Digital Commons Network^™

Substantially Enhanced Landscape Carbon Sink Due To Reduced Terrestrial-Aquatic Carbon Transfer Through Soil Conservation In The Chinese Loess Plateau, Lishan Ran, Nufang Fang, Xuhui Wang, Shilong Piao, Chun Ngai Chan, Siliang Li, Yi Zeng, Zhihua Shi, Mingyang Tian, Yi Jun Xu, Junyu Qi, Boyi Liu

Faculty Publications

Soil conservation is of global importance, as accelerated soil erosion by human activity is a primary threat to ecosystem viability. However, the significance and role of soil conservation in reshaping landscape carbon (C) accounting has not been comprehensively integrated in the terrestrial C sink. Here, we present the first integrated assessment of the modified terrestrial C sink and aquatic C transport due to soil conservation for the semiarid Chinese Loess Plateau (CLP), the world's most vulnerable region to soil erosion. We show a surprisingly low terrestrial-aquatic C transfer that offset the terrestrial net ecosystem productivity by only 7.5%, which we …

A Modified-Herringbone Micromixer For Assessing Zebrafish Sperm (Mags), Jorge A. Belgodere, Mustafa Alam, Valentino E. Browning, Jason Eades, Jack North, Julie A. Armand, Yue Liu, Terrence R. Tiersch, W. Todd Monroe

Faculty Publications

Sperm motility analysis of aquatic model species is important yet challenging due to the small sample volume, the necessity to activate with water, and the short duration of motility. To achieve standardization of sperm activation, microfluidic mixers have shown improved reproducibility over activation by hand, but challenges remain in optimizing and simplifying the use of these microdevices for greater adoption. The device described herein incorporates a novel micromixer geometry that aligns two sperm inlet streams with modified herringbone structures that split and recombine the sample at a 1:6 dilution with water to achieve rapid and consistent initiation of motility. The …

An Artemisia Scoparia Extract Attenuates Glucocorticoid-Induced Lipolysis In Adipocytes, Innocence Harvey, Jacqueline M. Stephens

Division of Basic Science Faculty Publications

Objective: Prescription glucocorticoid (GC) use is widespread across developed countries for the treatment of several inflammatory conditions. Elevated GCs are known to promote lipolysis and metabolic disorders. An extract of Artemisia scoparia (SCO) has been shown to reduce lipolysis and promote metabolic health but has not been investigated in the context of excess GCs. Our aim was to examine the effects of SCO on GC-induced lipolysis. Methods: Mature adipocytes were pretreated with vehicle or SCO, then exposed to either the synthetic GC dexamethasone (DEX) or tumor necrosis factor alpha (TNFα). Medium was collected and assayed for glycerol and fatty acids …

Obesogens And Obesity: State-Of-The-Science And Future Directions Summary From A Healthy Environment And Endocrine Disruptors Strategies Workshop, Jerrold J. Heindel, Jessica A. Alvarez, Ella Atlas, Matthew C. Cave, Vaia Lida Chatzi, David Collier, Barbara Corkey, Douglas Fischer, Michael I. Goran, Sarah Howard, Scott Kahan, Matthias Kayhoe, Suneil Koliwad, Catherine M. Kotz, Michele La Merrill, Tim Lobstein, Carey Lumeng, David S. Ludwig, Robert H. Lustig, Pete Myers, Angel Nadal, Leonardo Trasande, Leanne M. Redman, Matthew S. Rodeheffer, Robert M. Sargis, Jacqueline M. Stephens, Thomas R. Ziegler, Bruce Blumberg

Division of Basic Science Faculty Publications

On September 7 and 8, 2022, Healthy Environment and Endocrine Disruptors Strategies, an Environmental Health Sciences program, convened a scientific workshop of relevant stakeholders involved in obesity, toxicology, or obesogen research to review the state of the science regarding the role of obesogenic chemicals that might be contributing to the obesity pandemic. The workshop's objectives were to examine the evidence supporting the hypothesis that obesogens contribute to the etiology of human obesity; to discuss opportunities for improved understanding, acceptance, and dissemination of obesogens as contributors to the obesity pandemic; and to consider the need for future research and potential mitigation …

Current Discoveries And Future Implications Of Eating Disorders, Bing Feng, Jerney Harms, Emily Chen, Peiyu Gao, Pingwen Xu, Yanlin He

Division of Basic Science Faculty Publications

Eating disorders (EDs) are characterized by severe disturbances in eating behaviors and can sometimes be fatal. Eating disorders are also associated with distressing thoughts and emotions. They can be severe conditions affecting physical, psychological, and social functions. Preoccupation with food, body weight, and shape may also play an important role in the regulation of eating disorders. Common eating disorders have three major types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). In some cases, EDs can have serious consequences for an individual’s physical and mental health. These disorders often develop during adolescence or early adulthood and affect …

Long-Term Capture Data Uncover Shifts In The Daily Activity Patterns Of Amazonian Birds, Cameron L. Rutt, Philip C. Stouffer, Bruna R. Amaral, David A. Luther

Faculty Publications

Although the duration of biological rhythms varies from milliseconds to decades, daily cycles are especially widespread for individual organisms. These circadian rhythms are synchronized by light–dark cycles, which govern predictable changes in other microclimate variables. Despite the fixed, regular nature of these abiotic cycles at low latitudes, little is known about how different animals structure activity along these gradients. We used 25 years of capture–recapture data and ~ 25 000 unique captures to characterize ‘activity' (time of capture) for 65 species of Amazonian birds in the lowest forest stratum (0–2.5 m). To quantify vertical niche breadths, we also measured foraging …

Measuring In Vivo Adipose Tissue Kinetics In Humans Using The Deuterium (2h)-Labeling Approach, Dereck Kibodeaux, Jonathan Savoie, Eric Ravussin, Mark Fitch, Marc K. Hellerstein, Ursula White

Clinical Research Faculty Publications

White adipose tissue is a highly plastic organ that is necessary to maintain whole-body energy homeostasis. The adipose tissue mass and changes in the fat mass or distribution are regulated by changes in the synthesis and breakdown (i.e., turnover) of adipose cells and triacylglycerols. Evidence suggests that the manner and magnitude of subcutaneous adipose tissue expansion (i.e., hypertrophy vs. hyperplasia) and turnover can influence metabolic health, as adipogenesis has been implicated in the pathogenesis of obesity and related diseases. Despite the potential role of adipose turnover in human health, there is a lack of knowledge about the in vivo kinetics …

Extensive Independent Amplification Of Platy-1 Retroposons In Tamarins, Genus Saguinus, Jessica M. Storer, Jerilyn A. Walker, Thomas O. Beckstrom, Mark A. Batzer

Faculty Publications

Platy-1 retroposons are short interspersed elements (SINEs) unique to platyrrhine primates. Discovered in the common marmoset (Callithrix jacchus) genome in 2016, these 100 bp mobile element insertions (MEIs) appeared to be novel drivers of platyrrhine evolution, with over 2200 full-length members across 62 different subfamilies, and strong evidence of ongoing proliferation in C. jacchus. Subsequent characterization of Platy-1 elements in Aotus, Saimiri and Cebus genera, suggested that the widespread mobilization detected in marmoset (family Callithrichidae) was perhaps an anomaly. Two additional Callithrichidae genomes are now available, a scaffold level genome assembly for Saguinus imperator (tamarin; SagImp_v1) and a chromosome-level assembly …

Vcp Promotes Ttaf-Target Gene Expression And Spermatocyte Differentiation By Downregulating Mono-Ubiquitylated H2a, Tyler J. Butsch, Olga Dubuisson, Alyssa E. Johnson, K. Adam Bohnert

Faculty Publications

Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP translocates from the cytosol to the nucleus as germ cells transition into the meiotic spermatocyte stage. Importantly, nuclear translocation of VCP appears to be one crucial event stimulated by testis-specific TBP-associated factors (tTAFs) to drive spermatocyte differentiation. VCP promotes the expression of several …

Exploring Barriers To Sars-Cov-2 Testing Uptake In Underserved Black Communities In Louisiana, Peter T. Katzmarzyk, Candice A. Myers, Michelle R. Nelson, Kara D. Denstel, Emily F. Mire, Robert L. Newton, Stephanie T. Broyles, John P. Kirwan

Division of Basic Science Faculty Publications

Objective: To collect qualitative data on approaches that can potentially reduce barriers to, and create strategies for, increasing SARS-CoV-2 testing uptake in underserved Black communities in Louisiana. Methods: A series of eight focus groups, including 41 participants, were conducted in primarily Black communities. The Nominal Group Technique (NGT) was used to determine perceptions of COVID-19 as a disease, access to testing, and barriers limiting testing uptake. Results: Common barriers to SARS-CoV-2 testing were identified as lack of transportation, misinformation/lack of information, lack of time/long wait times, fear of the test being uncomfortable and/or testing positive, the cost of testing, and …

Association Between Maternal And Infant Screen Time With Child Growth And Development: A Longitudinal Study, Chelsea L. Kracht, Leanne M. Redman, Jayne Bellando, Rebecca A. Krukowski, Aline Andres

Clinical Research Faculty Publications

Background: Sedentary screen time is an early, modifiable risk factor for obesity and poor child development. Objectives: To examine the relationship between maternal and infant screen time with child growth and development. Methods: Pregnant women were recruited for a cohort study related to maternal and infant development. Screen time was assessed in mothers during pregnancy, and subsequently in children at 3 months, 12 months, and 24 months of age. Child anthropometry was measured, and nuclear magnetic resonance quantified child fat mass. Fat mass index (FMI) was calculated. The Bayley Scales of Infant Development-III were used to assess child development. Linear …

A Feasibility Study Of The Combination Of Intranasal Insulin With Dulaglutide For Cognition In Older Adults With Metabolic Syndrome At High Dementia Risk – Study Rationale And Design, Tal Davidy, Iscka Yore, Tali Cukierman-Yaffe, Ramit Ravona-Springer, Abigail Livny, Orit H. Lesman-Segev, Yossi Azuri, Owen Carmichael, Dimitrios Kapogiannis, Henrik Zetterberg, Hung Mo Lin, Mary Sano, Michal Schnaider Beeri

Clinical Research Faculty Publications

Introduction: We present the rationale and design of a double-blind placebo-controlled feasibility trial combining intranasal insulin (INI) with dulaglutide, a GLP-1 receptor agonist, to improve cognition in older adults with metabolic syndrome (MetS) and mild cognitive impairment (MCI). Since both INI and dulaglutide have beneficial effects on the cerebrovascular disease (CVD), we anticipate that improved CVD will underlie the hypothesized cognitive benefits. Methods: This 12-months trial will include 80 older adults aged > 60 with MetS and MCI, randomized to 4 groups: INI/dulaglutide injection, intranasal placebo/dulaglutide injection, INI/placebo injection, and intranasal placebo/placebo injection. Feasibility of combining INI with dulaglutide will be …

Gene Editing Provides A Tool To Investigate Genes Involved In Reproduction Of Pigs, Rodney D. Geisert, Destiny N. Johns, Caroline A. Pfeiffer, Riley M. Sullivan, Caroline G. Lucas, Constantine A. Simintiras, Bethany K. Redel, Kevin D. Wells, Thomas E. Spencer, Randall S. Prather

Faculty Publications

CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection of guide RNAs (gRNA) designed to specifically target genes, CRISPR-Cas9 gene editing allows investigation of factors proposed to regulate biological pathways involved with establishment and maintenance of pregnancy. The advantages and disadvantages of using the current gene editing technology in a large farm species is discussed. CRISPR-Cas9 gene editing of porcine conceptuses has generated new perspectives for the regulation of endometrial function during the establishment of pregnancy. The delicate orchestration …

Medical Libraries And Their Complicated Past: An Exploration Of The Historical Connections Between Medical Collections And Racial Science, Raymond Pun, Patrice R. Green, Nicollette Davis

Faculty Publications

For over a millennium, libraries and library workers have advanced the knowledge of human science by building, preserving, and sharing collections and research. Historically, libraries have also aligned their institutional responsibilities to adhere to and support the values and virtues of oppressive and colonial practices. Library history has shown the mistreatments and denials of information access of marginalized groups. The history of libraries in the health and medical sciences reveals how these institutions and their workers have preserved and circulated research studies perpetuating racial science. This commentary highlights how such institutions shape and contribute to racial science in the field …

Effects Of Alkylation On Potency Of Benz[A]Anthracene For Ahr2 Transactivation In Nine Species Of Freshwater Fish, Justin Dubiel, Hunter Johnson, Andreas N.M. Eriksson, A. Hontela, Jon A. Doering, Steve Wiseman

Faculty Publications

Polycyclic aromatic hydrocarbons (PAHs) are naturally occurring or anthropogenic organic chemicals that can activate the aryl hydrocarbon receptor 2 (AhR2) and induce toxicity in fishes. Alkyl PAHs are more abundant than nonalkylated PAHs in certain environmental matrices and there is growing evidence that alkylation can increase potency, dependent on the position of alkylation. However, it is unknown if the effect of alkylation on potency is conserved across species. In addition, relatively little is known regarding the extent of interspecies variation in sensitivity to PAHs and alkyl PAHs. Therefore, objectives of the present study were to characterize potency of benz[a]anthracene (BAA) …

Transcription Factor Pecs Mediates Agrobacterium Fabrum Fitness And Survival, George C. Nwokocha, Prava Adhikari, Asif Iqbal, Hannah Elkholy, William T. Doerrler, John C. Larkin, Anne Grove

Faculty Publications

The transcriptional regulator PecS is encoded by select bacterial pathogens. For instance, in the plant pathogen Dickeya dadantii, PecS controls a range of virulence genes, including pectinase genes and the divergently oriented gene pecM, which encodes an efflux pump through which the antioxidant indigoidine is exported. In the plant pathogen Agrobacterium fabrum (formerly named Agrobacterium tumefaciens), the pecS-pecM locus is conserved. Using a strain of A. fabrum in which pecS has been disrupted, we show here that PecS controls a range of phenotypes that are associated with bacterial fitness. PecS represses flagellar motility and chemotaxis, which are processes that are …

Reducing The Generation Time In Winter Wheat Cultivars Using Speed Breeding, Adam Schoen, Sydney Wallace, Meghan Fisher Holbert, Gina Brown-Guidera, Stephen Harrison, Paul Murphy, Nicholas Sanantonio, David Van Sanford, Richard Boyles, Mohamed Mergoum, Nidhi Rawat, Vijay Tiwari

Faculty Publications

Reducing generation time is critical to achieving the goals of genetic gain in important crops like wheat (Triticum aestivum). Speed breeding (SB) has been shown to considerably reduce generation times in crop plants. Unlike spring wheat cultivars, winter wheat varieties require typically 6–9 weeks of cold treatment, called vernalization, for flowering which extends the generation time for the development of improved winter wheat cultivars. Here, we optimized the SB method using a set of 48 diverse soft red winter wheat (SRWW) cultivars by testing vernalization duration, light and temperature requirements, and the viability of seeds harvested after different durations post-anthesis …

Multi-Functional Boron-Delivery Agents For Boron Neutron Capture Therapy Of Cancers, Sebastian O. Oloo, Kevin M. Smith, Maria Da Graça H. Vicente

Faculty Publications

Boron neutron capture therapy (BNCT) is a binary cancer treatment that involves the irradiation of ¹⁰B-containing tumors with low-energy neutrons (thermal or epithermal). The alpha particles and recoiling Li nuclei that are produced in the ¹⁰B-capture nuclear reaction are high-linear-energy transfer particles that destroy boron-loaded tumor cells; therefore, BNCT has the potential to be a localized therapeutic modality. Two boron-delivery agents have been used in clinical trials of BNCT in patients with malignant brain tumors, cutaneous melanoma, or recurrent tumors of the head and neck region, demonstrating the potential of BNCT in the treatment of difficult cancers. A …

Labrad : Vol 48, Issue 1 - July 2023, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Editorial
• Articles
• Toxicology In Public Health: Mitigating Risk, Fostering Well-Being
• Predictive And Prognostic Biomarkers in Histopathology
• Cancer Registry and Public Health Surveillance - Role of Pathologists
• Diagnosis of Celiac Disease DQA1*02,05; DQB1*02,03:02 (DQ2&DQ8) in patients
• Magnifying The Clinical Value of Expert Review and Reassessment
• Urine Cytology: A Screening and Surveillance Test
• An Overview of Convalescent Plasma for The Treatment of COVID-19
• Role of Imaging in Public Health Care
• Microsatellite Instability (MSI) Testing
• MRI Liver with Hepatocyte-Specific Contrast Agent
• Basics and Role of Cytopathology
• Bone Tumors: From Timely Diagnosis to Improved Patient Outcome
• Differentiating Between Dengue Fever and Malaria Using The …

Clear As Glass: Novel Antibiotic Glasses Vitrified From Solution, Claire Lamberti

Chemistry Theses and Dissertations

The World Health Organization (W.H.O.) has maintained a list of essential medicines since 1977 (1). This list contains the medications considered to be the most effective and of the utmost importance to the needs of worldwide healthcare systems. If new forms of these drugs can be created, they can be studied for potential stability and transportation purposes, as well as drug delivery mechanisms. There are strategies to try and improve the physicochemical properties including forming polymorphs, salts, cocrystals, and amorphous formulations. There are issues with these techniques, and a large one is that in most cases the crystal structures of …

Strategies For Improving Mental Health And Wellbeing Used By Adults Ageing With Hiv From The Kenyan Coast: A Qualitative Exploration, Peter Mwangala, Ryan G. Wagner, Charles R. Newton, Amina Abubakar

Institute for Human Development, East Africa

Background: Physical and mental health problems are common among older adults living with HIV (OALWH). Adaptive coping strategies play a vital role in improving these adults' mental health and well-being despite the deleterious effects of HIV and ageing. However, in sub-Saharan Africa, limited evidence exists on the commonly utilized coping strategies in this population. We explore the coping strategies used by Kenyan OALWH to improve their mental health and wellbeing.

Methods: Semi-structured in-depth interviews were conducted between October and December 2019 with 56 participants: 34 OALWH (53% female), 11 healthcare providers (63% female) and 11 primary caregivers (73% female) in …

The Sound Of Geological Targets On Mars From The Absolute Intensity Of Laser-Induced Sparks Shock Waves, C. Alvarez-Llamas, J. Laserna, J. Moros, P. Purohit, L. García-Gómez, S. M. Angel Ph.D., P. Bernardi, B. Bousquet, A. Cadu, E. Dauson, O. Forni, T. Fouchet, O. Gasnault, X. Jacob, G. Lacombe, N. L. Lanza, C. Larmat, J. Lasue, R. D. Lorenz, P. Y. Meslin, D. Mimoun, F. Montmessin, N. Murdoch, A. M. Ollila, P. Pilleri, N. Randazzo, A. L. Reyes-Newell, S. Schröder, A. Stott, J. Ten Cate, A. Udry, D. Vogt

Faculty Publications

Inspection of geological material is one of the main goals of the Perseverance rover during its journey across the landscape of the Jezero crater in Mars. NASA's rover integrates SuperCam, an instrument capable of performing standoff characterization of samples using a variety of techniques. Among those tools, SuperCam can perform laser-induced breakdown spectroscopy (LIBS) studies to elucidate the chemical composition of the targets of interest. Data from optical spectroscopy can be supplemented by simultaneously-produced laser-produced plasma acoustics in order to expand the information acquired from the probed rocks thanks to the SuperCam's microphone (MIC) as it can be synchronized with …

Isolation And Identification Of Phage-Host Protein Interactions As Possible Mediators Of Mycobacteriophage Phayonce Gene Host Cytotoxicity, Matthew Defreitas

Honors Theses

Bacteriophages are ubiquitous viruses containing extremely diverse genomes. Many phage genomes have been bioinformatically annotated; however, many genes lack wet-bench functional characterization. Elucidating individual phage gene function via the isolation of phage-host protein interactions allows for the exploration of novel antibacterial therapies within the context of phage-host biology. Mycobacteriophage Phayonce, infecting the host Mycobacterium smegmatis, encodes two cytotoxic gene, 41 and 64, which lack an annotated function. Using a bacterial two-hybrid screen along with the construction of fusion-protein expression vectors, multiple punitive phage-host protein interactions were isolated for both genes. Once these interactions were verified and sequenced, multiple host …

An Old Illness: How The United States Uses Racist And Xenophobic Ideas About Disease To Exclude Haitian Migrants During The Covid-19 Pandemic, Emily Mcconnville

Indiana Journal of Law and Social Equality

No abstract provided.

Teaching Learning Newsletter Vol 3 Issue 2, Sastra Deemed To Be University

TLC Newsletter

No abstract provided.

Extended Sentinel Monitoring Of Helicoverpa Zea Resistance To Cry And Vip3aa Toxins In Bt Sweet Corn: Assessing Changes In Phenotypic And Allele Frequencies Of Resistance, Galen P. Dively, Tom P. Kuhar, Sally V. Taylor, Helene Doughty, Kristian Holmstrom, Daniel O. Gilrein, Brian A. Nault, Joseph Ingerson-Mahar, Anders Huseth, Dominic Reisig, Shelby Fleischer, David Owens, Kelley Tilmon, Francis Reay-Jones, Pat Porter, Jocelyn Smith, Julien Saguez, Jason Wells, Caitlin Congdon, Holly Byker, Bryan Jensen, Chris Difonzo, William D. Hutchison, Eric Burkness, Robert J. Wright, Michael Crossley, Heather Darby, Tom Bilbo, Nicholas Seiter, Christian Krupke, Craig Abel, Brad S. Coates, Bradley Mcmanus, Billy Fuller, Jeffrey Bradshaw, Julie A. Peterson, David Buntin, Silvana L. Vieira De Paula Moraes, Katelyn Kesheimer, Whitney Crow

Department of Entomology: Faculty Publications

Transgenic corn and cotton that produce Cry and Vip3Aa toxins derived from Bacillus thuringiensis (Bt) are widely planted in the United States to control lepidopteran pests. The sustainability of these Bt crops is threatened because the corn earworm/bollworm, Helicoverpa zea (Boddie), is evolving a resistance to these toxins. Using Bt sweet corn as a sentinel plant to monitor the evolution of resistance, collaborators established 146 trials in twenty-five states and five Canadian provinces during 2020–2022. The study evaluated overall changes in the phenotypic frequency of resistance (the ratio of larval densities in Bt ears relative to densities in non-Bt ears) …

Early Health Conditions, Family Processes, And Educational Achievements, Han Liu

Legacy Theses & Dissertations (2009 - 2024)

This dissertation examines how childhood health affects children’s own and their siblings’ educational attainment through home environments and family processes. While health and socioeconomic status have been recognized as reinforcing dimensions of stratification in the past few decades, their linkage has not been contextualized in the critical social institution of families. To fill this gap in prior research, this project uses rich data on childhood health, home environments, academic achievement and educational attainment, sociodemographic background, and linkages between family members from the National Longitudinal Survey of Youth 1979 Children and Young Adults to (1) estimate the extent to which home …

Near-Optimal Motion Planning Algorithms Via A Topological And Geometric Perspective, Aakriti Kumari Upadhyay

Computer Science Theses & Dissertations

Motion planning is a fundamental problem in robotics, which involves finding a path for an autonomous system, such as a robot, from a given source to a destination while avoiding collisions with obstacles. The properties of the planning space heavily influence the performance of existing motion planning algorithms, which can pose significant challenges in handling complex regions, such as narrow passages or cluttered environments, even for simple objects. The problem of motion planning becomes deterministic if the details of the space are fully known, which is often difficult to achieve in constantly changing environments. Sampling-based algorithms are widely used among …

Knowledge Regarding Covid-19 Disease Among Primary Health Care Centers' Reviewers In Baghdad City, Tabarek Ayad Noori, Ishraq Ahmed Chiad, Essa Khalil Hasan

Al-Nisour Journal for Medical Sciences

Corona virus disease is an infectious, viral disease caused by SARS-CoV-2 and resulted in high percentage of morbidity and mortality throughout the world since December 2019. Several kinds of vaccines developed after short period of time. Is determine the knowledge about Corona (covid_19) among attendance in primary health care centers in Baghdad city. A cross sectional study performed in Baghdad city with 100 persons selected conveniently who visit primary health care centers, which are (Abdul-Saheb Al-dakhil, first Al-Hurriya and second Al-Hurriya primary health care center); the study begun at December 2022 to March 2023. From the participants there were 32% …

Hpv Vaccine Hesitancy: Improving Vaccination Rates In The Pediatric Primary Care Setting, Stephanie Meltzer Carper

Doctor of Nursing Practice Scholarly Projects

Problem statement: The Human Papillomavirus (HPV) vaccine protects against carcinogenic strains of HPV and is administered during childhood to provide maximum protection during peak risk for exposure and HPV disease. Despite demonstrated efficacy, HPV vaccine hesitancy leads to decreased vaccination rates in the pediatric primary care setting. Purpose: This quality improvement project aims to improve HPV vaccination rates at SouthernMED Pediatrics, Summerville, South Carolina. Methods: A pre-intervention survey was administered to identify parental concerns regarding the HPV vaccine to create a customized educational handout. Health care providers systematically used motivational interviewing, presumptive approach communication techniques, and a customized educational handout …