Digital Commons Network^™

Decreasing Surgical Complications In Diabetic Patients, Bandana Mahato

DNP Qualifying Manuscripts

Executive Summary

Objective: This manuscript aims to determine if controlling diabetes prior to undergoing low back surgery could decrease complications and disability.

Contexts: Despite the overwhelming information on the complications of uncontrolled diabetes, patients continue to have elevated HgA1C before having surgery. Furthermore, there is a plethora of data showing uncontrolled diabetic patients will have higher complications after surgery, yet patients continue to have elective surgery despite having unchecked diabetes. There are no clear guidelines for primary care providers or surgeons on when they should allow patients to have elective surgery. Therefore, it is vital that HgA1c needs to be …

Medical School Watercooler Newsletter - December 8, 2023, Lindsey Lyle

Watercooler Newsletter

This is the December 8, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA breaks ground on $200 million Whiddon College of Medicine building
• Rayner awarded grant funding for biotechnology research center
• Meet a Med Student: Caroline Kinchler
• USA to break ground on new Whiddon COM building
• Alumnus and board-certified pediatrician joins pediatrics faculty

Improving Access To Early Interventions For Prediabetic Patients, Kimberleigh M. Telling

Doctor of Nursing Practice Projects

Approximately 88 million Americans, or nearly one-third of the population, have prediabetes. This condition has a high rate of progression to type 2 diabetes, reaching 70%. However, early identification, diagnosis, and participation in lifestyle interventions can effectively reduce the risk and promote euglycemia. Regrettably, 85% of those with prediabetes are unaware. The goal of this quantitative quality improvement project was to enhance the use of the prediabetes diagnosis code by primary care providers, who play a crucial role in preventing type 2 diabetes. The purpose was to improve access to early intervention for individuals with prediabetes, following the guidelines of …

Adaptive Social Distancing Strategies For Controlling Infection Inequality In Emerging Infectious Diseases, Asma Azizi, Caner Kazanci, Sunmi Lee

Faculty Articles

People fare in outbreaks of emerging infections based on social factors shaping their exposure and vulnerability to the virus. This different exposure cause a disproportionate share of prevalence among people with various socioeconomic statuses. Therefore, socioeconomic-based control strategies are needed to control the discrepancy in prevalence among socioeconomic groups. We propose and analyze a SIR mathematical model that is grouped based on individuals' income level (representing socioeconomic status). For the model's parameter, we use properties of a real-world social network of individuals residing in New Orleans, Louisiana. We then distribute the social distancing practice among different groups to minimize a …

The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim

Faculty, Staff and Student Publications

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 …

Development Of An Automated Delivery System To Apply Copper Sulfate Crystals Using Precision Dry Fertilizer Application Technology, Kevin Charles Wise

Theses and Dissertations

The digenetic trematode, Bolbophorus damnificus, poses a substantial threat to catfish aquaculture, causing significant economic losses. Infestations lead to suppressed feed consumption, secondary bacterial infections and poor production performance. Survey data reveals widespread infestation in the in the southeastern United States. Current control strategies involve the application of a concentrated copper sulfate solution to reduce snail populations which serve as the first intermediate host of the trematode life cycle. This study aimed to improve treatment efficacy by developing a granular copper sulfate application system. A modified Gandy fertilizer applicator, equipped with a programmable control system, demonstrated accurate distribution of copper …

The Impact Of Prior Pandemic Planning On Health Outcomes During The Covid-19 Pandemic: A Study Of Local Government Pandemic Planning In The United States, Karissa D. Bergene

Theses and Dissertations

In late 2019, scientists discovered a novel strain of coronavirus originating out of Wuhan, China. By January 2020, the United States (U.S.) saw its first positive case of coronavirus and the public was still unsure how serious of an epidemic this would be. By the time the World Health Organization declared the novel coronavirus disease (COVID-19) epidemic a “global pandemic” on March 11, 2020, world leaders, public health experts, scientists, and public administrators kicked into high gear to start serious pandemic response efforts. The public sector is typically the responsible authority for the preparedness, response, mitigation, and recovery of such …

The Migration Ecology Of North American Turkey Vultures Wintering In The Neotropics: Spatial And Population Dynamics, Adrián José Naveda-Rodríguez

Theses and Dissertations

The spatial and population dynamics of avian scavengers are poorly understood. This information is key for management and conservation interventions that guarantee long-term species conservation. My goal in this dissertation is to fill information gaps on the movement ecology of New World vultures using the Turkey Vulture (Cathartes aura) as a model species. I used a continental-wide satellite telemetry dataset to study the migration ecology, space-use, and demography of the three North American breeding populations of Turkey Vultures wintering in the Neotropics during a 17-year period. I found that primary productivity, but not weather, triggered Turkey Vulture migratory …

Opportunities For Mental Health Interventions In Rural Mississippi Communities During The Covid-19 Pandemic: A Quantitative Analysis, Brice Fortinberry

Theses and Dissertations

COVID-19 presented unique challenges for rural Mississippi communities including impacts on the mental health of rural individuals. This research study aimed to identify opportunities for mental health interventions to provide health promotion professionals with quantitative data on the accessibility and the likelihood of engagement with mental health-fostering behaviors. A secondary objective of this research was to categorize these behaviors within the constructs of the Social Ecological Model. Demographics for rural Mississippi communities were collected and displayed, and using multivariate analyses including Spearman’s correlation and a Mann-Whitney U test the correlation between mental health fostering behaviors and demographic factors was obtained. …

Increased Coding Potential Of Bovine Herpesvirus 1, Victoria Jefferson

Theses and Dissertations

Bovine respiratory disease (BRD) costs the cattle industry millions of dollars in costs in treatment and loss every year in the United States. A significant pathogen often contributes to BRD is Bovine Herpesvirus 1 (BoHV-1), a double stranded DNA virus with the ability to establish latency in the trigeminal ganglia and neurons. Primary infection with BoHV-1 results in immunosuppression that increases the risk of secondary bacterial infection and pneumonia. Because herpesviruses infect their hosts for life and can be reactivated in times of stress, BoHV-1 can present a recurring risk of BRD. The following research aims to expand the knowledge …

Therapeutic Effect Of Echinococcus Granulosus Cyst Fluid On Bacterial Sepsis In Mice, Shuying Wang, Donghui Jiang, Feifei Huang, Yayun Qian, Meitao Qi, Huihui Li, Xiaoli Wang, Zhi Wang, Kaigui Wang, Yin Wang, Pengfei Du, Bin Zhan, Rui Zhou, Liang Chu, Xiaodi Yang

Faculty, Staff and Students Publications

BACKGROUND: The primary pathophysiological process of sepsis is to stimulate a massive release of inflammatory mediators to trigger systemic inflammatory response syndrome (SIRS), the major cause of multi-organ dysfunction and death. Like other helminths, Echinococcus granulosus induces host immunomodulation. We sought to determine whether E. granulosus cyst fluid (EgCF) displays a therapeutic effect on sepsis-induced inflammation and tissue damage in a mouse model.

METHODS: The anti-inflammatory effects of EgCF were determined by in vitro culture with bone marrow-derived macrophages (BMDMs) and in vivo treatment of BALB/C mice with cecal ligation and puncture (CLP)-induced sepsis. The macrophage phenotypes were determined by …

Predictors Of Lung Cancer Screening Recommendation In Virginia Using The Community Health Assessment Survey, Aashish Batheja, Carrie Miller, Sunny Jung Kim, Bernard Fuemmeler F., Rajsh Balkrishnan

Virginia Journal of Public Health

Purpose: The purpose of this analysis was to determine the factors that may influence the probability of being recommended a lung cancer screening by a health professional in Virginia.

Methods: Data were obtained from the Community Health Assessment Survey conducted by the University of Virginia (UVA) Health System and Cancer System in collaboration with Virginia Commonwealth University (VCU) Cancer Center. SAS software was used to conduct a logistic regression with the following variables: age, sex, race, current smoking status, cancer history, education level, income level, insurance, and rurality.

Results: Statistically significant positive predictors included being a current smoker (OR: 3.504, …

Social Determinants Of Health, Telehealth, And Hiv/Aids: Implications For Public Health Research And Practice In The State Of Virginia, Sonal S. Sathe, Adati Tarfa

Virginia Journal of Public Health

Purpose: The purpose of this commentary is to assert the importance of addressing the social determinants of health to support HIV/AIDS control efforts, to describe the importance of telehealth in HIV/AIDS control, and to recommend courses of action to support HIV/AIDS control efforts within the state of Virginia.

Discussion: We provide an overview of the social determinants of health and their role in HIV/AIDS control, telehealth and its uptake within the HIV/AIDS community, and issues in Virginia facing HIV/AIDS control.

Conclusion and Recommendations: We conclude that addressing social determinants of health, especially stigma, is an important measure of HIV/AIDS control …

Virginia Journal Of Public Health Fall 2023

Virginia Journal of Public Health

No abstract provided.

Development Of Computational And Experimental Approaches For Rna Virus Serology, Brittany Kaye Smith

Arts & Sciences Graduate Student Theses and Dissertations

Neutralization assays like the plaque reduction neutralization test (PRNT) and focus reduction neutralization test (FRNT) are the most specific ways to measure neutralizing antibodies, which provide a good estimate of protection for RNA viruses. However, these assays are time-consuming, labor-intensive, and low-throughput. Alternative methods that are faster and convenient are necessary to quantify antibody responses in large-scale studies. In this dissertation, I develop a mix of computational and experimental methods to quantify antibody responses to dengue viruses (DENV) and SARS-CoV-2. DENV is the most significant mosquito-borne viral infection in humans. Four serotypes of DENV exist. Traditionally, infection with one serotype …

Strategies For Improving Small Farm Profitability In Sierra Leone, Christian Joe Sama

Walden Dissertations and Doctoral Studies

No abstract provided.

Carbapenem Resistant Enterobacterales In The United Arab Emirates: A Retrospective Analysis From 2010 To 2021, Jens Thomsen, Najiba M. Abdulrazzaq, The Uae Amr Surveillance Consortium, Dean B. Everett, Godfred Antony Menezes, Abiola Senok, Carole Ayoub Moubareck

All Works

Carbapenem-resistant Enterobacterales (CRE) are spreading in the United Arab Emirates (UAE) where their dissemination is facilitated by international travel, trade, and tourism. The objective of this study is to describe the longitudinal changes of CRE as reported by the national AMR surveillance system of the UAE. In this study, we retrospectively describe CRE isolated from 317 surveillance sites, including 87 hospitals and 230 centers/clinics from 2010 to 2021. The associated clinical, demographic, and microbiological characteristics are presented by relying on the UAE national AMR surveillance program. Data was analyzed using WHONET microbiology laboratory database software (http://www.whonet.org). A total of 14,593 …

Methicillin Resistant Staphylococcus Aureus In The United Arab Emirates: A 12-Year Retrospective Analysis Of Evolving Trends, Jens Thomsen, Najiba M. Abdulrazzaq, The Uae Amr Surveillance Consortium, Godfred Antony Menezes, Carole Ayoub Moubareck, Dean B. Everett, Abiola Senok

All Works

IntroductionMethicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program.MethodsWe carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR …

An Analysis Of Physical Wellness During Pregnancy, Mary Elizabeth Reynolds-Licciardello

Doctoral Dissertations and Projects

There is a lack of proper physical wellness increasing in society. This qualitative phenomenological study explored physical wellness during pregnancy using the theoretic framework of Social Cognitive Theory to show perceptions and lived experiences of women who are pregnant or who have been pregnant in the past three years. Three research questions were the focus of this qualitative study. RQ1: what aspects of physical wellness are important to women who are pregnant? RQ2: what are women’s physical wellness experiences during pregnancy? RQ3: how are women who are pregnant educated about physical wellness? Ten women in central Florida who are pregnant …

Exploring Educator Experiences Of Instructing Students With Disabilities During A Crisis: A Phenomenological Study, Laqueta Marie Wilson

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe teacher experiences in educating students with disabilities during a pandemic for K-5 teachers at John James K-8 school in the southeastern United States. The theory guiding this study was Bandura’s (1986) social cognitive learning theory, as it related to the importance of social learning on learners' cognition. Also, Universal Design for Learning was highlighted to suggest that all students should be taught in an inclusive setting. The central research question driving this study was, what are the lived post-pandemic experiences of general K-5 educators who instruct students with disabilities who return …

Novel Insights Into The Pathogenesis Of Human Post-Primary Tuberculosis From Archival Material Of The Pre-Antibiotic Era, 1931-1947, Syeda Mariam Riaz, Kurt Hanevik, Lars Helgeland, Lisbet Sviland, Robert L Hunter, Tehmina Mustafa

Faculty, Staff and Student Publications

OBJECTIVES: Primary and post-primary tuberculosis (TB) are distinct entities. The aim of this study was to study the histopathology of primary and post-primary TB by using the unique human autopsy material from the pre-antibiotic era, 1931-1947.

MATERIAL AND METHODS: Autopsy data were collected from the autopsy journals, and the human tissue was collected from the pathology archives at the Department of Pathology, the Gades Institute.

RESULTS: Histological presentations of TB lesions showed great diversity within a single lung. Post-primary TB starts as a pneumonia forming early lesions, characterized by the infiltration of foamy macrophages containing mycobacterial antigens within alveoli, and …

Biophysical Factors Affecting Habitat Suitability For Crassostrea Virginica, Jason D. Tilley

Dissertations

Oyster reefs provide a variety of important ecosystem services. However, the mortality rate of eastern oyster, Crassostrea virginica, the dominant species that produces oyster reefs in the northern Gulf of Mexico, is increasing at an alarming rate due to a variety of abiotic and biological factors. I examined how biophysical factors, including the less-studied fatty acid profiles of the suspended particulate matter on which oysters feed, influenced morphometric condition of C. virginica.

I sampled suspended particulate matter (SPM) and oysters in-situ in the western Mississippi Sound, which historically supported the majority of oyster production in Mississippi waters. Sampling …

Whole Genome Analysis Of Snv And Indel Polymorphism In Common Marmosets (Callithrix Jacchus), R Alan Harris, Muthuswamy Raveendran, Wes Warren, Hillier W Ladeana, Chad Tomlinson, Tina Graves-Lindsay, Richard E Green, Jenna K Schmidt, Julia C Colwell, Allison T Makulec, Shelley A Cole, Ian H Cheeseman, Corinna N Ross, Saverio Capuano, Evan E Eichler, Jon E Levine, Jeffrey Rogers

Faculty, Staff and Students Publications

The common marmoset (Callithrix jacchus) is one of the most widely used nonhuman primate models of human disease. Owing to limitations in sequencing technology, early genome assemblies of this species using short-read sequencing suffered from gaps. In addition, the genetic diversity of the species has not yet been adequately explored. Using long-read genome sequencing and expert annotation, we generated a high-quality genome resource creating a 2.898 Gb marmoset genome in which most of the euchromatin portion is assembled contiguously (contig N50 = 25.23 Mbp, scaffold N50 = 98.2 Mbp). We then performed whole genome sequencing on 84 marmosets …

Covid-19 Breakthrough Infections In Type 1 Diabetes Mellitus: A Cross-Sectional Study By The Covid-19 Vaccination In Autoimmune Diseases (Covad) Group, Suhrud Panchawagh, Naveen Ravichandran, Bhupen Barman, Arvind Nune, Mahnoor Javaid, Abraham Edgar Gracia-Ramos, Jessica Day, Mrudula Joshi, Masataka Kuwana, Sreoshy Saha

Medical College Documents

To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated …

A Qualitative Inquiry Into The Role Of Communication In Reputation Management During Compounding Health Crises, Shawna Dias, Romy Rw

Kaleidoscope: A Graduate Journal of Qualitative Communication Research

This research aims to evaluate how organizations manage their reputations with publics through compounding crises. The research applies concepts of public relations and crisis management, including situational crisis communication theory and organization-public relationship management. The research investigates a case of compounding health crises at a prominent American University, and assesses how communication managers prioritized publics and issue response, coordinated their communication strategies, and revised their communication practices in the wake of the compounding crises. Interviews were conducted with the three public relations managers who managed the events, and analysis was conducted on the University’s published social media content and artifacts …

Investigating The Effects Of Message Framing On College Students' Risk Perceptions And Protective Responses To Adenovirus, Shawna Dias, Romy Rw

Kaleidoscope: A Graduate Journal of Qualitative Communication Research

The purpose of this study is to investigate how message framing influences people’s risk perceptions, protective action decision making, and behavioral response. We make a case for both revising and extending the use of the protective action decision model (PADM) and message framing theory to examine the message characteristics of the adenovirus warnings during this crisis event, as well as participants’ impressions and behavioral responses to health risk communication messages. The data were collected from three focus group sessions, held at the University of Maryland. We found evidence to suggest that fear appeals and efficacy focused messaging may increase the …

Constructing And Validating Of The Covid-19 Fear Scale: Psychometric Evidence And Optimal Cut-Off Score From Palestine, Fakher Khalili

An-Najah University Journal for Research - B (Humanities)

Background: Various corona-phobia scales have been constructed to measure the levels of fear related to COVID-19. However, probably these scales were established based on the individualistic perspective, without pay attention to fear for others’ destiny. Objective: The current study is addressing the fear of COVID-19 in light of collectivistic values. Method: The present study constructed and validated a new scale measuring fear of COVID-19 among Palestinians (C-19FSP) based on a sample size of (885) respondents. Further, this study was designed to provide an optimal cut-off score for diagnosing corona-phobia. The study was carried out through two phases using a convenient …

Sutterella And Its Metabolic Pathways Positively Correlate With Vaccine-Elicited Antibody Responses In Infant Rhesus Macaques, Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K.A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana

School of Graduate Studies Faculty Publications

Introduction: It is becoming clearer that the microbiota helps drive responses to vaccines; however, little is known about the underlying mechanism. In this study, we aimed to identify microbial features that are associated with vaccine immunogenicity in infant rhesus macaques. Methods: We analyzed 16S rRNA gene sequencing data of 215 fecal samples collected at multiple timepoints from 64 nursery-reared infant macaques that received various HIV vaccine regimens. PERMANOVA tests were performed to determine factors affecting composition of the gut microbiota throughout the first eight months of life in these monkeys. We used DESeq2 to identify differentially abundant bacterial taxa, PICRUSt2 …

Flu Vaccine Hesitancy And Accessibility On The Onu Campus, Adia Welch

Honors Capstone Enhancement Presentations

I collected data from students and faculty at Ohio Northern about their ability to receive their flu vaccine on campus. Along with that, collecting opinions on why people did not receive their vaccine and addressing those issues. My goal is to use this information to help improve the vaccine clinics on campus so that more students and faculty can receive their vaccine. This includes making the clinics more accessible or at a more convenient time. This could also include raffles for clinics to improve attendance and the overall vaccination status of the university

Determinants Of Undernutrition In Children Under Five Years In The Southern Africa Sub-Region: A Scoping Review, George Gw Waliomuzibu Mukisa, Tonderai Tw Shumba, Andrit Al Lourens

Journal of Health Research

Background: Undernutrition remains a fundamental public health challenge responsible for impaired growth, mortality, and morbidity in children under five years. This review aimed to assess the current evidence on child undernutrition determinants within the Southern African subregion.

Methods: The review followed the Joanna Briggs Institute (JBI) methodology for scoping reviews. The search was conducted from electronic databases: PubMed, Cochrane, Google Scholar, Scopus, Embase, HINARI, EbscoHost and CINAHL. The search focused on studies on child undernutrition determinants conducted in the Southern African subregion and published in English between January 2000 and November 2022.

Results: The review showed that there …