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Hard To Be Won: A Theatrical Interpretation Of Elizabeth Keckly’S “Behind The Scenes, Or Thirty Years A Slave And Four Years In The White House”, Selah Degering

Undergraduate Honors Theses

Hard to Be Won is a musical adaptation of a memoir by Elizabeth Keckly, a black woman of considerable success who earned the confidence of Abraham Lincoln and his wife, Mary, in war-torn 1860s America. My adaptation of this story showcases a new perspective: that of Elizabeth herself. Despite her memoir narrating these events in her own voice, Elizabeth as an individual has been largely ignored or misrepresented in modern, idealistic, and racially ignorant retellings and criticism. Elizabeth as a token black person in the narrative of the Lincoln household cannot stand as representation of this woman’s legacy when she …

In Vivo Gene Delivery Into Mouse Mammary Epithelial Cells Through Mammary Intraductal Injection, Wen Bu, Yi Li

Faculty, Staff and Students Publications

Mouse mammary glands comprise ductal trees, which are lined by epithelial cells and have one opening at the tip of each nipple. The epithelial cells play a major role in mammary gland function and are the origin of most mammary tumors. Introducing genes of interest into mouse mammary epithelial cells is a critical step in evaluating gene function in epithelial cells and generating mouse mammary tumor models. This goal can be accomplished through the intraductal injection of a viral vector carrying the genes of interest into the mouse mammary ductal tree. The injected virus subsequently infects mammary epithelial cells, bringing …

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh Kariyat, Joe Louis, Sajjan Grover

Department of Entomology: Faculty Publications

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Moving Beyond Fulfillment: Wisdom Years Stories Of Passion, Perseverance, And Productivity, Kenneth A. Kiewra, Jessica Walsh, Chris Labenz

Department of Educational Psychology: Faculty Publications

Seven participants were interviewed to uncover how they remain so productive in their wisdom years, those typically marked by retirement. Participants included a leading educational psychologist, a renowned national television news anchor, a four-time national champion collegiate coach, the founder and former chief executive of Arbor Day Foundation, a university scholar turned playwright, and two female adventurers who quit their jobs, sold their possessions, and have lived a nomadic life, hiking thousands of miles throughout America. Their wisdom years stories describe how and why they shun retirement and remain productive. The article concludes with seven advice-laden conclusions for readers: (a) …

Dual-Specificity Phosphatases 22-Deficient T Cells Contribute To The Pathogenesis Of Ankylosing Spondylitis, Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan

Children’s Nutrition Research Center Staff Publications

Background: Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS).

Methods: Sixty AS patients and 45 healthy controls were enrolled in this study. Associations of gene expression of 23 DUSPs in peripheral T cells with inflammatory cytokine gene expression and disease activity of AS were analyzed. Finally, we investigated whether the characteristics of AS are developed in DUSP-knockout mice.

Results: The mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral …

A Monographic Revision Of The Jewel Scarabs Genus Chrysina From Panama, Colombia, And Ecuador (Coleoptera: Scarabaeidae: Rutelinae: Rutelini), Manuel D. Barria

Zea E-Books Collection

The work is a taxonomic revision of 28 species of the genus Chrysina Kirby (Scarabaeidae: Rutelinae: Rutelini) found in Panama (25), Colombia (2), and Ecuador (3). Chrysina tricolor (Ohaus), Chrysina chalcothea (Bates), and Chrysina cupreomarginata (F. Bates) are new re­cords for Panama. A new country record from northern Colombia is confirmed for Chrys­ina mercedesae Barria. Chrysina gaitalica Curoe and Hawks and Chrysina galbina Hawks are discovered at new localities in Panama; females of both species are discovered and described. Chrysina aurora (Bates) known from other localities in the west of the country, is rediscov­ered in Veraguas province 147 years after …

Phase Ib Study Of Telisotuzumab Vedotin In Combination With Erlotinib In Patients With C-Met Protein-Expressing Non-Small-Cell Lung Cancer, D Ross Camidge, Fabrice Barlesi, Jonathan W Goldman, Daniel Morgensztern, Rebecca Heist, Everett Vokes, Alex Spira, Eric Angevin, Wu-Chou Su, David S Hong, John H Strickler, Monica Motwani, Martin Dunbar, Apurvasena Parikh, Elysa Noon, Vincent Blot, Jun Wu, Karen Kelly

Faculty, Staff and Student Publications

Purpose: Overexpression of c-Met protein and epidermal growth factor receptor (EGFR) mutations can co-occur in non-small-cell lung cancer (NSCLC), providing strong rationale for dual targeting. Telisotuzumab vedotin (Teliso-V), a first-in-class antibody-drug conjugate targeting c-Met, has shown a tolerable safety profile and antitumor activity as monotherapy. Herein, we report the results of a phase Ib study (ClinicalTrials.gov identifier: NCT02099058) evaluating Teliso-V plus erlotinib, an EGFR tyrosine kinase inhibitor (TKI), in patients with c-Met-positive (+) NSCLC.

Patients and methods: This study evaluated Teliso-V (2.7 mg/kg once every 21 days) plus erlotinib (150 mg once daily) in adult patients (age …

Deep Learning For Detecting And Elucidating Human T-Cell Leukemia Virus Type 1 Integration In The Human Genome, Haodong Xu, Johnathan Jia, Hyun-Hwan Jeong, Zhongming Zhao

Faculty, Staff and Student Publications

Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus, is the causative agent for adult T cell leukemia/lymphoma and many other human diseases. Accurate and high throughput detection of HTLV-1 virus integration sites (VISs) across the host genomes plays a crucial role in the prevention and treatment of HTLV-1-associated diseases. Here, we developed DeepHTLV, the first deep learning framework for VIS prediction de novo from genome sequence, motif discovery, and cis-regulatory factor identification. We demonstrated the high accuracy of DeepHTLV with more efficient and interpretive feature representations. Decoding the informative features captured by DeepHTLV resulted in eight representative clusters …

The Process Theology Of John Elof Boodin, Michael A. Flannery

Libraries Professional Work

Despite his impeccable academic pedigree, a protégé of Josiah Royce and a friend and student of William James, John Elof Boodin is nearly forgotten today among American philosophers; hence, an essential aspect of his thought lost to history is his contribution to process theology. The leading features of process thought demonstrate Boodin’s connections to this unique theology and show it to have been established early on, as early as 1900 and 1904. This places Boodin’s writing on process philosophy/theology well before Alfred North Whitehead, the putative pioneer in modern process metaphysics, by more than twenty years, and co-extensive with Henri …

Micrornas And Gene Regulatory Networks Related To Cleft Lip And Palate, Chihiro Iwaya, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding questions is how environmental factors lead to craniofacial developmental anomalies. Recent studies highlight non-coding RNAs as potential epigenetic regulators in cleft lip and palate. In this review, we will discuss microRNAs, a type of small non-coding RNAs that can simultaneously regulate expression of many downstream target genes, as a causative mechanism of cleft lip and palate in humans …

Fgl2-Targeting T Cells Exhibit Antitumor Effects On Glioblastoma And Recruit Tumor-Specific Brain-Resident Memory T Cells, Qingnan Zhao, Jiemiao Hu, Lingyuan Kong, Shan Jiang, Xiangjun Tian, Jing Wang, Rintaro Hashizume, Zhiliang Jia, Natalie Wall Fowlkes, Jun Yan, Xueqing Xia, Sofia F Yi, Long Hoang Dao, David Masopust, Amy B Heimberger, Shulin Li

Faculty, Staff and Student Publications

Although tissue-resident memory T (TRM) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain TRM cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)–specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8+ TRM cells that prevent glioblastoma recurrence. These CD8+ TRM cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue. When adoptively transferred to the brains of either immunocompetent or T cell-deficient naïve mice, these CD8+ TRM cells reject glioma cells. Mechanistically, T-αFGL2 …

A Phase Ib/Ii Study Of Lenvatinib And Pembrolizumab In Advanced Endometrial Carcinoma (Study 111/Keynote-146): Long-Term Efficacy And Safety Update, Vicky Makker, Carol Aghajanian, Allen L Cohn, Margarita Romeo, Raquel Bratos, Marcia S Brose, Mark Messing, Lea Dutta, Corina E Dutcus, Jie Huang, Emmett V Schmidt, Robert Orlowski, Matthew H Taylor

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The open-label phase Ib/II Study 111/KEYNOTE-146 of daily lenvatinib 20 mg plus pembrolizumab 200 mg once every 3 weeks showed promising efficacy and tolerable safety in patients with previously treated advanced endometrial carcinoma (EC; primary data cutoff …

Cascading Effects Of Cover Crops On The Subsequent Cash Crop Defense Against The Polyphagous Herbivore Fall Armyworm (Spodoptera Frugiperda), Adegboyega Fajemisin, Alexis Racelis, Rupesh R. Kariyat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Simple Summary

Although studies have started to show that the effects of cover crops can translate into the cash cropping season, there is little information on the cascading effects of cover crops on the subsequent cash crop defenses, especially against polyphagous herbivores. To bridge this information gap, we conducted a field and laboratory study to investigate the cascading effects of different cover crop species on the subsequent cash crop defense against the polyphagous herbivore fall armyworm (Spodoptera frugiperda) across three fields in the Lower Rio Grande Valley in south Texas. Our field and laboratory results revealed that cover crop treatments …

Improving Phosphorus Acquisition Efficiency Through Modification Of Root Growth Responses To Phosphate Starvation In Legumes, Zhijian Chen, Linjie Wang, Juan Andres Cardoso, Shengnan Zhu, Guodao Liu, Idupulapati M. Rao, Yan Lin

All Peer-Reviewed Publications

Phosphorus (P) is one of the essential macronutrients for plant growth and development, and it is an integral part of the major organic components, including nucleic acids, proteins and phospholipids. Although total P is abundant in most soils, a large amount of P is not easily absorbed by plants. Inorganic phosphate (Pi) is the plant-available P, which is generally immobile and of low availability in soils. Hence, Pi starvation is a major constraint limiting plant growth and productivity. Enhancing plant P efficiency can be achieved by improving P acquisition efficiency (PAE) through modification of morpho-physiological and biochemical alteration in root …

2023-02-10 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

Institutional Animal Care and Use Committee meeting minutes for February 10, 2023.

Agriculture Water Use And Economic Value In The Great Salt Lake Basin, Cody Zesiger, Burdette Barker, Sarah Null, Earl Creech, Matt Yost, Ryan Larsen, Joshua Dallin

All Current Publications

This fact sheet briefly describes human impacts on GSL water volume, human population growth, surface water withdrawals, and agricultural water use from 1985 and 2015 in the GSL Basin. Finally, agriculture’s economic impact and food production in the GSL Basin are summarized.

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh R. Kariyat, Joe Louis, Sajjan Grover

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Phase Ib Study Of Telisotuzumab Vedotin In Combination With Erlotinib In Patients With C-Met Protein-Expressing Non-Small-Cell Lung Cancer, D Ross Camidge, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

PURPOSE: Overexpression of c-Met protein and epidermal growth factor receptor (

PATIENTS AND METHODS: This study evaluated Teliso-V (2.7 mg/kg once every 21 days) plus erlotinib (150 mg once daily) in adult patients (age ≥ 18 years) with c-Met+ NSCLC. Later enrollment required presence of an

RESULTS: As of January 2020, 42 patients were enrolled (N = 36 efficacy-evaluable). Neuropathies were the most common any-grade adverse events reported, with 24 of 42 patients (57%) experiencing at least one event. The pharmacokinetic profile of Teliso-V plus erlotinib was similar to Teliso-V monotherapy. Median PFS for all efficacy-evaluable patients was 5.9 months …

The Metabolic And Physiological Demands Of A Simulated Fire Ground Test Versus A Live-Fire Training Evolution In Professional Firefighters, Drew Edward Gonzalez, Hunter Waldman, Matthew J. Mcallister

International Journal of Exercise Science

International Journal of Exercise Science 16(7): 230-241, 2023. Objective: This study examined the similarities in metabolic and physiological demands of a fire ground test (FGT) and a live fire training evolution. Methods: Twenty-seven firefighters completed either a FGT (n = 13) or a live fire training evolution (n = 14). Salivary samples were collected pre, immediately post, and 30-minutes post FGT and live fire training evolution, and analyzed for cortisol, uric acid, and interleukin-1β (IL-1β). Heart rate (HR) was measured pre- and post-task. Results: Both tasks resulted in significant elevations in cortisol, IL-1β, and HR. Conclusions: Both the …

Modern Approaches To Addressing The Mass Incarceration Of America's Mentally Ill Population, Cameron A. Bice, April N. Terry

Academic Leadership Journal in Student Research

Correctional facilities negatively affect individuals with pre-existing mental and behavioral health concerns while also creating an environment that manifests future mental illness. Issues include facility overcrowding, restrictive housing practices, lack of accessible services, and ill-informed practices and procedures when working with individuals with mental illness. Incarcerated individuals with mental illness also face disparities through (1) sentence length, (2) race/ethnicity and gender, and (3) increased risk in victimization. This paper draws attention to a long-standing, yet current critical issue in the American criminal justice system—the use of jails and prisons as modern-day psychiatric hospitals. This literature yields many options for disrupting …

A New Species Of Scorpio From Jordan (Scorpiones: Scorpionidae), Mohammad Al-Saraireh, Ersen A. Yağmur, Bassam Abu Afifeh, Zuhair Amr

Euscorpius

A new species Scorpio granulomanus sp. n. is described and illustrated from Dibbeen Forest, Jerash Governorate, Jordan. The new species is compared with the previously recorded species of the genus Scorpio L., 1758 in the Middle East; it can be distinguished from all other congeners by its very large, pointed granules on the dorsoexternal surface of the chela manus, and an untypically elongated chela manus.

Pride And Prejudice Playbill, Providence College

Playbill and Promotion

Providence College Department of Theatre, Dance & Film

Angel Blackfriars Theatre

Jane Austen's Pride and Prejudice, adapted by Janet Munsil

February 9-12, 2023

Director, Erin J. Schmidt

Scenic and Prop Design, Lindsay Fuori

Lighting Design, Michael Clark Wonson

Sound Design/Musical Direction & Choreography, Aubrey Atwater & Elwood Donnelly

Costume, Make-Up, and Wig Design, Rachel Padula-Shufelt

Vocal Coach, Megan Chang

Featuring the Music of The Atwater-Donnelly Duo

Cast: Jane Bennet - Maisie Cocker, Lizzie Bennet - Madelyn Rich, Mary Bennet - Sara D'Andrea, Kitty Bennet - Caitlyn Mitchell, Lydia Bennet - Christina Schwab, Mr. …

Using Oral Histories As An "Avenue To Difficult Truth-Telling", Rebecca Lauck Cleary

Blog Posts

Sarah Rodriguez blends love for food and meaningful conversation at Southern Foodways Alliance Sarah Rodriguez engages with people through her work as an oral historian, honing skills such as honesty and empathy building. She also enjoys connecting with them over a meal, which is not surprising, given her job with the Southern Foodways Alliance.

Massive Loss Of Proprioceptive Ia Synapses In Rat Spinal Motoneurons After Nerve Crush Injuries In The Postnatal Period, Ariadna Arbat-Plana, Sara Bolívar, Xavier Navarro, Esther Udina, Francisco J. Alvarez

Neuroscience, Cell Biology & Physiology Faculty Publications

Peripheral nerve injuries (PNIs) induce the retraction from the ventral horn of the synaptic collaterals of Ia afferents injured in the nerve, effectively removing Ia synapses from α-motoneurons. The loss of Ia input impairs functional recovery and could explain, in part, better recovery after PNIs with better Ia synaptic preservation. Synaptic losses correlate with injury severity, speed, and efficiency of muscle reinnervation and requires ventral microglia activation. It is unknown whether this plasticity is age dependent. In neonates, axotomized motoneurons and sensory neurons undergo apoptosis, but after postnatal day 10 most survive. The goal of this study was to analyze …

Great Salt Lake Policy Assessment: A Synthesized Resource Document For The 2023 General Legislative Session, William Anderegg, Craig Buttars, Joel Ferry, Natalie Gochnour, Kim Shelley, Brian Steed, David Tarboton, Leila Ahmadi, Eric Albers, Blake Bingham, Paul Brooks, Joanna Endter-Wada, Candice Hasenyager, John Lin, Anna Mcentire, Bethany Neilson, Sarah Null, Kevin Perry, Ben Stireman, Courenay Strong, Kyla Welch, Matt Yost

Watershed Sciences Faculty Publications

Declining water levels threaten economic activity, public health, and ecosystems of Great Salt Lake and surrounding communities. This policy assessment provides a summary of data, insights, and policy options that will inform strategies to improve water management and increase deliveries to the lake.

College Of Natural Sciences Newsletter, November 2022 - January 2023, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volme 3, Issue 7

Page 1 Dean's Message
Page 2 Awards & Recognition
Page 3 Sioux Falls Middle School Visit
Page 4 Bio-Micro Day of Scholars
Page 5 GIS Day at USGS EROS
Page 6 Indigenous People's Festival, & Visiting Jack's Imagination Lab
Page 7 Media Coverage of CNS, & Research Highlights from Geography & Geospatial Sciences
Page 8 Media Coverage of CNS. cont.
Page 9 Open PRAIRIE Data
Page 10 Recent Publications from CNS
Page 11 Recent Publications from CNS. cont.
Page 12 CNS Holiday Snapshots
Page 13 & 14 Fall 2022 Dean's List
Page 12-14 Fall 2022 Outreach …

Investigating The Reptilian Innate Immune System: A Review And Examination Of The Relationship Between Immunity, Stress, And Reproduction, Emily Katherine Field

Student Theses and Dissertations

Ecoimmunology examines the relationship between the physiology of an organism, its immune responses, and the external environment. As such, this field is critical to answering important questions in ecology, physiology, and evolution, and it can be vital in making policy and conservation decisions. As the only ectothermic amniotes, class Reptilia represents a group of unique study organisms. However, in comparison to other vertebrate taxa, this group has remained relatively understudied in the field of ecoimmunology. Though reptilian immunology has gained some attention in the last decade, we still lack data assessing immunity across the four orders of class Reptilia. Immune …

Novel Data-Driven Approaches To Elucidate Interactions Between Soybean And Phytopthora Sojae, Thivanka Sandaruwan Ratnayake

Student Theses and Dissertations

Phytophthora sojae is a soil-borne oomycete and the causal agent of Phytophthora stem and root rot (PSR) in soybean (Glycine max [L.] Merrill). Yield losses attributed to P. sojae are devastating in disease-conducive environments, with global estimates surpassing 1.1 million tonnes annually. Historically, management of PSR has entailed host genetic resistance (i.e., vertical and horizontal) complemented by disease-suppressive cultural practices (e.g., oomicide application). However, the vast expansion of complex and/or diverse P. sojae pathotypes complicated by climate instability necessitates the development of novel technologies for the attenuation of PSR in field environments. Therefore, the objective of the present study was …

Periconceptual Maternal Nutrition Affects Fetal Liver Programming Of Energy- And Lipid-Related Genes, Wellison J. S. Diniz, Alison K. Ward, Kacie L. Mccathy, Cierrah J. Kassetas, Friederike Baumgaertner, Lawrence P. Reynolds, Pawel P. Borowicz, Kevin K. Sedivec, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen

Department of Animal Science: Faculty Publications

During pregnancy, the fetus relies on the dam for its nutrient supply. Nutritional stimuli during fetal organ development can program hepatic metabolism and function. Herein, we investigated the role of vitamin and mineral supplementation (VTM or NoVTM—at least 71 days pre-breeding to day 83 of gestation) and rate of weight gain (low (LG) or moderate (MG)—from breeding to day 83) on the fetal liver transcriptome and the underlying biological pathways. Crossbred Angus beef heifers (n = 35) were randomly assigned to one of four treatments in a 2 × 2 factorial design (VTM_LG, VTM_MG, NoVTM_LG, and NoVTM_MG). Gene expression …

Exploring Disability, Spirituality And Community At Lourdes Sanctuary, Liz Hutter

Marian Forum

Liz Hutter, assistant professor of English, presents on her research topic of therapeutic and spiritual healing in Lourdes. Her presentation is followed by a Q&A session as well as the opportunity to visit the Rituals of Healing: Body, Mind, Spirit exhibit curated in part by students in Hutter’s ENG 100 writing seminar.