Digital Commons Network^™

A Biologic-Device Combination Product Delivering Tumor-Derived Antigens Elicits Immunogenic Cell Death-Associated Immune Responses Against Glioblastoma, Christopher Cultrara, Christopher Uhl, Kenneth Kirby, Essam Abed Elrazaq, Amelia Zellander, David W. Andrews, Charles B. Scott, Lorenzo Galluzzi, Mark A. Exley, Jenny Zilberberg

Department of Neurosurgery Faculty Papers

Background IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of immunostimulatory signals to patients with glioblastoma (GBM). IGV-001 consists of patient-derived GBM cells treated with an antisense oligodeoxynucleotide against insulin-like growth factor 1 receptor (IGF1R) and placed in proprietary biodiffusion chambers (BDCs). The BDCs are then exposed to 5–6 Gy radiation and implanted at abdominal sites for ~48 hours. IGV-001 has previously been shown to be generally safe with promising clinical activity in newly diagnosed GBM patients.

Methods Mouse (m) or human (h) variants of IGV-001 …

Heavy Metals Within The Hawaiian Islands Archipelago As Evidenced In The Hawaiian Monk Seal And Their Prey, Yvanna M. Strait

All HCAS Student Capstones, Theses, and Dissertations

The Hawaiian monk seal (HMS) is an endangered, endemic seal native to the Northwestern Hawaiian Islands (NWHI). During the 21^st century, members of the HMS population have established residency within the Main Hawaiian Islands (MHI). This habitat shift may increase exposure of the animals to greater anthropogenic (urban industrialization, agricultural practices, and military activity) and natural (volcanic activity) heavy metal contaminants. Induced coupled plasma mass spectroscopy (ICPMS) analysis compared 16 heavy metal concentrations in HMS bone segregated by region, age, and sex. In additions, metal concentrations from potential prey items from the southern extent of the Northwestern Hawaiian Islands …

Ocean-Based Climate Action And Human Rights Implications Under The International Climate Change Regime, Elisa Morgera, Mitchell Lennan, Kati Kulovesi, Bianca G La, Holly J. Niner, Ellycia Harrould-Kolieb, Piva E Recio, Jeremy Hills, Mara Ntona, Alana Malinde Sn Lancaster, Mia Strand, Bernadette Snow, Kira Erwin, Lynne Shannon, Sian Rees, Kieran Hyder, Georg Engelhard, Kerry Howell

School of Biological and Marine Sciences

After drawing attention to the crucial role of marine biodiversity, including that of deep-sea ecosystems, in current scientific understanding of the ocean-climate nexus, this article highlights the limited extent to which the international climate change regime has so far addressed the ocean. The focus then shifts to how the international climate change regime could contribute to the protection of marine biodiversity as part of mitigation, adaptation and finance, taking into account human rights impacts and standards, drawing a comparison with REDD+. The article concludes with an original proposal, inspired by the Climate and Clean Air Coalition, to develop urgent, synergistic …

Victim Protection And The Dynamic Situation Of Human Trafficking: Indonesia Experience, Nathalina Naibaho

Indonesian Journal of International Law

Human trafficking is a global issue. It can arise in the context of national and/or transnational acts and are regulated by national and transnational criminal law mechanisms. However, in trafficking in person cases there are links between human trafficking and other related crimes such as drugs trafficking. Meanwhile, Indonesia has enacted laws which provide mandatory protection for victims of human trafficking. It also has mandatory drug laws which, in some cases, subject to the death penalty. This legislative conflict together with investigative and prosecutorial failure risks the conviction of human trafficked victims who are used as drug dealers in organized …

Green Infrastructure Intervention To Improve Waste And Water System In Urban Areas, Muthiah Hakim Hadini, Farah Bulqis Muzakar, Nurlina Yustiningrum, Nicole Hall, Peicong Li, Freya Ward, Ova Candra Dewi, Coriesta Dian Sulistiani, Andrew Flynn

Smart City

The increase in waste generation and water use in urban areas may lead to local flooding that is dangerous for health if it is not appropriately managed by waste and water systems in urban infrastructure. Sponge City is a concept that utilizes Green Infrastructures (GIs) to manage waste and water systems while still maintaining open and public spaces function. This study aims to review the waste and water infrastructure systems in Depok, Indonesia which are compared with Gainesville in the United States, America and Cardiff, United Kingdom, to give recommendations for preventing flooding in urban areas. Analysis is done by …

The First Chilean Satellite Swarm: Approach And Lessons Learned, Cristobal Garrido, Elías Obreque, Matias Vidal-Valladares, Samuel Gutierrez, Marcos Diaz Quezada, Carlos Gonzalez, Camilo Rojas, Tamara Gutierrez

Small Satellite Conference

SUCHAI 2, SUCHAI 3, and Plansat are three 3U CubeSats designed, manufactured, integrated, and tested by the Space and Planetary Exploration Laboratory at the University of Chile (SPEL). They were launched into space on April 1, 2022, aboard a D-Orbit ION platform. The ION deployer was carried into space on the SpaceX Falcon 9 Transporter 4 mission. The nanosatellites included payloads and experiments from several other national and international groups, all featuring different missions and configurations.

We developed the three CubeSats simultaneously. Some subsystems are the same, while others are specific to each satellite. They include scientific and technical payloads. …

Cloaked In Shadow: The Biopolitics Of Sauron’S Middle-Hell, Journee Cotton

Online Midwinter Seminar (OMS)

This paper considers hellish aspects of The Lord of the Rings through an environmental bioethical framework focusing on the intersection of biopolitics, race, and ecology. Key figures that shall be examined include Sauron, Saruman, Uruk-hai, and the body of Middle-earth. Sauron shall be read as a Hades figure; they share numerous connections, such as their domain is hell, influence over invisibility (Hades’ cloak and Sauron’s Ring), characterization of giver of gifts, possession of dead bodies, and connection to the earth’s fertility (or lack). Sauron’s possession over dead bodies arises from the necropolitical power he incites over bodies in his sphere …

On The Challenges Of Reaching Pupils With Spacetech-Related Extracurricular Activities, David Freismuth, David Wagner, Raphael Behrle, Stephan Galavics, Patrick Kappl

Small Satellite Conference

Today's rapid progress in space exploration leads to a high impact on our society. Especially young people are highly affected by this fascination. Despite this large pool of curious pupils, it remains challenging to find entry points into space and aeronautic-related careers for them. Often, these topics seem to be out of reach for most pupils. Educational programs like AstroPi (offered by ESA) or High School Aerospace Scholars (offered by NASA) target this issue. However, those projects never get into contact with actual outer space and remain mostly theoretical. The goal of the mission "SpaceTeamSat1" and the CubeSat with the …

Representing Quantum Spins In Different Coordinate Systems For Modelling Rigid Body Orientation, Nadjet Zioui, Aicha Mahmoudi, Mohamed Tadjine

Karbala International Journal of Modern Science

Various methods for representing the spatial orientation and rotation of objects are presented and compared with the quantum bit state representation. By contrasting spherical, Euler angle, quaternion, and quantum spin coordinate systems, this work highlights important concepts regarding the rotation axis of the X gate. Several ambiguities and incomplete definitions associated with the qubit state representation are discussed, such as the spin around the qubit itself and the explanation of the considered rotation angles and signs. A mathematical analysis of the physical meaning of each eigenstate is provided along with a new comprehensive and meaningful YPR-based 3D representation of a …

Quercetin As An Anticancer Candidate For Glioblastoma Multiforme By Targeting Akt1, Mmp9, Abcb1, And Vegfa: An In Silico Study, Muhammad Hermawan Widyananda, Setyaki Kevin Pratama, Arif Nur Muhammad Ansori, Yulanda Antonius, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Vikash Jakhmola, Maksim Rebezov, Mars Khayrullin, Marina Derkho, Emdad Ullah, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Alexander Patera Nugraha, Annise Proboningrat, Amaq Fadholly, Mada Triandala Sibero, Rahadian Zainul

Karbala International Journal of Modern Science

Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Protein-protein interaction (PPI) and functional annotation are carried out based on the obtained target proteins. Molecular docking and dynamics simulations are employed using AutoDock Vina and WebGro tools to analyze the interaction between Quercetin and its target proteins. The prediction of protein targets reveals that Quercetin directly targets four proteins associated …

Improving The Burt’S Sensitivity Using Noise Calibration Unit Via Crab Nebula Observations, Uday E. Jallod, Lana T. Ali, Hareth S. Mahdi, Kamal M. Abood

Karbala International Journal of Modern Science

Radio observations from astronomical sources like supernovae became one the most important sources of information about the physical properties of those objects. However, such radio observations are affected by various types of noise such as those from sky, background, receiver, and the system itself. Therefore, it is essential to eliminate or reduce these undesired noise from the signals in order to ensure accurate measurements and analysis of radio observations. One of the most commonly used methods for reducing the noise is to use a noise calibrator. In this study, the 3-m Baghdad University Radio Telescope (BURT) has been used to …

Elucidation Of Antibacterial, Synergistic, Antioxidant, And Anticancer Activities Of Green Synthesized Copper Oxide Nanoparticles Against Human Breast Cancer Cells, Ravindran Muthukumarasamy, Muhammad Luqman Bin Nisa, Nur Absarina Binti Rosli, Nurul Syazwani Binti Kamaruddin, Mohammad Danish, Afzan Binti Mahmad, M.N. Mohamad Ibrahim, Shahnaz Majeed

Karbala International Journal of Modern Science

The study conducted biosynthesis of copper oxide nanoparticles using an aqueous extract of Aspergillus niger and in-vestigated their potential biomedical applications. The nanoparticles were characterized using various techniques in-cluding UV-Vis, SEM, TEM, and EDX, revealing their spherical to crystalline shape with sizes ranging from 21 nm to 48 nm. The nanoparticles demonstrated notable antimicrobial activity against Staphylococcus aureus with a zone of 8 mm and Escherichia coli recorded high synergistic activity with 20.93%, as well as antioxidant properties. Furthermore, selective cytotoxicity towards breast cancer cells was observed with an IC50 of 107.81 ug/ml and an IC50 of 250.93 ug/ml on …

Assessing The Impact Of Daily Chlorhexidine Baths In Prevention Of Central Line Associated Bloodstream Infections: An Evidence Based Project, Brooke Rea

MSN Capstone Projects

Background: The rates of central line associated bloodstream infections (CLABSI) is a major concern in the healthcare industry. It is imperative that healthcare professionals take every precaution to prevent these life-threatening infections to the already critically ill patient.

Objective: The reason for this paper is to assess the effectiveness of the use of daily chlorhexidine baths in patients with central lines in the prevention of CLABSIs.

Narrative Review: A narrative review of evidence was conducted to assess the effectiveness of daily chlorhexidine bathing in patients with central lines. Twelve studies were moved forward in the project. Each of the twelve …

Gsk-J4 Inhibition Of Kdm6b Histone Demethylase Blocks Adhesion Of Mantle Cell Lymphoma Cells To Stromal Cells By Modulating Nf-Κb Signaling, Laia Sadeghi, Anthony P H Wright

Faculty, Staff and Student Publications

Multiple signaling pathways facilitate the survival and drug resistance of malignant B-cells by regulating their migration and adhesion to microenvironmental niches. NF-κB pathways are commonly dysregulated in mantle cell lymphoma (MCL), but the exact underlying mechanisms are not well understood. Here, using a co-culture model system, we show that the adhesion of MCL cells to stromal cells is associated with elevated levels of KDM6B histone demethylase mRNA in adherent cells. The inhibition of KDM6B activity, using either a selective inhibitor (GSK-J4) or siRNA-mediated knockdown, reduces MCL adhesion to stromal cells. We showed that KDM6B is required both for the removal …

Sars-Cov-2 Infection In Unvaccinated High-Risk Pregnant Women In The Bronx, Ny, Usa Is Associated With Decreased Apgar Scores And Placental Villous Infarcts, Sandra E. Reznik, Patricia M. Vuguin, Alexa Cohen, Rasha Khoury, Olivier Loudig, Ridin Balakrishnan, Susan A. Fineberg, Francine Hughes, Malini Harigopal, Maureen J. Charron

School of Medicine Faculty Publications

Babies born to severe acute respiratory syndrome corona virus-2 (SARS-CoV-2)-infected mothers are at greater risk for perinatal morbidity and more likely to receive a neurodevelopmental diagnosis in the first year of life. However, the effect of maternal infection on placental function and neonatal outcomes varies depending upon the patient population. We set out to test our hypothesis that maternal SARS-CoV-2 infection in our underserved, socioeconomically disadvantaged, mostly unvaccinated, predominantly African American and Latina population in the Bronx, NY would have effects evident at birth. Under IRB approval, 56 SARS-CoV-2-positive patients infected during the “first wave” of the pandemic with alpha …

Response To Conophillips' Opposition To Un Rapporteurs Amicus Brief, William Snape, David Hunter

Amicus Briefs & Court Filings

Defendant-Intervenor ConocoPhillips made a number of incorrect and misleading statements in their opposition to the UN Special Rapporteurs proposed amicus brief. This response explains the relationship of the UN Special Rapporteurs to American University’s Washington College of Law, as well as the employment status of the two attorneys who authored the UN Rapporteurs’ amicus brief.

The Good, The Bad, And The Mind-Body Problem: Dualistic Punishment And Torture In The Good Place, Katelynn Baerg

Online Midwinter Seminar (OMS)

Theories about the afterlife have been a constant fixation of humanity throughout history, illustrated through diverse mediums and genres. Literary and philosophical movements reflect and influence the shifts between the worldviews of traditional and modern writers. In comparing Michael Schur’s sitcom The Good Place with Dante Alighieri’s Inferno, this paper demonstrates how the writer’s depictions of torture and punishment reflect their respective positions on philosophical concepts of the human self. Through the lens of the mind-body problem proposed by Rene Descartes, I analyze how the relationship between the mind and body in the afterlife is explored in each depiction. …

Petrel For Astrophysics And Carbon Business, Hiroyuki Kobayashi, Kei Watanabe, Toshiki Ozawa, Kiyona Miyamoto, Yuki Amaki, Moe Yasuda, Keito Otsubo, Haruta Miki, Akihiro Tokuyasu, Daiki Kobayashi, Riku Nishio, Yusaku Ozeki, Katsuki Tashiro, Yusuke Arai, Ryo Saito, Asuka Ohira, Ryotaro Noto, Minori Fukuda, Yoichi Yatsu, Saburo Matunaga, Hiroaki Kobayashi, Toru Nakano, Masashi Uo, Takashi Yoshikawa, Eriko Kusunoki, Yu Murata, Norihide Takeyama, Akito Enokuchi

Small Satellite Conference

A multi-purpose 50kg class microsatellite hosting astrophysical mission and earth remote sensing, "PETREL", will be launched in 2023. In the night side, PETREL observe the ultra-violet sky with a wide-field telescope covering 50 deg^2 for surveying transient objects related to supernovae, tidal disruption events, and gravitational wave events. Our UV telescope can detect the early phase UV emission from a neutron star merger occurred within 150 Mpc. In addition to the satellite observation, PETREL sends a detection alert including the coordinate and brightness of the UV transient to the ground via the real time communication network within several minutes after …

The Green Future And The Golden Past: Issues And Approaches Regarding The Sustainability Of Historical Structures And Sites, Steven Moctezuma

Pace Environmental Law Review

This Article illustrates the harmonies and conflict between historic preservation and environmental law in the context of urgently meeting climate change challenges. The Article presents an overarching analysis of the relationship between historic preservation and environmentalism, discerning unifying aspects and modern conflicts through statutory laws and case studies. It begins with detailing the parallel goals between the two causes, drawing on key similarities between the National Historic Preservation Act and the National Environmental Policy Act, the main tools for ensuring federal review for each field, and highlighting sustainable refurbishment as a prime example on achieving both ends with the same …

The Need To Reconceptualize Wild Animals Post-Covid 19: Miscoordination Of Wildlife Regulations In China’S Food Legal Order, Yi Seul Kim

Pace Environmental Law Review

Today, China is one of the largest markets for wild animal trading. Yet, wild animals are in a regulatory grey area. There is an increasing need to revisit how wild animals are simultaneously but differently regulated in the food and wildlife protection regimes. Rarely do attempts to understand these two regimes occur, making this article's analysis of miscoordination in these bodies of law crucial in addressing the hindrance of nationwide food safety improvement efforts.

From Hell (Or Not): Representations Of Merlin And His Origins In The Comics, Michael A. Torregrossa

Online Midwinter Seminar (OMS)

The Arthurian figure of Merlin has a long literary history, but he never seems able to shake off the effects of his parentage. In medieval tradition, Merlin is sired by inhuman powers: first a seemingly benign dæmon and then a decidedly wicked demon. This preternatural aspect to his conception grants Merlin the skills and powers he uses to support the realm, yet it also taints him as someone potentially dangerous. Although Merlin’s background cannot be changed, creative artists often choose to ignore or alter his origins, especially when retelling his story for mass audiences. In contrast, other creators, usually those …

Control Of Small Spacecraft By Optimal Output Regulation: A Reinforcement Learning Approach, Joao Leonardo Silva Cotta, Omar Qasem, Paula Do Vale Pereira, Hector Gutierrez

Small Satellite Conference

The growing number of noncooperative flying objects has prompted interest in sample-return and space debris removal missions. Current solutions are both costly and largely dependent on specific object identification and capture methods. In this paper, a low-cost modular approach for control of a swarm flight of small satellites in rendezvous and capture missions is proposed by solving the optimal output regulation problem. By integrating the theories of tracking control, adaptive optimal control, and output regulation, the optimal control policy is designed as a feedback-feedforward controller to guarantee the asymptotic tracking of a class of reference input generated by the leader. …

Freeze-Drying As Chromobacterium Violaceum's Preservation Method For The Bixo Mission, Martín Blanco Prego, Zavier Manuel De Rada Piñeiro, Manuel Diz-Folgar, Daniel García-Lojo

Small Satellite Conference

Over the past few years, the space sector has witnessed a growing interest in exploring how biological organisms, such as Escherichia coli or Saccharomyces cerevisiae, respond to high radiation and microgravity environments. Among the various biological space missions, CubeSats, particularly SmallSats, have emerged as a popular platform for conducting such experiments owing to their reduced size and cost-effectiveness, which allows for the integration of miniaturized labs to study microorganisms onboard. However, the biggest challenge facing such missions is the preservation of living organisms for extended periods before the start of the experiments.

The UVigo SpaceLab team is currently developing a …

Records Management Practices In Government Ministries In Akwa Ibom State, Nigeria, Udoh Isaac Unwana, Angela Okeoghene Bello, Osaze Patrick Ijiekhuamhen

Library Philosophy and Practice (e-journal)

This study was on a survey of records management practices in state ministries in Akwa Ibom State, Nigeria. The survey design was used for the study, with the questionnaire as the instrument for data collection. The population of the study was one hundred and six (106) records management staff of the ministries studied. Two research questions were posed for investigation. The study revealed that various records are created by the ministries which include records on general administration, accounts and finance, sports, health, laws, education and environments. The study also revealed that the ministries used such facilities as wooden shelves, metallic …

A Summary Of Neural Radiance Fields For Shadow Removal And Relighting Of Satellite Imagery, Caleb Adams, Ignacio Lopez-Francos, Ellemieke Van Kints, Aiden Hammond

Small Satellite Conference

Multi-view stereo photogrammetric techniques are conventionally utilized to generate Global Digital Elevation Models (GDEM) of planetary and lunar surfaces. However, these methods, relying on conventional feature detectors, are often subject to inaccuracies caused by changes in lighting conditions, including diffuse reflection and harsh shading. This has limited the ability of these methods to accurately reconstruct shadowed regions in orbital imagery, such as highly shaded urban areas and the permanently shadowed regions (PSRs) located on the lunar surface, which are critical targets for NASA’s Artemis program. Neural Radiance Fields (NeRFs) offer a novel solution to these limitations by breaking away from …

Gene Expression Genetics Of The Striatum Of Diversity Outbred Mice., Vivek M. Philip, Hao He, Michael C Saul, Price E Dickson, Jason A. Bubier, Elissa J Chesler

Faculty Research 2023

Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. In this study, we profiled transcript abundance in the striatum of 386 Diversity Outbred (J:DO) mice of both sexes using RNA-Seq. All mice were characterized using a behavioral battery of widely-used exploratory and risk-taking assays prior to transcriptional profiling. We performed eQTL mapping, incorporated the results into a browser-based eQTL viewer, and deposited co-expression network members in GeneWeaver. The eQTL viewer allows researchers to query specific genes to obtain allelic effect …

Commencement Convocation Program, Usf, August 8, 2023, University Of South Florida

USF Graduation and Convocation Programs

King O'Neal Scholars - Emma Grace Atherton, Alisa Bakieva, Ginelle Renae Lauryn Brown, Tatyana Soribel Butler, Carter E. Casko, Carli Lilibeth Cohoon, Sarah Lou Shalom Dasent Shuler, Carlos Manuel Figueroa Palomino, Lanette Gonzalez-Lewis, Grace Angelique Heeke, Daniel Thomas Kortenhaus, Emily Margaret Logan, Makayla Long, Abigail Clariece McCurter, Elijah Callaway Mceuen, Sofia Elizabeth Mejia-Naccarato, Rachel Yvonne Stanton, Edward B. Williams, and Parisa Yazdankhah Kenary; Global Citizens Award - Sarah Bagnasco, Sydney Black, Carly Burton, Gladys D. Cantu, Sara Chaj, Lauren Flannery, Emily Hernandez, Anagha Hesaraghatta, Faith Pinamang, Katie Sarnelli, Natalie Spanhake, Kenya A. Sanchez Torres, and Neha Vemuri

Proposing A Measure Of Ethicality For Humans And Ai, Alejandro Jorge Napolitano Jawerbaum

Electronic Theses and Dissertations

Smarter people or intelligent machines are able to make more accurate inferences about their environment and other agents more efficiently than less intelligent agents. Formally: ‘Intelligence measures an agent’s ability to achieve goals in a wide range of environments.’ (Legg, 2008)

In this dissertation we extend this definition to include ethical behaviour and we will offer a mathematical formalism and a way to estimate how ethical an action is or will be, both for a human and for a computer, by calculating the expected values of random variables. Formally, we propose the following measure of ethicality, which is computable, or …

Analyzing Pseudomonas Aeruginosa With Bacteriophage Tags Using Photoacoustic Flow Cytometry, Jennifer C. Schinke

Electronic Theses and Dissertations

The number of daily bacterial infections is climbing and the CDC explains that this is due to the antibiotic-resistant threat in the United States. Finding a faster way of bacterial identification is necessary as it currently takes 1-4 days for a medical lab to culture and identify bacteria. Photoacoustic flow cytometry (PAFC) can be used as an alternative method resulting in swift identification within an hour (Edgar, 2019). Pseudomonas aeruginosa, cell line PA01, will be coated in up to a few hundred red dyed phages making it detectible by the photoacoustic flow cytometry system. Bacteriophages (phages) are viruses that …

Contributors

The Mythic Circle

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