Digital Commons Network^™

Assessing Leadership In Business: A Critical Investigation Of Mary Barra, Krisha Patel

Honors Scholar Theses

Understanding what makes a good leader is a topic of ongoing interest in the practice of business. Research to-date has distinguished between being a manager and being a leader and also has established a set of principles to consider in assessing leadership. In this thesis, I draw upon principles of leadership, including emotional intelligence; vision creation; inspiring others; leading in good and difficult times; fostering, developing, and recognizing others; and creating a winning culture to offer a critical assessment of Mary Barra as a leader within the business arena.

Using A Three-Dimensional Theoretical Orientation Matching Model To Predict Therapeutic Outcomes, Daniel Rhodes

Electronic Theses and Dissertations

Matching helpers and clients in a therapeutic setting is inefficient and ineffective. So far, there are no significant and enduring variables that reliably match helpers and clients that lead to positive therapeutic outcomes. This study attempts to match helper and client using theoretical orientation. It uses a quantitative methodology to predict therapeutic outcomes given match quality in the therapeutic dyad. Participants were 30 dyadic pairs—consisting of one helper and one client—who had a pre-existing therapeutic relationship. Each was given an assessment tool, used to measure their theoretical orientation to psychotherapy. Results showed no statistically significant relationships between theoretical orientation match …

Interactive Effects Of Sublethal Concentrations Of Fracking Biocides And Abandoned Mine Drainage On Amphipod Behavior, Kelly Lenhart

Electronic Theses and Dissertations

This thesis examined the sublethal effects of three pollutants, namely glutaraldehyde, 4,4-dimethyloxazolidine (DMO), and abandoned mine drainage (AMD), on amphipods. The primary objective was to investigate their combined effects on amphipods. The three pollutants, despite having the potential to combine in the environment, have not been studied to determine their potential for detrimental interactive effects which could result in unexpected environmental damage.

The research employed a series of experimental setups involving controlled exposure of amphipods to varying, putatively sublethal, concentrations of the chemicals of interest. Subsequently, effects were assessed via both behavioral and feeding assessments. To facilitate this analysis, novel …

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump

Electronic Theses and Dissertations

Biomanufactured 3D-organoids show promise for modeling and treating various conditions, particularly insulin-dependent diabetes mellitus (type-1 diabetes). Pancreatic islet organoids serve as sustainable sources of insulin-producing β-cells, potentially restoring insulin regulation in patients and providing a long-term solution for diabetes. Hydrogel droplet printing is an emerging technique in regenerative medicine due to its advantageous tunability and biocompatibility; however, challenges of consistency, quality control, and scalability persist. To address these issues, we developed a novel air-jetting based droplet bioprinting system for the generation of monodispersed alginate micro-droplets. The objective of this project was to incorporate human induced pluripotent stem cells (hiPSCs) into …

Large - Scale Manufacturing Of Fluorescent Perfluorocarbon Nanoemulsions For Oxygen Delivery, Anneliese Troidle

Electronic Theses and Dissertations

Over 100,000 Americans are currently waiting for a life – saving organ transplant, yet 17 patients die daily waiting for a transplant they will never receive [1]. Preservation of organs is an area that has seen innovation throughout the years and can improve rates of transplantation, yet vascularized composite allotransplantation preservation has not followed suit [2]. Current standard of care is use of electrolyte solutions such as Histidine – Tryptophan – Ketoglutarate (HTK) or University of Wisconsin (UW) Solution, yet these perfusates lack an oxygen carrying component [3]. Hemoglobin – based oxygen carriers (HBOCs) …

Retreat Village Design In Letchworth State Park Region: An Architecture Development In A Highly Valued State Park Meets The Triple Bottom Line Of Sustainability, Jing Hua

Theses

Letchworth State Park, located in Livingston and Wyoming counties, New York, renowned as the “Grand Canyon of the East”, is one of the most scenically magnificent areas in the eastern United States. However, there are no well-developed leisure centers around or in the park. The lack of good accommodations, in contrast to the availability of restaurants with local character, leisure activities, and other supporting facilities in the area, fails to fully achieve the development potential of the natural scenery of the region. This thesis demonstrates that a retreat complex village that brings people closer to the natural landscape of Letchworth …

Evaluating The Impact Of Biosimilars In The Drug Market, Olivia Sitter

Theses

Drug pricing has increase to the point where many Americans are unable to afford prescriptions for both long- and short-term diseases. Within the last decade, U.S lawmakers have changed legislation so that biosimilars can be added into the drug market in hopes of creating affordable products. Biosimilars allow more options for consumers and add increased competition for manufactures which should decrease the overall price of the original biopharmaceutical the biosimilar is modeled after. In current research, the impact of biosimilars within the European Union has been investigated heavily, but the US approved biosimilars much later and there is less information …

Robochurch: Baptizing Bots And Sanctifying Silicon?, Peter Bellini

Witness

No abstract provided.

Galonsky V. East 17th Llc

All Decisions

No abstract provided.

Top Tips For Effective Use Of Periodontal Instruments In Primary Care, Morag Powell, Ruth Potterton, Ewen Mccoll

Peninsula Dental School

Stabilisation of primary disease is a key pillar of successful treatment and in addition to managing caries, managing periodontal disease is a crucial component of a successful treatment plan. The recent European Federation of Periodontology (EFP) S3 level clinical practice guidelines (CPG)1 are evidence‐based clinical guidelines providing recommendations to treat periodontitis. Crucial to successful implementation of these recommendations is delivering behavioural change and non-surgical instrumentation. Often this is given passing attention with insufficient time allocated to behaviour change in treatment planning. Similarly, poorly maintained periodontal instruments and equipment not used to their full utility or design can lead to poorer …

Modeling Of Frontal Polymerization Of Carbon Fiber And Dicyclopentadiene Woven Composites With Stochastic Material Uncertainty, Ahmadreza Mohammad Sharifi, Dong-Jun Kwon, S. Z. H. Shah, Juhyeong Lee

Mechanical and Aerospace Engineering Faculty Publications

A novel finite element modeling framework is proposed for simulating dicyclopentadiene (DCPD) frontal polymerization in carbon fiber (CF) woven composites. A mesoscale CF/DCPD representative volume element (RVE) model was developed with two triggering directions, resulting in out-of-plane and in-plane DCPD polymerization. The Arrhenius equation coupled with a modified Prout-Tompkins autocatalytic model was used to evaluate the dynamic DCPD polymerization process. The rate and degree of DCPD cure were calculated by the material property uncertainties of DCPD with and without random void inclusions (3% used as a reference in this work). The DCPD frontal polymerization in CF/DCPD composite was strongly influenced …

Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

Highlights

• Metformin alleviates HIO and ferroptosis in HFD-induced NAFLD

• FPN is involved in the molecular mechanism of metformin on HIO in HFD-induced NAFLD

• Metformin upregulates FPN expression by reducing lysosomal ubiquitination degradation

Summary

Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron …

Supplementary Information On Early-Stage Floating Offshore Wind Platform Designs, Emma Edwards, Anna Holcombe, Scott Brown, Edward Ransley, Martyn Hann, Deborah Greaves

Faculty of Science and Engineering Datasets

This document serves as supplementary information to the authors' review paper on early-stage floating offshore wind turbine (FOWT) platform designs. The review paper is the second part in a study on FOWT platform designs, following a review of FOWT platforms which currently have or have previously had a prototype, demonstration, or farm scale project at-sea. The present review covers 86 past and current early-stage platform designs, ranging from early conceptual designs to platforms which have undergone lab tests simulating extreme conditions. In this supplementary information document, more details are provided about all 86 platforms reviewed. For each device, the following …

The Normative Requirement For Shared Decision Making (Sdm) In Healthcare Ethics, Margaret Nornor-Quadjie

Electronic Theses and Dissertations

Medicine and medical technology started to advance after World War II. During that period, the practice of medicine became technical. A lot began to happen in the biomedical world during the period after WWII that attracted comments, criticisms, and analyses from scholars. Perhaps, the 1947 Doctors’ Trial at the Nuremberg Tribunal and the Nuremberg Code may be said to be the defining moment for bioethics. These events eventually led to, in the United States, the passage of the National Research Act of 1974 that established the Institutional Review Board system and the National Commission for Protection of Human Subjects of …

Comparative Functional And Genomic Analysis Of Protein Targets Of Sexual Selection In Primates, Brianna Ports

Electronic Theses and Dissertations

Sexual selection is driven by the differential reproductive success of individuals, which is influenced by competition for mates and mate choice. In primates, this selective pressure has been attributed to the development of distinct anatomical, physiological, and behavioral characteristics. By employing comparative functional and genomic methodologies, this study aimed to assess the repercussions of primate sexual selection. To better understand the mechanisms driving sexually selected traits, an unbiased genome-wide analysis was used to associate rates of protein evolution with relative testes size and sexual size dimorphism. While previous research focused on the rapid evolution of male reproductive proteins in response …

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey H Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen

Faculty, Staff and Student Publications

Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced tumor …

Plants As Vectors For Environmental Prion Transmission, Christina M Carlson, Samuel Thomas, Matthew W Keating, Paulina Soto, Nicole M Gibbs, Haeyoon Chang, Jamie K Wiepz, Annabel G Austin, Jay R Schneider, Rodrigo Morales, Christopher J Johnson, Joel A Pedersen

Faculty, Staff and Student Publications

Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In chronic wasting disease of deer, elk, moose, and reindeer and in scrapie of sheep and goats, prions are transmitted via environmental routes and the ability of plants to accumulate and subsequently transmit prions has been hypothesized, but not previously demonstrated. Here, we establish the ability of several crop and other plant species to take up prions via their roots and translocate them to above-ground tissues from various growth media including soils. We demonstrate that plants can accumulate prions in above-ground tissues …

Bayesian Longitudinal Tensor Response Regression For Modeling Neuroplasticity, Suprateek Kundu, Alec Reinhardt, Serena Song, Joo Han, M Lawson Meadows, Bruce Crosson, Venkatagiri Krishnamurthy

Faculty, Staff and Student Publications

A major interest in longitudinal neuroimaging studies involves investigating voxel-level neuroplasticity due to treatment and other factors across visits. However, traditional voxel-wise methods are beset with several pitfalls, which can compromise the accuracy of these approaches. We propose a novel Bayesian tensor response regression approach for longitudinal imaging data, which pools information across spatially distributed voxels to infer significant changes while adjusting for covariates. The proposed method, which is implemented using Markov chain Monte Carlo (MCMC) sampling, utilizes low-rank decomposition to reduce dimensionality and preserve spatial configurations of voxels when estimating coefficients. It also enables feature selection via joint credible …

Factors Affecting Adoption Of Tiktok Among Students In The Dhaka City Area., Mahafizur R. Jim, Muhammad I. Alam

Business Review

This study investigates the factors affecting adoption of TikTok among the students in Dhaka city area. A structured survey questionnaire was developed through the survey tool, Google form and data were obtained from 529 respondents living in various locations of Dhaka city by an online survey method through using the social media platform, Facebook. Moreover, the multiple regression analysis was performed to test the research hypotheses. Results show that students perceive this app in a different way and do not consider this app as a great source of enjoyment. Moreover, they do not perceive this app as a decent media …

Implementing A Standard Work Process For Food Insecurity Screening, Referral, And Connection Tracking In A Safety-Net Clinic, Aisha Keplinger

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Social determinants of health (SDOH) screening and referral programs are crucial to achieving health equity, fundamental to providing the best care, and are critical to the United States’ pursuit of the Institute for Healthcare Improvement’s (IHI) Triple Aim (Berwick et al., 2008). Employing the PRECEDE-PROCEED model, a systematic screening and referral program was implemented at a safety-net clinic to increase SDOH screening and referral rates, and to identify the number of patients who connect with community resources. The program was guided by the IHI Triple Aim framework and evaluated using the Institute of Medicine (IOM) Six Aims of Healthcare Quality …

Effect Of Temperature And Steam-To-Carbon Monoxide (Co) Ratio On Hydrogen Production In Water-Gas Shift Reaction Using Cu-Zno-Al2o3 Catalyst, Sekar Kumala Desi, Restu Siti Nursa'adah, Hana Nabila Anindita, Bambang Muharto, Nurdiah Rahmawati, Tyas Puspita Rini, Erlan Rosyadi

Makara Journal of Science

This study investigates the effect of steam-to-CO molar ratio and temperature on hydrogen production in a water gas shift reaction using a Cu-ZnO-Al₂O₃ catalyst. Herein, different steam-to-CO molar ratios (1:1, 2:1, and 3:1) and temperatures (200 °C, 250 °C, and 300 °C) were applied to investigate their impact on the reaction and H₂ production. The Cu-ZnO-Al₂O₃ catalyst was characterized by its surface area, pore size distribution, and chemical composition. Moreover, the experimental setup enabled the control of temperature and steam-to-CO molar ratio while monitoring the product gas composition. The results revealed a considerable …

Functionalized Surface Of Plga Nanoparticles In Thermosensitive Gel To Enhance The Efficacy Of Antibiotics Against Antibiotic Resistant Infections In Endodontics: A Randomized Clinical Trial, Mona Arafa, Hadeel Moussa, Mohamed Medhat Kataia

Pharmacy

Enterococcus faecalis plays the key role in endodontic infections and is responsible for the formation of biofilm on dentin, which causes a resistance against periradicular lesions treatment, consequently the aim of this study is to use nanoparticles entrapping anibacterial agents coated with chitosan that in authors previous study showed a successful in vitro biofilm inhibition, additionally incorporated in thermoresponsive gel.to benefit nanoparticles` small size, and the positive charge of their surfaces that binds with the negatively charged surface of bacterial cell causing its destruction, in addition to the sustained release pattern of the drug based nanoparticles in gel. Therefore, Ciprofloxacin …

Advances In Diagnostic Tools And Therapeutic Approaches For Gliomas: A Comprehensive Review, Gayathree Thenuwara Nanolab Research Centre, James Curtin, Furong Tian Nanolab Research Centre

Articles

Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as …

A Comparative Analysis Of The Baghdad And Babylon Universities Exploring Factors Affecting Their Competitiveness In World University Rankings, Ahmed Kanaan Suleiman

Alustath Journal for Human and Social Sciences

In recent years, global university rankings have gained popularity as a means of evaluating the quality of higher education institutions because they provide valuable insights into the best institutions around the globe; therefore, employers, academics, and students use this ranking to decide from where to hire new employees, where to pursue higher education, and where to conduct research. This holds true for Iraqi universities as well, as they strive to assess their standing and competitiveness on a global scale. In this study, the findings of Baghdad and Babylon universities in the Times Ranking are analyzed and compared. Additionally, the factors, …

Life Skills And Psychological Immunity Among University Students In The Southern Governorates In Palestine, Khaled Mahmoud Abu Nada, Ahmed Abdel Wahhab

Alustath Journal for Human and Social Sciences

This study aims to investigate the level of life skills and psychological immunity among university students in the Southern governorates in Palestine. Moreover, it checks the feasibility of predicting psychological immunity in the light of the life skills of students. Further, it explores the relationship between psychosocial skills and innate immunity. Furthermore, it examines the difference between university students based on demographic variables (gender, academic level, specialization. The study sample consists of 1116 male and female students from institution. This survey also uses study tool variables (tools the life skills scale and the psychological immunity scale). The findings demonstrate …

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …

Terahertz Permittivity Parameters Of Monoclinic Single Crystal Lutetium Oxyorthosilicate, Sean Knight, Steffen Richter, Alexis Papamichail, Megan Stokey, Rafał Korlacki, Vallery Stanishev, Philipp Kühne, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

The anisotropic permittivity parameters of monoclinic single crystal lutetium oxyorthosilicate, Lu₂SiO₅ (LSO), have been determined in the terahertz spectral range. Using terahertz generalized spectroscopic ellipsometry (THz-GSE), we obtained the THz permittivities along the a, b, and c^⋆ crystal directions, which correspond to the ε_a; ε_b, and ε_c? on-diagonal tensor elements. The associated off diagonal tensor element ε_ac? was also determined experimentally, which is required to describe LSO’s optical response in the monoclinic a–c crystallographic plane. From the four tensor elements obtained in the model fit, we calculate the …

Monitoring Time Domain Characteristics Of Parkinson's Disease Using 3d Memristive Neuromorphic System, Md Abu Bakr Siddique, Yan Zhang, Hongyu An

Michigan Tech Publications

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the symptoms of PD. The CL-DBS system consists of an electrode sending electrical stimulation signals to a specific region of the brain and a battery-powered stimulator implanted in the chest. The electrical stimuli in CL-DBS systems need to be adjusted in real-time in accordance with the state of PD symptoms. Therefore, fast and precise monitoring of PD symptoms is a critical function for CL-DBS systems. However, the current CL-DBS techniques suffer from high computational demands for real-time …

Habitat And Demography Of The Ozark Chinquapin (Castanea Ozarkensis) At Roaring River State Park In Barry County, Missouri, Danielle Evilsizor

Electronic Theses & Dissertations

The Ozark chinquapin, Castanea ozarkensis Ashe, is a chestnut tree with a range concentrated in the Interior Highlands of North America. Like other North American members of Castanea, it was reduced from an overstory tree to an understory shrub by the invasive chestnut blight fungus (Cryphonectria parasitica [Murrill] M.E. Barr) during the early 20^th century. However, relatively little is known about the habitat of this species or its health and reproductive capability post chestnut blight. Chapter one of this study analyzed the habitat of this species through a random forest species distribution model (SDM) to predict where …

Microplate-Like Metal Pyrophosphate Engineered On Ni-Foam Towards Multifunctional Electrode Material For Energy Conversion And Storage, Rishabh Srivastava

Electronic Theses & Dissertations

High clean energy demand, dire need for sustainable development, and low carbon footprints are the few intuitive challenges, leading researchers to aim for research and development for high-performance energy devices. The development of materials used in energy devices is currently focused on enhancing the performance, electronic properties, and durability of devices. Tunning the attributes of transition metals using pyrophosphate (P₂O₇) ligand moieties can be a promising approach to meet the requirements of energy devices such as water electrolyzers and supercapacitors, although such a material’s configuration is rarely exposed for this purpose of study.

Herein, we grow …