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2023 February 9 - Academic Council Agenda And Minutes, Academic Council, East Tennessee State University

Academic Council Agenda and Minutes

No abstract provided.

Association Between The Choice Of The Conditioning Regimen And Outcomes Of Allogeneic Hematopoietic Cell Transplantation For Myelofibrosis, Guru Subramanian Guru Murthy, Soyoung Kim, Noel Estrada-Merly, Muhammad Bilal Abid, Mahmoud Aljurf, Amer Assal, Talha Badar, Sherif M. Badawy, Karen Ballen, Amer Beitinjaneh, Jan Cerny, Saurabh Chhabra, Zachariah Defilipp, Bhagirathbhai Dholaria, Miguel Angel Diaz Perez, Shatha Farhan, Cesar O. Freytes, Robert Peter Gale, Siddhartha Ganguly, Vikas Gupta, Michael R. Grunwald, Nada Hamad, Gerhard C. Hildebrandt, Yoshihiro Inamoto, Tania Jain, Omer Jamy, Mark Juckett, Matt Kalaycio, Maxwell M. Krem, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Guillermo Ortí, Sagar S. Patel, Marjolein Van Der Poel, David A. Rizzieri, Bipin N. Savani, Sachiko Seo, Melhem Solh, Leo F. Verdonck, Baldeep Wirk, Jean A. Yared, Ryotaro Nakamura, Betul Oran, Bart Scott, Wael Saber

Hematology/Oncology Articles

Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment for myelofibrosis. However, the optimal conditioning regimen either with reduced intensity conditioning (RIC) or myeloablative conditioning (MAC) is not well known. Using the Center for International Blood and Marrow Transplant Research database, we identified adults aged ≥18 years with myelofibrosis undergoing allo-HCT between 2008-2019 and analyzed the outcomes separately in the RIC and MAC cohorts based on the conditioning regimens used. Among 872 eligible patients, 493 underwent allo-HCT using RIC (Fludarabine/busulfan=166, Fludarabine/melphalan=327) and 379 using MAC (Fludarabine/busulfan=247, Busulfan/cyclophosphamide=132). In multivariable analysis with RIC, Fludarabine/melphalan was associated with inferior overall survival …

Curriculum Minutes 02/09/2023, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Health Disparities In Aging: Improving Dementia Care For Black Women., Caleigh A Findley, Makayla F Cox, Adam B Lipson, Ratasha Bradley, Kevin N Hascup, Carla Yuede, Erin R Hascup

Articles

In the United States, 80% of surveyed Black patients report experiencing barriers to healthcare for Alzheimer's disease and related dementias (ADRD), delaying the time-sensitive treatment of a progressive neurodegenerative disease. According to the National Institute on Aging, Black study participants are 35% less likely to be given a diagnosis of ADRD than white participants, despite being twice as likely to suffer from ADRD than their white counterparts. Prior analysis of prevalence for sex, race, and ethnicity by the Centers for Disease Control indicated the highest incidence of ADRD in Black women. Older (≥65 years) Black women are at a disproportionately …

Global Epidemiology And Clinical Outcomes Of Carbapenem-Resistant Pseudomonas Aeruginosa And Associated Carbapenemases (Pop): A Prospective Cohort Study, Jinnethe Reyes, Lauren Komarow, Liang Chen, Lizhao Ge, Blake M. Hanson, Eric Cober, Erica Herc, Thamer Alenazi, Keith S. Kaye, Julia Garcia-Diaz, Lanjuan Li, Souha S. Kanj, Zhengyin Liu, Jose M. Oñate, Robert A. Salata, Kalisvar Marimuthu, Hainv Gao, Zhiyong Zong, Sandra L. Valderrama-Beltrán, Yunsong Yu, Paul Tambyah, Gregory Weston, Soraya Salcedo, Lillian M. Abbo, Qing Xie, Karen Ordoñez, Minggui Wang, Martin E. Stryjewski, Jose M. Munita, David L. Paterson, Scott Evans, Carol Hill, Keri Baum, Robert A. Bonomo, Barry N. Kreiswirth, Maria Virginia Villegas, Robin Patel, Cesar A. Arias, Henry F. Chambers, Vance G. Fowler, Yohei Doi, David Van Duin, Michael J. Satlin

Infectious Diseases Articles

BACKGROUND: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the distribution and clinical significance of carbapenemases are unclear. The aim of this study was to define characteristics and outcomes of CRPA infections and the global frequency and clinical impact of carbapenemases harboured by CRPA.

METHODS: We conducted an observational, prospective cohort study of CRPA isolated from bloodstream, respiratory, urine, or wound cultures of patients at 44 hospitals (10 countries) between Dec 1, 2018, and Nov 30, 2019. Clinical data were abstracted from health records and CRPA isolates were whole-genome sequenced. The primary outcome was 30-day mortality from the day …

Health Disparities In Aging: Improving Dementia Care For Black Women., Caleigh A Findley, Makayla F Cox, Adam B Lipson, Ratasha Bradley, Kevin N Hascup, Carla Yuede, Erin R Hascup

Articles

In the United States, 80% of surveyed Black patients report experiencing barriers to healthcare for Alzheimer's disease and related dementias (ADRD), delaying the time-sensitive treatment of a progressive neurodegenerative disease. According to the National Institute on Aging, Black study participants are 35% less likely to be given a diagnosis of ADRD than white participants, despite being twice as likely to suffer from ADRD than their white counterparts. Prior analysis of prevalence for sex, race, and ethnicity by the Centers for Disease Control indicated the highest incidence of ADRD in Black women. Older (≥65 years) Black women are at a disproportionately …

Does Bergmann’S Rule Apply To North American Birds In The Context Of Climate Change?, Peridot Derrin Galloway

Student Theses and Dissertations

Over the past half century, birds have changed, including in their morphology. Biogeographic rules including Bergmann’s and Allen’s rules have been used to try to elucidate morphological changes; however, there has been dispute over the rules’ applicability. Thus, I aimed to identify 1) morphometric trends over time of 15 North American bird species, including eastern bluebirds (Sialia sialis); 2) if these morphometric trends follow Bergmann’s rule; and 3) if the observed morphometric trends are associated with life history and other traits, as well as climatic variables (e.g., average, maximum and minimum temperatures, and total precipitation). Using short- and long-term morphological …

Shell Shocked: The Effects Of Stress And Bacterial Challenges On The Chelonian Innate Immune Response, Alyssa Hartzheim

Student Theses and Dissertations

In the realm of immunology, the use of reptilian models remains low in comparison to their mammalian counterparts. Consequently, much of the inner workings of reptilian immunity remain to be elucidated. Specifically, chelonian species are vastly understudied. In the past decade, research focusing on reptilian immunology has increased. This thesis seeks to contribute to the growing body of work concerning immune trade-offs. I studied reptilian innate immune ability in both captive and free-living populations with consideration of both intrinsic and extrinsic factors. In the zoo-housed Indian star tortoises (Geochelone elegans) and northern spider tortoises (Pyxis arachnoides brygooi), I demonstrated species-specific …

Comparing The Toxicant Responses And Culturing Characteristics Of Long-Term Laboratory-Reared And Field Populations Of Ceriodaphnia Dubia, Victoria Rose Lydy

Student Theses and Dissertations

Ceriodaphnia dubia is an EPA-recommended organism used in regulatory toxicity testing of surface waters and commercial chemicals. They are often cultured for extended periods in the laboratory with little knowledge of how it impacts subsequent generations. This thesis investigated if C. dubia cultured for an extended period were representative of three recently-collected field populations by comparing their culturing characteristics and sensitivities to toxicants. Comparative chronic toxicity tests with sodium chloride, the neonicotinoid insecticide thiamethoxam, and mixtures of the two toxicants measured differences in sensitivities among the laboratory and field cultures, specifically in the variability of responses. For culturing characteristics, the …

Evaluation Of Woodchip Bioditch Reactors As A Nutrient Reduction Conservation Strategy, Geoffrey K. Payne

Student Theses and Dissertations

Continued increases in nitrogen and phosphorus loads in waterways cause problems with water quality, impacting human health, the economy, and the environment. To reach nutrient load reduction targets, innovative conservation strategies should be evaluated. This study aimed to assess (1) the potential of using woodchip bioditch reactors for the mitigation of nitrate (NO3-) and soluble reactive phosphorus (SRP) in agricultural waterways; (2) the influence of orientation of the bioditch reactor to flow direction on NO3- and SRP concentrations and loads; and (3) the impact that differing wet/dry cycles have on NO3- and SRP concentrations and loads when bioditch reactors are …

Assessment Of Variable Rate Nitrogen Application On Rice Cultivars Using Remote Sensing, Rush Matthew Evans

Student Theses and Dissertations

Application of the right time and amount of fertilizer N is challenging in rice fertilization because crop N supply is highly variable in the field. Research plots were established at four research plot fields and one commercial field in Arkansas. Independent variables included six nitrogen (N) application rates (0, 67, 101, 134.5, 168, and 202 kg N ha-1), multiple rice cultivars, and five locations. The response variable was 24 vegetative indices values using high spatio-temporal multispectral and thermal imagery obtained from an Unmanned Aerial Vehicle (UAV). The 134 and 168 kg N ha-1 rates were identified as the control group …

Early Restrictive Or Liberal Fluid Management For Sepsis-Induced Hypotension, Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, Adit A Ginde, Michelle N Gong, Colin K Grissom, Douglas Hayden, Catherine L Hough, Weixing Huang, Theodore J Iwashyna, Alan E Jones, Akram Khan, Poying Lai, Kathleen D Liu, Chadwick D Miller, Katherine Oldmixon, Pauline K Park, Todd W Rice, Nancy Ringwood, Matthew W Semler, Jay S Steingrub, Daniel Talmor, B Taylor Thompson, Donald M Yealy, Wesley H Self

Faculty, Staff and Student Publications

BACKGROUND: Intravenous fluids and vasopressor agents are commonly used in early resuscitation of patients with sepsis, but comparative data for prioritizing their delivery are limited.

METHODS: In an unblinded superiority trial conducted at 60 U.S. centers, we randomly assigned patients to either a restrictive fluid strategy (prioritizing vasopressors and lower intravenous fluid volumes) or a liberal fluid strategy (prioritizing higher volumes of intravenous fluids before vasopressor use) for a 24-hour period. Randomization occurred within 4 hours after a patient met the criteria for sepsis-induced hypotension refractory to initial treatment with 1 to 3 liters of intravenous fluid. We hypothesized that …

Greg Fournier, Oral History Interview, 2023, Katherine Hacanyan

Oral Histories

In the Fall of 2022, Matt Jones’s Oral History Techniques class conducted a set of interviews documenting the stories behind the student unrest on Eastern Michigan University’s campus from 1966-1972. Greg Fournier is a current author and EMU alum who was witness to the student unrest on campus, which was happening at the same time John Norman Collins was committing his crimes. Now, Greg has written about John in his book, "Terror in Ypsilanti."

The Student Movement Volume 107 Issue 15: Moving Forward: Au Rings In Black History Month, Anna Pak, Grace No, Nora Martin, Jonathon Woolford-Hunt, Aiko J. Ayala Rios, Andrew Francis, Hannah Cruse, Gloria Oh, Alannah Tjhatra, T Bruggemann, Gabriela Francisco, Elizabeth Getahun, Wambui Karanja, Charisse Lapuebla, Chris Ngugi

The Student Movement v. 107 (2022-2023)

HUMANS

Current Book Reads, Anna Pak

Interview with Kayla Goodman, Lamson Student Dean, Interviewed by: Grace No

Meet Julaine Phillips, BSCF Vice President, Interviewed by: Grace No

ARTS & ENTERTAINMENT

Creatives on Campus: Black History Month, Mora Martin

Currently: You People, Jonathon Woolford-Hunt

Shining Talent at Young Artists Concert 2023, Aiko J. Ayala Rios

NEWS

BSCF's IMPACT Vespers Kicks off Black History Month, Andrew Francis

Death of Tyre Nichols: Catalyst for Change or Recurring Event?, Hannah Cruse

Honors Agape Feast, Gloria Oh

Pre-Vet Club Fundraisers for Stray Cats, Alannah Tjhatra

IDEAS

I Don't Understand Poetry, T Bruggemann

Open AI's Chat …

Evaluation Of Polyacrylamide (Pam) Effects On Irrigation Efficiency, Soil Conservation, And Water Quality In Midsouth Cotton Production, Brittany D. Barnes

Student Theses and Dissertations

The polymer, polyacrylamide (PAM), is a high molecular weight, chemical anionic polymer that is prescribed and used for irrigation improvement in row crops primarily in the United States. A field research study was conducted in 2014, 2015 and 2016 in Northeast Arkansas to evaluate how addition of PAM in furrow irrigation affected soil erosion, water infiltration, movement of nutrients and sediments, and crop yields in cotton (Gossypium hirsutum). Overall results from the study were mixed. Sediment loss was similar among treatments. Irrigation advancement rates were not significantly different. No differences in crop yield were observed associated with PAM. Differences in …

The Montclarion, February 9, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Expression Of Malic Enzyme Reveals Subcellular Carbon Partitioning For Storage Reserve Production In Soybeans, Usda Agricultural Research Service, Donald Danforth Plant Science Center, Donald Danforth Plant Science Center, Thomas E. Clemente, Hanh T. Nguyen

Department of Agronomy and Horticulture: Faculty Publications

• Central metabolism produces amino and fatty acids for protein and lipids that establish seed value. Biosynthesis of storage reserves occurs in multiple organelles that exchange central intermediates including two essential metabolites, malate, and pyruvate that are linked by malic enzyme. Malic enzyme can be active in multiple subcellular compartments, partitioning carbon and reducing equivalents for anabolic and catabolic requirements. Prior studies based on isotopic labeling and steady-state metabolic flux analyses indicated malic enzyme provides carbon for fatty acid biosynthesis in plants, though genetic evidence confirming this role is lacking. We hypothesized that increasing malic enzyme flux would alter carbon partitioning …

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Natural Variation In Host Feeding Behaviors Impacts Host Disease And Pathogen Transmission Potential, Alaina C. Pfenning-Butterworth, Rachel E. Vetter, Jessica L. Hite

School of Biological Sciences: Faculty Publications

Animals ranging from mosquitoes to humans often vary their feeding behavior when infected or merely exposed to pathogens. These so-called “sickness behaviors” are part of the innate immune response with many consequences, including avoiding orally transmitted pathogens. Fully understanding the role of this ubiquitous behavior in host defense and pathogen evolution requires a quantitative account of its impact on host and pathogen fitness across environmentally relevant contexts. Here, we use a zooplankton host and fungal pathogen as a case study to ask if infection-mediated feeding behaviors vary across pathogen exposure levels and natural genetic variation in susceptibility to infection. Then, …

Spartan Daily, February 9, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 7

February 9, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Landscape Of Immunotherapy For Retroperitoneal Sarcoma, Alicia A Gingrich, Elise F Nassif, Christina L Roland, Emily Z Keung

Faculty, Staff and Student Publications

Significant multidisciplinary scientific effort has been undertaken to understand the heterogeneous family of neoplasms that comprise soft tissue sarcomas. Within this family of neoplasms, outcomes for retroperitoneal sarcomas (RPS) are currently limited given a lack of effective therapies. In this review, we focus on immunotherapy and its relationship with the common RPS histologic subtypes. Although initial outcomes for RPS patients with immune checkpoint inhibition alone have been somewhat disappointing, subsequent analyses on histologies, the tumor microenvironment, sarcoma immune class, tumor infiltrating lymphocytes and genetic analysis for tumor mutational burden have yielded insight into the interplay between sarcomas and immunotherapy. Such …

Deep Seabed Mining Lacks Social Legitimacy, A Jaeckel, H Harden-Davies, Dj Amon, Der Grient J Van, Q Hanich, Leeuwen J Van, Hj Niner, Katherine Seto

School of Biological and Marine Sciences

IntroductionThe technology to mine the ocean floor for valuable minerals such as copper, nickel, and cobalt is currently being developed. Scientists have warned repeatedly about potentially serious and irreversible environmental impacts from deep seabed mining (DSM), including but not limited to: removal and destruction of sensitive and poorly known seafloor habitats and species; metal-contaminated and fine-particle sediment plumes that can impact benthic and pelagic fauna; changes to water properties; and increases in noise and light1,2. What remains to be substantially debated are the social impacts of DSM.

Splicing Factor Srsf1 Deficiency In The Liver Triggers Nash-Like Pathology And Cell Death, Waqar Arif, Bhoomika Mathur, Michael F Saikali, Ullas V Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M Blue, Brian A Yee, Eric L Van Nostrand, Sushant Bangru, Grace Guzman, Gene W Yeo, Kannanganattu V Prasanth, Sayeepriyadarshini Anakk, Carolyn L Cummins, Auinash Kalsotra

Faculty, Staff and Students Publications

Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its many roles in mRNA metabolism, it is also crucial for maintaining genome stability. We show that acute liver damage in the setting of targeted SRSF1 deletion in mice is associated with the excessive formation of deleterious RNA-DNA hybrids (R-loops), which induce DNA damage. Combining hepatocyte-specific transcriptome, proteome, and RNA binding analyses, we demonstrate that widespread genotoxic stress following SRSF1 depletion results in global inhibition of mRNA …

Nrf2 Sequestration By Ssh1 Tips The Balance From Neuroprotection To Neurodegeneration In Alzheimer’S Disease, Sara G. Cazzaro Buosi

USF Tampa Graduate Theses and Dissertations

Oxidative damage is one of the earliest events in Alzheimer’s disease (AD) pathogenesis and precedes the clinical stage of disease. The nuclear factor erythroid 2-related factor (Nrf2) is activated in response to oxidative stress, which protects the brain from oxidative damage and AD pathogenesis. Although Nrf2-mediated oxidative stress response declines with age and becomes dysfunctional in AD brains, the mechanistic basis for this dysfunction is unknown. Here, we demonstrate through in vitro and in vivo models, as well as in human AD brain tissue, that Slingshot homolog-1 (SSH1) acts as a counterweight to neuroprotective Nrf2 in response to oxidative stress …

Acceptability And Tolerability Of Extended Reality Relaxation Training With And Without Wearable Neurofeedback In Pediatric Migraine., Mark Connelly, Madeline Boorigie, Klanci Mccabe

Manuscripts, Articles, Book Chapters and Other Papers

Objective. To determine the acceptability of using extended reality (XR) relaxation training as a preventive treatment for pediatric migraine. Methods. Youths aged 10-17 years old with migraine were recruited from a specialty headache clinic and completed baseline measures evaluating their vestibular symptoms and attitudes about technology. The patients were then instructed in three XR-based relaxation training conditions (fully immersive virtual reality with and without neurofeedback, and augmented reality with neurofeedback), in counterbalanced order, and completed acceptability and side effect questionnaires after each. The patients also took XR equipment home for one week to use for relaxation practice and again completed …

Atomistic Simulation Studies Of Thin Film Growth And Plastic Deformation In Metals And Metal/Ceramic Nanostructures, Reza Namakian

LSU Doctoral Dissertations

Despite the significant improvements in manufacturing and synthesis processes of metals and ceramics in the past decades, there are still areas in which the procedure is still frequently more of an art or skill rather than a science. Therefore, systematic and combined experimental and computational studies are required to facilitate the development of techniques that offer thorough understanding of the events taking place during manufacturing and synthesis processes. With regard to these issues, it is paramount to address microscale characterizations and atomic scale understanding of the events during fabrication processes. One of the focuses of this study is unraveling fundamental …

The Clinical And Genetic Spectrum Of Autosomal-Recessive Tor1a-Related Disorders, Afshin Saffari, Tracy Lau, Homa Tajsharghi, Ehsan Ghayoor Karimiani, Ariana Kariminejad, Stephanie Efthymiou, Giovanni Zifarelli, Tipu Sultan, Mehran Beiraghi Toosi, Shahnaz Ibrahim

Department of Paediatrics and Child Health

In the field of rare diseases, progress in molecular diagnostics led to the recognition that variants linked to autosomal-dominant neurodegenerative diseases of later onset can, in the context of biallelic inheritance, cause devastating neurodevelopmental disorders and infantile or childhood-onset neurodegeneration. TOR1A-associated arthrogryposis multiplex congenita 5 (AMC5) is a rare neurodevelopmental disorder arising from biallelic variants in TOR1A, a gene that in the heterozygous state is associated to torsion dystonia-1 (DYT1 or DYT-TOR1A), an early-onset dystonia with reduced penetrance. While 15 individuals with TOR1A-AMC5 have been reported (less than 10 in detail), a systematic investigation of the full disease-associated spectrum has …

Chikungunya Virus And Its Envelope Protein E2 Induce Hyperalgesia In Mice: Inhibition By Anti-E2 Monoclonal Antibodies And By Targeting Trpv1, Carina Z Segato-Vendrameto, Felipe A Pinho-Ribeiro, Et Al.

2020-Current year OA Pubs

Chikungunya virus is an arthropod-borne infectious agent that causes Chikungunya fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly the extremities but also the large joints such as the knees. Chronic disease symptoms persist for months, even after clearance of the virus from the blood. Envelope proteins stimulate the immune response against the Chikungunya virus, becoming an important therapeutic target. We inactivated the Chikungunya virus (iCHIKV) and produced recombinant E2 (rE2) protein and three different types of anti-rE2 monoclonal antibodies. Using these tools, we observed that iCHIKV and rE2 protein induced mechanical hyperalgesia (electronic aesthesiometer test) …

The Mechanism Of Enantioselective Neurosteroid Actions On Gaba, Hiroki Tateiwa, Satyanarayana M Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L Germann, Spencer R Pierce, Douglas F Covey, Gustav Akk, Alex S Evers

2020-Current year OA Pubs

The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABA

Evaluation Of Qpcr To Detect Shifts In Population Composition Of The Rhizobial Symbiont Mesorhizobium Japonicum During Serial In Planta Transfers, Kenjiro W. Quides, Yoobeen Lee, Teresa Hur, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Microbial symbionts range from mutualistic to commensal to antagonistic. While these roles are distinct in their outcome, they are also fluid in a changing environment. Here, we used the Lotus japonicus–Mesorhizobium japonicum symbiosis to investigate short-term and long-term shifts in population abundance using an effective, fast, and low-cost tracking methodology for M. japonicum. We use quantitative polymerase chain reaction (qPCR) to track previously generated signature-tagged M. japonicum mutants targeting the Tn5 transposon insertion and the flanking gene. We used a highly beneficial wild type and moderately beneficial and non-beneficial mutants of M. japonicum sp. nov. to demonstrate the specificity …