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2023

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Development Of A Scalable Edge-Cloud Computing Based Variable Rate Irrigation Scheduling Framework, Eric J. Wilkening, Derek M. Heeren, Yeyin Shi, Abia Katimbo, Precious N. Amori, Guillermo R. Balboa, Laila A. Puntel, Kuan Zhang, Daran R. Rudnick Jul 2023

Development Of A Scalable Edge-Cloud Computing Based Variable Rate Irrigation Scheduling Framework, Eric J. Wilkening, Derek M. Heeren, Yeyin Shi, Abia Katimbo, Precious N. Amori, Guillermo R. Balboa, Laila A. Puntel, Kuan Zhang, Daran R. Rudnick

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Currently, variable-rate precision irrigation (VRI) scheduling methods require large amounts of data and processing time to accurately determine crop water demands and spatially process those demands into an irrigation prescription. Unfortunately, irrigated crops continue to develop additional water stress when the previously collected data is being processed. Machine learning is a helpful tool, but handling and transmitting large datasets can be problematic; more rural areas may not have access to necessary wireless data transmission infrastructure to support cloud interaction. The introduction of “edge-cloud” processing to agricultural applications has shown to be effective at increasing data processing speed and reducing the …


Etsu Today - Summer 2023, University Marketing And Communication, East Tennessee State University Jul 2023

Etsu Today - Summer 2023, University Marketing And Communication, East Tennessee State University

ETSU Today [magazine]

In the last edition of ETSU Today, I introduced our new university tagline: Bucs Go Beyond. This concise yet powerful phrase encapsulates not just our rich history of achievements, but also serves as an energetic rallying cry, urging us to consistently strive for higher levels of excellence. Unsurprisingly, our campus community has answered this call with numerous noteworthy successes throughout the past few months. Our accomplishments, led by the diligence, talent, and hard work of our ETSU family, have shone brightly. Our women’s basketball team, for instance, etched a new record for the most single-season wins in program history. Adding …


Republication Of "Uses Of Braces And Orthotics For Conservative Management Of Foot And Ankle Disorders"., Osama Elattar, Tyler Smith, Adam Ferguson, Daniel Farber, Keith Wapner Jul 2023

Republication Of "Uses Of Braces And Orthotics For Conservative Management Of Foot And Ankle Disorders"., Osama Elattar, Tyler Smith, Adam Ferguson, Daniel Farber, Keith Wapner

Orthopedic Surgery Resident Research

Nonsurgical management is almost always considered the first-line treatment for the vast majority of foot and ankle pathologies. Foot orthoses, shoe modifications, and therapeutic footwear are considered essential tools for successful conservative management of different foot and ankle disorders. Orthopedic foot and ankle surgeons should have a meticulous understanding of the lower extremity biomechanics as well as the pathoanatomy and the sequelae of diseases affecting the foot and/or ankle. This is essential to the understanding of the desired effects of the different inserts, orthotics, shoe modifications, or braces that may be prescribed for these conditions. In this article, we will …


Title Ix And "Menstruation Or Related Conditions", Marcy L. Karin, Naomi Cahn, Elizabeth B. Cooper, Bridget J. Crawford, Margaret E. Johnson, Emily Gold Waldman Jul 2023

Title Ix And "Menstruation Or Related Conditions", Marcy L. Karin, Naomi Cahn, Elizabeth B. Cooper, Bridget J. Crawford, Margaret E. Johnson, Emily Gold Waldman

Michigan Journal of Gender & Law

Title IX of the Education Amendments Act of 1972 (“Title IX”) prohibits sex discrimination in educational programs or activities receiving federal financial assistance. Neither the statute nor its implementing regulations explicitly define “sex” to include discrimination on the basis of menstruation or related conditions such as perimenopause and menopause. This textual absence has caused confusion over whether Title IX must be interpreted to protect students and other community members from all types of sex-based discrimination. It also calls into question the law’s ability to break down systemic sex-based barriers related to menstruation in educational spaces. Absent an interpretation that there …


Additive Manufacturing For The Rapid Prototyping Of Economical Biosensors, Alejandra Almaraz, Fereshteh Rajabi-Kouchi, Hailey M. Burgoyne, Naqsh E. Mansoor, Jessica Koehne, David Estrada Jul 2023

Additive Manufacturing For The Rapid Prototyping Of Economical Biosensors, Alejandra Almaraz, Fereshteh Rajabi-Kouchi, Hailey M. Burgoyne, Naqsh E. Mansoor, Jessica Koehne, David Estrada

Idaho Conference on Undergraduate Research

Current methods of developing wearable electronics through reductive manufacturing pose a substantial ecological footprint. To address this issue, it is imperative to investigate alternative additive manufacturing techniques. Aerosol jet printing (AJP) is a promising approach that relies on the optimization of gas flow rates and ink rheology to produce high-resolution printed structures. Implementing a low-intensity layered delamination approach to synthesize titanium carbide MXene, and further produce MXene ink, reduces environmental impact while enhancing the device performance. MXene ink yields desirable rheology, including viscosity, surface tension, density, and contact angles compatible with AJP technique. In terms of cost, ecological effect, time, …


No Fire On The Mountain: Has Fire Suppression Caused Population Declines Of An Imperiled Ground Squirrel?​, Alyssa Livingston, Courtney Conway, Eva Strand Jul 2023

No Fire On The Mountain: Has Fire Suppression Caused Population Declines Of An Imperiled Ground Squirrel?​, Alyssa Livingston, Courtney Conway, Eva Strand

Idaho Conference on Undergraduate Research

The Northern Idaho Ground Squirrel (Urocitellus brunneus) is listed as threatened under the Endangered Species Act. A prevailing hypothesis suggests that one reason for the species decline is encroachment of trees into its habitat due to fire suppression. However, this hypothesis has not been rigorously tested. Using geographic information systems and aerial imaging, I compared changes in abundance of the squirrels' populations to changes in forest canopy coverage over the past 40 years. These comparisons allowed me to test the prevailing hypothesis for the population declines of this rare species by testing the prediction that forest fire suppression …


Lipid Order In Red Blood Cell Membranes Exposed To Hypo-Osmotic Stress And Self-Inserting Pore-Forming Proteins, Aviana R. Smith, Rosey Whiting, Maryna Kucheriava, Jacob Kammer, Zhiyu Li, Daniel Fologea Jul 2023

Lipid Order In Red Blood Cell Membranes Exposed To Hypo-Osmotic Stress And Self-Inserting Pore-Forming Proteins, Aviana R. Smith, Rosey Whiting, Maryna Kucheriava, Jacob Kammer, Zhiyu Li, Daniel Fologea

Idaho Conference on Undergraduate Research

The packing of lipids comprising a cell membrane, known as lipid order, has been under increasing scrutiny due to continuous findings of its biological significance. There is extensive literature detailing the changes in lipid order, and multiple temperature-induced phase transitions have been clarified. However, these experiments have not considered common external factors, such as hypo-osmotic stress and protein insertion. To fill these gaps in our knowledge, Red Blood Cell (RBC) membranes stained with membrane probes were investigated by general polarization (GP) and anisotropy (p). We evaluated RBC membranes under hypo-osmotic shock, and membranes with pore-forming toxins. Significant changes in lipid …


A Case Of A Large And Rare Incidental Pleural Tumor In An Elderly Female, Ruchi Mangal, Muneer F. Hasso, Mark S. Obri, M. Ramzi Almajed, Abigail L. Entz Jul 2023

A Case Of A Large And Rare Incidental Pleural Tumor In An Elderly Female, Ruchi Mangal, Muneer F. Hasso, Mark S. Obri, M. Ramzi Almajed, Abigail L. Entz

Internal Medicine Articles

Solitary fibrous tumors are very rare in the pleura, and they are generally found incidentally. Even though they can potentially become malignant and metastasize, they have minimal clinical symptoms and can still be benign. Due to the low incidence of these tumors, there is no standard of therapy beyond surgical resection. We present an asymptomatic case of a large, rapidly expanding solitary fibrous tumor of the pleura in an elderly female.


2021 Oyster Coverage Gis Layer For Mosquito Lagoon, Fl, Linda Walters, Melinda Donnelly, Gabriel Benson, Paul E. Sacks Jul 2023

2021 Oyster Coverage Gis Layer For Mosquito Lagoon, Fl, Linda Walters, Melinda Donnelly, Gabriel Benson, Paul E. Sacks

CEELAB Research Data

Intertidal reefs of Crassostrea virginica (eastern oyster) provide ecologically valuable habitat in estuaries along the Atlantic coast of North America. In Mosquito Lagoon, a shallow-water estuary on the east coast of central Florida, USA, historical aerial imagery was used to document a 24% decline in the live C. virginica reef area between 1943 and 2009. Using 2021 imagery, every living and dead reef in the same region was manually digitized to identify changes during the intervening 12 years. Positive impacts of C. virginica reef restoration that took place between 2007 and 2021 were also digitized to quantify long-term restoration impact. …


Predicting Corrosion Damage In The Human Body Using Artificial Intelligence: In Vitro Progress And Future Applications Applications, Michael A. Kurtz, Ruoyu Yang, Mohan S. R. Elapolu, Audrey C. Wessinger, William Nelson, Kazzandra Alaniz, Rahul Rai, Jeremy L. Gilbert Jul 2023

Predicting Corrosion Damage In The Human Body Using Artificial Intelligence: In Vitro Progress And Future Applications Applications, Michael A. Kurtz, Ruoyu Yang, Mohan S. R. Elapolu, Audrey C. Wessinger, William Nelson, Kazzandra Alaniz, Rahul Rai, Jeremy L. Gilbert

Publications

Artificial intelligence (AI) is used in the clinic to improve patient care. While the successes illustrate the impact AI can have, few studies have led to improved clinical outcomes. A gap in translational studies, beginning at the basic science level, exists. In this review, we focus on how AI models implemented in non-orthopedic fields of corrosion science may apply to the study of orthopedic alloys. We first define and introduce fundamental AI concepts and models, as well as physiologically relevant corrosion damage modes. We then systematically review the corrosion/AI literature. Finally, we identify several AI models that may be Preprint …


Freeman Honors Newsletter, Spring/Summer 2023 Issue, Texas Southern University, Thomas F. Freeman Honors College Jul 2023

Freeman Honors Newsletter, Spring/Summer 2023 Issue, Texas Southern University, Thomas F. Freeman Honors College

Honor's College Newsletters

Spring/Summer 2023 Newsletter


Hypo-Osmotic Stress And Pore-Forming Toxins Adjust The Lipid Order In Sheep Red Blood Cell Membranes, Rose Whiting, Sevio Stanton, Maryna Kucheriava, Aviana R. Smith, Matt Pitts, Daniel Robertson, Jacob Kammer, Zhiyu Li, Daniel Fologea Jul 2023

Hypo-Osmotic Stress And Pore-Forming Toxins Adjust The Lipid Order In Sheep Red Blood Cell Membranes, Rose Whiting, Sevio Stanton, Maryna Kucheriava, Aviana R. Smith, Matt Pitts, Daniel Robertson, Jacob Kammer, Zhiyu Li, Daniel Fologea

Physics Faculty Publications and Presentations

Lipid ordering in cell membranes has been increasingly recognized as an important factor in establishing and regulating a large variety of biological functions. Multiple investigations into lipid organization focused on assessing ordering from temperature-induced phase transitions, which are often well outside the physiological range. However, particular stresses elicited by environmental factors, such as hypo-osmotic stress or protein insertion into membranes, with respect to changes in lipid status and ordering at constant temperature are insufficiently described. To fill these gaps in our knowledge, we exploited the well-established ability of environmentally sensitive membrane probes to detect intramembrane changes at the molecular level. …


The Association Of Sex Ratio On Suicide Rates In United States Counties: An Exploration Of Mechanisms, Kristin Snopkowski, Hallie Turner Jul 2023

The Association Of Sex Ratio On Suicide Rates In United States Counties: An Exploration Of Mechanisms, Kristin Snopkowski, Hallie Turner

Anthropology Faculty Publications and Presentations

Researchers have long puzzled over suicidal behavior. In this paper, we posit that when people are unable to attract mates given unfavorable sex ratios, suicide rates increase. Sex ratio, the proportion of males in a population, is linked to a variety of behaviors, including marriage stability, violence, depression, and infidelity. We test whether suicide rates are associated with county-level sex ratios utilizing data from 1999 to 2018, controlling for a variety of factors known to be associated with suicide risk. We find that sex ratio is associated with suicide rates, where a greater proportion of males in a county (age …


Wpa News 121 (2023), World Pheasant Association Jul 2023

Wpa News 121 (2023), World Pheasant Association

Galliformes Specialist Group and Affiliated Societies: Newsletters

WPA News (Summer 2023), number 121

Published by the World Pheasant Association


Coping Mechanisms During The Covid-19 Pandemic And Lockdown In Metropolitan Johannesburg, South Africa: A Qualitative Study, Nerli Paredes Ruvalcaba, Andrew Wooyoung Kim, Nokubonga Ndaba, Lindile Cele, Someleze Swana, Edna Bosire, Aneesa Moolla Jul 2023

Coping Mechanisms During The Covid-19 Pandemic And Lockdown In Metropolitan Johannesburg, South Africa: A Qualitative Study, Nerli Paredes Ruvalcaba, Andrew Wooyoung Kim, Nokubonga Ndaba, Lindile Cele, Someleze Swana, Edna Bosire, Aneesa Moolla

Brain and Mind Institute

Background: The COVID-19 pandemic has caused prolonged stress on numerous fronts. While the acute health impacts of psychosocial stress due to the pandemic are well-documented, less is known about the resources and mechanisms utilized to cope in response to stresses during the pandemic and lockdown.

Objective: The aim of this study was to identify and describe the coping mechanisms adults utilized in response to the stressors of the COVID-19 pandemic during the 2020 South African lockdown.

Methods: This study included adults (n=47: 32 female; 14 male; 1 non-binary) from the greater Johannesburg region in South Africa. Interviews …


Socioeconomic Status And Home Affordances Moderate Effects Of Motor Delay And Intervention, Iryna Babik, Andrea B. Cunha, Dongho Choi, Natalie A. Koziol, Lin-Ya Hsu, Regina T. Harbourne, Stacey C. Dusing, Sarah W. Mccoy, James A. Bovaird, Sandra L. Willett, Michele A. Lobo Jul 2023

Socioeconomic Status And Home Affordances Moderate Effects Of Motor Delay And Intervention, Iryna Babik, Andrea B. Cunha, Dongho Choi, Natalie A. Koziol, Lin-Ya Hsu, Regina T. Harbourne, Stacey C. Dusing, Sarah W. Mccoy, James A. Bovaird, Sandra L. Willett, Michele A. Lobo

Psychological Sciences Faculty Publications and Presentations

This study explored effects of socioeconomic status (SES) and home affordances on motor, language, and cognitive development in children with motor delays; it also tested whether SES and home affordances moderate the effect of the novel START-Play early intervention or motor delay severity on development. Participants were 112 children (64 males, 36.6% low SES) with motor delays tested longitudinally across 12 months (baseline age: Mean = 10.80, SD = 2.59 months). The results showed that more advanced motor, language, and cognitive development of children with motor delays is associated with high SES and enriched home affordances. Importantly, SES and home …


Sers Of Human Red Blood Cells In Non-Resonant Conditions: Benefits, Limitations, And Complementary Tools (Cytoviva And Gfaas), Kelsey L. Wells, Praveen K. Alla, Kyra G. Kaiser, Ioana T. Murgulet, Norma C. Adragna, Ioana E. Pavel Jul 2023

Sers Of Human Red Blood Cells In Non-Resonant Conditions: Benefits, Limitations, And Complementary Tools (Cytoviva And Gfaas), Kelsey L. Wells, Praveen K. Alla, Kyra G. Kaiser, Ioana T. Murgulet, Norma C. Adragna, Ioana E. Pavel

Pharmacology and Toxicology Faculty Publications

Herein, Raman and surface-enhanced Raman spectroscopies (SERS) were successfully employed to establish the chemical interactions of citrate-capped silver nanoparticles (AgNPs, 10–15 nm) with human red blood cells (RBCs). The Raman/SERS spectra offered spectral evidence for the cellular uptake of AgNPs and the subsequent change in the conformation of the most abundant component, hemoglobin (Hb), from oxyhemoglobin to deoxyhemoglobin. The spectral characterization of AgNPs’ interactions with other RBC biomarkers (membrane proteins and lipids) was impeded by the dominant Hb bands, even for non-resonant Hb conditions. CytoViva hyperspectral imaging and graphite furnace atomic absorption spectroscopy (GFAAS) served as complementary tools to effectively …


Undergraduate And Graduate Course Descriptions, 2023 Summer, Wright State University Jul 2023

Undergraduate And Graduate Course Descriptions, 2023 Summer, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Summer 2023.


Journal For The Philosophical Study Of Education, Allan Johnston, Guillemette Johnston Jul 2023

Journal For The Philosophical Study Of Education, Allan Johnston, Guillemette Johnston

Research Resources

J P S E

Journal for the Philosophical Study of Education

Vol. 4 (2023)

Editors: Allan Johnston, DePaul University and Columbia College Chicago Guillemette Johnston, DePaul University

Special Symposium Editor: Elias Schwieler, Stockholm University

Outside Readers:

Sabrina Bacher, Universität Innsbruck

Christian Kraler, Universität Innsbruck

James Magrini, College of DuPage

Alexander Makedon, Chicago State University/Arellano University (emeritus)


You Can't Play With Us: Fifty- Year Anniversary Of Title Ix Marred By Trend Of Anti Transgender Inclusion Acts, Samantha Gill Jul 2023

You Can't Play With Us: Fifty- Year Anniversary Of Title Ix Marred By Trend Of Anti Transgender Inclusion Acts, Samantha Gill

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.


Return To Play In Pa: The Need For Increased Protection For Youth Athletes Impacted By Concussions, Stephanie Waltersdorff Jul 2023

Return To Play In Pa: The Need For Increased Protection For Youth Athletes Impacted By Concussions, Stephanie Waltersdorff

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.


An Occupation-Based Intergenerational Program, Jennifer Luong Jul 2023

An Occupation-Based Intergenerational Program, Jennifer Luong

Occupational Therapy Student Capstones

No abstract provided.


Mitigating Student Anxiety In The Secondary Classroom: A Culturally Sustaining Approach, Erin Hawley Cronin Jul 2023

Mitigating Student Anxiety In The Secondary Classroom: A Culturally Sustaining Approach, Erin Hawley Cronin

Theses and Dissertations

This study emerged in response to broader trends of increasing anxiety among schoolchildren and my own observations as a teacher. Suicide is now the second-leading cause of death for youth (Curtin et al., 2022), and anxiety is a known factor in most deaths by suicide (Nepon et al., 2010). Teachers are often the first point of contact for anxious students, but a shortage of counselors in U.S. schools and other systemic barriers prevent widespread access to counseling services (Cratty, 2019). Moreover, identity-based anxieties are often misattributed to aggression or attention-seeking, and punished in school settings, instead of recognized and supported …


A Genome-Wide Association Study Reveals Region Associated With Seed Protein Content In Cowpea, Yilin Chen, Haizheng Xiong, Waltram Ravelombola, Gehendra Bhattarai, Casey Barickman, Ibtisam Alatawi, Theresa Makawa Phiri, Kenani Chiwina, Beiquan Mou, Shyam Tallury, Ainong Shi Jul 2023

A Genome-Wide Association Study Reveals Region Associated With Seed Protein Content In Cowpea, Yilin Chen, Haizheng Xiong, Waltram Ravelombola, Gehendra Bhattarai, Casey Barickman, Ibtisam Alatawi, Theresa Makawa Phiri, Kenani Chiwina, Beiquan Mou, Shyam Tallury, Ainong Shi

Horticulture Faculty Publications and Presentations

Cowpea (Vigna unguiculata L. Walp., 2n = 2x = 22) is a protein-rich crop that complements staple cereals for humans and serves as fodder for livestock. It is widely grown in Africa and other developing countries as the primary source of protein in the diet; therefore, it is necessary to identify the protein-related loci to improve cowpea breeding. In the current study, we conducted a genome-wide association study (GWAS) on 161 cowpea accessions (151 USDA germplasm plus 10 Arkansas breeding lines) with a wide range of seed protein contents (21.8~28.9%) with 110,155 high-quality whole-genome single-nucleotide polymorphisms (SNPs) to identify …


Effects Of Landslides On Terrestrial Carbon Stocks With A Coupled Geomorphic-Biologic Model: Southeast Alaska, United States, Adam M. Booth, Brian Buma, S. Nagorski Jul 2023

Effects Of Landslides On Terrestrial Carbon Stocks With A Coupled Geomorphic-Biologic Model: Southeast Alaska, United States, Adam M. Booth, Brian Buma, S. Nagorski

Geology Faculty Publications and Presentations

Landslides influence the global carbon (C) cycle by facilitating transfer of terrestrial C in biomass and soils to offshore depocenters and redistributing C within the landscape, affecting the terrestrial C reservoir itself. How landslides affect terrestrial C stocks is rarely quantified, so we derive a model that couples stochastic landslides with terrestrial C dynamics, calibrated to temperate rainforests in southeast Alaska, United States. Modeled landslides episodically transfer C from scars to deposits and destroy living biomass. After a landslide, total C stocks on the scar recover, while those on the deposit either increase (in the case of living biomass) or …


Phytochemical Profile, Hplc Analysis, And Cns Activity Of Ethanol Extract From The Flowers Of Borage, Haritha Polimati, Ho Viet Hieu, Rajeswari Pasupula, Srilakshmi Nallapaty, Srilekhya Ketha, Alekhya Ketha Jul 2023

Phytochemical Profile, Hplc Analysis, And Cns Activity Of Ethanol Extract From The Flowers Of Borage, Haritha Polimati, Ho Viet Hieu, Rajeswari Pasupula, Srilakshmi Nallapaty, Srilekhya Ketha, Alekhya Ketha

The Thai Journal of Pharmaceutical Sciences

Purpose of the research: The study of medicinal plants has made it possible to develop products and drugs for the treatment of different diseases. Several plants in India have a history of popular use for the treatment of CNS disorders. The objective of this work was to provide information on the phytochemical profile and central nervous system (CNS) activity of the ethanolic extract of Borago officinalis flowers (Ee). Results: The preliminary phytochemical and HPLC evaluation of Ee established the presence of alkaloids, flavonoids, phenols, tannins, terpenes and steroids. The acute toxicity study revealed that administration of 2000 mg/kg …


Development And Validation Of Uplc-Tqd/Ms Method For Quantification Of Six Bioactive Constituents In Thai Herbal Benjakul Formula, Benyathip Trakoolsilp, Manmas Vannabhum, Pravit Akarasereenont, Suksalin Booranasubkajorn Jul 2023

Development And Validation Of Uplc-Tqd/Ms Method For Quantification Of Six Bioactive Constituents In Thai Herbal Benjakul Formula, Benyathip Trakoolsilp, Manmas Vannabhum, Pravit Akarasereenont, Suksalin Booranasubkajorn

The Thai Journal of Pharmaceutical Sciences

Introduction: Thai herbal Benjakul formula (BKF) is a Thai traditional medicine for balancing and nourishing body elements in unhealthy persons. It is composed of five pungent plants, namely fruits of Piper retrofractum Vahl., roots of Piper sarmentosum Roxb., stems of Piper wallichii (Miq.) Hand.-Mazz., roots of Plumbago indica L., and rhizome of Zingiber officinale Roscoe. There was no efficient method for quantification of the bioactive constituents in BKF using UPLC-TQD/MS. Objective: The objective of the study was to establish a method for quantification of some constituents of BKF, namely pellitorine (PE), piperine (PI), piperlonguminine (PLM), plumbagin (PG), 6-gingerol …


A Comprehensive Assessment On Coumarin–Thiazole Composite As A Versatile Scaffold For The Potent Multifunctional Bioactive Agents, Swethan Babu Ravi, Muthu Kumaradoss Kathiravan Jul 2023

A Comprehensive Assessment On Coumarin–Thiazole Composite As A Versatile Scaffold For The Potent Multifunctional Bioactive Agents, Swethan Babu Ravi, Muthu Kumaradoss Kathiravan

The Thai Journal of Pharmaceutical Sciences

In the discovery of new drugs, the molecular hybridization approach has emerged as a promising strategy as a multitargeted approach to prevent, treat, and address drug resistance and unmet needs. Several hybrid molecules are currently under various stages of clinical trials and could be implemented into clinical practice shortly to treat various diseases. In such purview, thiazole and coumarins play an essential role due to their diverse biological activities in medicinal chemistry. The hybridization approach of these two potential pharmacophores may lead to the discovery of newer drug candidates with a more comprehensive therapeutic application with multiple mechanisms of action. …


Drug-Induced Pseudoallergy Reaction Through Mas-Related G-Protein-Coupled Receptor X2: A Narrative Review, Zulfi Azizah, Ika Puspitasari, Muhammad Novrizal Abdi Sahid Jul 2023

Drug-Induced Pseudoallergy Reaction Through Mas-Related G-Protein-Coupled Receptor X2: A Narrative Review, Zulfi Azizah, Ika Puspitasari, Muhammad Novrizal Abdi Sahid

The Thai Journal of Pharmaceutical Sciences

Pseudoallergy is a hypersensitivity condition not triggered by immunoglobulin E (IgE). These conditions can cause various health problems with symptoms identical to IgE-mediated allergic. The symptoms range from mild such as hives, to severe symptoms, such as anaphylactoid. Several drugs are known to activate mast cells directly through the mas-related G protein-coupled receptor X2 (MRGPRX2). MRGPRX2 is a receptor expressed on mast cells and responsible for their activation without being mediated by IgE. This review focuses on the types and methods of drugs that can induce pseudoallergy through MRGPRX2. The literature was collected with keywords in the form of “pseudo …


In Silico Study Of Polyphenol Compounds From Green Tea (Camellia Sinensis L.) As Inhibitors Of 3clpro Of Sars-Cov2, Junaidin Junaidin, Selvira Anandia Intan Maulidya, Krisyanti Budipramana, Faisal Ismail, Tegar Achsendo Yuniarta, Diana Sylvia Jul 2023

In Silico Study Of Polyphenol Compounds From Green Tea (Camellia Sinensis L.) As Inhibitors Of 3clpro Of Sars-Cov2, Junaidin Junaidin, Selvira Anandia Intan Maulidya, Krisyanti Budipramana, Faisal Ismail, Tegar Achsendo Yuniarta, Diana Sylvia

The Thai Journal of Pharmaceutical Sciences

Background: Coronavirus disease (COVID-19) outbreak prompts the world to develop novel drugs to treat the disease. Targeting the virus protein has attracted a great interest in COVID-19 drug discovery. The 3-chymotrypsin-like cysteine protease (3CLpro) of SARS-CoV-2 protein is one of the promising targets for its important role in viral replication. Various efforts have been made to find a specific therapeutic for COVID-19, including those derived from plants as anti-COVID-19. Green tea (Camellia sinensis L.) contains polyphenols which have been known for their health benefits. Objectives: This study aims to discover the activity of green tea polyphenols as 3CLpro …