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Hptlc – Bioautographic Detection Of Pancreatin-Inhibitory Activity And Cell-Based Detection Of Glucose Absorption Activity Of Mathurameha Formulation, Jiranuch Mingmuang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mathurameha (MT) is a Thai traditional herbal formulation consisting of 26 herbs used for diabetes over 30 years. The study was to identify inhibitory compounds in Mathurameha against pancreatin amylase using the HPTLC-bioautographic technique. The results showed that MT inhibited pancreatin amylase activities, and the most active compounds were identified as andrographolide and gallic acid. The hypoglycemic effect of MT was determined using cell-based assays in L6 myotubes, 3T3-L1 adipocytes, and Caco2 cells. The study revealed that MT water extract (MTW, 125-1000 µg/mL), gallic acid (12.5-50 µM), and andrographolide (12.5-50 µM) significantly promoted glucose uptake in L6 myotubes and inhibited …

The Optimization And Expression Of Human Serum Albumin In Nicotiana Benthamiana, Ittichai Sujarittham

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human serum albumin (HSA), primarily derived from human plasma, is limited by supply constraints and safety concerns due to potential contamination with blood-borne pathogens. Given the global shortage, hundreds of tons of HSA are required for clinical and cell culture applications. To address this, our study explored the production of recombinant HSA using Nicotiana benthamiana as an alternative production platform. The transient expression of recombinant HSA in plants was optimized by adjusting the harvesting days, plants aged and the OD600 of Agrobacterium. These several parameters can impact recombinant protein expression levels in plants. An Ni-NTA affinity chromatography method was used …

Design And Synthesis Of Quaternized Hyaluronic Acid-Quercetin-Carrageenan Nanocomplexes For Anticancer Drug Delivery, Ifra Aslam

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this research is to synthesize a polyelectrolyte nano-complex for anticancer drug delivery, utilizing natural biopolymers with enhanced therapeutic capabilities, biodegradability, and low toxicity. Traditional anticancer drugs are often hydrophobic and pose significant challenges in delivery, as well as causing toxicity to normal cells. In this study, Plai extract, known for its anticancer properties, was employed into a novel polyelectrolyte complex carrier composed of quaternized hyaluronic acid-quercetin (Quat-HA-QT) with carrageenan. The design involved: (i) utilizing hyaluronic acid (HA) for its CD-44 receptor affinity on tumor cells, (ii) modifying HA with Quat-188 to impart a positive charge and incorporating …

Scaffolds From Natural Polymers And Soy Protein For Cultured Meat Production, Utumporn Butkatanyoo

Chulalongkorn University Theses and Dissertations (Chula ETD)

To overcome the problems of livestock farming, cultured meat technologies have been developed. Cultured meat is an alternative way to produce meat by culturing cells in vitro using tissue engineering technology. The construction of cultured meat requires a scaffold to support cell proliferation and differentiation. Herein this research, polysaccharides namely high acyl gellan gum (HG) and konjac (KJ) together with a plant-based protein, soy protein isolate (SP) were used to develop scaffolds for cultured meat production. The composite scaffolds were prepared by freeze-drying and followed by ionic crosslinking. The composition of HG, KJ, and SP had a strong influence on …

การกำจัดคาร์บอนไดออกไซด์จากสารละลายไตรเอทาโนลามีนโดยใช้คอมพอสิตชีวภาพที่มีชีวิตจุลสาหร่าย-ใยบวบ, ธนกฤต คมขำ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ปัจจุบัน การบรรเทาวิกฤติการเปลี่ยนแปลงสภาพภูมิอากาศเป็นปัญหาเร่งด่วนสำหรับโลกของเรา คาร์บอนไดออกไซด์ (Carbon dioxide: CO2) เป็นหนึ่งในแก๊สเรือนกระจก ซึ่งเป็นสาเหตุหลักของการเกิดภาวะโลกร้อน ความเข้มข้นเฉลี่ย CO2 ทั่วโลกมากกว่า 410 ppm หนึ่งในวิธีการทั่วไปสำหรับดักจับการปลดปล่อย CO2 ใช้ตัวทำละลายเอมีนในหน่วยดูดซึม กระบวนการนี้เป็นที่รู้กันว่ามีประสิทธิภาพและอัตราการดูดซึมสูง อย่างไรก็ตาม ข้อเสียของกระบวนการนี้ส่วนใหญ่เกี่ยวข้องกับการใช้พลังงานสำหรับการคืนสภาพตัวทำละลายจากการให้ความร้อนสูงในหน่วยไล่แก๊ส ดังนั้น จึงจำเป็นต้องหาทางเลือกอื่น เช่น การคืนสภาพเอมีนผ่านกระบวนการเชิงชีวภาพโดยใช้จุลสาหร่าย ซึ่งไม่ต้องใช้ความร้อนและสามารถสร้างผลิตภัณฑ์มูลค่าเพิ่มจากชีวมวลอย่างเชื้อเพลิงชีวภาพได้ อย่างไรก็ตาม จุลสาหร่ายมีข้อเสียในแง่ของอัตราการดูดซึม CO2 ต่ำ ดังนั้น การบูรณาการกระบวนการทั้งสองอาจเป็นกุญแจสำคัญเพื่อยกระดับความสามารถการดักจับ CO2 เมื่อไม่นานมานี้ คอมพอสิตชีวภาพที่มีชีวิต (Living biocomposites) ที่ยกระดับการเพาะเลี้ยงแขวนลอยแบบดั้งเดิมได้ถูกพัฒนาขึ้น ด้วยเทคโนโลยีนี้ การตรึงจุลสาหร่ายบนวัสดุรองรับที่เข้ากันได้ทางชีวภาพโดยใช้สารยึดเกาะเหนือกว่าระบบแขวนลอยในแง่ของอัตราการดักจับ CO2 ในงานวิจัยนี้ คอมพอสิตชีวภาพที่มีชีวิตจุลสาหร่าย-ใยบวบด้วยการตรึง Scenedesmus acuminatus TISTR 8457 โดยใช้สารยึดเกาะอะคริลิกถูกสร้างขึ้นเพื่อกำจัด CO2 จากสารละลายไตรเอทาโนลามีน (Triethanolamine: TEA) ที่เต็มไปด้วย CO2 การทดสอบการกำจัด CO2 โดยใช้ TEA 1 M ที่อัตราส่วนการโหลด CO2 แตกต่างกัน (0.2 0.4 0.6 และ 0.8 โมล CO2 ต่อโมล TEA) แสดงให้เห็นว่าคอมพอสิตชีวภาพมีอัตราการกำจัด CO2 มากกว่าระบบแขวนลอย 3 ถึง 4 เท่าในช่วงระยะเวลา 28 วันทุกอัตราส่วนการโหลด CO2 ที่ทดสอบ

Characterization Of Volatile Organic Compounds In Black Goji Berry Lycium Ruthenicum Juice Fermented With Lactobacillus Spp. Using Gas Chromatography-Mass Spectrometry, Sehrish Javed

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this work, volatile organic compounds (VOCs) in fermented black goji berry juice with Lactobacillus spp. (L.rhamnosus and L.paracasei) were characterized by gas chromatography-mass spectrometry combined with headspace-solid phase microextraction (HS-SPME-GC-MS). The fermented black goji berry juice samples were found to contain at least 60 VOCs, including alcohols, aldehydes, esters, ketones, phenols and organic acids, with five major VOCs such as 3,7-dimethylocta-1,6-dien-3-ol, 2-ethylidene-6-methylhepta-3,5-dienal, (E)-1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one, 2,5-ditert-butylcyclohexa-2,5-diene-1,4-dione, 2-ethyl-3-hydroxyhexyl-2-methylpropanoate. In overall comparison, fermented black goji berry (GB) samples promoted VOCs in order (i) 24HF > 0HF, and (ii) 10% GB slightly > 5% GB > 2.5% GB. In addition, L. rhamnosus predominantly promoted particular VOCs in …

Development Of Novel Detection Methods For Food Safety Using State-Of-The-Art Technology Platforms, Prae Noppakuadrittidej

Chulalongkorn University Theses and Dissertations (Chula ETD)

Foodborne illness is a significant global public health concern, impacting both the economy and human health. These illnesses are caused by bacteria, viruses, parasites, toxins, and chemicals. This research developed two technology platforms for Bacillus cereus and tropane alkaloid compounds detections. First, traditional detection methods for B. cereus have limitations in long analysis time, and dependence on analysis and interpretation by skilled personnel. Therefore, this study introduces a robust detection method using peptide nucleic acids (PNAs) bearing with a prolyl-2-aminocyclopentanecarboxylic acid (ACPC) backbone as probes in a bead array method. PNAs with groEL, motB, and 16S rRNA sequences were covalently …

Characterization Of Animal And Plant Proteins Glycated With Konjac Glucomannan Hydrolysate, Pachara Pomsang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to prepare Konjac glucomannan hydrolysate (KGMH) and investigate its glycation with animal and plant proteins through the Maillard reaction, focusing on varying degrees of polymerization (DPs). Initially, KGMH was produced from high-content Konjac glucomannan (KGM) using beta-mannanase (200 to 300 U/g) within 60 minutes, resulting in KGMH with DPs ranging from 2 to 9 and reduced viscosity. Under optimized conditions (40% KGM and 250 U/g enzyme), KGMH samples with the widest DP range (4.20 to 6.11) were used to assess antioxidant and antiglycation activities. Lower DPs of KGMH showed superior antioxidant activities in DPPH and ABTS assays …

Carbon-Based Polymer Composite For Electrochemical Sensing Of Creatinine Sodium Potassium And Calcium Ions, Kanyapat Teekayupak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Electrochemical sensors have emerged as indispensable tools for various applications including environmental monitoring, food safety, and biomedical diagnostics owing to their simplicity, sensitivity, and fast response. However, traditional methods for electrode fabrication are often associated with drawbacks such as cleanroom requirements, multi-step processes involving toxic materials, high waste consumption, and high costs. To address the limitations, this dissertation evaluates the utilization of 3D printing, laser engraving, and inkjet printing technologies for the fabrication of electrochemical sensors based on carbon-based polymer composites. In the first part, a 3D-printed electrochemical sensor based on a copper oxide nanoparticle-ionic liquid/reduced graphene oxide (CuO-IL/rGO) modified …

Modification Of Natural Fibrous Materials For Sar-Cov-2 Diagnostic And Ph-Simulated Theranostic Applications, Pornchanok Punnoy

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation investigates the development of colorimetric sensors utilizing natural fibrous materials modified by nanomaterials to enhance the performance of chemical sensors and theranostic devices for healthcare applications. The work is divided into two main sections. The first section, cellulose is utilized as a dual-function platform for qualitative screening of SAR-CoV-2 for COVID-19 diagnosis by colorimetric sensor and quantitative detection by mass spectrometry. The cellulose is modified with gold nanoparticles conjugated to monoclonal antibodies, enabling the specific detection of viral protein antigens through colorimetric changes resulting from nanoparticle aggregation. This platform demonstrates a detection range from 0.01 to 1 µg·mL−1 …

Cisplatin - Loaded Calcium Citrate Nanoparticlesfor Inhibition Of Lung Cancer Cell Growthand Quantum Mechanical Study Of Cisplatin And Citrate, Lipika Oopkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

The International Organization for Research on Cancer (International Agency for Research on Cancer (IARC) issued a statement saying lung cancer is a cancer with high incidence rates of new cases and deaths. Although there are current therapeutic approaches such as surgery, radiation therapy, and chemotherapy. However, these treatments exhibit ineffectiveness; the main limitation is severe side effects to normal cells or non-target organs. To address this challenge, the development of targeted therapy by nanoparticle-based drug delivery system is applied to increase drug stability and control the specificity to cancer cells with target-specific proteins that play an important role in intracellular …

Development Of Technetium-99m Labeled Psma For Spect Prostate Cancer Imaging, Kalapaphuk Tachatumvitoon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Technetium-99m (Tc-99m) is the most employed radionuclide in nuclear imaging diagnosis because of its ideal physiochemical properties and ready availability. It particularly suitable for Single Photon Emission Computed Tomography (SPECT), leading to cost-effective compared to other radionuclides. This study consists of two aims to expand the utilization of Tc-99m radiopharmaceutical for prostate cancer which is one of the highest incidence rates and mortality cancer among men. Currently, Tc-99m radiopharmaceutical for SPECT diagnosis is not clinically available for prostate cancer. Firstly, the new formulation for Tc-99m complexation with PSMA-617, a current ligand for radionuclide therapy of prostate cancer with lutetium-177 (Lu-177), …

Cascade Synthesis Of 4h-Chromenes By Dialkyldithiocarbamate Organocatalyst, Ayodele Joshua Atibioke

Chulalongkorn University Theses and Dissertations (Chula ETD)

Environmentally benign N,N-didodecylammonium N,N-didodecyldithiocarbamate (AmDTC-C12C12) is used as an organocatalyst in water. AmDTC-C12C12 self-assembles into a CatAnionic vesicular nanoreactor in water and is synthesized with a high yield (98%) from N,N-didodecylamine and carbon disulfide. The catalytic activity of AmDTC-C12C12 (10 mol%) was investigated in the cascade synthesis of 4H-chromene via double cascade Michael addition/hemiketalization between 2-hydroxy-trans-β-nitrostyrene and acetylacetone in water at room temperature, yielding 2-chromanols. Dehydration of 2-chromanols with catalytic p-toluene sulfonic acid produced 4H-chromenes in moderate yields (34–60%) and -nitro ketones as co-products (13–27%). Using Michael donors with aromatic moieties led to a spontaneous triple cascade (Michael addition/hemiketalization/retro-Claisen fragmentation) …

Green Synthesis For Silver Nanoparticle /Natural Rubber/ Nanocellulose Bio-Polymeric Composites, Puttakhun Meemai

Chulalongkorn University Theses and Dissertations (Chula ETD)

A green synthesis method was developed to produce biobased semiconducting composites of silver nanoparticles (AgNPs), skim natural rubber (SNR), and bacteria cellulose. A solution of silver nitrate (AgNO3) ranging from 40 to 160 mM was added to skim natural rubber latex (SNRL) to facilitate the reduction of silver ions to AgNPs at temperatures between 50 and 80 °C. Subsequently, BC pellicle was immersed in the prepared AgNPs-SNRL suspension for 48 hours, followed by washing and drying. The resulting AgNPs/SNR/BC films were then analyzed for their chemical, mechanical, antibacterial, and electrical properties. The strain at break of the films was significantly …

Intersectionality And Gender Injustice In Higher Education In Pre- And Post-Coup Myanmar, Ei Yin Yin Phyu

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research examines gender injustice in Higher Education in pre- and post-coup Myanmar. It explores how gender injustice has been perceived and practiced during the semi- civilian government and after the 2021 coup, both in private and public spaces. Using intersectionality and gender injustice concepts, this research employs a qualitative approach, collecting primary data through interviews with women university scholars, as well as secondary sources such as legal documents, education laws, university policies and regulations regarding gender equality. It incorporates other gender-related concepts and frameworks in order to strengthen its empirical findings. Primary data collection included 17 female participants from …

Investigating The Impacts Of Ammonium Phosphate-Based Fire Retardants On Cyanobacteria (Anabaena) Growth, Gavin Sutter, Brenda Gonzalez Flores, Grace Laskey, Shane Jurak

Humboldt Journal of Microbiology

In recent years the effects of climate change have taken a devastating toll on ecosystems around the world. With high temperatures and extreme droughts, wildfires have become increasingly common. In order to combat these natural disasters wildland firefighters, drop millions of gallons of fire retardant on public lands and forests. These fire retardants consist of between 80%-100% ammonium phosphate which are incredibly effective as fire suppressants yet is more commonly known for its use in fertilizer. Ammonium phosphate fertilizers can lead to stream eutrophication and undesirable environmental impacts. Our research aims to address the effects of fire retardant on growth …

Protein Extraction And Purification By Differential Solubilization, Barry J. Ryan, Gemma K. Kinsella, Gary T. Henehan

Books/Book Chapters/ Proceedings

The preparation of purified soluble proteins for biochemical studies is essential and the solubility of a protein of interest in various media is central to this process. Selectively altering the solubility of a protein is a rapid and economical step in protein purification and is based on exploiting the inherent physicochemical properties of a polypeptide. Precipitation of proteins, released from cells upon lysis, is often used to concentrate a protein of interest before further purification steps (e.g., ion exchange chromatography, size exclusion chromatography etc).

Recombinant proteins may be expressed in host cells as insoluble inclusion bodies due to various influences …

Fostering Inclusivity And Resilience: Challenges To Community-Based Empowerment For Trans Elders In Roanoke, Virginia, Summer Skye Allison

Undergraduate Honors Theses

As popular media disseminates harmful “culture war” rhetoric regarding trans folk it has become increasingly necessary to amplify their voices to give them power over how they are perceived by society. Though political discourse regarding trans children has become a hot-button topic, this paper seeks to explore the overlooked experiences of trans elders as they contend with intersecting instances of ageism and transphobia from individuals and institutions in Roanoke, Virginia. Since community-based organizations like the Roanoke Diversity Center and Ladies and Gents of the Blue Ridge have been instrumental to strengthening the LGBTQ+ community in Roanoke, this research focuses on …

Buckets In A Deep Well: Essays About Shakespeare’S History Play Characters And An Original Drama, Brian C. Bassett

Theses and Dissertations

Buckets in a Deep Well is a set of essays that examines various characters portrayed in Shakespeare’s history plays, as well as parallel figures in 20th and 21st century works. Each essay primarily focuses on a single character’s response to a power structure: Richard Gloucester to the Tudor England of his audience in Richard III; Richard Nixon’s campaign-produced version of himself to 20th century American democracy in “Checkers;” Falstaff to organized society in Henry IV, Part 1; Marlo Stanfield to the drug economy of early 2000’s Baltimore in The Wire; the Duke of York to the disrupted monarchy of The …

Climate, Physiology, And Distributions: The Role Of Thermal Physiology In Biological Invasions, Sean D. Powers

Theses and Dissertations

Climate is a primary factor influencing species range dynamics, particularly for ectotherms whose body temperature is closely tied to the surrounding conditions. While range shifts of ectotherms are attributed to climate warming, the mechanism driving these shifts are not well understood. Studies in macrophysiology demonstrate that the interaction of climate with thermal physiology plays a key role in determining large-scale spatial and temporal patterns for many temperature-sensitive physiological traits. This work has revealed a clear relationship between thermal tolerance breadth and range size. However, more recent analyses of this relationship demonstrate that thermal tolerance breadth only provides a partial explanation …

Myopia Outcome Study Of Atropine In Children: Two-Year Result Of Daily 0.01% Atropine In A European Population, James Loughman, Emmanuel Kobia-Acquah, Gareth Lingham, John Butler, Ekaterina Loskutova, David A. Mackey, Samantha S.Y. Lee, Daniel I. Flintcroft

Articles

The Myopia Outcome Study of Atropine in Children (MOSAIC) is an investigator-led, double-masked, randomized controlled trial investigating the efficacy and safety of 0.01% atropine eye drops for managing myopia progression in a predominantly White, European population.

Redescription Of Adults And First Description Of The Larva Of Haemaphysalis (Rhipistoma) Adleri Feldman-Muhsam, 1951 (Acari: Ixodidae), Parasite Of Carnivorans In Western Asia, Cole Anderson

Honors College Theses

The adult ticks of Haemaphysalis (Rhipistoma) adleri Feldman-Muhsam, 1951 (Acari: Ixodidae) are redescribed and the larva of this species is described for the first time here. The adults of H. adleri that we studied were collected from various canid, felid and hyaenid carnivorans (Carnivora: Canidae, Felidae, Hyaenidae) as well as a hedgehog (Erinaceomorpha: Erinaceidae) in Iraq, Israel and West Bank. The males, females and larvae of H. adleri can be differentiated from Haemaphysalis (Rhipistoma) species occurring in the Palearctic portion of West Asia and Egypt as well those in the H. asiatica subgroup by the length of idiosomal …

Extraction, Quantification, Characterization, And Application In Food Packaging Of Chitin And Chitosan From Mushrooms: A Review, Buliyaminu A. Alimi, Shivani Pathania, Jude Wilson, Brendan Duffy, Jesus Maria Frias

Articles

The application of chitin in food systems is limited by its insolubility in some common solvents and poor degradability. Hence, it is deacetylated to obtain chitosan, an industrially important derivative with excellent biological properties. Fungal-sourced chitosan is gaining prominence and industrial attraction because of its superior functional and biological properties, and vegan appeal. Further, the absence of such compounds as tropomyosin, myosin light chain, and arginine kinase, which are known to trigger allergic reactions, gives it an edge over marine-sourced chitosan in food and pharmaceutical applications. Mushrooms are macro-fungi with a significant content of chitin, with many authors reporting the …

Resisting Readability: Dyslexia And Sexuality In Alan Hollinghurst’S The Sparsholt Affair, Helena Gurfinkel Dr.

SIUE Faculty Research, Scholarship, and Creative Activity

No abstract provided.

First Review Of Equilibrium Landscape Of Ingress/Egress Channels And Gating Residues Of The Cytochrome P450 3a4, Edward Ackad Ph.D, Maria Kontoyianni

SIUE Faculty Research, Scholarship, and Creative Activity

The review document and changes made to "Equilibrium Landscape of Ingress/Egress Channels and Gating Residues of the Cytochrome P450 3A4".

Examining The Effects Of A Behavioral Skills Training Package On The Emotional Regulation Skills Of A Child With Autism Spectrum Disorder, Kate Flynn

All Graduate Theses, Dissertations, and Other Capstone Projects

One of the most common symptoms experienced by individuals diagnosed with autism spectrum disorder (ASD) is a difficulty understanding, interpreting, and dealing with one’s own emotions and the emotions of others which often leads to an impairment in regulating emotional experiences. Emotional regulation includes the processes whereby we influence which emotions we have, when we have them, and how we experience and express them. The purpose of the current study is to function as a preliminary analysis to determine if a behavioral skills training (BST) package with video modeling (VM) can be used to increase appropriate emotional regulation skills for …

Apobec3 Regulation By Thyroid Hormone, Michelle Santiago

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is crucial for many biological processes, including the development of the auditory system. Appropriate thyroid hormone signaling is important for the development of the cochlea, leading to the successful onset of hearing. More specifically, TH influences the timing of remodeling of the greater epithelial ridge (GER), a transient cochlear structure that secretes proteins that contribute to the formation of the tectorial membrane. Developmental hypothyroidism results in delayed GER regression, whereas excess TH results in premature remodeling. Both conditions result in deafness. However, it is unknown how TH mediates GER remodeling. Expression profiling identified APOBEC3 (A3) as a …

Determining The Effectiveness Of Rosemary Essential Oil On The Shelf Life Of Ground Beef Under Different Lighting Conditions, Jordan T. Looper, Kelly R. Vierck

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

This study determined the effectiveness of rosemary extract on the shelf life of ground beef patties under different retail display conditions. Ground beef patties were produced from an 85%:15% blend (lean:fat). Patties were formed from batches of control or amended with rosemary extract. Patties were individually packaged using overwrap. Groups were assigned into one of two lighting groups (3000K and 3500K). Patties were placed in a simulated retail display for 5 d under continuous lighting and rotated once a day. Lipid oxidation and color samples were taken each day. Relating to lipid oxidation, there was no three-way interaction between display …

I Am An Influencer And I Approve This Message! Examining How Political Social Media Influencers Affect Political Interest, Political Trust, Political Efficacy, And Political Participation, Ben Wasike

Communication Faculty Publications

This study surveyed a random sample of social media users (N = 813) to examine how following political social media influencers (PSMIs) affects political interest and political trust. The study also examined whether political interest and political trust affect internal and external online political efficacy (OPE) and political participation. Structural equation analysis indicated that following a PSMI increased political interest and political trust, with a pronounced effect on political interest. Additionally, political interest boosted both internal and external OPE, while political trust boosted external OPE only. Mediated effects analysis indicated that political interest improved the relationship between following a PSMI …

Neurobiology Of Ptsd In Adults And Children: The Impact Of Stress-Induced Brain Abnormalities Across The Lifespan, Catherine Clover

Undergraduate Honors Theses

In the scholarly community, there is disagreement about the effects of PTSD or chronic stress on the brain of adults and children. Though PTSD or chronic stress are known to negatively affect neurobiological structures, specifically due to prolonged glucocorticoid excess, volumetric discrepancies between traumatized and control groups are not unanimously confirmed. This review sought to address the common understandings in academia of the effects of PTSD on the brains of adults and children. Literature on this topic indicated that, in adults, the hippocampus, cingulate gyrus, and prefrontal cortex bilaterally appeared to decrease in gray matter volume and the corpus callosum …