Digital Commons Network^™

Microplate-Like Metal Pyrophosphate Engineered On Ni-Foam Towards Multifunctional Electrode Material For Energy Conversion And Storage, Rishabh Srivastava

Electronic Theses & Dissertations

High clean energy demand, dire need for sustainable development, and low carbon footprints are the few intuitive challenges, leading researchers to aim for research and development for high-performance energy devices. The development of materials used in energy devices is currently focused on enhancing the performance, electronic properties, and durability of devices. Tunning the attributes of transition metals using pyrophosphate (P₂O₇) ligand moieties can be a promising approach to meet the requirements of energy devices such as water electrolyzers and supercapacitors, although such a material’s configuration is rarely exposed for this purpose of study.

Herein, we grow …

Optimization Of Transition-Metal Inclusive Carbon Aerogels For Electrochemical Energy Applications, Allen Dalton Davis

Electronic Theses & Dissertations

The ever-growing need for energy alongside rising concerns for climate change demands the development of renewable energy technologies. Hydrogen fuel cells are a promising technology that can serve to either supplement energy generation or act as a lone power source. Yet for these devices to be truly green, the hydrogen that serves as fuel must be procured from a renewable resource. Electrolytic water splitting is a process that allows for the dissociation of water into H₂ and O₂. For this process to be practical, the electrolyzer needs to demonstrate high efficiency and stability, as well as a …

Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

Highlights

• Metformin alleviates HIO and ferroptosis in HFD-induced NAFLD

• FPN is involved in the molecular mechanism of metformin on HIO in HFD-induced NAFLD

• Metformin upregulates FPN expression by reducing lysosomal ubiquitination degradation

Summary

Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron …

The 2005 Bosnian Law On Defense; A Policy Change Case Study, Gregory D. Vuksich

Political Science ETDs

The Dayton Peace Accord (DPA) in 1995 ended the civil war in Bosnia and Hercegovina and established a constitution for the newly institutionalizing state. It permitted the three ethnicities – Bosniaks, Croats and Serbs – to retain their wartime armed forces in place under ethnic command, a prerogative the Serbs guarded strenuously. International organizations, however, sought a single, multiethnic military institution for the whole of the country. In 2005, however, the Serbs reversed their opposition and agreed to the international organization preference. This study explores why Bosnia’s Serbian community reversed its earlier and acceded to the creation of a single …

Gatekeeping At Bio, Daniel A Gorelick

Faculty, Staff and Students Publications

No abstract provided.

Early Cellular And Molecular Signatures Correlate With Severity Of West Nile Virus Infection, Ho-Joon Lee, Yujiao Zhao, Ira Fleming, Sameet Mehta, Xiaomei Wang, Brent Vander Wyk, Shannon E Ronca, Heather Kang, Chih-Hung Chou, Benoit Fatou, Kinga K Smolen, Ofer Levy, Clary B Clish, Ramnik J Xavier, Hanno Steen, David A Hafler, J Christopher Love, Alex K Shalek, Leying Guan, Kristy O Murray, Steven H Kleinstein, Ruth R Montgomery

Faculty, Staff and Students Publications

Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we employed systems profiling of peripheral blood from asymptomatic and severely ill individuals infected with WNV. We interrogated immune responses longitudinally from acute infection through convalescence employing single-cell protein and transcriptional profiling complemented with matched serum proteomics and metabolomics as well as multi-omics analysis. At the acute time point, we detected both elevation of pro-inflammatory markers in innate immune cell types and reduction of regulatory T cell …

Targeting Eif4a Triggers An Interferon Response To Synergize With Chemotherapy And Suppress Triple-Negative Breast Cancer, Na Zhao, Elena B Kabotyanski, Alexander B Saltzman, Anna Malovannaya, Xueying Yuan, Lucas C Reineke, Nadia Lieu, Yang Gao, Diego A Pedroza, Sebastian J Calderon, Alex J Smith, Clark Hamor, Kazem Safari, Sara Savage, Bing Zhang, Jianling Zhou, Luisa M Solis, Susan G Hilsenbeck, Cheng Fan, Charles M Perou, Jeffrey M Rosen

Faculty, Staff and Students Publications

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we show that therapeutically targeting the RNA helicase eIF4A with zotatifin, the first-in-class eIF4A inhibitor, exerts pleiotropic effects on both tumor cells and the tumor immune microenvironment in a diverse cohort of syngeneic triple-negative breast cancer (TNBC) mouse models. Zotatifin not only suppresses tumor cell proliferation but also directly repolarizes macrophages toward an M1-like phenotype and inhibits neutrophil infiltration, which sensitizes tumors to immune checkpoint blockade. Mechanistic studies revealed that zotatifin reprograms the tumor translational landscape, inhibits the translation of Sox4 …

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Li Ding, Feng Chen, Et Al.

2020-Current year OA Pubs

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …

Leaf Thermal Regulation Strategies Of Canopy Species Across Four Vegetation Types Along A Temperature And Precipitation Gradient, Yingying Zhou, Nawatbhrist Kitudom, Sophie Fauset, Martijn Slot, Zexin Fan, Jianping Wang, Weiwei Liu, Hua Lin

School of Geography, Earth and Environmental Sciences

The ecophysiological processes of leaves are more related to leaf temperature (Tl) than air temperature (Ta). Transpiration and leaf physical traits enable plants to maintain Tl within a thermal range. However, it is challenging to quantitatively study leaf thermal regulation strategies, due to the complex interaction between thermal effects of transpiration and leaf physical traits. We utilized a 3-T method that compares Tl, Ta, and Tn (the temperature of non-transpiring leaves) investigate thermal regulation strategies of dominant canopy species in four vegetation types, including a savanna woodland, a tropical rain forest, a subtropical evergreen broad-leaved forest, and a temperate mixed …

Crank Shaft Road Electromagnetic Road Energy Harvester For Smart City Applications, Niloufar Zabihi, Zewen Gu, Mohamed Saafi

School of Engineering, Computing and Mathematics

This paper addresses the issue of providing cheap and on-demand electricity to low-power devices and sensors of smart cities and infrastructures. A new design for an electromagnetic road energy harvester is proposed, and its performance is evaluated through numerical simulations and experiments. The new method can generate sufficient electricity to run the low-power facilities of the smart cities in real-time and provide enough power for further applications using energy storage devices. Unlike the current road energy harvesters, the new harvester has a compact design, negligible mismatch risk between the components, and is more compatible with high-speed roadways. It can be …

Sanford A. French Family, Hattiesburg, Mississippi

Pine Belt Region

This postcard features a black and white portrait of the S. A. French Family in Hattiesburg, Mississippi Ca. 1908. Sanford A. French (Sept. 3, 1845-April 18, 1917), a Virginian-born engineer and grocer is pictured with his Kentucky-born wife Harriette “Hattie” E. Hickman French (Oct. 16, 1863-March 9, 1932). Their daughter, Gay is pictured behind Harriette and the two women at the back are unidentified. All the women are wearing white dresses and French is wearing a bowler hat with a suit and bowtie. The group is standing in front of a porch with flowers and plants in front of them. …

Barred Owl Adventures In Hampstead, Alfred Maley

Bird Observer

No abstract provided.

Respecting Birds, People, And History At Mount Auburn Cemetery, Dave Barnett, Regina Harrison

Bird Observer

No abstract provided.

Winter Quarters And Migration Routes Of Common And Roseate Terns Revealed By Tracking With Geolocators, Ian C. T. Nisbet, Carolyn S. Mostello

Bird Observer

No abstract provided.

Learning To Notice: A Birding Adventure, M. F. Badger

Bird Observer

No abstract provided.

The Snowy Owl Winter Of 2013-14, Norman Smith

Bird Observer

No abstract provided.

Oceans Changing: Do Seabirds Tell Us Something About Ocean Changes?, Thomas Robben, Stephen Broker, Shoon N. Robben

Bird Observer

No abstract provided.

Chester Albert Reed: Author Of The First Field Guide To Birds In 1905, Michel Chevalier

Bird Observer

No abstract provided.

The Allen Bird Club—100 Years Young, George C. Kingston

Bird Observer

No abstract provided.

Birding Quabbin Park (South Quabbin), Mark Lynch

Bird Observer

No abstract provided.

Catch Basin Cover Grates: Another Hazard For Young Birds, Alan Rawle, Wendy Howes

Bird Observer

No abstract provided.

Alfred Otto Gross, Bowdoin Academic And Renowned Field Ornithologist, William E. Davis Jr.

Bird Observer

No abstract provided.

Arthur Cleveland Bent And His Life Histories Of North American Birds, William E. Davis Jr.

Bird Observer

No abstract provided.

Accessible Birding Sites In Massachusetts, Marcy Marchello, Marsha Salett

Bird Observer

No abstract provided.

Hordes Of Nesting Ducks Invade Suburban House Lot, Alfred Maley

Bird Observer

No abstract provided.

Feathers And Flares, Joey Mason

Bird Observer

No abstract provided.

The March Of Ross’S Goose, Paul Roberts

Bird Observer

No abstract provided.

Birding The Cumberland Farms Fields In Middleboro/Halifax, Jim Sweeney

Bird Observer

No abstract provided.

Birding Scarborough Marsh, Scott Cronenweth

Bird Observer

No abstract provided.

Taken A Bird Walk Lately?, Pamela Hunt

Bird Observer

No abstract provided.