Digital Commons Network^™

Strategic Insights From Antarctic Mpas: Navigating The Future Framework For High Seas Mpas Under The Bbnj Agreement, Alyssa Huffman

University of Miami International and Comparative Law Review

Current area-based management systems regulate only about 1.18% of the high seas, leaving highly migratory fish species at risk of overexploitation. As a result, new legal mechanisms are essential for protecting and managing high seas fisheries. In recent decades, stakeholders have debated how to balance competing interests while ensuring equitable and sustainable access to areas beyond national jurisdiction. One proposed solution is the establishment of Marine Protected Areas (MPAs). However, creating and managing high seas MPAs is a complex process. The Parties to the Convention on the Conservation of Antarctic Marine Living Resources have undertaken this effort, establishing two MPAs …

Evaluating The Performance Of Bayesian Removal Models For Estimating Population Density And Detecting Trends With Variable Detection Probability, David R. Stewart

Mathematics & Statistics ETDs

Removal models have long been used to estimate population abundance by progressively capturing and removing individuals from a closed population. These models provide a valuable tool for ecological monitoring, but their accuracy depends heavily on assumptions about detection probability, which may decline over successive sampling passes. Traditional removal models assume constant detection probabilities, an assumption that is often violated in real-world applications. This thesis aims to advance hierarchical Bayesian models by accounting for variable detection probabilities, improving the reliability of abundance estimates and trend detection. By integrating simulation-based analyses with empirical data from Lahontan Cutthroat Trout (Oncorhynchus clarkia henshawi …

Achieving Periodontal Disease Stabilization: Assessing The Impact Of Laser Therapy In Scaling And Root Planing And Periodontal Maintenance Visits, Cassandra Charlotte Cooper

Dental Hygiene ETDs

Purpose: This study examined the effectiveness of laser utilization in stabilizing periodontal disease over a one-year period. This research focused on the results following scaling and root planing with adjunctive laser-assisted periodontal therapy and laser bacterial reduction at subsequent periodontal maintenance visits. While short-term advantages are documented in the literature, research on sustained effectiveness is limited. Methods: A retrospective chart review of 30 adult patients who received the above treatment was conducted. Periodontal charting was recorded at three visits over one year. Data was collected and analyzed utilizing Statistical Package for Social Sciences (SPSS) to determine statistical significance of periodontal …

Cyber And Tech-Based Partner Stalking In Jefferson County, Norah Wulkopf

Undergraduate Theses

Since stalking laws were enacted in the 1990s, they have been historically difficult to enforce. As less and less of our lives become private due to our ever-present devices, stalkers frankly have more access to their targets than ever before. The tenuous nature of stalking laws and the growing resources for stalkers place targets of stalking in a very precarious situation: the legal system has never been adequately equipped to handle stalking cases, and local justice systems do not have the resources to handle tech-based crimes. Through interviews with actors in the criminal justice system, this presentation considers how these …

The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta

Undergraduate Theses

Discrimination has profoundly shaped the lives of individuals within disadvantaged communities, but its impact on mental and physical health has often been overlooked. In this project, I review literature on perceived discrimination based on immigrant status and its effects on psychological and physical health and examine a potential mediator and moderator of these relationships. Specifically, the relationships between immigration-based discrimination and both mental health and physical health may be mediated by perceived stress, meaning that discrimination may lead to higher stress levels, which results in poorer health outcomes. Furthermore, these relationships may be moderated by psychological resilience; individuals with higher …

Effect Of Heat Stress On Ileal Epithelial Barrier Integrity In Broilers Divergently Selected For High- And Low-Water Efficiency, Elizabeth S. Greene, Brooklee Roach, Maria Fernandez Cuadrado, Sara Orlowski, Sami Dridi

Poultry Science Faculty Publications and Presentations

Water scarcity and rising global temperatures are two of the greatest current and future threats to poultry sustainability. Therefore, selection for water efficiency (WE) and heat resilience are of vital importance. Additionally, intestinal integrity is of critical importance under challenging conditions to maintain nutrient absorption and therefore, growth and performance of broilers. Here, we examined the effect of chronic cyclic heat stress (HS) on the ileal expression profile of tight-junction, gap-junction, adherens, and desmosome genes in the fourth generation of divergently selected low (LWE)- and high water efficient (HWE)-chicken lines. LWE birds exhibited higher levels of gut permeability, regardless of …

Biochemical And Structural Insights Into The Yersinia Effector Yopm And Its Negative Regulation Of The Pyrin Inflammasome, Bethany Wairimu Mwaura

Dartmouth College Ph.D Dissertations

Bacteria utilize sophisticated secretion systems to inject effectors into host cells in order to facilitate their survival and replication in the host. Some pathogenic species of Gram-negative bacteria use a conserved contact-dependent T3SS to inject a wide array of effectors. While the effectors diverge in their structures, functions and cell-localization, the T3SS is well conserved. Several effectors discussed in this thesis target key host inflammasome responses. The focus of this work is how the Yersinia effector YopM inhibits the pyrin inflammasome. During Yersinia infection, two effectors, YopE and YopT inadvertently activate the pyrin inflammasome while targeting RhoA to avoid phagocytosis. …

The Free Press Vol. 56, Issue 11, 04-07-2025, Chris Tiner, Cayley Bowman

Free Press, The

Rooted in Resilience--WMPG Mardi Gras--Op=Ed on Trump Administration--Snatched in Broad Daylight--The Studio Review--Playboi Carti's MUSIC Album Review--Off Season Check in--Letters from the Editors

Environmental Education Professionals And K-12 School Counselors: Collaboration For Engaging The Conservation And Natural Resources Workforce Of The Next Generation, Brent M. Erb

Education Doctorate Dissertations

Environmental education (EE) professionals often fail to reflect the diverse, intersectional identities of the students and communities they serve. As frontline professionals among the conservation and natural resources (CNR) professions, addressing this requisite and urgent disparity is vital for fostering equitable teaching and learning environments that are safe, welcoming, accessible, and inclusive. EE professionals play a pivotal role in filling knowledge gaps, fostering ecological literacy, and introducing students to CNR careers, just as K-12 school counselors play a meaningful role in helping students expand upon their interests and acquire experience and skills to cultivate self-efficacy to support the belief in …

The Echo: April 7, 2025, Taylor University

2024-2025 (Volume 112)

No abstract provided.

Shared Pathway Of Wdfy4-Dependent Cross-Presentation Of Immune Complexes By Cdc1 And Cdc2, Suin Jo, Ray A Ohara, Derek J Theisen, Sunkyung Kim, Tiantian Liu, Christopher B Bullock, Michelle He, Feiya Ou, Jing Chen, Sytse J Piersma, J Luke Postoak, Wayne M Yokoyama, Michael S Diamond, Theresa L Murphy, Kenneth M Murphy

2020-Current year OA Pubs

Priming CD8+ T cells against tumors or viral pathogens results largely from cross-presentation of exogenous antigens by type 1 conventional dendritic cells (cDC1s). Although monocyte-derived DCs and cDC2s can cross-present in vitro, their physiological relevance remains unclear. Here, we used genetic models to evaluate the role of cDC subsets in presentation of cell-associated and immune complex antigens to CD4+ and CD8+ T cells in vivo. For cell-associated antigens, cDC1s were necessary and sufficient to prime both CD4+ and CD8+ T cells. In contrast, for immune complex antigens, either cDC1 or cDC2, but not monocyte-derived DCs, could carry out cross-presentation to …

Loss Of Atg7 In Microglia Impairs Upr, Triggers Ferroptosis, And Weakens Amyloid Pathology Control, Zhangying Cai, Shoutang Wang, Siyan Cao, Yun Chen, Silvia Penati, Vincent Peng, Carla M Yuede, Wandy L Beatty, Kent Lin, Yiyang Zhu, Yingyue Zhou, Marco Colonna

2020-Current year OA Pubs

Microglia impact brain development, homeostasis, and pathology. One important microglial function in Alzheimer's disease (AD) is to contain proteotoxic amyloid-β (Aβ) plaques. Recent studies reported the involvement of autophagy-related (ATG) proteins in this process. Here, we found that microglia-specific deletion of Atg7 in an AD mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity. Single-cell RNA sequencing, biochemical, and immunofluorescence analyses revealed that Atg7 deficiency reduces unfolded protein response (UPR) while increasing oxidative stress. Cellular assays demonstrated that these changes lead to lipoperoxidation and ferroptosis of microglia. In aged mice without Aβ buildup, UPR reduction and …

The Grand Narratives: The Rise And Fall Of Universal Philosophical Systems, Gavin S. Litchford

Senior Honors Theses

This thesis reviews the development of narrative and systematic methods of argumentative legitimation in the Western tradition of philosophy from its conception until the present day. Utilizing both primary sources from central figures in key movements within this development process and supplementary secondary sources, this analysis notes which systems were used as appeals to higher authority and the trends in the adoption and transformation of new models. It is demonstrated that the Enlightenment era punctuated a progression begun in the premodern era from simple, cultural narratives to individualized, subjective, and self-perpetuating Grand Narrative systems, and that it generated the preconditions …

Alterations In Dna Methylation, Proteomic, And Metabolomic Profiles In African Ancestry Populations With Apol1 Risk Alleles, Xinruo Zhang, Ashley W Scadden, Amarnath Marthi, Victoria L Buchanan, Yishu Qu, Kendra R Ferrier, Brian D Chen, Mariaelisa Graff, Julian Avila, Eric Boerwinkle, Steven Buyske, Clary B Clish, Dan Cruz, Myriam Fornage, Robert E Gerzsten, Christopher R Gignoux, Lashaunta Glover, Lifang Hou, Anne E Justice, Charles Kooperberg, Holly Kramer, Leslie Lange, Ruth J F Loos, Tara Matise, Josyf C Mychaleckyj, Opeyemi A Olabisi, Ulrike Peters, Laura M Raffield, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Kent D Taylor, Bing Yu, Yinan Zheng, Kari E North, Amy K Mottl, Heather M Highland, Maggie A Stanislawski

Faculty, Staff and Student Publications

Key Points:

1. We aimed to elucidate potential methylation, proteomic, and metabolomic mechanisms by which APOL1 variants may be linked to kidney disease.

2. We report distinct methylation profiling between APOL1 risk allele carriers and noncarriers, many near APOL gene family.

3. We report higher APOL1 protein and lower C18:1 cholesteryl ester in two risk allele carriers.

Background: The APOL1 high-risk haplotype has been associated with CKD and the deterioration of kidney function, particularly in populations with West African ancestry. However, the mechanisms by which APOL1 risk variants increase the risk for kidney disease and its progression have not been fully elucidated.

Methods: …

Old Habits Die Hard: How The Maine Indian Claims Settlement Act Perpetuates Settler Colonialism And Denies Indigenous Sovereignty, Brandon Dodds

Emory Law Journal Online

Around the time it was passed, the Maine Indian Claims Settlement Act of 1980 was considered by many to be a great victory for the Wabanaki Nations in Maine. But in the decades since, the Act has substantially hindered the Wabanaki Nations’ self-determination efforts. Frequent litigation between the Nations and the state of Maine, narrow interpretation by courts, and the state of Maine’s opposition to remedying the Act’s most harmful provisions have constrained the sovereignty of the Wabanaki Nations. As a result, the Wabanaki Nations have been largely excluded from the significant social, economic, and political gains that tribes throughout …

Exploring The Impact Of Reduction In Methamphetamine Use On Sexual Risk Behaviors Among Men Who Have Sex With Men And Women: Findings From The Adapt- 2 Trial, Chukwuemeka N Okafor, Jin H Yoon, Ducel Jean-Berluche, Taryn L Mayes, Steve Shoptaw, Madhukar H Trivedi, Jennifer S Potter, Joy Schmitz

Faculty, Staff and Student Publications

Background: Methamphetamine (MA) use has been linked to engaging in sexual risk behaviors (SRBs) that are associated with HIV/STIs, particularly among men who have sex with men (MSM) and men who have sex with men and women (MSMW; hereafter MSM/W). The objectives of this analysis were to determine whether reduced MA is associated with decreases in SRBs in a sample of MSM/W.

Method: Data came from the ADAPT- 2 trial, a randomized, double-blind, two-stage sequential parallel design trial evaluating extended-release injectable naltrexone (NTX) and oral bupropion (BUP) vs. placebo for MA use disorder. In the first 6 weeks of the …

Vestibular Neurons Link Motion Sickness, Behavioural Thermoregulation And Metabolic Balance In Mice, Longlong Tu, Xing Fang, Yongjie Yang, Meng Yu, Hailan Liu, Hesong Liu, Na Yin, Jonathan C Bean, Kristine M Conde, Mengjie Wang, Yongxiang Li, Olivia Z Ginnard, Qingzhuo Liu, Yuhan Shi, Junying Han, Yi Zhu, Makoto Fukuda, Qingchun Tong, Benjamin Arenkiel, Mingshan Xue, Yang He, Chunmei Wang, Yong Xu

Children’s Nutrition Research Center Staff Publications

Motion sickness is associated with thermoregulation and metabolic control, but the underlying neural circuitry remains largely unknown. Here we show that neurons in the medial vestibular nuclei parvocellular part (MVePC) mediate the hypothermic responses induced by motion. Reactivation of motion-sensitive MVePC neurons recapitulates motion sickness in mice. We show that motion-activated neurons in the MVePC are glutamatergic (MVePCGlu), and that optogenetic stimulation of MVePCGlu neurons mimics motion-induced hypothermia by signalling to the lateral parabrachial nucleus (LPBN). Acute inhibition of MVePC-LPBN circuitry abrogates motion-induced hypothermia. Finally, we show that chronic inhibition of MVePCGlu neurons prevents diet-induced obesity and improves glucose homeostasis …

Mrs. Marie Lee West

African American Funeral Programs

No abstract provided.

Mechanistic Insights Into The Structure-Based Design Of A Cspz-Targeting Lyme Disease Vaccine, Kalvis Brangulis, Jill Malfetano, Ashley L Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen, Yi-Pin Lin

Faculty, Staff and Students Publications

Borrelia burgdorferi (Bb) causes Lyme disease (LD), one of the most common vector-borne diseases in the Northern Hemisphere. Here, we solve the crystal structure of a mutated Bb vaccine antigen, CspZ-YA that lacks the ability to bind to host complement factor H (FH). We generate point mutants of CspZ-YA and identify CspZ-YAI183Y and CspZ-YAC187S to trigger more robust bactericidal responses. Compared to CspZ-YA, these CspZ-YA mutants require a lower immunization frequency to protect mice from LD-associated inflammation and bacterial colonization. Antigenicity of wild-type and mutant CspZ-YA proteins are similar, as measured using sera from infected people or immunized …

Just Like Us: Mdl Is Eating Weedkiller, Andrew H. Paul

Georgia State University Law Review

The ingestion of an herbicide called glyphosate is currently unavoidable in America. It is the main ingredient of a consumer product called Roundup. People who regularly used Roundup have brought civil lawsuits against its manufacturer, Monsanto (now owned by Bayer), claiming Roundup caused their cancer diagnoses. Juries, particularly those in state courts, have awarded some plaintiffs massive damages awards. But jury trials elude most of the glyphosate plaintiffs who find themselves in federal court. There, the same can be said for nearly all products liability litigants. This is due to the procedure that has slowly come to dominate mass torts …

Simplifying 3d Printing Using Natural Language Processing, Jared E. Rosenberger

Undergraduate Theses

3D printing is a crucial technology with many applications in different fields. To be able to use this technology to its full extent, expertise in computer aided design (CAD) technology and 3D modeling is required. Many people interested in 3D printing do not have this expertise and thus cannot build custom models, and are consequently forced to buy them instead. Natural language processing (NLP) is one tool that can vastly simplify 3D modeling for those lacking CAD experience. Using NLP, someone can simply dictate what they want to be able to print, and a computer can then build a 3D …

No Vaccine? Why Not: Causes Of Vaccine Hesitancy And How Governments Can Stop It, Alexander (Alec) Mccarty '25

Honor Scholar Theses

Vaccine hesitancy is a term that has entered the spotlight since the beginning of the COVID-19 pandemic. With concerns about efficacy, safety, and individual choice, many people have developed a hesitancy toward receiving any vaccine, creating concerns for public and global health. Through responses from local and state health departments about their actions during the COVID-19 pandemic, and through analysis of state vaccine rates based on political affiliation, this study suggests that vaccine hesitancy is a current issue that is likely politically motivated. States that are Republican affiliated have lower rates of vaccine uptake, and in turn they have higher …

Service Learning & Community Engagement Showcase, Erika Grodzki, Seok Kang, David Grannis, Chandra Clark

Faculty and Staff Publications & Presentations

No abstract provided.

The Interaction Of Nitrogen And Potassium Nutrients In Increasing Growth, Yield, And Quality Of Sweet Corn Products, Risqa Naila Khusna Syarifah, Purwanto, Agus Sarjito, Hana Hanifa, Lafi Na'imatul Bayyinah

Jurnal Kultivasi

Fertilizer application is a strategy that can be used to increase sweet corn production and maintain environmental balance. This research aims (i) to determine the optimal dose of nitrogen and potassium fertilizers for sweet corn production; (ii) to study the agronomic and physiological responses of sweet corn plants at different nitrogen and potassium dose; and (iii) to determine the nitrogen (N) and potassium (K) nutrient uptake and efficiency by sweet corn at different fertilizer doses and their interactions on yield and yield quality. The research was conducted from March to November 2022 in the Faculty of Agriculture, Universitas Jenderal Soedirman. …

Life On The Dry Side: A Roadmap To Understanding Desiccation Tolerance And Accelerating Translational Applications, R A Marks, J T B Ekwealor, M A S Artur, L Bondi, T C Boothby, O M S Carmo, D C Centeno, K K Coe, H J W Dace, S Field, A Hutt, S Porembski, A Thalhammer, L Van Der Pas, A J Wood, P Alpert, D Bartels, S Boeynaems, M N Datar, T Giese, W I Seidou, S M Kirchner, J Köhler, U G V S S Kumara, J Kyung, R Lyall, B D Mishler, J B V T Ndongmo, M S Otegui, V Reddy, J Rexroth, S M Tebele, R Vanburen, J Verdier, U C Vothknecht, M F Wittenberg, E Zokov, M J Oliver, S Y Rhee

Duncan NRI Faculty and Staff Publications

To thrive in extreme conditions, organisms have evolved a diverse arsenal of adaptations that confer resilience. These species, their traits, and the mechanisms underlying them comprise a valuable resource that can be mined for numerous conceptual insights and applied objectives. One of the most dramatic adaptations to water limitation is desiccation tolerance. Understanding the mechanisms underlying desiccation tolerance has important potential implications for medicine, biotechnology, agriculture, and conservation. However, progress has been hindered by a lack of standardization across sub-disciplines, complicating the integration of data and slowing the translation of basic discoveries into practical applications. Here, we synthesize current knowledge …

Role And Key Species Of Freshwater Snails In Enhancing Plant Growth Performance Of Duckweeds (Spirodela Polyrhiza) In Rice Paddy Fields, Dwi Harya Yudistira, Fariz Ardiansyah Gunawan, Shahla Aurelia Arif, Satoru Sato

Jurnal Kultivasi

Freshwater snails are widely distributed in the rice field ecosystem. Freshwater snails’ feeding and metabolic activities can potentially increase the complexity of freshwater ecosystems, particularly through the nutrient cycle. Cipangopaludina chinensis, Physa acuta, and Semisulcospira libertina are commonly found in Japan's paddy field ecosystems. Spirodela polyrhiza is expected to support biodiversity, improve soil fertility, and reduce greenhouse gas emissions in paddy field ecosystems, while providing food and shelter for the snails. In this study, we investigated the effects of these three snail species on the growth of Spirodela polyrhiza. The results showed that the presence of P. acuta or C. …

The Effect Of Weed Control Using Herbicide On Soil Bacteria, Growth, And Yield Of Sweet Corn, Lafi Na'imatul Bayyinah, Purwanto, Risqa Naila Khusna Syarifah, Rama Adi Pratama, Ida Widiyawati, Hendra

Jurnal Kultivasi

Weeds are managed by herbicides, but this can reduce the abundance of soil bacteria. This research aimed to determine the effect of active compounds of herbicides on weeds, the abundance of soil bacteria, growth and yield of sweet corn. The experiment was conducted from June to October 2023 in the fields and Laboratory of Agronomy and Horticulture, Universitas Jenderal Soedirman, Purwokerto. A randomized block design was used, consisting of eight treatments and four replications. The treatments included control (H0); weeding (H1); paraquat (H2); glyphosate (H3); paraquat, atrazine, mesotrione (H4); glyphosate, atrazine, mesotrione (H5); paraquat, atrazine, mesotrione, nicosulfuron (H6); and glyphosate, …

Loz, A Feature-Length Screenplay By Audrey Ickes & The Midwest’S Playground: An Autoethnography Of “The Lake” In Accompaniment To The Screenplay Loz, Audrey M. Ickes '25

Honor Scholar Theses

The following screenplay and critical paper mold together into one comprehensive project. The historical context found in the critical paper informs the screenplay as much as the screenplay weaves its way into the critical paper’s autoethnography. For example, the unique section breaks throughout the critical paper were taken directly from my grandfather's letterheads that he used for his seasonal business letters.

Queering The Mean Girl: Spectating The Post-Feminist Melodrama, Anne Gregg '25

Honor Scholar Theses

Ultimately this thesis will examine how Mean Girls melodramas moralize gender and sexuality. The Mean Girl is not an embodiment of moral hegemony. She may look like the perfect subject, but she is imperfect, because she tries to be perfect. She is a failure of femininity, because her attempts to be feminine reveal the masquerade. Womaniliness is not inherent; it is not real. The Mean Girl is attractive to the sapphic spectator because she exposes the alienation and artifice of gender and heterosexuality. The stereotypical image of the Mean Girl is plastic perfection, but she is not.

Tiny Creatures, Big Lessons: Using Music Education And Ecoliteracy To Impact Young Learners' Perspectives On Bugs And Nature, Paige Burgess '25

Honor Scholar Theses

This thesis aims to demonstrate that relationships between students and nature can be improved through teaching young learners about music and bugs together, potentially leading to a greater overall love for and willingness to protect nature. The thesis features original teacher action research conducted over multiple weeks in a first grade classroom, with observations and data to support the efficacy of the methods discussed. This thesis analyzes literature that supports how increasing empathy toward bugs at a young age can have tangible benefits for the environment, how ecoliteracy as a framework is an effective means of teaching about nature, and …