Digital Commons Network^™

Il-17a Inhibitors For The Treatment Of Psoriasis, Mangesh Bankhele

Electronic Theses and Dissertations

Psoriasis is a long-lasting skin condition caused by the immune system, which is characterized by red, scaly areas. It mainly affects the scalp, elbows, knees, and lower back. Psoriasis, which affects around 2-3% of the world's population, has a substantial influence on the quality of life of people who suffer from it. The disorder arises due to an atypical immunological response in which the immune system mistakenly attacks skin cells, causing fast cell reproduction, inflammation, and excessive growth. Psoriasis can be treated with topical therapies, systemic drugs, and biologics. Topical therapies, including corticosteroids, vitamin D analogs, and retinoids, are commonly …

Apartments, Michael Pontacoloni

Electronic Theses and Dissertations

The following poems engage with themes of placemaking in the twenty-first century. A critical introduction centers the accompanying poems within a developing tradition of poetry in the twenty-first century that challenge common conceptions of home, romantic relationships, and transience. Other topics approached in the poems include adolescence, the environment, sport, and friendship.

Emirati Comics & Illustrations, Sarah Laura Nesti Willard

CoHSS Faculty Work

No abstract provided.

SchröDinger’S Dissent: The Hybrid Authority Of A Dissenting Opinion, Christina M. Frohock

Marquette Law Review

A dissenting opinion is the Schrödinger’s cat of authorities: both the law and not the law simultaneously. Courts and scholars often clarify that a dissenting opinion is not binding. Outside the universe of precedent, that authority defies easy description. Emerging from the pen of a judge wearing a black robe and acting in an official capacity, a dissenting opinion exhibits the form of the law. Yet, beneath that lofty sheen, a dissent exhibits the substance of commentary. A dissenting judge writes to undercut the law, providing a case law coda. This Article describes the traditional categories of authority, primary and …

In Silico Identifcation Of New Potential Inhibitors Of Quorum Sensing By Gram‑Positive Bacteria Through Specialized Molecular Docking, Amgad Albohy, Najla A. Obaid, Mariam Mojally, Mohammed Abou Rehab, Najd Ahmad Alkhudhir

Pharmacy

Quorum sensing is the process by which bacterial cells can communicate by producing substances to regulate viable processes such as gene expression, virulence, and bioflm formation. Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis have specifc enzymes (autoinducers) that control the quorum sensing system. Sortase A is a surface protein that regulates virulence and cell‒cell communication in Gram-positive bacteria. To interfere with this system and reduce virulence and cell‒cell communication, quorum sensing inhibitors are used, which are nonantibiotic substances. In this study, we aimed to use Food and Drug Administration-approved drugs (analgesics and antipsychotics) and investigate their activity using …

Changes In Flanker Task Performance Following High-Intensity Exercise In Endurance Athletes, Felix E. Cottet-Puinel

Dissertations, Master's Theses and Master's Reports

Executive function performance following acute aerobic exercise can be influenced by multiple variables. However, little is known about the lasting effects of these exercise-induced changes. This study aimed to determine the extent to which exercise intensity impacts executive function. 14 young endurance-trained adults (5 female, 9 male) performed an Eriksen flanker task before and immediately after running high-intensity until failure and isochronal moderate-intensity (~12 min). Pre- to post-exercise-induced changes in reaction time (ms), accuracy (%), and self-reported mental effort (1-9 rating) were analyzed by overall tasks and through tasks subsections. Results showed improvement in reaction time following high- and moderate-intensity …

Sustainable Materials For Environment − Multifunctional Material Made From Dead Leaves And Nanostructured Materials For Antibiotic Degradation, Siyuan Fang

Dissertations, Master's Theses and Master's Reports

As environmental pollution from industrial processes and human activities continues to rise, finding efficient approaches to recycle waste materials and degrade persistent contaminants becomes increasingly critical. Dead leaves, an abundant but underutilized biomass, present an opportunity for creating value-added materials if their biocomponents can be preserved and transformed. Simultaneously, antibiotics such as tetracycline are widely found in water bodies but pose serious ecological and health risks, necessitating effective degradation methods. This dissertation addresses these challenges by leveraging natural and nanostructured materials to develop multifunctional products and advanced photocatalytic processes.

Chapter 3 of this dissertation addresses the challenge of converting waste …

Does Earth Feel? (2021) By Marc Majewski, Alaina Gostomski

Picture Books

With spare prose and evocative paintings, author-illustrator Marc Majewski asks fourteen critical questions -- including Does Earth feel calm? Does Earth feel curious? Does Earth feel hurt? Does Earth feel heard? -- to encourage active thinking and discussion about our planet.

Gibberish (2022) By Young Vo, Peter Shea

Picture Books

Everyone sometimes doesn’t understand what is going on, can’t find a way in, and everyone in that situation has impulses to retreat and to growl. Gibberish takes the point of view of the newcomer, the non-native speaker. One of the virtues of this presentation is that many people will say: yes, that’s what it was like – when I started school; the first day of my new job; when I first opened the chemistry book; when I landed in Vienna; as the first person in my family to go to college; when I started playing violin. And that common topic …

Cat Way (2024) By Sara Lundberg, Maughn Rollins Gregory

Picture Books

When a human gives her cat a turn to lead the way on their daily walk, they encounter the unexpected. The philosophical quandaries this story raises – When do routines become too confining? How do domestic habits prevent us from experiencing the natural world? Can humans and pets have genuinely inter-species relationships? – can be discussed and experimented with by people of most ages.

Moving Forward, Looking Back: Narratives Of Indigenous Identity In Montana, 2024, University Of Montana--Missoula. School Of Journalism. Native News Honors Project

Native News Honors Project, 1992-2026

An annual publication that is reported, photographed, edited, and designed by students in the University of Montana’s School of Journalism.

Southern Animals: Multispecies Encounters In Midcentury Southern Fiction, Kacee M. Mckinney

Electronic Theses and Dissertations

This dissertation expands our understanding of how nonhuman animal figures, symbols, and encounters within southern literature have had ideologically profound impacts on our conceptions of humanity, southernness, and relationality. This dissertation examines prose fiction, including short stories, novellas, and novels, from four influential southern writers—Richard Wright, Carson McCullers, Tennessee Williams, and Flannery O’Connor—who were all actively engaged with representing, critiquing, and expanding American conceptions of the south, the nation, and the ‘human’ at midcentury. With an understanding of southern literature as a rich site for not only regional representation but also broader disruptions of national injustices and ideologies of domination …

Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker

Electronic Theses and Dissertations

The global human population continues to grow exponentially, and agriculture will need to become more productive to meet growing food demands. Humans also need clean water and other services that ecosystems provide. This requires future agriculture production to reduce environmental and wildlife impacts through improved efficiencies and best management practices. Migratory shorebirds rely on wetlands throughout North and South America as stopover habitat for rest and refueling during migration. Temporarily flooded farmlands in the Mississippi Delta have proven to be beneficial locations for shorebirds during migrations along the central flyway. This conservation practice also enhances wetland properties that promote excess …

Evaluation Of Male And Female Performance And The Role Of Cerebellar Lesions And Local Aromatase Inhibition In Motor And Cognitive Tasks In The Zebra Finch (Taeniopygia Castanotis), Mathew Joseph Thibodeaux

Electronic Theses and Dissertations

Most studies involving sex differences in songbirds are devoted to song learning and development. However, songbirds, such as zebra finches, are excellent models for studying general roles of steroids on behavior post-brain injury because they have high degrees of adult neuroplasticity and neurosteroidogenesis. The role of estradiol (E2) in recovery of function after neural insults in mammals has been well-studied for decades. Only recently has the role of E2 and aromatase in neuroprotection been examined in songbirds, and our lab is one of the few to study the role of E2 and aromatase in behavioral recovery and the only to …

Development Of New Radiotracers For Positron Emission Tomography Targeting C-X-C Chemokine Receptor Type 4 In Cancers, Piyapan Suwattananuruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to develop novel positron emission tomography (PET) tracers for C-X-C chemokine receptor type 4 (CXCR4) imaging. [68Ga]Ga-TD-01 and [18F]PICO-F were designed as PET tracers based on the molecular scaffolds of two potent CXCR4 antagonists, TIQ15 and PICO. TIQ15 was used to prepare a bifunctional (BFC) to facilitate 68Ga-labeling while structural modification of PICO was made to obtain a precursor, PICO-Br for 18F-labeling. The BFC, TD-01 was obtained in a moderately high yield (61%) via the conjugation of TIQ15 with a chelator derivative and successfully radiolabeled with 68Ga to yield [68Ga]Ga-TD-01, a PET tracer. For 18F-based tracer, the …

Native Forbs Provide Pollinator Resources And Improve Forage Nutrient Composition, Animal Performance, And Pasture Productivity, Jessica L. Prigge, Eric Bisangwa, Jonathan D. Richwine, Virginia R. Sykes, Jennie Lz Ivey, Patrick D. Keyser

Faculty Publications

Pollinator declines and expectations for more sustainable agriculture, including pasture-based enterprises, bring attention to strategies to enhance the habitat value of grazing lands. We evaluated native warm-season grass (NWSG) pastures with (FORB) and without (CONT) interseeded native forbs in 2021–2023. An analysis was conducted using R with the significance set at p ≤ 0.05. The grass appeared to be weakened predominantly by grazing management practices. Forb density and mass had an inverse relationship in seasons two and three. Total forage mass declined in response to increased grazing days and weakened stands. The forage nutritive compositions differed, with more stable, season-long …

Building A Human Digital Twin (Hdtwin) Using Large Language Models For Cognitive Diagnosis: Algorithm Development And Validation, Gina Sprint, Maureen Schmitter-Edgecombe, Diane Cook

Computer Science Faculty Scholarship

Background: Human digital twins have the potential to change the practice of personalizing cognitive health diagnosis because these systems can integrate multiple sources of health information and influence into a unified model. Cognitive health is multifaceted, yet researchers and clinical professionals struggle to align diverse sources of information into a single model. Objective: This study aims to introduce a method called HDTwin, for unifying heterogeneous data using large language models. HDTwin is designed to predict cognitive diagnoses and offer explanations for its inferences. Methods: HDTwin integrates cognitive health data from multiple sources, including demographic, behavioral, ecological momentary assessment, n-back test, …

Research And Design A Lifeboat Virtual Reality Simulation System For Maritime Safety Training In Vietnam, Nguyen Dinh Thach, Nguyen Van Hung

Journal of Marine Science and Technology–Taiwan

Ensuring maritime safety and security is crucial for all nations. Training trainees and operational officers in this field aims to enhance their professional skills and ability to manage and resolve incidents at sea. This article outlines the development of a lifeboat simulation system that integrates Virtual Reality (VR) technology in accordance with international maritime regulations. It describes the creation of an algorithm designed to optimize data transmission between simulation systems using the ant colony optimization technique in conjunction with intelligent control algorithms on Unity 3D software for human interaction. In particular, the system combines training with a maritime simulation framework …

Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr

Journal of Medicine in Scientific Research

Objective: In this article, garden cress and ozone were evaluated for their potential therapeutic properties of PDL and resorption of alveolar bone in the periodontal tissues based on rats' experimental periodontitis and to assess the clinical effectiveness of local application of garden cress and ozone for treatment and management of periodontitis patients using scaling and root planing. Methodology: Thirty mature Wistar male albino rats. Three groups of rats were formed; periodontitis without treatment, periodontitis with garden cress, and periodontitis plus ozone therapy. The present study also included thirty periodontitis Patients were randomly allocated to one of three groups of ten …

The Rage Gene Crucial Function In The Etiology And Consequences Of Type I Diabetes, Amal A. Mohamed, Mohamed O. Mahmoud, Gamil M. Abdallah, Nada S. Ali, Mona Abdelmotaleb Abdelfatah Hussein, Ibrahim T. Ibrahim

Journal of Medicine in Scientific Research

Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It is an auto-immune illness brought on by an association of environmental and genetic variables. that cause T lymphocytes to destroy insulin-producing β-cells. Its prevalence continues to rise by 3-4% annually worldwide, enhancing the risk of mortality. So, the idea of diabetic kidney disease (DKD) is widely established, and systemic treatment is essential. RAGEs are linked to inflammatory disorders that exist in a variety of TID-related cells; especially T cells. Variations in circulating RAGE concentrations have been linked to a …

Oral Collagen Supplementation In 2nd Degree Burn And Chronic Pressure Ulcers, Wesam Ibrahem Homouda, Helmy Ahmed Soliman, Esayed Hussien Elmokadem

Journal of Medicine in Scientific Research

Background: Healing of wounds requires adequate intake of protein, iron, Vitamin-C and zinc. In case of deficiency in the dietary intake, supplements may be prescribed. Collagen-peptide supplements can enhance skin hydration, elasticity, and reduce wrinkles. Burns, caused by various agents, severely damage skin layers. Pressure ulcers occur when prolonged pressure on the skin leads to tissue ischaemia, disrupting nutrition and oxygen supply, resulting in tissue necrosis. Systematic reviews show that oral collagen, either intact or hydrolyzed, effectively improves skin health.

Objectives: This article aim to evaluate the effect of oral collagen intake as a healing promoting supplementation in management of …

Pierre V. Midland Credit Management, Inc., Syma Birenbaum

NYLS Law Review

No abstract provided.

Strategies Of Utilizing Sex-Sorted Semen To Improve Beef Cattle Herd Production And Using Lasia Spinosa Thw. And Zinc Supplementation To Improve Semen Quality Of Bulls And Boars With Poor Semen Profile, Supitcha Kaewma

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of the thesis were i) to improve the success of using sex-sorted semen and ii) to enhance the semen quality in low semen quality bulls and boars. Four experiments were conducted to test the hypothesis as 1) on-farm factors influence the success of sexed semen artificial insemination (AI) in cattle herds, 2) estrus synchronization protocols can be integrated in sex-sorted semen AI in cattle herd, 3) Lasia spinosa Thw. (LST) supplementation for improving semen quality in bull and boar sires with poor semen quality, 4) zinc supplementation for improving semen quality in subfertile boar. Study 1: Experiment 1, …

Research On The Soft Power Of Thai Traditional Food Culture Under The Process Of Globalization, Lu Han

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research explores the role of Thai traditional food culture as a form of soft power in the context of globalization. According to Joseph S. Nye, Soft power operates through the resources of culture, political ideals, and foreign policies. Influenced by factors such as history, geography, climate, and social development, Thai traditional food culture has integrated the characteristics of multiple cultures with its inclusive and innovative ideas to form a unique culture. Through globalization, Thai food culture has gained widespread popularity. This research analyzes the mechanisms by which Thai food culture promotes Thailand’s soft power, including nation branding, gastro-diplomacy, tourism, …

A Study Of Developing Artificial Coral Innovation In Line With The Context Of Promoting Thailand’S Economy And Society, Chawin Poomee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to develop innovative artificial reef technology to align with the context of promoting the Thai economy and society. The objectives were to understand the development direction of artificial reefs to meet the needs of tourists and conservationists, explore the feasibility of introducing new technology into artificial reef production, and study methods to reduce environmental destruction caused by reef deployment. The research employed exploratory and qualitative research methods, including in-depth interviews with a target group of 10 individuals and questionnaire surveys to study consumer behavior and product acceptance among a general consumer group of 100 individuals. Data analysis …

Using Machine Learning Algorithms To Enhance Iot System Security, M. Samir Abou El-Seoud

Computer Science

The term “Internet of Things” (IoT) refers to a system of networked computing devices that may work and communicate with one another without direct human intervention. It is one of the most exciting areas of computing nowadays, with its applications in multiple sectors like cities, homes, wearable equipment, critical infrastructure, hospitals, and transportation. The security issues surrounding IoT devices increase as they expand. To address these issues, this study presents a novel model for enhancing the security of IoT systems using machine learning (ML) classifiers. The proposed approach analyzes recent technologies, security, intelligent solutions, and vulnerabilities in ML IoT‑based intelligent …

Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon

Electronic Theses and Dissertations

Fisheries management is a complex process that often requires consideration of many factors to be implemented effectively. Stocking is one of the most often used fisheries management techniques for addressing a myriad of issues in the fisheries field. Stocking is also one of the largest expenses for many fisheries management agencies. Due to license sale declines, management actions including stocking, are being evaluated by many agencies to determine if there are ways to improve efficiency and effectiveness to reduce costs and enhance angler participation. For my second chapter, I evaluated the current fish stocking decision-making process within South Dakota Game, …

Hsp70 Is A Critical Regulator Of Hsp90 Inhibitor's Effectiveness In Preventing Hcl-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-Nkansah, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke acute and chronic lung injury. Because of its extensive production for industrial use, frequent accidental exposures occur, making HCl one of the top five chemicals causing inhalation injuries. There are no Food and Drug Administration (FDA)-approved treatments for HCl exposure. Heat shock protein 90 (HSP90) inhibitors modulate transforming growth factor-β (TGF-β) signaling and the development of chemical-induced pulmonary fibrosis. However, little is known on the role of Heat Shock Protein 70 (HSP70) during injury and treatment with HSP90 inhibitors. We hypothesized that administration of geranylgeranyl-acetone (GGA), an HSP70 inducer, or gefitinib (GFT), an …

Honk!: Meaning And Activism In 21st Century American Street Bands, Isaac Maupin

Theses and Dissertations--Music

In this dissertation, I explore activism, music, and meaning through the lens of HONK! Bands in the United States. HONK! A Festival of Activist Street Bands began in Sommerville, Massachusetts, in 2006. Since its inception, the festivals have grown on a national and global scale. The festivals, however, operate as a convenient organizing structure for the bands themselves and are not a primary focus of this work. Instead, I examine activism, learning, and value as systems within the HONK! culture (each topic with a devoted chapter) to, through a phenomenological lens, better understand how HONK! bands fit within American culture. …

Ecuadorian Vocal Anthology In Four Rhythms, Wagner Mauricio Pástor Pazmiño Dr.

Theses and Dissertations--Music

Ecuador is a pluricultural and multilingual territory with four natural regions, several musical genres, and interpretations. Amazon, Galápagos, Mountain Range, and Coastal region. In the following dissertation, the author develops concepts of four traditional rhythms, their composers, and harmonic and phonetic characteristics from the mountain range region of his homeland, Ecuador.

The present document is a descriptive study of vocal Andean music and the application of the operatic style in classical vocal technique for performance practice.

The dissertation will support a lecture recital to fulfill the doctoral program's requirement in voice performance from the University of Kentucky.