ideal gas confined in a rectangular channel with top and …
The Role Of Lymph-Adipose Crosstalk In Alcohol-Induced Perilymphatic Adipose Tissue Dysfunction, Kourtney D. Weaver, Liz Simon, Patricia E. Molina, Flavia Souza-Smith
The Role Of Lymph-Adipose Crosstalk In Alcohol-Induced Perilymphatic Adipose Tissue Dysfunction, Kourtney D. Weaver, Liz Simon, Patricia E. Molina, Flavia Souza-Smith
School of Graduate Studies Faculty Publications
Chronic alcohol use leads to metabolic dysfunction in adipose tissue. The underlying mechanisms and the contribution of alcohol-induced adipose tissue dysfunction to systemic metabolic dysregulation are not well understood. In our previous studies, we found that chronic alcohol feeding induces mesenteric lymphatic leakage, perilymphatic adipose tissue (PLAT) inflammation, and local insulin resistance in rats. The goal of this study was to further explore the link between alcohol-induced lymphatic leakage and PLAT immunometabolic dysregulation, locally and systemically, using in vivo and ex vivo approaches. Male rats received a Lieber–DeCarli liquid diet, of which 36% of the calories were from alcohol, for …
Promoting Healthful And Diverse Eating Behaviours Through An Extracurricular Culinary Skills Intervention In Philadelphia, Matthew D. Kearney, Arlene R. Maheu, Madalyn Booth, Andrew B. Newberg, Peter F. Cronholm, Soussan Ayubcha
Promoting Healthful And Diverse Eating Behaviours Through An Extracurricular Culinary Skills Intervention In Philadelphia, Matthew D. Kearney, Arlene R. Maheu, Madalyn Booth, Andrew B. Newberg, Peter F. Cronholm, Soussan Ayubcha
SKMC Student Presentations and Publications
In the current study we evaluated an afterschool nutrition education programme, called Vetri Cooking Lab (VCL), for promoting healthy and diverse eating habits among at-risk children in the Greater Philadelphia area. To understand potential programme impacts, we conducted a longitudinal analysis of survey data collected before and after participation in VCL. Main study included cooking confidence, cooking knowledge, changes in dietary consumption behaviours, and changes in vegetable preferences. Participants included students in grades 3-11 enrolled in VCL during the 2018-19 school year at VCL sites (n = 60) throughout Philadelphia, PA, and Camden, NJ. Eligible participants completed surveys both before …
Tca Metabolism Regulates Dna Hypermethylation In Lps And Mycobacterium Tuberculosis–Induced Immune Tolerance, Abhimanyu, Santiago Carrero Longlax, Tomoki Nishiguchi, Malik Ladki, Daanish Sheikh, Amera L Martinez, Emily M Mace, Sandra L Grimm, Thaleia Caldwell, Alexandra Portillo Varela, Rajagopal V Sekhar, Anna M Mandalakas, Mandla Mlotshwa, Sibuse Ginidza, Jeffrey D Cirillo, Robert S Wallis, Mihai G Netea, Reinout Van Crevel, Cristian Coarfa, Andrew R Dinardo
Tca Metabolism Regulates Dna Hypermethylation In Lps And Mycobacterium Tuberculosis–Induced Immune Tolerance, Abhimanyu, Santiago Carrero Longlax, Tomoki Nishiguchi, Malik Ladki, Daanish Sheikh, Amera L Martinez, Emily M Mace, Sandra L Grimm, Thaleia Caldwell, Alexandra Portillo Varela, Rajagopal V Sekhar, Anna M Mandalakas, Mandla Mlotshwa, Sibuse Ginidza, Jeffrey D Cirillo, Robert S Wallis, Mihai G Netea, Reinout Van Crevel, Cristian Coarfa, Andrew R Dinardo
Faculty, Staff and Students Publications
Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all-cause postinfectious morbidity and mortality. Oncology studies identified metabolic drivers of the epigenetic landscape, with the tricarboxylic acid (TCA) cycle acting as a central hub. It is unknown if the TCA cycle also regulates epigenetics, specifically DNA methylation, after infection-induced immune tolerance. The following studies demonstrate that lipopolysaccharide and Mycobacterium tuberculosis induce changes in DNA methylation that are mediated by the TCA cycle. Infection-induced DNA hypermethylation is mitigated by inhibitors of cellular metabolism (rapamycin, everolimus, metformin) and the TCA …