Digital Commons Network^™

Metformin Exposure After Glioblastoma Diagnosis And Mortality: A Large Population-Based Study, Vittorio Maio, Roshani Shah, Manisha Lin, Patrick J. Moeller, Iyad Alnahhas, Richard Hass, Wenyin Shi, Scott W Keith

College of Population Health Faculty Papers

BACKGROUND: Glioblastoma (GBM) is an aggressive primary brain malignancy with limited therapeutic options and poor survival outcomes. Recent real-world studies and early-phase clinical trials evaluating metformin have yielded mixed findings. This study assessed the association between post-diagnosis metformin exposure and all-cause mortality in a large population-based cohort of older adults with GBM.

METHODS: A retrospective cohort study was conducted utilizing the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Adults aged ≥66 years diagnosed with GBM between 2007 and 2018 were included, excluding those with other malignancies or diagnoses made by autopsy or death certificate. Metformin exposure was modeled as …

Modeling Spasticity: A Systematic Review, Gaby Gonzalez Chan, Jonathan Marsden, Alexander Besinis, Pablo Borja, Hilary Gunn

School of Health Professions

Spasticity, a type of hypertonia characterized by a velocity-dependent increase in muscle tone, is associated with damage to the brain and/or spinal cord in different neurological conditions. However, secondary non-neurological factors, such as soft tissue changes, can complicate the assessment and differentiation of the underlying causes. Accurate assessment is crucial for effective treatment planning, with clinicians relying on passive movement to grade the ‘feel’ of the spastic limb. This review aims to identify and evaluate the feasibility of spasticity models or simulations for clinical teaching. Models based on human spastic limbs were examined, with no restrictions on specific conditions or …

Synthetic Blood Data Generation For Fair Machine Learning, Sahithi Makam Ramakrishna, Fernando Perez-Tellez

Research Outputs: 2025-Present

Synthetic data generation is a promising solution to privacy concerns in healthcare analytics, particularly when working with sensitive patient information. This study evaluates the performance and fairness of generative models in creating realistic synthetic datasets derived from blood test and demographic data. Three distinct medical datasets are used, including anonymised clinical data from a public hospital in Ireland, a public UCI medical dataset, and a Korean National Health Insurance dataset from 2002. Seven generative models - CTGAN, TVAE, Gaussian Copula, CopulaGAN, MedGAN, DiscGAN, and FASTML - are applied to generate synthetic records. The quality of these records is assessed using …

Relationship Between Navigation Success, Diagnostic Accuracy, And Ventilation Strategy: Retrospective Chart Review Of 224 Consecutive Navigational Bronchoscopic Procedures Performed Under General Anesthesia, Basavana Goudra, Prarthna Chandar, Divakara Gouda, Harrison Yang, Ganan Muhunthan, Suvan Sundaresh, Michael Stuart Green

Department of Medicine Faculty Papers

Background: Navigational bronchoscopy (NB) enables precise sampling of peripheral and central pulmonary nodules using shape-sensing or electromagnetic guidance. A major challenge is anesthesia-induced atelectasis, which alters lung anatomy, reduces registration accuracy, and is known to lower diagnostic accuracy. To counteract this, ventilatory protocols such as the Ventilatory Strategy to Prevent Atelectasis (VESPA) and the Lung Navigation Ventilation Protocol (LNVP) have been recommended. Their adoption and clinical impact, however, remain uncertain. Methods: We conducted a retrospective review of 224 consecutive NB procedures performed under general anesthesia at a single academic medical center (January 2020–August 2024). Demographic, anesthetic, and ventilatory data were …

Strspy2.0: Unlocking The Potential Of Long Reads For Forensic Dna Profiling, Courtney L Hall, Rupesh K Kesharwani, Katherine E Mcbroom Henson, Bupe Kapema, Nicole R Phillips, Fritz J Sedlazeck, Roxanne R Zascavage

Faculty, Staff and Students Publications

Forensic human identification relies on length-based differences in short tandem repeats (STRs) across autosomal and Y chromosomes, which require separate reactions and provide limited resolution. While next-generation sequencing offers greater discriminatory power, most platforms are expensive and restricted to traditional lab settings. Nanopore sequencing has the potential to change this with the real-time, portable MinION sequencer. However, forensic-specific tools that generate STR profiles compatible with established length-based databases are lacking. To address this, we developed STRspy2.0, which simultaneously profiles autosomal and Y-STRs using nanopore reads. STRspy2.0 produced accurate profiles for 54 multiplexed control libraries and 41 mock casework samples (blood, …

Formulation And Development Of Skincare Cream Using Pleurotus Djamor, K. A. E. Madushanka, W. V. P. M. Weligalla, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms have emerged as versatile and valuable resources in the cosmetic industry, offering a plethora of benefits that range from skincare to haircare formulations. As natural alternatives to synthetic ingredients, mushrooms not only cater to the growing consumer demand for sustainable and eco-friendly products but also offer unique properties such as antioxidant, anti-inflammatory and moisturizing effects. Hence, Pleurotus djamor, which is a grown mushroom in Sri Lanka was selected to prepare a new cream formulation for skincare. In the study, an aqueous extract of P. djamor (AEPD) was used and phytochemical screening was done to screen alkaloids, saponins, flavonoids, …

Left Behind In Lockdown: A Scoping Review Of Covid-19’S Impact On The Lives Of Transition-Age Foster Youth, Johanna K P Greeson, Sarah Wasch, John Gyourko, Antonio R. Garcia, Hannah Bennett, Kate Greco, Liya Cha

Faculty Scholarship

This scoping review asked: What is known about the scope and nature of research on the COVID-19 pandemic and its effects on older youth with foster care experience in the United States, including the types of studies, samples and outcomes examined? Guided by the Joanna Briggs Institute framework and PRISMA-ScR, we searched 11 databases and grey literature sources (October2024 to January 2025). Eligible studies were United States based, published from 2020 onward and included primary data on foster youth or relevant professionals. Thirty-two studies met inclusion criteria. Most studies were descriptive or cross-sectional, reflecting early phases of the pandemic. Mapping …

Myelodysplastic Syndrome Secondary To Chimeric Antigen Receptor T-Cell (Car-T) Therapy For The Treatment Of Relapsed/Refractory Multiple Myeloma, Waqqas Tai, Daniel Kim, Joe Dib, Jessica Thomas, Swathi Gopishetty, Precious Idogun, Afoma Anyadibe, Anuoluwa Ayetoran, Syed Zaidi, Savitha Balaraman, Ishmael Jaiyesimi

Student Publications

We present the case of a 65-year-old man with relapsed/refractory multiple myeloma (RRMM) who developed therapy-related myelodysplastic syndrome (MDS) following chimeric antigen receptor T-cell (CAR-T) therapy with idecabtagene vicleucel (ide-cel). The patient, initially diagnosed in 2019, underwent multiple lines of therapy, including high-dose melphalan with autologous stem cell transplantation, before receiving ide-cel for progressive disease. Despite initial remission, a day 100 bone marrow biopsy revealed MDS with a 7q deletion, a cytogenetic abnormality not present on prior marrow evaluations. While CAR-T therapy has revolutionized RRMM treatment, long-term complications such as therapy-related hematologic malignancy remain under-recognized.

The temporal relationship between CAR-T …

Sting-Induced Blood-Brain Barrier Opening Combined With Radiotherapy Potentiates Antitumor Response In A High-Grade Glioma Model, Shashwat Tripathi, Hinda Najem, Lisa Hurley, Ruochen Du, Crismita Dmello, Heba Ali, Kathleen Mccortney, Karl J Habashy, Peng Zhang, Craig M Horbinski, Lara Leoni, Ryan J Avery, Rimas V Lukas, Timothy L Sita, David R Raleigh, Sean Sachdev, Roger Stupp, Maciej S Lesniak, David M Ashley, Daniele Procissi, Michael A Curran, Irina Balyasnikova, Amy B Heimberger

Faculty, Staff and Student Publications

Radiation therapy (RT) is the standard of care for glioblastoma but is not curative. Triggering the cGAS/stimulator of interferon genes (STING) pathway with potent agonists, such as 8803, exerts activity across high-grade glioma preclinical models. To determine if the combination of 8803 with RT warrants consideration in the up-front treatment setting and to clarify the underlying mechanisms of therapeutic activity, C57BL/6J mice harboring intracerebral CT-2A or QPP8v gliomas were treated with RT, intratumoral 8803, or both. The treatment with the combination resulted in 80% long-term survival in the CT-2A model but not in the radiation-resistant QPP8v model. This therapeutic effect …

Mutant Kras In Brain Endothelial Cells Promotes Vascular Inflammation And Impairs Vascular Integrity In Brain Arteriovenous Malformation, Jung-Eun Park, Bridger H Freeman, Hyejin Park, Sehee Kim, Adrian E Bafor, Ohnmar Myint, Song Gao, Zhen Xu, Jakob Körbelin, Jaroslaw Aronowski, Peng Roc Chen, Eunhee Kim, Eun S Park

Faculty, Staff and Student Publications

Somatic KRAS (KRASG12V) mutation in endothelial cells (EC) induces brain arteriovenous malformation (bAVM) that could lead to vascular instability and ultimately bleeding. However, the causes of bAVM instability remain unclear. Here we demonstrate that KRASG12V expressing cultured ECs (KRAS-G12V-EC) have increased expression of pro-inflammatory mediators and reduced expression of blood-brain-barrier (BBB) junction constituents. The conditioned medium from KRAS-G12V-EC can activate BV2-microglia (BV2-MG) and conditioned media from this primed BV2-MG can compromise the expression of EC-junction constituents when added to wild-type ECs. In an in vitro BBB model, KRAS-G12V-EC form a dysfunctional EC barrier that is further disrupted, leading to lower …

Assessment Of Antioxidant Retention Of Boiled And Non-Boiled Aqueous Extracts Of Broccoli, Cabbage, Kohlrabi And Cauliflower In Sri Lanka, D. M. S. S. Dassanayake, B. C. K. Kumari, P. R. H. Perera, G. M. Yasasvi, L. M. Hettihewa, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

The comparison of antioxidant activities between non-boiled and boiled aqueous extracts of selected vegetables from the Brassica oleracea L. species is an interesting study topic, particularly in a context like Sri Lanka, where traditional and modern medicinal practices often emphasize the role of dietary plants in health. Hence, this was aimed to evaluate the antioxidant potential of boiled and non-boiled aqueous extracts (BAE and NBAE respectively) of selected vegetables belonging to the Brassica oleracea L species, which are commonly consumed as a raw vegetable in fresh salads as well as a cooked vegetable in curry or fried form i.e. Brassica …

Assessment Of In-Vitro Anti-Diabetic And Antioxidant Activities Of Selected Edible Mushrooms, Agaricus Bisporus (Button Mushroom), Pleurotus Cystidiosus (Abalone) And Pleurotus Ostreatus (American Oyster) In Sri Lanka, E. J. Siriwardene, G. S. D. Nawaruwan, A. H. M. A. N. Abesinghe, H. D. Dedigama, K. H. E. Fernando, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms are a valuable source of proteins and vitamins as well as a food source with several pharmacological values. Hence, Higher mushroom consumption can lower the risk of certain diseases. However, a literature survey revealed that published scientific information on the therapeutic potential of some edible mushrooms is still being determined. Hence, this study evaluated and compared the antioxidant and α -amylase potential of some of the three commonly used mushroom varieties in Sri Lanka i.e. Agaricus bisporus (Button mushroom), Pleurotus cystidiosus (Abalone mushroom) and Pleurotus ostreatus (American oyster). The antioxidant activity of hot aqueous extracts of the above three …

Body Mass Index And Clinical Phenotypes Of Primary Dysmenorrhea In Female University Students: Evidence From Sri Lanka Using Walidd Scoring, H. K. A. N. Senanayake, K. L. A. S. I. Liyanarachchi, J. K. M. Jagoda, S. A. S. A. Maheepala, L. C. Mallawa, P. W. T. M. Dayarathne, Y. T. R. Somisena, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

This research investigates the relationship between body weight and the severity and characteristics of primary dysmenorrhea among female undergraduates in Sri Lanka, using the WaLIDD Score as an evaluative tool. The study aims to assess the practicality of the WaLIDD Score in native settings, examining its correlation with pain intensity, pain location, and common medication patterns, while addressing gaps in previous research conducted in Sri Lanka. A quantitative cross-sectional study was conducted among 389 female university students aged 19–27 years from both state and non-state universities in Sri Lanka, selected through stratified random sampling. Participants with chronic or menstrual diseases, …

Conceptual Analysis Of Ārthavavaha Srotas (Female Reproductive System): A Review Of The Theories And Literature, Pushpa Kulanatha, H. L. M. G. Sajeewani

Journal of Innovation in Science, Engineering and Technology

The reproductive health of females during their fertile years is foundational for individual well-being and societal prosperity. The purpose of this study was to bridge the analytical and epistemological gaps currently existing in the literature regarding Ārthavavaha Srotas (ĀvS), the Ayurvedic concept of the female reproductive system. A comprehensive literature review was conducted using forward and backward searches to analyse authentic Ayurvedic texts (Caraka and Sushruta Samhitas) alongside contemporary research articles published between 2014 and 2024. The analysis identified ten specific aspects of the ĀvS where prior interpretations were superficial or unclear. The results of this study epistemologically validate ancient …

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …

Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons

Journal of Counselor Preparation and Supervision

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …

Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook

Journal of Counselor Preparation and Supervision

No person is without biases, even the most culturally adept among us. Managing biases is critical to counselors’ continued journey of understanding clients contextually and holistically. In this article, we describe two novel bias management concepts: A specific type of bias called saintly corrections and the more clinically fruitful approach of realistic corrections. We define and illustrate saintly and realistic corrections, outline a multifold approach (i.e., cognitive complexity, cultural identity development, and the multicultural orientation model) for remediating saintly corrections, and offer recommendations counselor educators can use during planned and contextual learning opportunities, including an example of a contextual …

Holy Cross Magazine, Vol. 60 No. 1, Winter 2026, College Of The Holy Cross

Holy Cross Magazine

The Bell Was Stolen By 3
What the legendary, unsolved theft of the Fenwick Bell tells us about art, crime and absence.
Story by Marybeth Reilly-McGreen ’89
Photography by Michael Ivins

College Tradition Lives on in an Unexpected Place
How necessity, sustainability, happenstance and Jesuit identity converge in the office of Rev. Keith Maczkiewicz, S.J.
Story by Abby Riviello
Photography by Michael Ivins

What Good Can Come From Grief? Quite a Lot, It Turns Out.
Rev. James Hayes, S.J., ’72 has spent more than 50 years engaged in a ministry of consolation, a calling rooted in his own experience of …

Green Roofs For Grey Water Treatment – Comparative Study Of Economic And Environmental Impacts, Shaden S. Attia

Theses and Dissertations

Cities are under more pressure than ever to use sustainable methods for managing water and other resources because of urbanization, climate change, and a lack of water. Standard greywater treatment systems (SGTSs) work well, but they use a lot of resources and don't provide a lot of ecosystem services. Greywater-treating green roofs (GTGRs) have emerged as a promising Nature-Based Solution (NBS), combining wastewater recycling with benefits like regulating temperature, reducing greenhouse gas (GHG) emissions, and reducing the urban heat island (UHI) effect. Even with this potential, there is still not enough real-world research on how GTGRs affect both the economy …

Prephiral Bacterial Infectious Agent Triggers Neuroinflammatory Responses And Neurobehavioral Impairment In Wild-Type Mice, Hadeer Atalah

Theses and Dissertations

Neurodegenerative diseases, including Alzheimer's and Parkinson's, present an increasing global challenge, with chronic neuroinflammation identified as a principal factor alongside genetic, environmental, and infectious influences (Boyd et al., 2022).  Epidemiological data associate bacterial infections with a 40% heightened risk of Parkinson's disease; however, the mechanisms—especially the direct connection between peripheral sepsis and the silent onset of central nervous system pathology absent acute meningitis—are inadequately investigated (Smeyne et al., 2021), particularly concerning common pathogens like Klebsiella pneumoniae in high-burden areas such as Egyptian ICUs, where it constitutes 30% of cases (Alkompoz et al., 2023). This study filled the gap by creating …

Groove Goes The Distance: An Initial Inquiry Into Jazz Music In Egypt, Farida Gohar

Theses and Dissertations

Jazz music has been a historically contentious site of social, cultural, and political signification. From the violent subjugation that characterized its origins and aspirational freedom that animated its practice, to its transformation into a distinctly “American” music instrumentalized by the US State Department to counter Soviet influence, jazz’s capacity for the inscription of meaning is vast and regularly cause for debate. The particular configuration of jazz music in Egypt is no less complicated although seldom studied. This thesis ventures an initial mapping of the dynamics and negotiations that historically defined the initiation of “Egyptian” jazz, as well as the ones …

Lived Experiences Of Limited Sexual And Reproductive Health Education Among Egyptian Women, Nada Abdelhamid

Theses and Dissertations

In Egypt, sexual and reproductive health (SRH) education remains largely absent from national education and youth policy frameworks, reflecting a broader governance gap at the intersection of education, health, and gender policy. This qualitative study explores how the lack of formal sexuality education shapes women’s knowledge, perceptions, and sexual and reproductive experiences across the life course, drawing on in-depth interviews with twelve Egyptian women from diverse marital backgrounds. The findings point to persistent gaps in basic SRH knowledge, early exposure to shame and stigma, and reliance on informal and often unreliable sources of information, which participants linked to fear of …

A Damaging Mutation In Col6a3 Alters The Mechanobiologic Response Of Chondrocytes Derived From Human Induced Pluripotent Stem Cells, Zainab Harissa, Niek Bloks, Nancy Steward, Sara F Tufa, Douglas R Keene, Yolande F M Ramos, Ingrid Meulenbelt, Farshid Guilak

2020-Current year OA Pubs

Osteoarthritis (OA) is a complex disease associated with genetic, biological, and mechanical risk factors that act, in part, to alter chondrocyte homeostasis. Our recent exome sequencing studies identified a damaging genetic variant in COL6A3, a monomeric unit of collagen type VI and a distinguishing component of the pericellular matrix (PCM) of articular cartilage, a transducer of mechanical and biochemical signals for the chondrocyte. To study the effect of this genetic variant, human induced pluripotent stem cell (hiPSC)-derived chondrocytes, genetically edited to harbor the COL6A3 mutation, were used as an in vitro model to investigate chondrocyte mechanobiology and pathobiology. The COL6A3 …

Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability …

Adolescent Math Anxiety: Teachers' Grouping Approach At The Intersection Of Multiple Student Identities, Dara Shifrer, Hannah Sean Ellefritz, David Hernandez-Saca, Allison Roda, Karla Santana Martinez

Sociology Faculty Publications and Presentations

Math anxiety represents a substantial barrier to many students’ math learning. In this paper, we apply interdisciplinary perspectives to data on over 13,200 ninth graders and their math teachers from the High School Longitudinal Study. Results suggest that being perceived as dis/abled relates to heightened math anxiety regardless of adolescents’ gender, or race and ethnicity. Our intersectional approach reveals that adolescents’ expressions of math anxiety do not always correspond with gender, racial, and ethnic stereotypes, with Black girls, Black boys, and Latine boys expressing relatively low levels of math anxiety. Finally, consistent with the principles of inclusion and universal design, …

Exogenous Myrosinase From Mustard Seed Increases Bioavailability Of Sulforaphane From A Glucoraphanin-Rich Broccoli Seed Extract In A Randomized Clinical Study, Angela Mastaloudis, Lola Holcomb, Jed W. Fahey, Camila Olson, David C. Nieman, Colin Kay, Robert O'Donnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L. Ishaq, Giuseppe Valacchi

Pharmacy Faculty Scholarship

Inactive glucoraphanin (GR) in broccoli is converted to the antioxidant, anti-inflammatory, and anti-bacterial sulforaphane (SF) by cruciferous vegetable enzyme myrosinase (Myr), or similar enzymes from specific gut bacteria; both sources have variable efficiency. The effects of exogenous Myr on the conversion efficiency of GR to SF was compared to gut microbial Myr-like activity. In a randomized, double-blind, crossover study, sixteen subjects (9 F: 7 M) received a single oral dose of GR in broccoli seed extract with Myr-containing mustard seed powder, or broccoli seed extract alone, both with ascorbic acid. GR + Myr, on average, doubled the bioavailability of SF …

Observations Of Puddling Butterflies In Maryland, Usa, Aydin Örstan

The Taxonomic Report of the International Lepidoptera Survey

Six butterfly species in four families were observed puddling on damp soil, scat and carrion in various locations in Montgomery County, Maryland and on small islands in the Potomac River. Four species preferred damp soil to nearby mud, but the reason for this behavior is unknown. The presence of butterflies on small islands in the Potomac River is documented for the first time.

The Impact Of Sleep On Physical Performance And Behavior In Adolescent Athletes: A Study In High School Strength And Conditioning Program, Daniel Higgins

Doctorate in Kinesiology

This study examined the relationship between sleep behaviors and strength performance in adolescent students enrolled in a high school strength and conditioning course. Participants included 112 students, ages 15–19, who completed daily self-reported sleep logs over an eight-week period assessing sleep duration, sleep quality, and pre-sleep technology use. Strength performance was measured through repeated assessments of the bench press, squat, and power clean. Data were analyzed using descriptive statistics, Pearson correlations, and linear regression. Results indicated that sleep duration and sleep quality did not significantly predict overall strength gains across the training period. However, strong relationships were observed among sleep-related …

Evolving Strategies In Prostate Cancer: Emerging Approaches And Unmet Needs From The Bridging The Gaps In Prostate Cancer Expert Panel, Rana Mckay, Benjamin Maughan, Alicia Morgans, Neal Shore, Evan Yu, Ravi Madan, Jacob Berchuck, Bradley Carthon, Steven Finkelstein, Leonard Gomella, Michael Gorin, Andrew Hahn, Stacy Loeb, Vivek Narayan, Daniel Petrylak, Charles Ryan, Karine Tawagi, Phuoc Tran, Tanya Dorff

Department of Urology Faculty Papers

BACKGROUND: The expansion of treatment options for prostate cancer (PC) has improved disease-specific and overall survival outcomes but has also raised questions about the optimal level of treatment needed for patients based on their individual prognosis and accounting for potential toxicity, incorporating quality of life considerations.

METHODS: A panel of experts met to discuss current controversies in the care of patients with PC across the disease continuum. Multidisciplinary experts review advances and persistent uncertainties in biomarker-guided assessment, imaging, and systemic therapy for prostate cancer. The discussion outlines priority gaps in evidence that must be addressed to optimize individualized patient care. …

Advanced Design Topics For The Engineering Of Agricultural And Mechanical Equipment, Robert M. Stwalley Iii, Roger Tormoehlen

Purdue University Press Books

Off-road equipment designs contend with some unusual challenges and environmental conditions that are not seen by standard on-road vehicles. Advanced Design Topics for the Engineering of Agricultural and Mechanical Equipment offers design topic reviews related to areas that need special consideration within off-road applications. CAN-BUS systems, soil compaction, composite bearings, field welding practices, and weld strength in bending applications are examined, among other subjects. Providing comprehensive coverage of these matters with the current state-of-the-art technologies and best practices as they relate to equipment design for the agricultural, construction, forestry, and mining industries, this book is well-aligned with collegiate advanced agricultural …