Digital Commons Network^™

Advanced Structural Brain Aging In Preclinical Autosomal Dominant Alzheimer Disease, Peter R Millar, Brian A Gordon, Julie K Wisch, Tammie L.S. Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Randall J Bateman, Beau M Ances, Eric M Mcdade, Et Al.

2020-Current year OA Pubs

BACKGROUND: "Brain-predicted age" estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is underexplored in autosomal dominant AD (ADAD), in which AD progression is highly predictable with minimal confounding age-related co-pathology.

METHODS: We modeled BAG in 257 deeply-phenotyped ADAD mutation-carriers and 179 non-carriers from the Dominantly Inherited Alzheimer Network using minimally-processed structural MRI scans. We then tested whether BAG differed as a function of mutation and cognitive status, or estimated years until symptom onset, and whether it was associated with established …

Choosing A Sophisticated, Robust, And Secure Programming Language, J. Simon Richard

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper explores which programming languages maximize the quality and efficiency of software development projects requiring high levels of sophistication, security, and stability. Of the four languages discussed in this paper—C, C++, Java, and Rust—we conclude that Rust is the best for this application.

Parasympathetic Activity And Bronchial Hyperresponsiveness In Athletes, Audrey Badza

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Bronchial hyperresponsiveness (BHR) is a term used to describe the bronchial constriction response to environmental stimuli. BHR is increasingly common in endurance athletes due to increased exposure to some stimuli. The purpose of this review is to evaluate Stang et al.'s (2016) article, "Parasympathetic Activity and Bronchial Hyperresponsiveness in Athletes" and discuss the significance of their results. The results concluded that BHR is related to the parasympathetic activity of the heart rather than the pupils. The study concluded that there is an association between BHR and parasympathetic activity of the heart, methacholine is associated with BHR and cardiac vagal activity, …

Announcements, Japas Editors

Journal of Amish and Plain Anabaptist Studies

No abstract provided.

Review Of: Better Safe Than Sorry: Real-Life Stories, Tips, And More–A Guide To Everyday Safety—Mike Atnip, Nathan Shrock

Journal of Amish and Plain Anabaptist Studies

This book was written from an Anabaptist perspective geared towards a younger Christian Anabaptist and seems directed at an Amish audience. The book has six different sections relating to various parts of home and farm life. The goal of this book is to encourage the Anabaptist community to use more thought in what risks they take. The sections are as follows: Home and Community, Fire Safety, Farm and Logging Safety, Shop and Construction Safety, Gun/Hunting Safety, and Road Safety. I will be addressing each section individually and giving a summary of my thoughts at the end. Atnip does not specify …

Review Of: Caring For The Low German Mennonites: How Religious Beliefs And Practices Influence Health Care—Judith Kulig, Christina Klassen Jeffries

Journal of Amish and Plain Anabaptist Studies

My personal interest in reviewing this particular book is that I am a Low German speaking Mennonite involved in healthcare. As a disclaimer, I am not super fluent in the language. I was also not technically raised in the culture as described in this book, but I live in this community and know many people in this culture. As a healthcare worker, I was interested in reading this book to see what would be applicable to my practice. I was also curious how the book would apply to living in the Low German community. [First paragraph.]

Symposium Review: The Highway And Me And My Earl Grey Tea—Emily Smucker, Julia Martin, Karen Conley

Journal of Amish and Plain Anabaptist Studies

With its poetic lilt, The Highway and Me and My Earl Grey Tea beckons with the lure of travel, comforting drink in hand. To Conservative Mennonite author Emily Smucker, it is time to explore. Her world of 28 years has been Willamette Valley, OR, a place of faith and family while dealing with West Nile Disease and finishing college. Moving beyond the educational structure to pursue a career in writing posed new questions. “Where should I live? Where do I belong? What is my purpose? What is my identity?” [First paragraph.]

Review Of: Pull Through Blessings: The Colorful Tapestry Of Hirschsprung’S Disease—Lisa Sensenig And Helen Zimmerman, Adin Stauffer

Journal of Amish and Plain Anabaptist Studies

Hirschsprung’s Disease (HD) is a genetic condition found in a child born without ganglion cells in part of the intestines. Ganglion cells send signals to intestinal muscles to contract to help pass bowel movements. No signal means no bowel movement, which results in babies not eating, becoming uncomfortable and sleepy, spitting up, and if not treated, eventually dying. [First paragraph.]

Plain Anabaptists And Covid-19: A Distinct Response To Government Restrictions?, Michael Sauder

Journal of Amish and Plain Anabaptist Studies

Plain Anabaptists have a distinct way of relating to the government. Does that mean they would have distinct decision making processes in relation to government-promulgated public health restrictions regarding COVID-19? This essay argues that plain Anabaptist populations did not exhibit particularly unique decision-making and responses to COVID-19.

Bedside Diaries And Caregiver Journals: Plain Authors’ Accounts Of Medical Experiences, Jennifer Anderson

Journal of Amish and Plain Anabaptist Studies

Plain populations (Amish and some Mennonites) write nonfiction accounts of their medical experiences as a means of networking and sharing knowledge about medical conditions and care. These stories serve as a means of creating space to normalize the condition. These accounts are written in the form of medical dramas, “bedside diaries” (such as autobiographies and caregivers’ journals), and reference books. In this article, I propose that healthcare providers read bedside diaries and medical experience stories to learn how plain people process their medical experiences, utilize community support systems, and create meaning based on their faith and beliefs. A select bibliography …

Promoting Culturally Accessible, Community-Centered, Midwifery Care In The Rural Anabaptist Population Of Southwestern Ontario, Canada, Cynthia Soulliere

Journal of Amish and Plain Anabaptist Studies

The experience of providing midwifery care in a rural Southwestern Ontario community is discussed, highlighting specific approaches to providing culturally accessible and community-centered care among the Old Order Anabaptists. Midwives in Ontario are primary care providers for perinatal care and the clinic described in this paper works primarily with families from Anabaptist communities. Success in providing culturally accessible care has come from community engagement and responsiveness to ways to improve access to healthcare in this region. Highlighted in this article are the scope of midwifery care in Ontario, home and hospital births, collaboration with other community agencies, and community-based genetic …

Mother’S Hope: A Residential Program Caring For Plain Mothers With Mental Health Challenges, Renee Bright, Naomi Raber

Journal of Amish and Plain Anabaptist Studies

Mother’s Hope is a culturally sensitive residential program of hope and healing for plain Anabaptist mothers struggling with postpartum depression and anxiety. The home is situated in central Ohio and run by paid staff and Amish volunteers. While in residence, mothers get intensive attention from professional counseling and medical staff at nearby SpringHaven Counseling Center. This home is unique in that mothers are permitted to keep their infants with them in the home so that mother-child bonding is not interrupted while they receive mental health treatment. Several women, former residents at Mother’s Hope, shared their stories, which are included in …

Oil Therapy Massage As Complementary Care Of Burns And Wounds, Tristate Burn Care Team, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

Oil therapy massage is a part of the care of burns and wounds done by plain, lay caregivers in Amish and Mennonite communities across the United States and Canada. Oil therapy massage is used to manage scarring and to improve joint functionality and skin and tissue integrity. The purpose of this article is to describe oil therapy massage as a complementary part of after-burn care in the context of sociocultural values of plain populations in which caregivers are a part of the B&W movement. This article includes a brief description of the caring and sharing culture of plain peoples; a …

Attitudes Toward The Amish Held By Nursing And Social Work Students At A Midwestern University, Lora Wyss, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

As Amish populations increase and move across North America, the likelihood grows that healthcare professionals will come into contact with them. No studies have been conducted to examine contact frequency with or attitudes of healthcare providers toward the Amish. The aims of this study were to examine attitudes toward the Amish among nursing and social work students attending a Christian liberal arts university in a Midwestern state, and, to determine the relationship between students’ cultural awareness, their knowledge of the Amish, their contact with the Amish, and their attitudes toward the Amish. The participants were anonymously surveyed using the Revised …

Partnering With The Old Order Mennonites In The Finger Lakes Region Of New York State To Identify The Mechanisms Of Protective Immunity Against Atopic Disease Development, Alexandra N. Kaplan, Camille A. Martina, Elizabeth R. Catlin, John Looney, Kirsi M. Järvinen

Journal of Amish and Plain Anabaptist Studies

Old Order Mennonites (OOM) follow a traditional agrarian lifestyle; key aspects include home births, large families, limited antibiotic usage, consumption of whole foods and unpasteurized milk, and early exposure to soil, stables, and farm animals. There is evidence that a farming lifestyle protects against asthma and allergies, yet the biological mechanisms behind this protective effect remain unknown. The “Zooming into Old Order Mennonites” (ZOOM) cohort study was established to further explore protective factors and mechanisms. This study compares immune development among OOM children from the Finger Lakes Region of New York to those residing 65 miles northwest in Rochester, NY. …

Vitamin D Status Of Anabaptist Children In Southwestern Ontario, Canada, Janis A. Randall Simpson, Natalee Miller, Taylor Hartwig, Jane Leach, Melissa Purdy, Emily Roth, Victoria Mok Siue, Cynthia Soulliere, Jacqui Tam, Ann Watt

Journal of Amish and Plain Anabaptist Studies

The objective was to determine vitamin D status of Old Order Anabaptist children in rural Southwestern, Ontario, Canada, given concerns of community healthcare professionals. Fifty-two children (2.5 months - 6.5 years) (56% female) were recruited. Finger prick blood spot (BSp) samples were analyzed for 25-hydroxy (OH) vitamins D2 & D3 (BSp25(OH)D). Three-day food records were evaluated using Dietary Reference Intakes and Canada’s Food Guide (CFG) (Bush, et al. 2007). Compared to national Canadian data: mean BSp25(OH)D concentrations (78±31 nmol/L) were similar; a slightly smaller proportion (0% vs 2%) were at risk of deficiency (<30 nmol/L) or had inadequate status (4% vs 7%) (<40 nmol/L); and 10% vs 1% had BSp25(OH)D higher than 125 nmol/L. BSp25(OH)D was significantly associated (r2=0.358; p=0.001) with total vitamin D intake. From food alone, vitamin D intake was 68±39 IU/day, lower than the Recommended Dietary Allowance (RDA) of 600 IU/day, and intakes were all below the Estimated Average Requirement (EAR) of 400 IU. Even including supplemental vitamin D, 87% were below the EAR (total intake=213±194 IU/day). No children had vitamin D intakes greater than the Upper Limit. Servings of milk and alternates were 1.6±0.8/day (CFG=2/day). Unfortified farm milk was consumed by 88% of children and 89% received a vitamin D supplement. Results were comparable to recent Canadian data suggesting that most children have adequate vitamin D status. Nevertheless, these findings support the need to encourage appropriate vitamin D intake (from food and supplements) to achieve the RDA for Old Order Anabaptist children in these communities. [Abstract by authors.]

Health Beliefs, Health Practices, And Health-Seeking Behaviors Among Swartzentruber Amish In Clark County, Wisconsin, Courtney J. Schoessow

Journal of Amish and Plain Anabaptist Studies

Although the literature contains valuable information about Amish culture, few qualitative studies have been conducted on the health beliefs, health practices, and health-seeking behaviors of the Swartzentruber Amish, the most conservative group of Old Order Amish. The purpose of this study was to describe these dynamics for the Swartzentruber Amish of Clark County, Wisconsin. Utilizing the grounded theory approach, 25 participants were interviewed and seven themes were identified: shared decision-making is common in families; causes of illness are believed to be etiological or the will of God; home remedies are the first choice; preventive medicine is an unfamiliar concept; health …

Assessing The Attitudes And Perceptions Of The Old Order Amish Toward Genetic Testing For Familial Defective Apolipoprotein B-100, Erin Sutcliffe, Laura J. Conway, Alan Shuldiner, Toni Pollin

Journal of Amish and Plain Anabaptist Studies

Through a founder effect, one in eight Lancaster County, PA, Amish harbors the pathogenic APOB variant R3527Q, causing Familial Defective Apolipoprotein B-100 (FDB) that is rare in the general population. Affected individuals are at increased risk for high low density lipoprotein (LDL) cholesterol levels and cardiovascular disease and may benefit from early screening and treatment. A qualitative interview approach was used to investigate the genetic risk perceptions of the Amish and their attitudes towards genetic testing for FDB. The goal was to identify elements necessary for a successful program that would identify high risk individuals in the Lancaster County Amish …

Perceptions Regarding Drinking Water Quality And Its Effects On Human And Animal Health Among Plain-Sect Community Members, Anil Kumar Chaudhary, Parmveer Singh, Sharmistha Basak

Journal of Amish and Plain Anabaptist Studies

The quality of drinking water can affect human and animal health, and plain-sect populations may be more susceptible than other rural populations due to their use of traditional farm management practices and their reliance on well water. Therefore, an interdisciplinary team conducted a pilot study to understand the status of existing drinking water quality, community perceptions regarding causes of water deterioration, its associated effect on human and animal health, and solutions to address such challenges. The study included water testing and a focus group discussion with plain-sect community members. The findings revealed that participants perceived the drinking water quality as …

Health And Healthcare Among The Plain Anabaptist People, Rosanna Hess, Braxton Mitchell

Journal of Amish and Plain Anabaptist Studies

This issue of the Journal of Amish and Plain Anabaptist Studies (JAPAS) marks the eleventh year of publication of this journal, the flagship journal of the Amish & Plain Anabaptist Studies Association (APASA). In the past we have devoted entire issues to specific topics, including Beachy Amish-Mennonite churches [2017 5(1)], past and future directions of Amish studies [2017 5(2)], Ohio Amish schisms [2019 7(2)], gender-focused research [2020 8(2)], agriculture and the environment [2021 9(2)], and the plain people at midcentury [2023 11(1)]. In addition, the 2018 6(2) issue included a special section on health among the Amish. This …

Title Page And Table Of Contents 11(2), Japas Editors

Journal of Amish and Plain Anabaptist Studies

No abstract provided.

Does Federal Law Ban Mailing Abortion Drugs? A Textual Analysis Of 18 U.S.C. § 1461, Peter Allevato

Pepperdine Law Review

As the regulation of abortion availability returned to the States, many have grappled with so-called trigger laws: dormant laws that were set to take effect to restrict or ensure access to abortion should constitutional protection be revoked. While the federal government has no true trigger law, it does have long-unenforced laws prohibiting the mailing of “[e]very article or thing designed, adapted, or intended for producing abortion.” 18 U.S.C. § 1461 is an old law, and it has not been enforced for at least fifty years. But the law’s potential effect on the growing practice of mail-distribution of chemical abortion pills …

Lessons Learned: John Oros, Mary Anne Chute Lynch, Rosalind Z. Wiggins

Journal of Financial Crises

John Oros was managing director at the private investment firm J.C. Flowers & Co. (JCF) during the Global Financial Crisis of 2007–2009 (GFC); he is now an operating partner at the firm. In the fall of 2008, Oros worked as a senior member of the JCF team on projects involving Lehman Brothers, Merrill Lynch, and American International Group [AIG], as these firms were negotiating with lending banks, investment companies, and federal regulators to avoid collapse. Earlier in his career, Oros served as chairman of the Federal Savings and Loan Council from 1987 to 1989, during the savings and loan (S&L) …

Bi-Negativity: An Assessment Of Negativity Surrounding Bisexuality From The Lgbtq+ And Heterosexual Communities, Whitney R. Ford

The Confluence

This study was conducted to test the hypothesis that negative attitudes towards bisexual people (bi-negativity) exists within the LGBTQ+ and heterosexual communities and to determine if levels of bi-negativity are higher within the LGBTQ+ group. I administered the Gender-Based Attitudes Towards Bisexuality (GBAB) Scale by Nielsen et al. (2022) to measure bi-negativity using an online survey. The results, obtained from 87 participants who identify as LGBTQ+ and 121 participants who identify as heterosexual between the ages of 18 and 80, support my hypothesis that bi-negativity exists within both groups. However, contrary to my second hypothesis, higher levels of bi-negativity were …

Lipid Membrane Self-Assembly And Synthesis In The Lab By Rapid, Low-Cost Microfluidics Approaches, Kathleen Hardwick, Shane O'Reilly

SURE Journal: Science Undergraduate Research Experience Journal

Lipid membranes, which self-assemble in nature and under laboratory conditions, can form vesicles called liposomes. The main uses for liposomes are in drug delivery systems and as animal cell models. From the initial research into lipid membrane science, to the systematic literature review using Web of Science, to refining the project scope, to the description of the method, this project follows the process of developing a method for lipid membrane self-assembly and synthesis in the lab. The result was a rapid prototyping method for fabricating microfluidic devices to test different designs for channels, for use with a liposome synthesis protocol. …

An Investigation Into Dietary Fibre Intake, Bowel Function And Mood Among A Sample Of Irish Adults, Sophie Mulligan, Ellen Lynch, Suzanne Doyle

SURE Journal: Science Undergraduate Research Experience Journal

Background

Previous studies have examined the relationship between dietary fibre intake and mood and bowel function separately, however, no cross-sectional study has yet explored the relationship between all three variables. This study examines the association between dietary fibre intake, bowel function and mood in a cohort of Irish adults at a university campus.

Methods

A cross-sectional study was conducted. An online questionnaire was distributed to staff and students of TU Dublin through email and publicised using posters. Three validated surveys were used in the design of the questionnaire, to assess dietary fibre intake, mood and bowel function. All staff and …

Regulation Of Mirnas In Obesity And Diabetes, Eva Maher, Ava O'Meara, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The prevalence of obesity and obesity-related secondary disorders has increased dramatically in recent years. Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. Furthermore, miRNA expression profiles have emerged as promising targets for the novel treatment of diseases such as obesity. In order to enhance miRNA-based therapies, the miRNA expression profile of obesity and its related disorders must be monitored to further understand the underlying mechanisms of obesity and to identify novel targets.

Aim: The aim of …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …

Tiny But Mighty, An Exploration Of Microbes And Plants As Sources Of Small Novel Bioactive Compounds Against Invasive Mycoses., Hannah Mai Peacock, James Anthony O'Connor

SURE Journal: Science Undergraduate Research Experience Journal

Despite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier.

In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and Taraxacum officinale (common dandelion)) and two bacteria (Lacticaseibacillus paracasei and Staphylococcus epidermidis) were extracted and assayed for antifungal activity against Candida albicans and Saccharomyces cerevisiae. Thin layer chromatography and bioautography were then employed to assess the activity of the constituent components of sources showing antifungal activity.

Metabolites of S.epidermidis, and extracts …

Melittin: A Natural Component Of Honeybee Venom As A Potential Anti-Cancer Therapy, Niamh Donnellan, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

Cancer is a major cause of death worldwide and while chemotherapy is the main approach there are many negative associations in current treatment procedures. These include lack of selectivity, side effects and drug resistance. The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells.

Melittin is a major peptide component of bee venom which has shown to be efficacious as an anticancer agent in preclinical and animal models. Melittin has many biological functions including pore formation in the phospholipid bilayer …