Digital Commons Network^™

Deletion Of Vβ3, Cheng Ye, Sadie A Clements, Weihong Gu, Aron M Geurts, Clayton E Mathews, David V. Serreze, Yi-Guang Chen, John P Driver

Faculty Research 2023

In both humans and NOD mice, type 1 diabetes (T1D) develops from the autoimmune destruction of pancreatic beta cells by T cells. Interactions between both helper CD4

Improving Emergency Department Patient Satisfaction And Grow A Hospital's Revenue, Dr. Shayma Pushpa Firoz

Walden Dissertations and Doctoral Studies

No abstract provided.

Chronic Absenteeism: Exploring Causes, Impacts, And Interventions In Education, Arlee M. Hoag

Masters Projects

Chronic absenteeism among students presents a significant challenge within the educational landscape, impacting academic performance and contributing to educational disparities. This research delves into the multifaceted issue of chronic absenteeism, aiming to identify its root causes, implications, and potential interventions. The study examines diverse factors influencing student attendance, including socioeconomic barriers, health conditions, transportation challenges, and their subsequent impact on academic achievement. Moreover, it explores the inequities prevalent in absenteeism, aiming to shed light on disparities among student populations.

Spartan Daily, December 5, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 43

Addressing Resource Constraints For Alzheimer’S Dementia Patients And Caregivers In The Global South: An Interdisciplinary Approach, Zaheen Rashed '24

Student Research

There are two main focuses of this paper: to address the care that AD patients in countries with few healthcare resources receive and to explore the experiences of familial caregivers who care for these patients. This thesis will investigate issues including access to the education required to administer informed care, who is ultimately responsible for caring for AD patients in countries with few health facilities, and the lack of resources that is apparent in countries that do not have AD specialists or clinics. This paper will pinpoint the root issue in treating AD patients globally to serve as the first …

Resolution Of The Tetrabothrius Jagerskioeldi Cryptic Species Complex Among Holarctic Alcidae (Charadriiformes): Cestodes Among Fraterculinae—Exploring Marine Diversity, Host Range, And Dynamic Oceanography In The Greater North Pacific, Eric P. Hoberg, Kaylen Marie Soudachanh, Svetlana K. Bondarenko

MANTER: Journal of Parasite Biodiversity

In the biosphere, limits for diversity among species, communities, and biomes are revealed through intensive and extensive field-based inventory and assembly of voucher specimens and associated informatics examined in a phylogenetic, historical, ecological, and biogeographic arena. Archival resources for specimens and information contribute to a cumulative view of faunal structure and assembly under a comparative umbrella. Ultimately, species definitions, and inclusive partitions among populations and lineages, are fundamental in articulating hypotheses that examine interactions about evolution, the nature of organisms, and the condition of environments across space and time. We conclude our proposals establishing species limits for tapeworms of the …

A Credentialing Protocol Education To Enhance Nurse Float Pool Competency, Dalton J. Skipper

Walden Dissertations and Doctoral Studies

No abstract provided.

Association Between Viral Infections And Glioma Risk: A Two-Sample Bidirectional Mendelian Randomization Analysis, Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng, Vinay K Puduvalli, Ke Sai, Yunqian Li, Ye Cheng, Yonggao Mou

Faculty, Staff and Student Publications

Background: Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma risk. In this study, we used Mendelian randomization (MR) analysis to explore the direction and magnitude of the causal relationship between viral infection and glioma.

Methods: We conducted a two-sample bidirectional MR analysis using genome-wide association study (GWAS) data. Summary statistics data of glioma were collected from the largest meta-analysis GWAS, involving 12,488 cases and 18,169 controls. Single-nucleotide polymorphisms (SNPs) associated with exposures were used as instrumental …

Variability In Provider Assessment Of Sepsis And Potential Of Host Response Technology To Address This Dilemma—Results Of An Online Delphi Study, Chadd K. Kraus, Hollis R. O’Neal, Nathan A. Ledeboer, Todd W. Rice, Wesley H. Self, Richard E. Rothman

School of Medicine Faculty Publications

Potentially septic patients have a huge clinical and economic impact on hospitals and often present to the emergency department (ED) with undifferentiated symptoms. The triage of these patients is complex and has historically relied heavily upon provider judgment. This study aims to evaluate the consistency of provider judgment and the potential of a new host response sepsis test to aid in the triage process. A modified Delphi study involving 26 participants from multiple specialties was conducted to evaluate provider agreement about sepsis risk and to test proposed actions based on the results of a sepsis test. The participants considered case …

Making The Rounds, 1995, V1 N3, October 9, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Making the Rounds in Health, Faith, & Ethics", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue features a report on the possibility of a baboon-to-human bone marrow transplant as a possible therapy for HIV/AIDS patients, as well as medical news, and an essay from a chaplain.

Teacher Perceptions Of Challenges And Supports That Influence Their Decisions To Stay In Or Leave The Profession, Gayle Warmbrodt

Walden Dissertations and Doctoral Studies

No abstract provided.

Analyzing The Efficacy Of Covid-19 Travel Bans: A Regression Analysis Approach, Mallory Kochanek

Honors Projects

Some might associate the term ‘public health’ with the pandemic that occurred in 2020. COVID-19 spread like most have never seen in their lifetime. It is useful to look at the effectiveness of the travel re- strictions in mitigating the spread of the global pandemic. Using linear regression and network regression, we obtain parameter estimates to determine the relation of predictors, such as network effect, percentage of urban population and GDP, on the COVID-19 incidence rate for the months January to April of 2020. Linear regression does not ac- count for the correlation structure of the data. Network regression, on …

Sepsis Criteria On Triage (Scot): Sepsis Alert, Kristie Givens

Doctor of Nursing Practice Projects

Sepsis is a serious life-threatening condition that kills hundreds of thousands of patients every year and is a major leading cause of death. Sepsis is a medical emergency where early identification and prompt treatment are crucial for survival. Despite assessment tools for early recognition, a delay in antibiotic therapy remains. A sepsis alert (Code Sepsis) in the emergency department could improve sepsis care, spare countless lives, and save billions of dollars nationwide, annually. The implementation of a Code Sepsis will trigger a team to deliver immediate treatment and ensure one hour antibiotic administration times. The John Hopkins Nursing Evidence-Based Practice …

Evaluating The Effectiveness Of The Internal Transcribed Sequences (Its) As Dna Barcodes To Estimate Fungal Diversity, Jailisa Linares

All HCAS Student Capstones, Theses, and Dissertations

Universal phylogenetic markers such as the nuclear ribosomal internal transcribed sequences (ITS), specifically ITS1 and ITS2, are routinely used to estimate fungal diversity in environmental samples. However, numerous studies report differences in the performance and efficacy of ITS1 and ITS2 in documenting fungal diversity. To better understand the implications of using ITS1 versus ITS2, a comprehensive representation of the diverse fungal taxa was necessary to conduct a meta-analysis of their use across multiple fungal taxa. In order to address this, a thorough literature review was conducted to compare and contrast the use of ITS1 and ITS2 as effective DNA barcodes. …

Suction Circuit Flushing With Chlorhexidine Decreases Ventilator-Associated Pneumonia: A Quasi-Experimental Study, Mohamed H. Eid, Monica –.Marilena Ţânţu, Jos M. Latour, Mohammed Ahmed Sultan, Nahed Attia Kandeel

School of Nursing and Midwifery

Background: Endotracheal suctioning of mechanically ventilated patients differs across the world. In many low and middle-income countries, endotracheal suctioning is often performed with a sterile suctioning catheter that is used for 12 h or during the length of one nursing shift. The effect of flushing multiple used endotracheal suction system with chlorhexidine after suctioning to reduce ventilator associated pneumonia (VAP) remains unclear. Aim: The aim of the study is to assess the effectiveness of flushing multiple-used open endotracheal suction catheters and suctioning system with chlorhexidine gluconate 0.2% to reduce VAP in mechanically ventilated patients in a resource-limited Intensive Care Unit …

Changing The Playbook For Immigrant Health, Cheryl Bettigole, Patricia C. Henwood, Sage Myers, Maura Sammon

Department of Emergency Medicine Faculty Papers

Philadelphia’s response to welcoming Afghan evacuees during the COVID-19 pandemic suggests the need for a new approach to immigrant health care.

Older Adults' And Caregivers' Perceptions About Urinary Tract Infection And Asymptomatic Bacteriuria Guidelines: A Qualitative Exploration, Michael J Durkin, Viktoria Schmitz, Kevin Hsueh, Zoe Troubh, Mary C Politi

2020-Current year OA Pubs

OBJECTIVE: To explore older adults' and caregivers' knowledge and perceptions of guidelines for appropriate antibiotics use for bacteria in the urine.

DESIGN: Semi-structured qualitative interviews.

SETTING: Infectious disease clinics, community senior living facilities, memory care clinics, and general public.

PARTICIPANTS: Patients 65 years or older diagnosed with a urinary tract infection (UTI) in the past two years, or caregivers of such patients.

METHODS: We conducted interviews between March and July 2023. We developed an interview guide based on the COM-B (capability, opportunity, motivation-behavior) behavior change framework. We thematically analyzed written transcripts of audio-recorded interviews using inductive and deductive coding techniques. …

Fostering Critical Thinking Through Simulation: An Integrative Review, Sarah Knapp, Raymonta Green

Master of Science in Nursing Final Projects

Over the past decade simulation has become a staple of nursing education with increasing use during the COVID-19 pandemic. Both manikin-based and virtual simulation are used to increase the preparedness of nursing students for their roles at the bedside. With the increasing experience-complexity gap, it is important that students enter the workforce prepared to effectively care for patients. Simulation allows students to work with a patient scenario without the possibility of injury; in simulation, mistakes are opportunities instead of harm. This integrative review searched the literature questioning if in pre-licensure Bachelor of Science in Nursing students, do virtual simulation and …

Young Infants Display Heterogeneous Serological Responses And Extensive But Reversible Transcriptional Changes Following Initial Immunizations., Nima Nouri, Raquel Giacomelli Cao, Eleonora Bunsow, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Bennett Smith, Santtu Heinonen, Sara Mertz, Amy Leber, Gaby Smits, Fiona Van Der Klis, Asunción Mejías, Jacques Banchereau, Virginia Pascual, Octavio Ramilo

Faculty Research 2023

Infants necessitate vaccinations to prevent life-threatening infections. Our understanding of the infant immune responses to routine vaccines remains limited. We analyzed two cohorts of 2-month-old infants before vaccination, one week, and one-month post-vaccination. We report remarkable hetero- geneity but limited antibody responses to the different antigens. Whole-blood transcriptome analysis in an initial cohort showed marked overexpression of interferon-stimulated genes (ISGs) and to a lesser extent of inflammation- genes at day 7, which normalized one month post-vaccination. Single-cell RNA sequencing in peripheral blood mononuclear cells from a second cohort identified at baseline a predominantly naive immune landscape including ISGhi cells. On …

Activity Patterns Of The Endangered Amargosa Vole (Microtus Californicus Scripensis), Austin N. Roy, Anna D. Rivera Roy, Deana L. Clifford, Janet E. Foley

School of Earth, Environmental, & Marine Sciences Faculty Publications

Examining the activity patterns of wildlife is an important aspect of understanding the ecology of a species and may be especially important for species of conservation concern. We used remotely triggered cameras to describe the daily and seasonal activity patterns and examine ecological factors that influence the activity of the Amargosa Vole (Microtus californicus scirpensis), a California endemic listed federally and by the state as Endangered, and is a marsh habitatspecialist in the Mojave Desert. We found that vole activity was greatest during crepuscular periods, followed by nocturnal and diurnal periods. We saw strong seasonal effects, with the highest activity …

Raman Spectroscopic Analysis Of Human Serum Samples Of Convalescing Covid-19 Positive Patients, Hugh Byrne, Naomi Jackson, Jaythoon Hassan

Articles

Rapid screening, detection and monitoring of viral infection is of critical importance, as exemplified by the rapid spread of SARS-CoV-2, leading to the worldwide pandemic of COVID-19. This is equally the case for the stages of patient convalescence as for the initial stages of infection, to understand the medium and long terms effects, as well as the efficacy of therapeutic interventions. Optical spectroscopic techniques potentially offer an alternative to currently employed techniques of screening for the presence, or the response to infection. In this study, the ability of Raman spectroscopy to distinguish between samples of the serum of convalescent COVID-19 …

Exploration Of Agricultural Iot Breeding Tracking Based On A Saliency Visual Targettracking Algorithm, Fuzhi Wang, Changlin Song, Daijun Jiang

Turkish Journal of Agriculture and Forestry

The Internet of Things (IoT) is a development trend in modern industry and life. It can not only reduce the cost of industry and agriculture, but also improve the quality of products and the quality of people’s lives. Therefore, IoT breeding is the embodiment of modern intelligent agriculture. For example, in the estrus detection of beef cattle, the quality of video images when tracking beef cattle is reduced due to changes in external climate conditions and the difference between daytime and nighttime illumination. This paper introduces a visual target tracking algorithm based on saliency, so that it has better applicability …

Bingroup2: Statistical Tools For Infection Identification Via Group Testing, Christopher R. Bilder, Brianna D. Hitt, Brad J. Biggerstaff, Joshua M. Tebbs, Christopher S. Mcmahan

Department of Statistics: Faculty Publications

Group testing is the process of testing items as an amalgamation, rather than separately, to determine the binary status for each item. Its use was especially important during the COVID-19 pandemic through testing specimens for SARS-CoV-2. The adoption of group testing for this and many other applications is because members of a negative testing group can be declared negative with potentially only one test. This subsequently leads to significant increases in laboratory testing capacity. Whenever a group testing algorithm is put into practice, it is critical for laboratories to understand the algorithm’s operating characteristics, such as the expected number of …

Lasiodiplodia Theobromae Keratitis: A Rare Tropical Fungal Keratitis In A Non-Tropical Climate, Calvin Hamerski, A D. Proia

Osteopathic Medicine, Jerry M. Wallace School of

PURPOSE: We present the clinical and histopathological findings of a geographically unique fungal keratitis case in North Carolina. . is a rare cause of fungal keratitis, and all but one of the 51 previously reported cases have occurred in patients living in the tropics. OBSERVATIONS: A man in his early 50s developed keratitis after being struck in the left eye by a piece of debris while using a flexible-cord weed trimmer. Intracapsular lensectomy and penetrating keratoplasty were necessary when initial antimicrobial therapy was ineffective. The best-corrected visual acuity was 20/40 four years postoperatively. CONCLUSIONS AND IMPORTANCE: Our patient is only …

The Impact Of Covid-19 On Hispanic Restaurants In South-Central Texas: A Qualitative Study, Javier Apolinar

Theses & Dissertations

Research Focus. The COVID-19 pandemic generated a major crisis for the restaurant industry in 2020 and 2021. The nationwide shutdown resulted in widespread restrictions on social gatherings, significantly impacting this industry. Hispanic businesses were not immune to this crisis, and its impact had profound effects on small businesses.

Most of the research in this field has primarily concentrated on small businesses and entrepreneurship under favorable circumstances, highlighting factors such as entrepreneurial drive, maximizing profits, taking risks, developing ideas, and promoting fair competition. Consequently, the current body of research is insufficient and fails to address the specific experiences of minority small …

Perceptions Of Stress In Community Clinic Nurses During The Covid-19 Pandemic, Jomeka Smith

Dissertations

The COVID-19 pandemic is one of the largest healthcare crises that has affected the entire healthcare industry. Community health nurses in the front-line roles are greatly threatened by the COVID-19 pandemic that has decimated healthcare systems. The well-being of nurses is vital to perform their full potential of adequate patient care. Increased demands and pandemic related stressors can increase the risk of mental health problems. Nurses work in a variety of healthcare settings, however, the expectations, the fear of the unknown, and changes in demands have largely contributed to the unprecedented stressors that accompany nurses in clinical settings. Stress among …

Evaluation Of Intravenous Immunoglobulin Utilization In Pediatric And Neonate Population Within A Community Health System., Hannah Davis Pharm D Candidate, Robert D. Beckett Pharmd, Bcps, Heather Nichols Pharm D, Bcpps, Norm Fenn Bcps, Bcpps

Parkview Pharmacy Department

This project evaluated appropriateness of intravenous immunoglobulin (IVIG) use in pediatric and neonatal patients within a community health system based on current evidence. Presented at 2023 ASHP Midyear Clinical Meeting

Candidate Signatures Of Positive Selection For Environmental Adaptation In Indigenous African Cattle: A Review., Sumaya Kambal, Abdulfatai Tijjani, Sabah A E Ibrahim, Mohamed-Khair A Ahmed, Joram M Mwacharo, Olivier Hanotte

Faculty Research 2023

Environmental adaptation traits of indigenous African cattle are increasingly being investigated to respond to the need for sustainable livestock production in the context of unpredictable climatic changes. Several studies have highlighted genomic regions under positive selection probably associated with adaptation to environmental challenges (e.g. heat stress, trypanosomiasis, tick and tick-borne diseases). However, little attention has focused on pinpointing the candidate causative variant(s) controlling the traits. This review compiled information from 22 studies on signatures of positive selection in indigenous African cattle breeds to identify regions under positive selection. We highlight some key candidate genome regions and genes of relevance to …

Neutralizing Antibodies Against Ebv Gp42 Show Potent In Vivo Protection And Define Novel Epitopes, Qian Wu, Ling Zhong, Dongmei Wei, Wanlin Zhang, Junping Hong, Yinfeng Kang, Kaiyun Chen, Yang Huang, Qingbing Zheng, Miao Xu, Mu-Sheng Zeng, Yi-Xin Zeng, Ningshao Xia, Qinjian Zhao, Claude Krummenacher, Yixin Chen, Xiao Zhang

College of Science & Mathematics Departmental Research

Epstein-Barr virus (EBV) is the first reported human oncogenic virus and infects more than 95% of the human population worldwide. EBV latent infection in B lymphocytes is essential for viral persistence. Glycoprotein gp42 is an indispensable member of the triggering complex for EBV entry into B cells. The C-type lectin domain (CTLD) of gp42 plays a key role in receptor binding and is the major target of neutralizing antibodies. Here, we isolated two rabbit antibodies, 1A7 and 6G7, targeting gp42 CTLD with potent neutralizing activity against B cell infection. Antibody 6G7 efficiently protects humanized mice from lethal EBV challenge and …

The Leadership Experience Of Academic Chief Nurse Administrators In The State Of Georgia During The Covid-19 Pandemic Upon Return To Campus After Full Virtual Instruction: A Qualitative Study, Susie Jonassen

Dissertations

The impact of the COVID-19 global pandemic has been rated as the highest factor of intent to leave the profession in nurses serving in a leadership role. During the pandemic, crisis leadership swept across academia partly because nursing academia was not prepared for the rapid transition to virtual instruction. The reopening of nursing programs, while pandemic restrictions were still required, caused unprecedented disruptions and stress for academic leaders. One-third of nursing faculty anticipate retirement within the next two years. With the present burnout and shortage of nursing academia leaders, there was a need to explore the lived experience of academic …