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Identification Of Dipeptidyl Peptidase-4 Inhibitory Compounds Of Paederia Foetida Twigs By Nuclear Magnetic Resonance Metabolomics, In Silico Models, And Liquid Chromatography–Mass Spectrometry Profiling, Dai Chuan Tan, Nur Kartinee Kassim, Intan Safinar Ismail, Siok Geok Chong

The Thai Journal of Pharmaceutical Sciences

Paederia foetida is a climber that has been traditionally used to treat various diseases, including diabetes. This study aims to investigate the dipeptidyl peptidase-4 (DPP-4) inhibitory activity of P. foetidaI/i> twig extracts and identification of the bioactive compounds by nuclear magnetic resonance (NMR) metabolomics, liquid chromatography–mass spectrometry (LC-MS), and in silico docking study. P. foetida twigs were extracted using organic solvents, namely hexane, chloroform, and methanol and submitted to DPP-4 inhibition assay. Ten milligram of each sample extract was diluted in 700 μL CDCl3 with 0.03% TMS and 1H-NMR spectra were recorded at 25°C on a JEOL FT-NMR spectrometer. The …

Anti-Inflammatory Activity Of Propolis Extract From The Stingless Bee, Tetragonula Pagdeni, In Mangosteen Orchard, Warisara Parichatikanond, Supachoke Mangmool, Savita Chewchinda, Vilasinee Hirunpanich, Boonyadist Vongsak

The Thai Journal of Pharmaceutical Sciences

In Thailand, Tetragonula pagdeni (TP) Schwarz is one of the most common and abundantly cultured stingless bee species in mangosteen orchards. The propolis extract of TP has been used as a traditional medicine to treat inflammation. TP propolis extract also exhibited antioxidant, antiproliferative, and antimicrobial properties in scientific reports. However, the anti-inflammatory effect of TP propolis extract has been limited. Thus, this study aims to evaluate the anti-inflammatory and antioxidant effects of TP propolis extract through alteration of mRNA expression of genes involved in inflammatory processes, including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines (e.g., tumor necrosis factor-α …

2023/2024 University Of The Pacific Graduate Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

Development And Reliability Analysis Of A Split-Administration Test Of The Math Epistemic Games Survey, Stephen Hackler, E. Elliott, M. Eichenlaub, Alison M. Sweeney

Physics & Astronomy Faculty Works

The increasing and diversifying student enrollments in introductory physics courses make reliable, valid, and usable instruments for measuring student skills and gains ever more important. In introductory physics, in addition to teaching facts about mechanics, we also seek to teach our students the skills of “thinking like a physicist,” or expertise in and intuition for physical problem solving. How and when these expert, intuitive problem-solving skills emerge during a STEM education, or what the most effective teaching methods might be, are not certain. A facile survey to measure students’ “physics-thinking” skills in a pretest and post-test format is therefore desirable …

Treatment Of Chronic Migraine With Botox (Onabotulinumtoxina): Development, Insights, And Impact, Catherine C. Turkel, Sheena Aurora, Hans-Christoph Diener, David W. Dodick, Richard B. Lipton, Stephen D. Silberstein, Mitchell F. Brin

Department of Jefferson Headache Center Papers and Presentations

Chronic migraine (CM) is a neurological disease characterized by frequent migraine attacks that prevent affected individuals from performing daily activities of living, significantly diminish quality of life, and increase familial burden. Before onabotulinumtoxinA was approved for CM, there were few treatment options for these seriously disabled patients and none had regulatory approval. The terminology and recognition of CM evolved in parallel with the onabotulinumtoxinA clinical development program. Because there were no globally accepted classification criteria for CM when onabotulinumtoxinA was in development, the patient populations for the trials conducted by Allergan were determined by the Allergan migraine team in collaboration …

The Viral Picture Of Well-Being: Biggest Concerns, Losses, And Unintended Gifts Of Covid-19 In The Philippines, Ma Teresa Tuason, Kelly Perniciaro, Richel Lamadrid, Jego Mallillin, C. Dominik Güss

Ateneo School of Medicine and Public Health Publications

The COVID-19 pandemic revealed more than anticipated about global human functioning and resiliency. This Philippines-based study replicated a recent U.S. COVID analysis on psychological well-being (PWB). Factors examined herein were grouped into categories for analysis: 1) predictors of PWB, 2) areas of greatest stress or worry (biggest concerns), 3) perceived or real losses across SES, and 4) identified “unintended gifts” across PWB. Participants (n = 1345) were volunteers who responded to an online survey from August to September 2021, peak of the Delta variant. Three general groups of predictors (biological, psychological, and socio-economic) contributed to PWB. A regression model containing …

Summer 2023, Echoes Staff

Rose Echoes

No abstract provided.

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Likelihood-Based Tests Of Species Tree Hypotheses, Richard Adams, Michael Degiorgio

Entomology and Plant Pathology Faculty Publications and Presentations

Likelihood-based tests of phylogenetic trees are a foundation of modern systematics. Over the past decade, an enormous wealth and diversity of model-based approaches have been developed for phylogenetic inference of both gene trees and species trees. However, while many techniques exist for conducting formal likelihood-based tests of gene trees, such frameworks are comparatively underdeveloped and underutilized for testing species tree hypotheses. To date, widely used tests of tree topology are designed to assess the fit of classical models of molecular sequence data and individual gene trees and thus are not readily applicable to the problem of species tree inference. To …

The Sheep Is A Body Of Knowledge, Stacie Denetsosie

CutBank

No abstract provided.

Cutbank 99

CutBank

No abstract provided.

Online But Unlawful Sales Of Unapproved And Misbranded Prescription Drugs: Internet Pharmacy Compliance With Food And Drug Administration Warning Letters, Yam B. Limbu, Bruce A. Huhmann

Department of Marketing Faculty Scholarship and Creative Works

Consumers increasingly use online pharmacies. However, illicit online pharmacies endanger consumer welfare with unapproved and counterfeit drugs. By linking Food and Drug Administration (FDA) warning letter content with observations of the 1108 websites cited in those letters, we identify factors associated with FDA-requested compliance and active/inactive website status. One in five online pharmacies failed to comply with FDA recommendations. Findings support the cost/benefit, social norm, and instrumental theories of compliance. Compliance declines with cost (e.g., when the FDA requests changes to more drug categories). Organized crime's social norms encourage law breaking; thus, illicit pharmacies comply less than other online pharmacies. …

Managing The Creative Frontier Of Generative Ai: The Novelty-Usefulness Tradeoff, Anirban. Mukherjee, Hannah H. Chang

Research Collection Lee Kong Chian School Of Business

In this paper, drawing inspiration from the human creativity literature, we explore the optimal balance between novelty and usefulness in generative Artificial Intelligence (AI) systems. We posit that overemphasizing either aspect can lead to limitations such as hallucinations and memorization. Hallucinations, characterized by AI responses containing random inaccuracies or falsehoods, emerge when models prioritize novelty over usefulness. Memorization, where AI models reproduce content from their training data, results from an excessive focus on usefulness, potentially limiting creativity. To address these challenges, we propose a framework that includes domain-specific analysis, data and transfer learning, user preferences and customization, custom evaluation metrics, …

Genomic Analysis Of Clostridioides Difficile Recovered From Horses In Western Australia, Natasza M. R. Hain-Saunders, Daniel R. Knight, Mieghan Bruce, David Byrne, Thomas V. Riley

Research outputs 2022 to 2026

Clostridioides difficile poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in community-associated C. difficile infection (CDI) and growing evidence of inter-species transmission suggest a wider perspective is required for CDI control. In horses, C. difficile is a major cause of diarrhoea and life-threatening colitis. This study aimed to better understand the epidemiology of CDI in Australian horses and provide insights into the relationships between horse, human and environmental strains. A total of 752 faecal samples from 387 Western Australian horses were collected. C. difficile was isolated from …

July 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist

Electronic Theses and Dissertations

The unique set of impairments and limitations presented by students with autism spectrum disorder (ASD) make the accessing of campus-based nonacademic resources more difficult and complicated than their typically developed peers. Each year, the rate of students entering college with disabilities continues to grow, but their mental well-being is relatively poor. The purpose of this qualitative case study was to apply the conceptual framework of the Andersen behavioral model of health services use (ABMHSU) to the experiences of college students with ASD to understand and predict their utilization of campus-provided mental health resources. The participants were seven college students with …

Photocatalytic Degradation Of Fluorescein Dye Through Sns2/Sno2 Photocatalyst For Efficient Environmental Remediation, Saddam Alaskary

Chemical Engineering

The SnS2/SnO2 nanocomposite, employed as a photocatalyst for the photodegradation of fluorescein dye, demonstrates the significant role of mass ratio and catalyst dosage in photocatalytic degradation. The relatively small disparity between the conduction bands of SnS2 (ECB = -0.895 eV) and SnO2 (ECB = 0.15 eV) is conducive for the formation of a Z-scheme, which curbs the recombination process and elevates photocatalytic activity. The nanocatalyst was synthesized using the sol-gel method and subsequently characterized through XRD, SEM, TEM, EDX, mapping, DRS, and XPS. The peak intensity of the photoluminescence (PL) study, relating to the optical property of the catalyst, was …

Hacking The Library Exhibition Pdfs, Sally Brown, Christine Hoffmann, Lois Ann Raimondo, Karen Diaz, Sarah Pahlfrey

Faculty & Staff Scholarship

The hacker ethos in the positive sense is about the ability to deconstruct and reconstruct information systems. Hacking starts with reconceptualizing libraries. L Hacking the Library presents artwork that highlights the intersecting values that shape our libraries through an artistic lens, reflecting on challenges and definitions of libraries past and as we move into the future. To provide personal context, "Community Connections" complement the art from librarians across the nation who responded to the artwork.

Artists included: Jackie Andrews (Maryland, mixed media), Trudy Borenstein- Sugiura (New Jersey, book arts), Sally Jane Brown (West Virginia, drawing), Shan Cawley (West Virginia, painting), …

Summer 2023 Gsbms Alumni Connections, New York Medical College

Graduate School of Biomedical Sciences

• NYMC Celebrates the Class of 2023 at 164th Commencement Exercises
• Days of Giving Raises $480,000 for Student Scholarships
• Graduate Student Research Forum Highlights Impressive Student Research
• Alumni Resume Local Gatherings
• Study Demonstrates Novel Area of Investigation to Treat Hypertension
• NYMC Researchers Invited to Publish Chapter in Advances in Pharmacology
• NYMC Hosts Ninth Annual Drs. Gabor and Harriette Kaley Endowed Lecture
• The Family Health Center Celebrates Three Years at NYMC
• NYMC Supports Relief Efforts for Victims of Turkey and Syria Earthquake
• Yom Hashoah Observance Explores the “Dachau Ashes”
• NYMC and TU Presented “Ninety Minutes: The Medical Magazine of the Web”
• Student …

Genome-Wide Association Analysis Identifies Ancestry-Specific Genetic Variation Associated With Acute Response To Metformin And Glipizide In Sugar-Mgh, Josephine H. Li, Laura N. Brenner, Varinderpal Kaur, Katherine Figueroa, Philip Schroeder, Alicia Huerta-Chagoya, Alicia Huerta-Chagoya, Ji Chen, Cassandra N. Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’An Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud S. Boutin, Reedik Mägi, Johannes Waage, Ruifang Li-Gao, Kei Hang Katie Chan, Jie Yao, Mila D. Anasanti, Audrey Y. Chu, Annique Claringbould, Jani Heikkinen, Jaeyoung Hong, Jouke Jan Hottenga, Shaofeng Huo, Marika A. Kaakinen, Tin Louie, Winfried März, Hortensia Moreno-Macias

Population and Public Health Science Faculty Publications

Aims/hypothesis: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic associations for the response to common glucose-lowering medications in individuals at risk of type 2 diabetes. Methods: One thousand participants at risk for type 2 diabetes from diverse ancestries underwent sequential glipizide and metformin challenges. A genome-wide association study was performed using the Illumina Multi-Ethnic Genotyping …

Why We Work: Exploring The Relationships Between Work Rewards, Burnout, And Intention To Leave For Professional Nurses, Jacqueline Christianson

Dissertations (1934 -)

Nurse burnout leads to attrition from hospital nursing positions and the nursing profession prior to typical retirement age. Yet some nurses choose to stay despite burnout. Previous research indicates that nurses stay due to the rewards they receive from work but the relationships between different types of work rewards, work-related burnout, and intention to leave are poorly described. The ability to implement or execute altruistic behaviors may also represent an under-recognized work reward. Thus, the purpose of this study is to investigate the relationships between work rewards, work-related burnout, and intention to leave nursing positions and the nursing profession and …

Horizontal Transfer Of Probable Chicken-Pathogenicity Chromosomal Islands Between Staphylococcus Aureus And Staphylococcus Agnetis, Douglas D. Rhoads, Jeff Pummil, Nnamdi S. Ekesi, Adnan A.K. Alrubaye

Cell and Molecular Biology Faculty Publications and Presentations

Staphylococcus agnetis is an emerging pathogen in chickens but has been most commonly isolated from sub-clinical mastitis in bovines. Previous whole-genome analyses for known virulence genes failed to identify determinants for the switch from mild ductal infections in cattle to severe infections in poultry. We now report identification of a family of 15 kbp, 17–19 gene mobile genetic elements (MGEs) specific to chicken osteomyelitis and dermatitis isolates of S. agnetis. These MGEs can be present in multiple copies per genome. The MGE has been vectored on a Staphylococcus phage that separately lysogenized two S. agnetis osteomyelitis strains. …

Teacher Use Of Computer Generated Feedback Through Online Programs, Sheena Wehr

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Since the COVID-19 pandemic, the use of computer-based supplemental programs has grown in popularity (Li & Zhao, 2022). These programs provide both teachers and students with varying amounts of feedback and data for each standard addressed (Shin et al., 2021). However, since many schools implemented these programs during the pandemic there was a lack of training or professional development, therefore teachers relied on learn-as-you-go methods. The goal of this research was to determine how teachers in Florida were currently using computer-generated feedback to drive their instruction and improve overall student achievement. The study concentrated on secondary mathematics teachers who utilize …

Evidence For Two Soybean Looper Strains In The United States With Limited Capacity For Cross-Hybridization, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker) is an economically important pest of soybeans (Glycine max (L.) Merr.) in the southeastern United States. It has characteristics that are of particular concern for pest mitigation that include a broad host range, the capacity for annual long-distance flight, and resistance in some populations to important pesticides such as pyrethroids and chitin synthesis inhibitor. The biology of SBL in the United States resembles that of the fellow noctuid fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), a major pest of corn and several other crops. FAW exhibits a population structure in that …

Investigating The Migratory Behavior Of Soybean Looper, A Major Pest Of Soybean, Through Comparisons With The Corn Pest Fall Armyworm Using Mitochondrial Haplotypes And A Sex-Linked Marker, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The Noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker), is an economically important pest of soybean (Glycine max (Linnaeus) Merrill). Because it is not known to survive freezing winters, permanent populations in the United States are believed to be limited to the southern regions of Texas and Florida, yet its geographical range of infestations annually extend to Canada. This indicates annual migrations of thousands of kilometers during the spring and summer growing season. This behavior is like that of the fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), also a Noctuid that is a major global pest of corn. SBL and …

Louisiana Agriculture Magazine, Summer 2023

Louisiana Agriculture

Rice, alligators and sugarcane are quintessential Louisiana products, and LSU AgCenter researchers and extension agents devote themselves to helping the producers who grow them. Economists are finding ways to improve the market for alligators while specialists focus on innovation in the sugar industry and creating new varieties of rice.

AgCenter researchers also have an eye on the natural world. They are protecting the roseau cane that thrives on the coast and the ironwood trees of Guam. All these efforts are detailed in this issue of Louisiana Agriculture magazine.

Clathrin-Mediated Endocytosis Facilitates The Internalization Of Magnaporthe Oryzae Effectors Into Rice Cells, Ely Oliveira-Garcia, Tej Man Tamang, Jungeun Park, Melinda Dalby, Magdalena Martin-Urdiroz, Clara Rodriguez Herrero, An Hong Vu, Sunghun Park, Nicholas J. Talbot, Barbara Valent

Faculty Publications

Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and control plant processes needed for infection. Little is known about the mechanism by which these pathogens translocate effector proteins across the plasma membrane into the plant cytoplasm. The blast fungus Magnaporthe oryzae secretes cytoplasmic effectors into a specialized biotrophic interfacial complex (BIC) before translocation. Here, we show that cytoplasmic effectors within BICs are packaged into punctate membranous effector compartments that are occasionally observed in the host cytoplasm. Live cell imaging with fluorescently labeled proteins in rice (Oryza sativa) showed that these effector puncta colocalize with the plant …

A Cyclical Phenomenon Among Stock & Commodity Markets, Hector O. Zapata, Junior E. Betanco, Maria Bampasidou, Michael Deliberto

Faculty Publications

Considerable studies have examined the relationship between commodity markets and stock markets. This paper studies the cyclical relationship between commodity markets and stock markets with implications for investing based on index relationships. Stock markets are represented by the U.S. S&P 500 index and aggregate commodity markets by the U.S. producer price index (PPI). Tradeable market indexes readily available to investors, namely the S&P GSCI Index and the Bloomberg Commodity Index (BCOM), are also studied. An optimal bandpass filter is used to estimate the cyclical component using a pricing-performance measure of the S&P 500 relative to the PPI, based on annual …

Extended Sentinel Monitoring Of Helicoverpa Zea Resistance To Cry And Vip3aa Toxins In Bt Sweet Corn: Assessing Changes In Phenotypic And Allele Frequencies Of Resistance, Galen P. Dively, Tom P. Kuhar, Sally V. Taylor, Helene Doughty, Kristian Holmstrom, Daniel O. Gilrein, Brian A. Nault, Joseph Ingerson-Mahar, Anders Huseth, Dominic Reisig, Shelby Fleischer, David Owens, Kelley Tilmon, Francis Reay-Jones, Pat Porter, Jocelyn Smith, Julien Saguez, Jason Wells, Caitlin Congdon, Holly Byker, Bryan Jensen, Chris Difonzo, William D. Hutchison, Eric Burkness, Robert Wright, Michael Crossley, Heather Darby, Tom Bilbo, Nicholas Seiter, Christian Krupke, Craig Abel, Brad S. Coates, Bradley Mcmanus

Faculty Publications

Transgenic corn and cotton that produce Cry and Vip3Aa toxins derived from Bacillus thuringiensis (Bt) are widely planted in the United States to control lepidopteran pests. The sustainability of these Bt crops is threatened because the corn earworm/bollworm, Helicoverpa zea (Boddie), is evolving a resistance to these toxins. Using Bt sweet corn as a sentinel plant to monitor the evolution of resistance, collaborators established 146 trials in twenty-five states and five Canadian provinces during 2020–2022. The study evaluated overall changes in the phenotypic frequency of resistance (the ratio of larval densities in Bt ears relative to densities in non-Bt ears) …

Large Uncertainties In Co2 Water–Air Outgassing Estimation With Gas Exchange Coefficient Kt For A Large Lowland River, Anamika Dristi, Y. Jun Xu

Faculty Publications

Aquatic CO2 emission is typically estimated (i.e., not measured) through a gas exchange balance. Several factors can affect the estimation, primarily flow velocity and wind speed, which can influence a key parameter, the gas exchange coefficient KT in the balancing approach. However, our knowledge of the uncertainty of predictions using these factors is rather limited. In this study, we conducted a numeric assessment on the impact of river flow velocity and wind speed on KT and the consequent CO2 emission rate. As a case study, we utilized 3-year (2019–2021) measurements on the partial pressure of dissolved carbon dioxide (pCO2) in …