Digital Commons Network^™

The Effects Of Ultra-Marathon Trail Running And The Physiological Response Of Stress On Salivary Biomarkers, Kevan W. Stout, Jeremy R. Pearson, Catherine A. Hambleton, Jake A. Deckert, Philip M. Gallagher

Journal of Human Performance in Extreme Environments

PURPOSE: This study investigated changes in salivary α-amylase (sAA), cortisol, and interleukin-1β (IL-1β) concentrations following completion of an ultra-marathon trail run (UMT) to better understand the physiological stressors imposed by this extreme type of race. METHODS: Eight subjects participated in this study. Each subject completed a 50 km UMT. Two-minute oral salivary swabs were taken 10 minutes prior to race start and again within 1 minute of race finish. Samples were analyzed for sAA, cortisol and IL-1β using ELISA kits. RESULTS: Our results demonstrated a significant increase in both sAA (p = 0.002) and cortisol (p < 0.001) from baseline. No significant differences were observed for IL-1β. There was no significant relationship between the observed sAA increase and race speed. The observed increase in cortisol was significantly correlated with race speed (R² = 0.582, p …

Optimizing The Timing Of Biologic And Surgical Therapy For Patients With Refractory Chronic Rhinosinusitis With Nasal Polyposis (Crswnp), Emily Garvey, Bita Naimi, Alexander Duffy, Paavali Hannikainen, Chase Kahn, Douglas Farquhar, Marc Rosen, Mindy R. Rabinowitz, Elina Toskala, Gurston G. Nyquist

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

INTRODUCTION: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is often treated with endoscopic sinus surgery (ESS); however, patients may require revision surgery due to recurrence. To date, no studies have compared outcomes for combined surgery and biologic therapy for CRSwNP compared with biologic therapy alone.

METHODS: Retrospective case-control study of CRSwNP patients who underwent ESS while on dupilumab or mepolizumab (ESS-biologic cohort) compared with CRSwNP patients on biologic therapy (biologic-only controls). Cohorts were matched according to indication, aspirin-exacerbated respiratory disease (AERD), sinonasal outcome test-22 (SNOT-22), and total polyp scores.

RESULTS: Sixteen patients underwent ESS while on biologic therapy (13 dupilumab and …

Annotation Of Non-Model Species’ Genomes, Taiya Jarva

Master's Theses

The innovations in high throughput sequencing technologies in recent decades has allowed unprecedented examination and characterization of the genetic make-up of both model and non-model species, which has led to a surge in the use of genomics in fields which were previously considered unfeasible. These advances have greatly expanded the realm of possibilities in the fields of ecology and conservation. It is now possible to the identification of large cohorts of genetic markers, including single nucleotide polymorphisms (SNPs) and larger structural variants, as well as signatures of selection and local adaptation. Markers can be used to identify species, define population …

Design And Characteristics Of The Prophylactic Intra-Operative Ventricular Arrhythmia Ablation In High-Risk Lvad Candidates (Pivatal) Trial, David T. Huang, Igor Gosev, Katherine L. Wood, Hima Vidula, William Stevenson, Frank Marchlinski, Gregory Supple, Sandip K. Zalawadiya, J. Peter Weiss, Roderick Tung, Wendy S. Tzou, Joshua D. Moss, Krishna Kancharla, Sunit-Preet Chaudhry, Parin J. Patel, Arfaat M. Khan, Claudio Schuger, Guy Rozen, Michael S. Kiernan, Gregory S. Couper, Marzia Leacche, Ezequiel J. Molina, Anand D. Shah, Michael Lloyd, Jakub Sroubek, Edward Soltesz, Kalyanam Shivkumar, Casey White, Sinan Tankut, Brent A. Johnson, Scott Mcnitt, Valentina Kutyifa, Wojciech Zareba, Ilan Goldenberg

Cardiology Articles

BACKGROUND: The use of a Left Ventricular Assist Device (LVAD) in patients with advanced heart failure refractory to optimal medical management has progressed steadily over the past two decades. Data have demonstrated reduced LVAD efficacy, worse clinical outcome, and higher mortality for patients who experience significant ventricular tachyarrhythmia (VTA). We hypothesize that a novel prophylactic intra-operative VTA ablation protocol at the time of LVAD implantation may reduce the recurrent VTA and adverse events postimplant.

METHODS: We designed a prospective, multicenter, open-label, randomized-controlled clinical trial enrolling 100 patients who are LVAD candidates with a history of VTA in the previous 5 …

Cell Surface B2m-Free Human Leukocyte Antigen (Hla) Monomers And Dimers: Are They Neo-Hla Class And Proto-Hla?, Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan, Fatiha El Hilali, Carly J. Amato-Menker, Edward J. Filippone

Division of Nephrology Faculty Papers

Cell surface HLA-I molecules (Face-1) consist of a polypeptide heavy chain (HC) with two groove domains (G domain) and one constant domain (C-domain) as well as a light chain, B2-microglobulin (B2m). However, HCs can also independently emerge unfolded on the cell surface without peptides as B2m-free HC monomers (Face-2), B2m-free HC homodimers (Face 3), and B2m-free HC heterodimers (Face-4). The transport of these HLA variants from ER to the cell surface was confirmed by antiviral antibiotics that arrest the release of newly synthesized proteins from the ER. Face-2 occurs at low levels on the normal cell surface of the lung, …

Understanding User Behavior Related To Interlibrary Loan Requests: Insights From The Entire Journey, Heidi Webb

Conference Presentations

No abstract provided.

Visualizing Oceanographic Data To Depict Long-Term Changes In Phytoplankton, Patricia S. Thibodeau, Jongsun Kim

School of Earth, Environmental, & Marine Sciences Faculty Publications

Oceanographic time series provide an important perspective on environmental processes in ecosystems. The Narragansett Bay Long-Term Plankton Time Series (NBPTS) in Narragansett Bay, Rhode Island, USA, represents one of the longest plankton time series (1959-present) of its kind in the world and presents a unique opportunity to visualize long-term change within an aquatic ecosystem. Phytoplankton represent the base of the food web in most marine systems, including Narragansett Bay. Therefore, communicating their importance to the 2.4 billion people who live within the coastal ocean is critical. We developed a protocol with the goal of visualizing the diversity and magnitude of …

Serum Metabolomic Profiling For Colorectal Cancer Using Machine Learning, Ria Nur Puspa Sari, Diah Balqis Ikfi Hidayati, Arleni Bustami

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Colorectal cancer is one of the deadliest diseases with a high prevalence worldwide and is characterized by the appearance of adenomatous polyps in the colon mucosa which are at high risk of developing into colorectal cancer. This study aims to use serum metabolites as promising non-invasive biomarkers for colorectal cancer detection and prognostication. Differences in serum metabolites in patients with adenomatous polyps, colorectal cancer, and healthy controls are considered to be able to support the prognosis of colorectal cancer. Methods: Metabolite dataset is taken from the Metabolomic Workbench. Analysis and validation are carried out in silico using machine learning …

The Effectiveness Of Drawing As A Study Tool For Success In Human Anatomy And Physiology, Gracie C. Willis

Honors Theses

Human Anatomy and Physiology courses are packed with substantial information to obtain and retain over a semester. Study techniques students integrate into their studies are indispensable in affecting their success or failure in Human Anatomy and Physiology courses. This study aimed to determine if using drawing as a study technique would positively or negatively impact students' success or failure rate in Human Anatomy and Physiology I (A&P I) at the University of Mississippi. Participants were divided into three groups based on the degree of participation. Group A students chose only to release their unidentified test scores. Group B students released …

Researching The Profitability And Necessity For An Orthobiologics Center For The Lehigh Valley Orthopedic Institute (Lvoi) At Lehigh Valley Health Network, Matthew Barraco, Jennifer Roeder Mba, Jennifer Burrell Mha, Chelsea Evans Do

Research Scholars

No abstract provided.

Ifit2 Restricts Murine Coronavirus Spread To The Spinal Cord White Matter And Its Associated Myelin Pathology, Madhav Sharma, Debanjana Chakravarty, Afaq Hussain, Ajay Zalavadia, Amy Burrows, Patricia Rayman, Nikhil Sharma, Lawrence C. Kenyon, Cornelia Bergmann, Ganes C. Sen, Jayasri Das Sarma

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Interferon-induced protein with tetratricopeptide repeats 2, Ifit2, is critical in restricting neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2-deficient (-/-) compared to wild-type (WT) mice results in impaired acute microglial activation, reduced CX3CR1 expression, limited migration of peripheral lymphocytes into the brain, and impaired virus control followed by severe morbidity and mortality. While the protective role of Ifit2 is established for acute viral encephalitis, less is known about its influence during the chronic demyelinating phase of RSA59 infection. To understand this, RSA59 infected Ifit2-/- and Ifit2+/+ (WT) were observed for neuropathological outcomes at day 5 (acute phase) and 30 …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

Georgia Southern Sets Fundraising Record for Third Year in a Row

2023 Summer Undergraduate Research Program, University Of Northern Iowa. Sumer Undergraduate Research Program.

Summer Undergraduate Research Program (SURP) Symposium Programs

The program for the Summer Undergraduate Research Symposium of the College of Humanities, Arts and Sciences.

Loss Of Metabolic Fitness Drives Tumor Resistance After Car-Nk Cell Therapy And Can Be Overcome By Cytokine Engineering, Li Li, Vakul Mohanty, Jinzhuang Dou, Yuefan Huang, Pinaki P Banerjee, Qi Miao, Jens G Lohr, Tushara Vijaykumar, Julia Frede, Birgit Knoechel, Luis Muniz-Feliciano, Tamara J Laskowski, Shaoheng Liang, Judy S Moyes, Vandana Nandivada, Rafet Basar, Mecit Kaplan, May Daher, Enli Liu, Ye Li, Sunil Acharya, Paul Lin, Mayra Shanley, Hind Rafei, David Marin, Stephan Mielke, Richard E Champlin, Elizabeth J Shpall, Ken Chen, Katayoun Rezvani

Faculty, Staff and Student Publications

Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is promising, with early-phase clinical studies showing encouraging responses. However, the transcriptional signatures that control the fate of CAR-NK cells after infusion and factors that influence tumor control remain poorly understood. We performed single-cell RNA sequencing and mass cytometry to study the heterogeneity of CAR-NK cells and their in vivo evolution after adoptive transfer, from the phase of tumor control to relapse. Using a preclinical model of noncurative lymphoma and samples from a responder and a nonresponder patient treated with CAR19/IL-15 NK cells, we observed the emergence of NK cell …

Recent Progress Of Bifunctional Electrocatalysts For Oxygen Electrodes In Unitized Regenerative Fuel Cells, Tian-Long Zheng, Ming-Yu Ou, Song Xu, Xin-Biao Mao, Shi-Yi Wang, Qing-Gang He

Journal of Electrochemistry

Unitized regenerative fuel cells (URFCs), which oxidize hydrogen to water to generate electrical power under thefuel cells (FCs) mode and electrolyze water to hydrogen under the water electrolysis (WE) mode for recycling, areknown as clean and sustainable energy conversion devices. In contrast to the hydrogen oxidation reaction (HOR) andhydrogen evolution reaction (HER) on the hydrogen electrode side, the sluggish kinetics of oxygen reduction reaction(ORR) and oxygen evolution reaction (OER) on the oxygen electrode side requires highly efficient bifunctional oxygencatalysts. Conventional precious metal oxygen catalysts combine Pt and IrO₂ with excellent ORR and OER activities toachieve bifunctional electrocatalysis performance, but …

The Prevalence Of Diabetes In Juveniles, Tatyana Johnson

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Diabetes mellitus, simply known as diabetes, is a metabolic disorder that impacts how the body makes use of glucose or blood sugar. Glucose is the primary supply of energy for the body’s cells, which is controlled by insulin, a pancreatic hormone. Diabetes results in high blood glucose levels (hyperglycemia), which are caused by either insufficient insulin production by the pancreas or ineffective insulin utilization by the body (Dean & McEntyre, 2004). Although there are several types of diabetes, the two main types are type 1 and type 2. Type 1, also known as juvenile diabetes, is an inflammatory condition in …

Biotic Interactions And The Maintenance Of Biodiversity Across A Tropical Elevational Gradient, David Henderson

Arts & Sciences Graduate Student Theses and Dissertations

A major goal of community ecology is to elucidate the processes that create patterns of biodiversity. Specifically, the discipline focuses on the processes that influence community assembly, diversity gradients, and/or species coexistence. Coexistence mechanisms have been traditionally thought of in terms of resource competition, whereby species are able to coexist by having different niche requirements, both biotic and abiotic, that maximize their fitness. Much of the previous work in this arena focused on the abiotic factors that influence species coexistence. However, many of the seminal ideas about the forces that drive abundance and coexistence patterns hypothesized that it was differences …

Vascular Plants Of The Caribou-Targhee National Forest And Curlew National Grassland In Southeastern Idaho, Western Wyoming, And Northern Utah, Michael Daines

Electronic Theses & Dissertations

Due to a historical paucity of collections from and the absence of a comprehensive floristic treatment for parts of the Caribou-Targhee National Forest and Curlew National Grassland, an updated inventory for the area was needed. I present an annotated checklist of the vascular plants documented from the Caribou-Targhee National Forest and Curlew National Grassland. A total of new 3189 voucher specimens were collected for this project in 2021 and 2022. To compile the annotated checklist, I consulted both newly collected specimens and specimen data from online botanical databases. A total of 1557 taxa (species, subspecies, varieties, and hybrids), 1423 species …

Neutral Theory And Beyond: A Systematic Review Of Molecular Evolution Education, Desiree Forsythe, Jeremy L. Hsu

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Molecular evolution—including the neutral theory of molecular evolution—is a major sub-discipline of evolution and is widely taught in undergraduate evolution courses. However, despite its ubiquity, there have not been any previous attempts to compile and review the molecular evolution education literature. Here, we draw upon the framework proposed in a past literature review examining the broader evolution education landscape to conduct a literature review of papers related to molecular evolution education, classifying the contributions of such papers to evolution pedagogy as well as evolution education research. We find that there remains very limited coverage of molecular evolution in the education …

Nanoparticle-Mediated Therapy With Mir-198 Sensitizes Pancreatic Cancer To Gemcitabine Treatment Through Downregulation Of Vcp-Mediated Autophagy, Christian Marin-Muller, Dali Li, Jian-Ming Lü, Zhengdong Liang, Osvaldo Vega-Martínez, Sue E Crawford, Mary K Estes, William E Fisher, Changyi Chen, Qizhi Yao

Faculty, Staff and Students Publications

Pancreatic ductal adenocarcinoma (PDAC) remains an extremely aggressive disease characterized by rapidly acquired multi-drug resistance, including to first-line chemotherapeutic agent gemcitabine. Autophagy is a process that is often exploited by cancer and is one of several intrinsic factors associated with resistance to gemcitabine. We have previously found that miR-198 acts as a tumor suppressor in PDAC through the targeting of factors including Valosin-containing protein (VCP). VCP has been reported to play an important role in autophagic flux. In this study, we investigated whether the repression of VCP through miR-198 administration disrupts the autophagy process and sensitizes PDAC cells to gemcitabine …

Perspectives In Melanoma: Meeting Report From The Melanoma Bridge (December 1st–3rd, 2022-Naples, Italy), Paolo A Ascierto, Sanjiv S Agarwala, Allison Betof Warner, Marc S Ernstoff, Bernard A Fox, Thomas F Gajewski, Jérôme Galon, Claus Garbe, Brian R Gastman, Jeffrey E Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S Leidner, Roger S Lo, Alexander M Menzies, Olivier Michielin, Poulikos I Poulikakos, Jeffrey S Weber, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

Faculty, Staff and Student Publications

Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). Combinations of these checkpoint therapies with other agents are now being explored to improve outcomes and enhance benefit-risk profiles of treatment. Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. Unfortunately, many patients still progress and …

The Pulse, 1983 Spring, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on treating back pain, hospice services, medical research, an employee interview with a nurse, celebration of National Volunteer Week, and updates to personnel.

The Pulse, 1984 Winter, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on the new employee assistance program, Mount Sinai's involvement and history with medical students and research, the gift of a tapestry entitled "Compassion", laser technology, radiation therapy, and interviews with eight employees celebrating their 10-year anniversaries.

Effects Of Water Application Rates And Sawdust Biochar On The Physicochemical Properties Of Soil And Performance Of Five Tree Species Used In Urban Landscaping In Ondo, Nigeria, Ayodeji Adeyemi Ogunwole, Samuel Ohikhaena Agele Prof., Oluyemisi Dorcas Ogunwole

Cities and the Environment (CATE)

This study assessed the response to irrigation rate and the minimum irrigation rate for optimum growth of seedlings of five tropical tree species used in urban landscaping in Ondo, Nigeria. The study also evaluated the effects of irrigation rate and sawdust biochar on growth attributes and biochemical constituents of the seedlings and the changes in the physical and chemical properties of the soil on which the tree seedlings were grown. Seedlings of five tree species, Bauhinia monandra, Delonix regia, Terminalia catappa, Dypsis lutescens, and Veitchia merrillii, were subjected to six treatments as follows; The first three treatments comprised of seedlings …

Relationship Between Pedestrian Activity And Avian Body Condition During Fall Migration, Laura Marsh, David A. Aborn

Cities and the Environment (CATE)

Many North American landbirds undergo biannual migrations, which are energetically costly. Quality stopover sites are crucial to avian survival, as they provide opportunities to quickly replenish fat stores, rest, and avoid predation. One component of habitat quality that is often overlooked is the level of pedestrian activity, which birds may interpret as a predatory threat. If intrusion levels are high, birds will flush repeatedly and may not adequately restore energy reserves, which hinders successful migration. We compared body mass index between birds at different intrusion levels, testing the hypothesis that birds near continuous intrusion will be in poorer condition. Results …

Infinite Diversity Or Infinite Opportunity: A Look At Star Trek And Its Cultural Influence, Kendra Vaughan

History in the Making

No abstract provided.

Mixing: A History Of Anti-Miscegenation Laws In The United States, Nyla Provost

History in the Making

For over a century, many Americans believed that interracial marriage was unnatural. From the late 1860s through the late 1960s, the American legal system supported the belief that interracial marriages were illegitimate. In this paper, I examine how anti-miscegenation laws promoted and sustained white supremacy, socioeconomic position, and racial caste using antimiscegenation literature, legislation, and court cases. This study is significant because it examines the impact that anti-miscegenation laws had on the United States’ racial caste system and the American justice system.

Reproductive Abuse And The Sterilization Of Women Of Color, Bshara Alsheikh

History in the Making

Women of color have long suffered targeted and systematic racial discrimination and attempts to control their populations by the state. Well after eugenic rhetoric and policies’ prime in the 1930s and 1940s, and the Civil Rights movements of the mid-century, Chicana, Black, and Indigenous women continued to be victimized by state-sanctioned eugenic policy. This paper examines the way that eugenic rhetoric and policy evolved from the first sterilization laws in the nation passed in California that targeted criminality to later legislation and rhetoric that explicitly targeted racial minorities.

Redefining “Lgbtq+ Interculture” In Academia, Samantha Winterberg, Michelle Mccraney

Journal of Educational Research and Practice

Members of the LGBTQ+ community often face discrimination, harassment, and exclusion in academic settings, which can negatively impact their academic and personal success. Studies have shown that LGBTQ+ students are more likely to experience negative mental health conditions, drop out of school, and struggle to find employment after graduation. Cultural humility fosters diversity, equity, and inclusion, which is critical to ensuring an equitable educational experience for all students, particularly those from marginalized communities. Intercultural understanding is essential to develop cultural humility so that attitudes reflect empathy and tolerance of differences, including sexual or gender orientation variances or ambiguity. Understanding how …

The Passavant, 1976, V22 N1, March, Advocate Aurora Health

Historical Documents - Combined

Lutheran Hospital of Milwaukee, Milwaukee, WI: Annual news bulletin from the Lutheran Hospital of Milwaukee, Inc. This issue is a review of services and updates at the hospital in 1975. One of the new services is a Cardiac Pulmonary Rehabilitation Center.