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Virtual Screening On Indonesian Herbal Compounds As Sars-Cov-2 Spike (S2) Glycoprotein Inhibitors: Pharmacophore Modelling & Molecular Docking Approaches, Syailendra Karuna Sugito, Artha Uli Cristina, Putri Saskia Harimurti, Gabriella Regita Cendani, Fauzi Azhar Insani, Linda Erlina, Rafika Indah Paramita, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: There are still no specific treatments for coronavirus disease (COVID-19) until present days. Several studies have been conducted to determine whether herbal medicine can be an option to be used as a definitive medicine for COVID-19. S2 subunit of spike protein which is responsible for SARS-CoV-2 entry to the host cell, is a potential drug target to inhibit the viral infection. In this study, we aimed to find some compounds from the HerbalDB database that have potential as SARS-CoV-2 spike (S2) glycoprotein inhibitor.

Methods: The 6LXT protein was used as the target protein. The procedure in this study consisted …

Response To: What Is Missing From The 2022 Practice Recommendation Updates From The World Consensus Conference On Bia-Alcl?, Fabio Santanelli Di Pompeo, Mark W Clemens, Michael Atlan, Giovanni Botti, Peter G Cordeiro, Daphne De Jong, Arianna Di Napoli, Dennis Hammond, Cara L Haymaker, Steven M Horwitz, Kelly Hunt, Peter Lennox, Patrick Mallucci, Roberto N Miranda, Alexandre M Munhoz, Demosthenes Panagiotakos, Eric C Swanson, Suzanne D Turner, Guido Firmani, Michail Sorotos

Faculty, Staff and Student Publications

No abstract provided.

Spatial Regulation Of The Glycocalyx Component Podocalyxin Is A Switch For Prometastatic Function, Alvaro Román-Fernández, Mohammed A Mansour, Fernanda G Kugeratski, Jayanthi Anand, Emma Sandilands, Laura Galbraith, Kai Rakovic, Eva C Freckmann, Erin M Cumming, Ji Park, Konstantina Nikolatou, Sergio Lilla, Robin Shaw, David Strachan, Susan Mason, Rachana Patel, Lynn Mcgarry, Archana Katoch, Kirsteen J Campbell, Colin Nixon, Crispin J Miller, Hing Y Leung, John Le Quesne, James C Norman, Sara Zanivan, Karen Blyth, David M Bryant

Faculty, Staff and Student Publications

The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types. How PODXL presents this duality in effect remains unknown. We identify an unexpected function of PODXL as a decoy receptor for galectin-3 (GAL3), whereby the PODXL-GAL3 interaction releases GAL3 repression of integrin-based invasion. Differential cortical targeting of PODXL, regulated by ubiquitination, is the molecular mechanism controlling alternate fates. Both PODXL high and low surface levels occur in parallel subpopulations within …

A Focused Review Of Multidimensional Well-Being Assessments, Samantha Schonhardt, Stephanie Sullivan, Rebecca Shisler Marshall

Journal of Wellness

Introduction: Interest in the topic of well-being continues to grow and has resulted in the creation of a variety of well-being assessments. However, each assessment often brings its own terminology, theories, definitions, and dimensions. This creates a muddled research base that produces inconsistencies in the field of well-being. Therefore, the aim of this review was to identify assessments that measure multiple dimensions of well-being, catalogue and group the dimensions into categories, and develop definitions for the categories based on the conceptualizations in the literature. In doing so, the dimensionality of well-being portrayed in the literature can be better understood. …

Spatially Resolved Single-Cell Assessment Of Pancreatic Cancer Expression Subtypes Reveals Co-Expressor Phenotypes And Extensive Intratumoral Heterogeneity, Hannah L Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S Winter, Kevin S Kapner, Scott P Ginebaugh, Sara A Väyrynen, Juha P Väyrynen, Chen Yuan, Andrew W Navia, Junning Wang, Annan Yang, Timothy L Bosse, Radha L Kalekar, Kristen E Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A Rubinson, Harshabad Singh, Kimberly Perez, James M Cleary, Thomas E Clancy, Jiping Wang, Joseph D Mancias, Lauren K Brais, Emma R Hill, Margaret M Kozak, David C Linehan, Richard F Dunne, Daniel T Chang, Albert C Koong, Aram F Hezel, William C Hahn, Alex K Shalek, Andrew J Aguirre, Jonathan A Nowak, Brian M Wolpin

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent work has uncovered greater complexity to transcriptional subtypes than was initially appreciated using bulk RNA expression profiling. To provide a deeper understanding of PDAC subtypes, we developed a multiplex immunofluorescence (mIF) pipeline that quantifies protein expression of six PDAC subtype markers (CLDN18.2, TFF1, GATA6, KRT17, KRT5, and S100A2) and permits spatially resolved, single-cell interrogation of pancreatic tumors from resection specimens and core needle biopsies. Both primary and metastatic tumors displayed striking intratumoral subtype heterogeneity that was associated with patient outcomes, existed …

Cognitive Appraisal, Workplace Social Courage, And Psycap, Quinn Denny

Doctoral Dissertations and Projects

This study responds to calls for empirical investigation of courage as well as the discovery of positive psychological capital (PsyCap) antecedents. Courage and PsyCap are considered positive constructs associated with beneficial workplace outcomes. As an example, Workplace Social Courage (WSC) predicts organizational citizenship behavior (OCB). PsyCap is robustly correlated with performance outcomes, well-being, and sustainability. For its societal appeal, courage is not yet robustly validated. Further, interventions have demonstrated resultant increases in PsyCap, yet little is known of its antecedent variables. Also, to be discovered, are what variables mediate WSC. These gaps in research present opportunity for additional empirical investigation …

A Phenomenological Study Of The Lived Experiences Of Former Foster Students Learning Through Online Educational Environments, Tiffany Sue Beckwith

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the experiences of former foster students in online educational environments. Maslow’s hierarchy of needs acted as the theory guiding this study, as it was essential when investigating how unmet needs for foster children affected their motivation to learn and feelings of belongingness with their school. This study was designed to answer the following central research question: What are the experiences of former foster students who have taken part in online education? Using a transcendental phenomenological approach, I collected the lived experiences of the participants to uncover emerging themes during online …

Shame, Stigma, And Callousness: A Moderated Mediation Study Of Sex Offender Empathy Strength, Robert M. Ferow

Doctoral Dissertations and Projects

Callous, lacking sympathy, heartless, and cold are but a few synonyms for people that demonstrate a deficit in empathy. Psychologists, criminologists, and sociologists have tried to explain this phenomenon of callousness, or lack of empathy found in criminals for hundreds of years. Issues of definitions of empathy, personality disorders, character flaws, and even neurobiological issues have been studied in their relation to empathy. Theories of criminology have been presented to explain the reasons for lack of empathy. However, as of yet, no conclusive findings demonstrate the order or function in loss of empathy strength. This study will endeavor to describe …

Philosophical Psychopathology And Individuation: The Archetype Of The Self And Rediscovering Personality, Alyc Jordan-Crump Rideout

Doctoral Dissertations and Projects

Psychopathology has been associated to personality in trait characteristics as a contributing factor to mental illness, but the degree to which personality development as an influence in mental pathologies remains under researched at a phenomenological level. Thus, leaving a significant gap in psychopathological clinical literature on the functional role personality development is associated with psychopathology. In the modern era, the medical symptomology model of mental illness set by the DSM serves as the justification for psychotropic medication prescription as well as the diagnostic criteria for mental pathology but, there is limitations to functional ideals of mental health based off diagnostic …

A Phenomenological Study In Understanding The Influence Of Educators On Strengthening Resiliency In Homeless And Highly Mobile Students, Mary E. Thrasher

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to discover how educators identified homeless and highly mobile students and encouraged the characteristics of resiliency. This study was conducted using the educators at an urban school district in southern California. The theory guiding this study was Garmezy’s theory on resiliency as it pertained to the development and encouragement of the characteristics of resiliency in homeless and highly mobile students. The study was a transcendental phenomenological study. The sample were volunteers who are educators at the urban southern California school district. To facilitate triangulation, data collection was conducted by semi-structured interviews, a focus …

Gender Roles In Super Bowl Commercials: A Qualitative Longitudinal Content Analysis From 2013-2022, Christa Loree Havenhill

Doctoral Dissertations and Projects

Although numerous studies have examined gender stereotypes in advertising, relatively few have investigated the communication of gender roles in Super Bowl commercials. The Super Bowl attracts the largest televised audience in the United States; thus, it holds the power to shape, influence, and reinforce attitudes and beliefs. Through a sociocultural lens, this qualitative study examines the communication of gender roles in Super Bowl commercials across a 10-year period from 2013 to 2022. Utilizing a longitudinal content analysis design, 279 Super Bowl advertisements from 2013, 2016, 2019, and 2022 were analyzed. The problem addressed is how the depiction of gender roles …

Effect Of Intense Social Media Use On Middle School At-Risk Students Test Scores In Science And Math: An Ordinal Logistic Regression Analysis, Terry M. Johnson

Doctoral Dissertations and Projects

The purpose of this quantitative correlational study was to investigate the intensity of social networking use, gender, and socioeconomic status as possible predictors of eighth grade at-risk middle school students’ math and science test scores. Because this study hypothesized a general linear model between an ordinal response variable and more than one explanatory variables, ordinal logistic regression analysis was used. Social media is pervasive in the daily lives of students and so it can have a possible deleterious influence on student achievement. This idea continues to animate practitioners, researchers, parents, and all others interested in the achievement and success of …

Alternative Polyadenylation Transcriptome-Wide Association Study Identifies Apa-Linked Susceptibility Genes In Brain Disorders, Ya Cui, Frederick J Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J Wagner, Albert R La Spada, Wei Li

Faculty, Staff and Students Publications

Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes. Here, we performed a 3' untranslated region (3'UTR) APA TWAS (3'aTWAS) for 11 brain disorders by combining their genome-wide association studies data with 17,300 RNA-seq samples across 2,937 individuals. We identified 354 3'aTWAS-significant genes, including known APA-linked risk genes, such as SNCA in Parkinson's disease. Among these 354 genes, ~57% are not significant in traditional expression- and splicing-TWAS studies, since APA may regulate the translation, localization and protein-protein interaction of the target genes independent of mRNA level …

Lef1 Drives A Central Memory Program And Supports Antitumor Activity Of Natural Killer T Cells, Ho Ngai, Gabriel A Barragan, Gengwen Tian, Julien C Balzeau, Chunchao Zhang, Amy N Courtney, Linjie Guo, Xin Xu, Michael S Wood, Janice M Drabek, Thorsten Demberg, Caroline M Sands, Cynthia N Chauvin-Fleurence, Erica J Di Pierro, Jeffrey M Rosen, Leonid S Metelitsa

Faculty, Staff and Students Publications

Vα24-invariant natural killer T cells (NKT) possess innate antitumor properties that can be exploited for cancer immunotherapy. We have shown previously that the CD62L+ central memory-like subset of these cells drives the in vivo antitumor activity of NKTs, but molecular mediators of NKT central memory differentiation remain unknown. Here, we demonstrate that relative to CD62L- cells, CD62L+ NKTs express a higher level of the gene encoding the Wnt/β-catenin transcription factor lymphoid enhancer binding factor 1 (LEF1) and maintain active Wnt/β-catenin signaling. CRISPR/Cas9-mediated LEF1 knockout reduced CD62L+ frequency after antigenic stimulation, whereas Wnt/β-catenin activator Wnt3a ligand increased CD62L+ frequency. LEF1 overexpression …

Cellular Composition And Circuit Organization Of The Locus Coeruleus Of Adult Mice, Andrew Mckinney, Ming Hu, Amber Hoskins, Arian Mohammadyar, Nabeeha Naeem, Junzhan Jing, Saumil S Patel, Bhavin R Sheth, Xiaolong Jiang

Faculty, Staff and Students Publications

The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in the brain and regulates many fundamental functions, including fight and flight response, attention control, and sleep/wake cycles. While efferent projections of the LC have been extensively investigated, little is known about its local circuit organization. Here, we performed large-scale multipatch recordings of noradrenergic neurons in adult mouse LC to profile their morpho-electric properties while simultaneously examining their interactions. LC noradrenergic neurons are diverse and could be classified into two major morpho-electric types. While fast excitatory synaptic transmission among LC noradrenergic neurons was not observed in our preparation, these …

Covid-Dynamic: A Large-Scale Longitudinal Study Of Socioemotional And Behavioral Change Across The Pandemic, Tessa Rusch, Yanting Han, Dehua Liang, Amber R. Hopkins, Carolyn V. Lawrence, Uri Maoz, Lynn K. Paul, Damian A. Stanley, The Covid-Dynamic Team

Pharmacy Faculty Articles and Research

The COVID-19 pandemic has caused enormous societal upheaval globally. In the US, beyond the devastating toll on life and health, it triggered an economic shock unseen since the great depression and laid bare preexisting societal inequities. The full impacts of these personal, social, economic, and public-health challenges will not be known for years. To minimize societal costs and ensure future preparedness, it is critical to record the psychological and social experiences of individuals during such periods of high societal volatility. Here, we introduce, describe, and assess the COVID-Dynamic dataset, a within-participant longitudinal study conducted from April 2020 through January 2021, …

Genome-Wide Screening Reveals The Genetic Basis Of Mammalian Embryonic Eye Development, Justine M Chee, Louise Lanoue, Dave Clary, Kendall Higgins, Lynette Bower, Ann Flenniken, Ruolin Guo, David J Adams, Fatima Bosch, Robert E Braun, Steve D M Brown, H-J Genie Chin, Mary E Dickinson, Chih-Wei Hsu, Michael Dobbie, Xiang Gao, Sanjeev Galande, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabe De Angelis, Fabio Mammano, Lauryl M J Nutter, Helen Parkinson, Chuan Qin, Toshi Shiroishi, Radislav Sedlacek, J-K Seong, Ying Xu, Brian Brooks, Colin Mckerlie, K C Kent Lloyd, Henrik Westerberg, Ala Moshiri

Faculty, Staff and Students Publications

BACKGROUND: Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment. Although the predominant cause of eye malformations is known to be heritable in nature, with 80% of cases displaying loss-of-function mutations in the ocular developmental genes OTX2 or SOX2, the genetic abnormalities underlying the remaining cases of MAC are incompletely understood. This study intended to identify the novel genes and pathways required for early eye development. Additionally, pathways involved in eye formation during embryogenesis are also incompletely understood. This study aims to identify the novel genes and pathways …

Immunogenetic Determinants Of Susceptibility To Head And Neck Cancer In The Million Veteran Program Cohort, Yanhong Liu, Jennifer R Kramer, Vlad C Sandulache, Robert Yu, Guojun Li, Liang Chen, Zenab I Yusuf, Yunling Shi, Saiju Pyarajan, Spyros Tsavachidis, Li Jiao, Michelle L Mierzwa, Elizabeth Chiao, Yvonne M Mowery, Andrew Shuman, Sanjay Shete, Andrew G Sikora, Donna L White

Faculty, Staff and Student Publications

Increasing rates of human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) have largely offset declines in tobacco-associated head and neck squamous cell carcinoma (HNSCC) at non-OPC sites. Host immunity is an important modulator of HPV infection, persistence, and clearance, and also of immune evasion in both virally- and nonvirally-driven cancers. However, the association between collective known cancer-related immune gene variants and HNSCC susceptibility has not been fully characterized. Here, we conducted a genetic association study in the multiethnic Veterans Affairs Million Veteran Program cohort, evaluating 16,050 variants in 1,576 immune genes in 4,012 HNSCC cases (OPC = 1,823; non-OPC = 2,189) and …

Tumor-Associated Nonmyelinating Schwann Cell-Expressed Nuclear Export Signal Mutation Of Epidermal Growth Factor Receptor Enhances Malignant Phenotypes Of Cancer Cells, Chengcao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Jun Yao, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang

Faculty, Staff and Student Publications

One of the major obstacles to treating pancreatic ductal adenocarcinoma (PDAC) is its immunoresistant microenvironment. The functional importance and molecular mechanisms of Schwann cells in PDAC remains largely elusive. We characterized the gene signature of tumor-associated nonmyelinating Schwann cells (TASc) in PDAC and indicated that the abundance of TASc was correlated with immune suppressive tumor microenvironment and the unfavorable outcome of patients with PDAC. Depletion of pancreatic-specific TASc promoted the tumorigenesis of PDAC tumors. TASc-expressed long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (

Netprophet 3: A Machine Learning Framework For Transcription Factor Network Mapping And Multi-Omics Integration, Dhoha Abid, Michael R Brent

2020-Current year OA Pubs

MOTIVATION: Many methods have been proposed for mapping the targets of transcription factors (TFs) from gene expression data. It is known that combining outputs from multiple methods can improve performance. To date, outputs have been combined by using either simplistic formulae, such as geometric mean, or carefully hand-tuned formulae that may not generalize well to new inputs. Finally, the evaluation of accuracy has been challenging due to the lack of genome-scale, ground-truth networks.

RESULTS: We developed NetProphet3, which combines scores from multiple analyses automatically, using a tree boosting algorithm trained on TF binding location data. We also developed three independent, …

The Impact Of Mental Health Diagnoses In Combination With Learning Disorders, Tanya S. Gulledge

Doctoral Dissertations and Projects

The purpose of this research is to build on previous research that showed a significant relationship between students with socially devalued identities, poor mental health, and lower academic achievement and suggested tailored and targeted treatments as a possible protective factor. To develop programs to assist students in achieving higher scores, one must first determine the impact of comorbid mental health diagnosis and specific learning disorder on academic achievement. A quantitative causal-comparative study was used to determine if there is an impact of mental health diagnoses in combination with specific learning disorders for students with an Individualized Education Plan (IEP) or …

The Chanticleer, 2023-02-02, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Vol.50 N.28 February 2nd 2023, Voice Media Ventures

Black Voice News

No abstract provided.

Have Underground Radiation Measurements Refuted The Orch Or Theory?: Comment On “At The Crossroad Of The Search For Spontaneous Radiation And The Orch Or Consciousness Theory”, Kelvin J. Mcqueen

Philosophy Faculty Articles and Research

"In [1] it is claimed that, based on radiation emission measurements described in [2], a certain 'variant' of the Orch OR theory has been refuted. I agree with this claim. However, the significance of this result for Orch OR per se is unclear. After all, the refuted 'variant' was never advocated by anyone, and it contradicts the views of Hameroff and Penrose (hereafter: HP) who invented Orch OR [3].

My aim is to get clear on this situation. I argue that it is indeed reasonable to speak of 'variants' here. Orch OR is not a complete model of reality but …

Sample Multiplexing-Based Targeted Pathway Proteomics With Real-Time Analytics Reveals The Impact Of Genetic Variation On Protein Expression., Qing Yu, Xinyue Liu, Mark P Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P Vaites, Steven R Shuken, Ernst Schmid, Gregory R Keele, Jiaming Li, Edward L Huttlin, Edrees H Rashan, Judith Simcox, Gary Churchill, Devin K Schweppe, Alan D Attie, Joao A Paulo, Steven P Gygi

Faculty Research 2023

Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of up to 200 proteins selected from >10,000 expressed proteins to directly measure their abundances, exploiting sample multiplexing to increase throughput by 16-fold. The strategy, termed GoDig, requires only a single-shot LC-MS analysis, ~1 µg combined peptide material, a list of up to 200 proteins, and real-time analytics to trigger simultaneous quantification of up to 16 samples for hundreds of analytes. We apply GoDig …

Complet+: A Computationally Scalable Method To Improve Completeness Of Large-Scale Protein Sequence Clustering, Rachel Nguyen, Bahrad A. Sokhansanj, Robi Polikar, Gail L. Rosen

Henry M. Rowan College of Engineering Departmental Research

A major challenge for clustering algorithms is to balance the trade-off between homogeneity, i.e., the degree to which an individual cluster includes only related sequences, and completeness, the degree to which related sequences are broken up into multiple clusters. Most algorithms are conservative in grouping sequences with other sequences. Remote homologs may fail to be clustered together and instead form unnecessarily distinct clusters. The resulting clusters have high homogeneity but completeness that is too low. We propose Complet+, a computationally scalable post-processing method to increase the completeness of clusters without an undue cost in homogeneity. Complet+ proves to effectively merge …

When Plaquing Is Not Possible: Computational Methods For Detecting Induced Phages, Taylor Miller-Ensminger, Genevieve Johnson, Swarnali Banerjee, Catherine Putonti

Mathematics and Statistics: Faculty Publications and Other Works

High-throughput sequencing of microbial communities has uncovered a large, diverse population of phages. Frequently, phages found are integrated into their bacterial host genome. Distinguishing between phages in their integrated (lysogenic) and unintegrated (lytic) stage can provide insight into how phages shape bacterial communities. Here we present the Prophage Induction Estimator (PIE) to identify induced phages in genomic and metagenomic sequences. PIE takes raw sequencing reads and phage sequence predictions, performs read quality control, read assembly, and calculation of phage and non-phage sequence abundance and completeness. The distribution of abundances for non-phage sequences is used to predict induced phages with statistical …

Bats Increased Foraging Activity At Experimental Prey Patches Near Hibernacula, Winifred F. Frick, Yvonne A. Dzal, Kristin A. Jonasson, Michael D. Whitby, Amanda M. Adams, Christen Long, John E. Depue, Christian M. Newman, Craig K. R. Willis, Tina L. Cheng

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

1. Emerging infectious diseases in wildlife can threaten vulnerable host populations. Actions targeting habitat improvements to aid population resilience and recovery may be beneficial long-term strategies, yet testing the efficacy of such strategies before major conservation investments are made can be challenging.

2. The disease white-nose syndrome (WNS) has caused severe declines in several species of North American hibernating bats. We tested a novel conservation approach targeted at improving foraging conditions near bat hibernacula by experimentally manipulating insect density in the pre-hibernation fattening period and spring emergence recovery period. We measured foraging (feeding buzzes) and echolocation activity of little brown bats Myotis …

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Ancyronyx Jhoanae Sp. Nov. (Coleoptera: Elmidae), A New Spider Riffle Beetle Species From Luzon, Philippines, And New Records For A. Tamaraw Freitag, 2013, Christalle Beatriz N. Seno, Hendrik Freitag

Biology Faculty Publications

Ancyronyx jhoanae sp. nov., a new species of genus Ancyronyx Erichson, 1847 from Luzon is described using an integrative taxonomic approach. Illustrations of habitus and diagnostic characters are provided. Molecular analysis of a fragment of the COI 5’-end was employed to support the morphological species concept. Differences from closely related species based on molecular and morphological data are discussed. First records of A. tamaraw Freitag, 2013 from Luzon are reported.

The Comment, February 2, 2023, Bridgewater State University

The Comment

No abstract provided.