Digital Commons Network^™

Hsp70 Is A Critical Regulator Of Hsp90 Inhibitor's Effectiveness In Preventing Hcl-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-Nkansah, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke acute and chronic lung injury. Because of its extensive production for industrial use, frequent accidental exposures occur, making HCl one of the top five chemicals causing inhalation injuries. There are no Food and Drug Administration (FDA)-approved treatments for HCl exposure. Heat shock protein 90 (HSP90) inhibitors modulate transforming growth factor-β (TGF-β) signaling and the development of chemical-induced pulmonary fibrosis. However, little is known on the role of Heat Shock Protein 70 (HSP70) during injury and treatment with HSP90 inhibitors. We hypothesized that administration of geranylgeranyl-acetone (GGA), an HSP70 inducer, or gefitinib (GFT), an …

Honk!: Meaning And Activism In 21st Century American Street Bands, Isaac Maupin

Theses and Dissertations--Music

In this dissertation, I explore activism, music, and meaning through the lens of HONK! Bands in the United States. HONK! A Festival of Activist Street Bands began in Sommerville, Massachusetts, in 2006. Since its inception, the festivals have grown on a national and global scale. The festivals, however, operate as a convenient organizing structure for the bands themselves and are not a primary focus of this work. Instead, I examine activism, learning, and value as systems within the HONK! culture (each topic with a devoted chapter) to, through a phenomenological lens, better understand how HONK! bands fit within American culture. …

Ecuadorian Vocal Anthology In Four Rhythms, Wagner Mauricio Pástor Pazmiño Dr.

Theses and Dissertations--Music

Ecuador is a pluricultural and multilingual territory with four natural regions, several musical genres, and interpretations. Amazon, Galápagos, Mountain Range, and Coastal region. In the following dissertation, the author develops concepts of four traditional rhythms, their composers, and harmonic and phonetic characteristics from the mountain range region of his homeland, Ecuador.

The present document is a descriptive study of vocal Andean music and the application of the operatic style in classical vocal technique for performance practice.

The dissertation will support a lecture recital to fulfill the doctoral program's requirement in voice performance from the University of Kentucky.

Blending European And Latin Sounds: A Study Of French Horn Repertoire In Mexico, Aj Bernal

Theses and Dissertations--Music

As a first generation Mexican-American, it is crucial that I advocate and promote music of the culture I grew up in. This project aims to unearth Mexican compositional techniques that derive from the fusion of European and Indigenous roots in an effort to promote diversity within the realm of Western Classical music. Music in Mexico is characterized by a unique blend of indigenous rhythms, European classical structures, and regional folk influences. This project will discuss how the bold timbre of the French horn intertwines with traditional Mexican and indigenous melodies, rhythms, and forms that create a unique style. The horn’s …

Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod

Electronic Theses and Dissertations

This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …

Contrastive Learning, With Application To Forensic Identification Of Source, Cole Ryan Patten

Electronic Theses and Dissertations

Forensic identification of source problems often fall under the category of verification problems, where recent advances in deep learning have been made by contrastive learning methods. Many forensic identification of source problems deal with a scarcity of data, an issue addressed by few-shot learning. In this work, we make specific what makes a neural network a contrastive network. We then consider the use of contrastive neural networks for few-shot learning classification problems and compare them to other statistical and deep learning methods. Our findings indicate similar performance between models trained by contrastive loss and models trained by cross-entropy loss. We …

Role Of Production Systems On Carcass And Palatability Attributes Of Bison, Lydia Margaret Hite O'Sullivan

Electronic Theses and Dissertations

The overall objective of this dissertation was to determine the impact of finishing systems on carcass and palatability attributes of bison. The specific objectives were 1) determine the influence of finishing system (grain-finished vs. grass-finished) on the mechanisms of tenderness formation in the longissimus lumborum of bison bulls, 2) determine the influence of diverse finishing systems on carcass characteristics and proximate composition of bison heifers, and 3) determine the influence of diverse finishing systems on palatability of striploin steaks from bison heifers. Results indicate that finishing systems differentially influence carcass characteristics, tenderness, and flavor attributes of bison. Specifically, this is …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Genetic And Ecologic Effects Of Seed Dormancy Genes On Seed Aging, Soil Seedbank Longevity, And Microbiome In An Isogenic Background Of Rice ( Oryza Sativa L.), Bhupinder Singh Batth

Electronic Theses and Dissertations

No abstract provided.

Whole Genome Crispr-Cas9 Screens Identify Genes Contributing To Viral Entry And Phagocytosis, Md Saddam Hossain

Electronic Theses and Dissertations

CRISPR/Cas9 is a revolutionary technique for genome editing where Cas9 nucleases can be targeted to specific genomic sites by single-guide RNAs (sgRNAs) containing roughly 20-nucleotide sequences that are complementary to the target region. Double strand breaks created by Cas9 are repaired through non-homologous end-joining (NHEJ) in most cells, resulting in insertions and deletions leading to frame shift mutations in coding regions. Thus, the CRISPR-Cas9 system can be exploited for systematic evaluation of gene function relationships by whole genome screening. We also developed a CRISPR whole‐genome screen and counter‐screen strategy based on a pseudoviral platform that allowed identification of genes specific …

Analysis Of Toxic Chemical Agents And Therapeutics For Toxic Inhaled Agents’ Exposure, Khadija Bilkis

Electronic Theses and Dissertations

When inhaled, toxic inhalation agents (TIAs) such as cyanide (CN), ammonia and sulfur compounds (e.g. methanethiol (MeSH)) can be fatal. Many TIAs cause cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, neurodegenerative disorder, circulatory collapse, seizures, and potential death by blocking mitochondrial cytochrome c oxidase. All TIA’s have the potential to be employed as chemical warfare agents, terrorist weapons, or dangerous occupational gases. Although many TIAs are potential threats, there are minimal FDA-approved treatments for these substances useful in a mass-casualty situation. Recently, cobinamide (Cbi) has come to light as a potential antidote for MeSH poisoning. However, methods for analyzing MeSH …

กระบวนการสื่อสารในการรวมกลุ่มของวัยรุ่น Gen Z ต่อสื่อการ์ตูนญี่ปุ่นในประเทศไทย, ชญานนท์ ครองบุญชู

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อวิเคราะห์และศึกษารูปแบบกลยุทธ์ กระบวนการ และการสื่อสารที่ก่อให้เกิดอิทธิพลในการรวมกลุ่มของวัยรุ่น Gen Z ในบริบทของสื่อการ์ตูนญี่ปุ่นที่ส่งผลต่อพฤติกรรมการบริโภคและการตอบสนองต่อกลยุทธ์การสื่อสารของบริษัทนำเข้าสื่อการ์ตูนญี่ปุ่น การวิจัยใช้ระเบียบวิธีวิจัยเชิงคุณภาพด้วยวิธีการสัมภาษณ์เชิงลึกกับกลุ่มตัวอย่างทั้งสิ้น 30 คน โดยแบ่งออกเป็น 2 ประเภท ได้แก่ ผู้ที่เป็นส่วนหนึ่งต่อการสร้างอิทธิพลในการรวมกลุ่มของสื่อการ์ตูนญี่ปุ่นในประเทศไทย จำนวน 9 คน และผู้รับชมสื่อการ์ตูนญี่ปุ่นที่เกิดในปี พ.ศ. 2540-2549 จำนวน 21 คน การวิเคราะห์ข้อมูลเชิงคุณภาพดำเนินการด้วยเทคนิคการวิเคราะห์แก่นสารผลการวิจัยพบว่า กระบวนการการรวมกลุ่มประกอบด้วย 4 ขั้นตอนหลัก ได้แก่ ขั้นตอนการค้นพบ ขั้นตอนการเรียนรู้ ขั้นตอนการมีส่วนร่วม และขั้นตอนการสร้างอัตลักษณ์ วงการการ์ตูนญี่ปุ่นในไทยมีการรวมกลุ่มแบบผสมผสานระหว่างสื่อออนไลน์และออฟไลน์ กลยุทธ์การสื่อสารที่มีประสิทธิภาพต้องเน้นหลักการ 3T ได้แก่ ความจริงใจในการสื่อสารที่ซื่อสัตย์และไม่มีการปิดบัง ความโปร่งใสในการเปิดเผยข้อมูลและกระบวนการที่จำเป็น และความรวดเร็วในการตอบสนองและอัปเดตข้อมูลอย่างทันท่วงที ผลการวิจัยยังพบว่าผู้บริโภค Gen Z ที่มีประสบการณ์แตกต่างกันมีพฤติกรรมและความต้องการในการรวมกลุ่มแตกต่างกัน การรวมกลุ่มมักเกิดขึ้นในพื้นที่ออนไลน์แล้วจึงนำไปสู่การรวมกลุ่มแบบออฟไลน์ ผ่านแฟนการ์ตูนญี่ปุ่นในโลกออนไลน์ที่มีบทบาทในฐานะผู้ร่วมผลิตที่ขับเคลื่อนวัฒนธรรม

What Does It Mean To Create Art? Intellectual Property Rights For Artificial Intelligence Generated Artworks, Zachary Bozard

South Carolina Journal of International Law and Business

No abstract provided.

Scalp Fast Oscillation As A Predictor For Epilepsy In Critically Ill Patients With Periodic Discharges, Kongpop Sutantikorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Periodic discharges (PDs) in critically ill patients due to diverse pathologies are not uncommon and carry varied prognosis. Scalp fast oscillations (SFOs) have been increasingly studied its association with clinical outcomes in many conditions. However, none has assessed its values in prognostication of the critically ill patients. Objectives: To assess the prognostic values of SFOs in prediction of short and long-term clinical outcomes in critically ill patients with PDs. Materials and Methods: All patients aged > 15 years with detection of PDs during 2014-2022 were recruited. Converted electroencephalography (EEG) files to the standard format were used for analysis. Time-frequency analysis …

Prediction Of Recurrent Lateral Ankle Sprain And Ankle Pain Using Applied Care Strategies And Patient-Reported Outcomes, Ryan S. Mccann, Elisabeth Ohrnberger, Kyle B. Kosik, Phillip A. Gribble

Rehabilitation Sciences Faculty Publications

Context

Patients with lateral ankle sprains (LASs) often have deficient patient-reported outcomes (PROs) at return to activity (RTA), potentially increasing risk for recurrent LAS and ankle pain. Additionally, applied care strategies are known to correct impairments, but their ability to mitigate risk for long-term consequences remains unknown.

Objective

To determine if applied care strategies and PRO scores at RTA and 6 months after RTA predict recurrent LAS and ankle pain 12 months after an acute LAS. DESIGN: Prospective cohort study.

Setting

Online survey.

Patients or Other Participants

We enrolled 63 individuals within 1 week of sustaining an acute LAS.

Main …

Effects Of Water Chemistry On Interaction Between Organic Contaminants And Microplastics And Their Passage In Microfiltration Membrane, Chutiporn Inchana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The agricultural activity is a critical source of organic contaminants and microplastics (MPs). Typically, the agricultural soil is contaminated by an abundance of MPs, leaching chemicals during weathering process, and pesticides, which subsequently end up in surface water through agricultural runoff. Polymers that are most frequently used in crop production and detected in surface water are PE and PET MPs. Bisphenol (A) and atrazine are frequently detected in surface water. Nevertheless, the fate and distribution of organic pollutants in water treatment as a consequent on MP-aided transport is constrained by little knowledge on photoaged PE and PET MPs. In this …

Determination Of Nutrients Digestibility In Commercial Dry Dog Food Containing Various Protein Sources, Phuong Anh Ta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated the nutritional adequacy and digestibility of commercial dry dog foods formulated with different protein sources (animal versus plant) and market tiers (premium versus economy). Eight commercial dog foods were analyzed for nutrient composition and amino acid profiles using proximate analysis and high-performance liquid chromatography (HPLC). Of these, four representative products were selected to assess digestibility through in vivo total fecal collection in Beagle dogs and in vitro digestion assays. All products exceeded 18% crude protein (the minimum crude protein requirement by AAFCO). However, deficiencies were examined in essential amino acids, particularly leucine, isoleucine, methionine, lysine, tryptophan, valine …

Les Espaces Sûrs, Population Council, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 4

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

Le Développement Curriculaire Pour Les Espaces Sûrs, Population Council, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 3

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

Safe Spaces, Population Council, Swedd

Adolescents and Young People

SWEDD Series: Best Practice Guide no. 4

This Guide is one of a series that retrospectively documents the process of implementing the interventions of the SWEDD project, and documents good practices, challenges and lessons learned. The “Sahel Women's Empowerment and Demographic Dividend” (SWEDD) project was launched in November 2015 with financial support from the World Bank, and technical support from the United Nations Population Fund (UNFPA) and the West African Health Organisation (WAHO). The research informing this Guide was led by the Population Council.

Deep Transfer Learning-Based Bird Species Classification Using Mel Spectrogram Images, Mrinal Kanti Baowaly, Bisnu Chandra Sarkar, Md.Abul Ala Walid, Md. Martuza Ahamad, Bikash Chandra Singh, Eduardo Silva Alvarado, Imran Ashraf, Md. Abdus Samad

School of Cybersecurity Faculty Publications

The classification of bird species is of significant importance in the field of ornithology, as it plays an important role in assessing and monitoring environmental dynamics, including habitat modifications, migratory behaviors, levels of pollution, and disease occurrences. Traditional methods of bird classification, such as visual identification, were time-intensive and required a high level of expertise. However, audio-based bird species classification is a promising approach that can be used to automate bird species identification. This study aims to establish an audio-based bird species classification system for 264 Eastern African bird species employing modified deep transfer learning. In particular, the pre-trained EfficientNet …

Generating Neutrosophic Random Variables Based Gamma Distribution, Maissam Ahmad Jdid, Florentin Smarandache, Khalifa Al Shaqsi

Branch Mathematics and Statistics Faculty and Staff Publications

In practical life, we encounter many systems that cannot be studied directly, either due to their high cost or because some of these systems cannot be studied directly. Therefore, we resort to the simulation method, which depends on applying the study to systems similar to real ones and then projecting these results if they are suitable for the real system. The simulation process requires a good understanding of probability distributions and the methods used to transform random numbers that follow a regular distribution in the field [0,1] into random variables that follow them, so that we can achieve the greatest …

Ermakov Equations Can Be Derived From Zel’Dovich Pancake, And They Are Cold And Nonlocal Through Using Neutrosophic Venn Diagram, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

As we argue in a previous article, the labyrinthine worlds of Jorge Luis Borges are more than captivating narratives; they are portals to a deeper understanding of existence. By weaving elements of science-fiction fantasy with philosophical and ethical inquiries, Borges's short stories bridge the seemingly disparate realms of physics and the humanities, offering fertile ground for contemporary physics research. The present-day universe consists of galaxies, galaxy clusters, one-dimensional filaments and two-dimensional sheets or pancakes, all of which combine to form the cosmic web. The so called ”Zeldovich pancakes”, are very difficult to observe, because their overdensity is only slightly greater …

Two Applications Of The Concepts Of Pole And Polar With Respect To A Circle, Ion Pătrașcu, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this article, we present in a unified form the theoretical results regarding the concepts of pole and polar with respect to a circle, and as applications of these, we offer a demonstration of Newton’s theorem related to the circumscribed quadrilateral and a demonstration of a theorem usually derived as a particular case of Pascal’s theorem related to the inscribed hexagon.

The Cardinal Of The M-Powerset Of A Set Of N Elements Used In The Superhyperstructures And Neutrosophic Superhyperstructures, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper, we find a formula for computing the cardinal of the m-th powerset of a set of n elements, which is needed in the SuperHyperStructures.

Remark On Falaco Soliton As A Tunneling Mechanism In A Navier-Stokes Universe, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This paper is a follow up to our previous article [1] suggesting that it is possible to find tunneling time solutions for Schrodinger equation considering quasicrystalline as interstellar matter, by virtue of quasicrystalline potential. The paper also discusses the mapping of these equations to Riccati equations, a class of nonlinear differential equations. This mapping can provide insights into the behavior of the Navier-Stokes equations and may lead to new methods for solving them. The Navier-Stokes equations, a set of nonlinear partial differential equations, are fundamental in fluid mechanics. They describe the motion of viscous fluids. In three dimensions, these equations …

Logical Pluralism And Neutrosophy: Reflections On The Nature Of Truth, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The article explores the shift from classical binary logic (true and false) to a more complex landscape of logical frameworks. It introduces logical pluralism, which suggests that no single, universally accepted system of logic exists. The paper connects this idea to neutrosophy, a framework that extends fuzzy logic by incorporating a third value: indeterminacy. This triadic approach, where every proposition has a degree of truth (T), falsity (F), and indeterminacy (I), is particularly useful for managing incomplete or contradictory information. The author argues that different logical systems, like different tools, are suited for different problems, and that the …

The Gutiérrez-Hubbell Estate: A Census Study Of Intergenerational Intersections Of A Family And Their Servants, Samuel E. Sisneros

University Libraries & Learning Sciences Faculty and Staff Publications

Census study and chronological narrative about the intersectionality of Indian servants and their enslavers in New Mexico, 1850-1940.

Día De Los Muertos: Guía Para Educadores K-12, Latin American And Iberian Institute

K-12 Lesson Plans

No abstract provided.